Paternal preconception alcohol consumption increased Angiotensin II‐mediated vasoconstriction in male offspring cerebral arteries via oxidative stress‐AT1R pathway

Zhang, Ze; Zhang, Yumeng; Liu, Mingxing; Su, Hongyu; He, Yun; Zheng, Qiutong; Xu, Zhice; Tang, Jiaqi

doi:10.1111/adb.13385

Title: Paternal preconception alcohol consumption increased Angiotensin II‐mediated vasoconstriction in male offspring cerebral arteries via oxidative stress‐AT1R pathway

Journal Article · 14 March 2024 · Addiction Biology

DOI: https://doi.org/10.1111/adb.13385 · OSTI ID:2324696

Zhang, Ze ^[1]; Zhang, Yumeng ^[1]; Liu, Mingxing ^[2]; Su, Hongyu ^[1]; He, Yun ^[3]; Zheng, Qiutong ^[1]; Xu, Zhice ^[4];

^[1]

Institute for Fetology First Hospital of Soochow University Suzhou China
Infection Management Department First Hospital of Soochow University Suzhou China
Taixing People's Hospital Taixing China
Institute for Fetology First Hospital of Soochow University Suzhou China, Wuxi Maternily and Child Health Hospital Wuxi China

Abstract Alcohol consumption is popular worldwidely and closely associated with cardiovascular diseases. Influences of paternal preconception alcohol consumption on offspring cerebral arteries are largely unknown. Male rats were randomly given alcohol or water before being mated with alcohol‐naive females to produce alcohol‐ and control‐sired offspring. Middle cerebral artery (MCA) was tested with a Danish Myo Technology wire myograph, patch‐clamp, IONOPTIX, immunofluorescence and quantitative PCR. Alcohol consumption enhanced angiotensin II (AngII)‐mediated constriction in male offspring MCA mainly via AT1R. PD123,319 only augmented AngII‐induced constriction in control offspring. AngII and Bay K8644 induced stronger intracellular calcium transient in vascular smooth muscle cells (VSMCs) from MCA of alcohol offspring. L‐type voltage‐dependent calcium channel (L‐Ca ²⁺ ) current at baseline and after AngII‐stimulation was higher in VSMCs. Influence of large‐conductance calcium‐activated potassium channel (BK _C _a ) was lower. Caffeine induced stronger constriction and intracellular calcium release in alcohol offspring. Superoxide anion was higher in alcohol MCA than control. Tempol and thenoyltrifluoroacetone alleviated AngII‐mediated contractions, while inhibition was significantly higher in alcohol group. The mitochondria were swollen in alcohol MCA. Despite lower Kcnma1 and Prkce expression, many genes expressions were higher in alcohol group. Hypoxia induced reactive oxygen species production and increased AT1R expression in control MCA and rat aorta smooth muscle cell line. In conclusion, this study firstly demonstrated paternal preconception alcohol potentiated AngII‐mediated vasoconstriction in offspring MCA via ROS‐AT1R. Alcohol consumption increased intracellular calcium via L‐Ca ²⁺ channel and endoplasmic reticulum and decreased BK _Ca function. The present study provided new information for male reproductive health and developmental origin of cerebrovascular diseases.

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Sponsoring Organization:: USDOE

OSTI ID:: 2324696

Alternate ID(s):: OSTI ID: 2324698

Journal Information:: Addiction Biology, Journal Name: Addiction Biology Journal Issue: 3 Vol. 29; ISSN 1355-6215

Publisher:: Wiley-BlackwellCopyright Statement

Country of Publication:: Country unknown/Code not available

Language:: English

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