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Title: Emodin ameliorates myocardial fibrosis in mice by inactivating the ROS/PI3K/Akt/mTOR axis

Journal Article · · Clinical and Experimental Hypertension
 [1];  [2];  [3];  [2];  [2];  [4]
  1. Department of Vascular Surgery, Hospital of Chengdu University of Traditional Chinese Medicine, Chengdu, P.R.China
  2. Department of biomedical engineer, General Hospital of Western Theater Command, Chengdu, P.R.China
  3. Department of Oncology, General Hospital of Western Theater Command, Chengdu, P.R.China
  4. School of Materials Science and Engineering, Southwest Jiaotong University, Chengdu, P.R.China

Not Available

Sponsoring Organization:
USDOE
OSTI ID:
2326133
Journal Information:
Clinical and Experimental Hypertension, Journal Name: Clinical and Experimental Hypertension Journal Issue: 1 Vol. 46; ISSN 1064-1963
Publisher:
Informa UK LimitedCopyright Statement
Country of Publication:
Country unknown/Code not available
Language:
English

References (28)

Tetrahydrocurcumin Ameliorates Diabetic Cardiomyopathy by Attenuating High Glucose-Induced Oxidative Stress and Fibrosis via Activating the SIRT1 Pathway journal May 2019
Emodin in Rheum undulatum inhibits oxidative stress in the liver via AMPK with Hippo/Yap signalling pathway journal January 2020
Emodin and emodin-rich rhubarb inhibits histone deacetylase (HDAC) activity and cardiac myocyte hypertrophy journal May 2020
Aloe-emodin attenuates myocardial infarction and apoptosis via up-regulating miR-133 expression journal August 2019
SGLT2 inhibition with empagliflozin attenuates myocardial oxidative stress and fibrosis in diabetic mice heart journal February 2019
Emodin Alleviates Liver Fibrosis of Mice by Reducing Infiltration of Gr1hi Monocytes journal January 2018
Emodin Attenuates Bleomycin-Induced Pulmonary Fibrosis via Anti-Inflammatory and Anti-Oxidative Activities in Rats journal January 2018
Emodin-induced autophagy against cell apoptosis through the PI3K/AKT/mTOR pathway in human hepatocytes journal September 2019
Asiatic acid inhibits cardiac fibrosis throughNrf2/HO-1 and TGF-β1/Smads signaling pathways in spontaneous hypertension rats journal September 2019
Emodin: A Review of its Pharmacology, Toxicity and Pharmacokinetics journal May 2016
Antiarrhythmic effect of lithium in rats after myocardial infarction by activation of Nrf2/HO-1 signaling journal December 2014
Emodin alleviates cardiac fibrosis by suppressing activation of cardiac fibroblasts via upregulating metastasis associated protein 3 journal July 2019
Linking LOXL2 to Cardiac Interstitial Fibrosis journal August 2020
Aloe-emodin prevents nerve injury and neuroinflammation caused by ischemic stroke via the PI3K/AKT/mTOR and NF-κB pathway journal January 2021
Emodin Retarded Renal Fibrosis Through Regulating HGF and TGFβ–Smad Signaling Pathway journal September 2020
Progesterone suppresses the progression of colonic carcinoma by increasing the activity of the GADD45α/JNK/c‑Jun signalling pathway journal April 2021
Understanding the Epidemiology of Heart Failure to Improve Management Practices: An Asia-Pacific Perspective journal April 2017
BMI1 promotes cardiac fibrosis in ischemia-induced heart failure via the PTEN-PI3K/Akt-mTOR signaling pathway journal January 2019
Aloe-emodin ameliorated MI-induced cardiac remodeling in mice via inhibiting TGF-β/SMAD signaling via up-regulating SMAD7 journal June 2023
Effects of emodin, a plant‐derived anthraquinone, on TGF‐β1‐induced cardiac fibroblast activation and function journal May 2021
Myocardial Interstitial Fibrosis in Heart Failure journal April 2018
Aloe-Emodin Ameliorates Renal Fibrosis Via Inhibiting PI3K/Akt/mTOR Signaling PathwayIn VivoandIn Vitro journal June 2019
Resveratrol ameliorates myocardial fibrosis by inhibiting ROS/ERK/TGF-β/periostin pathway in STZ-induced diabetic mice journal January 2016
BRD4 blockage alleviates pathological cardiac hypertrophy through the suppression of fibrosis and inflammation via reducing ROS generation journal January 2020
Pterostilbene Attenuates Fructose-Induced Myocardial Fibrosis by Inhibiting ROS-Driven Pitx2c/miR-15b Pathway journal December 2019
In vivo characterization of the aortic wall stress–strain relationship journal June 2010
Uncoupling Protein 2 Inhibits Myointimal Hyperplasia in Preclinical Animal Models of Vascular Injury journal October 2017
Epidemiology of heart failure: the prevalence of heart failure and ventricular dysfunction in older adults over time. A systematic review journal January 2016