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Title: Association of female reproductive and hormonal factors with gallbladder cancer risk in Asia: A pooled analysis of the Asia Cohort Consortium

Journal Article · · International Journal of Cancer
DOI: https://doi.org/10.1002/ijc.34916 · OSTI ID:2323596
ORCiD logo [1];  [2]; ORCiD logo [3];  [4];  [5]; ORCiD logo [6]; ORCiD logo [7]; ORCiD logo [8];  [9]; ORCiD logo [10]; ORCiD logo [11]; ORCiD logo [12];  [13];  [14];  [15];  [16]; ORCiD logo [17]; ORCiD logo [18];  [19];  [11] more »;  [20];  [13]; ORCiD logo [21];  [16]; ORCiD logo [16];  [19];  [22];  [23];  [24]; ORCiD logo [25]; ORCiD logo [26]; ORCiD logo [27]; ORCiD logo [11]; ORCiD logo [3]; ORCiD logo [28] « less
  1. Department of Preventive Medicine Seoul National University College of Medicine Seoul Republic of Korea, Cancer Research Institute Seoul National University Seoul Republic of Korea, Integrated Major in Innovative Medical Science Seoul National University College of Medicine Seoul Republic of Korea, Medical Research Centre, Genomic Medicine Institute Seoul National University College of Medicine Seoul Republic of Korea
  2. Department of Preventive Medicine Seoul National University College of Medicine Seoul Republic of Korea, Medical Research Centre, Genomic Medicine Institute Seoul National University College of Medicine Seoul Republic of Korea
  3. Division of Prevention, Centre for Public Health Sciences, National Cancer Centre Institute for Cancer Control Tokyo Japan
  4. Division of Prevention, Centre for Public Health Sciences, National Cancer Centre Institute for Cancer Control Tokyo Japan, Hitotsubashi Institute for Advanced Study Hitotsubashi University Tokyo Japan
  5. Division of Prevention, Centre for Public Health Sciences, National Cancer Centre Institute for Cancer Control Tokyo Japan, Research Centre for Child Mental Development Hamamatsu University School of Medicine Hamamatsu Japan
  6. Sustainable Society Design Center Graduate School of Frontier Science, The University of Tokyo Tokyo Japan
  7. Department of Preventive Medicine Seoul National University College of Medicine Seoul Republic of Korea
  8. Division of Cohort Research National Cancer Centre, Institute for Cancer Control Tokyo Japan, National Institute of Health and Nutrition, National Institutes of Biomedical Innovation, Health and Nutrition Osaka Japan
  9. The Daffodil Centre The University of Sydney, a joint venture with Cancer Council NSW Sydney New South Wales Australia
  10. Department of Biomedical Sciences Seoul National University Graduate School Seoul Republic of Korea
  11. Division of Epidemiology, Vanderbilt‐Ingram Cancer Centre, Vanderbilt Epidemiology Centre Vanderbilt University Medical Centre Nashville Tennessee USA
  12. Division of Cohort Research National Cancer Centre, Institute for Cancer Control Tokyo Japan
  13. Department of Public Health Hokkaido University Faculty of Medicine Sapporo Japan
  14. Healthy Longevity Translational Research Programme, Yong Loo Lin School of Medicine National University of Singapore Singapore Singapore, Singapore Institute for Clinical Sciences, Agency for Science Technology and Research (A*STAR) Singapore Singapore
  15. Radiation Effects Research Foundation Hiroshima Japan
  16. Tohoku University Graduate School of Medicine Miyagi Prefecture Japan
  17. Graduate School of Cancer Science and Policy, National Cancer Centre Gyeonggi‐do Republic of Korea
  18. Department of Preventive Medicine Seoul National University College of Medicine Seoul Republic of Korea, Cancer Research Institute Seoul National University Seoul Republic of Korea, Integrated Major in Innovative Medical Science Seoul National University College of Medicine Seoul Republic of Korea
  19. Department of Preventive Medicine Chonnam National University Medical School Gwangju Republic of Korea
  20. Division of Cohort Research National Cancer Centre, Institute for Cancer Control Tokyo Japan, Graduate School of Public Health International University of Health and Welfare Tokyo Japan
  21. Division of Cancer Control and Population Sciences, UPMC Hillman Cancer Centre University of Pittsburgh Pittsburgh Pennsylvania USA, Department of Epidemiology, Graduate School of Public Health University of Pittsburgh Pittsburgh Pennsylvania USA
  22. Department of Public Health Sciences University of Chicago Chicago Illinois USA
  23. Stony Brook Cancer Centre Stony Brook University Stony Brook New York USA, Department of Medical and Surgical Sciences University of Bologna Bologna Italy
  24. Saw Swee Hock School of Public Health National University of Singapore Singapore
  25. Division of Cancer Epidemiology and Prevention Aichi Cancer Centre Research Institute Nagoya Japan, Department of Cancer Epidemiology Nagoya University Graduate School of Medicine Nagoya Japan
  26. School of Population Medicine and Public Health, Chinese Academy of Medical Sciences and Peking Union Medical College Beijing China
  27. Division of Cancer Epidemiology &, Genetics, Occupational and Environmental Epidemiology Branch, National Cancer Institute Bethesda Maryland USA
  28. Department of Preventive Medicine Seoul National University College of Medicine Seoul Republic of Korea, Integrated Major in Innovative Medical Science Seoul National University College of Medicine Seoul Republic of Korea
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Abstract The female predominance of gallbladder cancer (GBC) has led to a hypothesis regarding the hormone‐related aetiology of GBC. We aimed to investigate the association between female reproductive factors and GBC risk, considering birth cohorts of Asian women. We conducted a pooled analysis of 331,323 women from 12 cohorts across 4 countries (China, Japan, Korea, and Singapore) in the Asia Cohort Consortium. Cox proportional hazard models were used to estimate the hazard ratios (HRs) and corresponding 95% confidence intervals (CIs) to assess the association between reproductive factors (age at menarche, parity, age at first delivery, breastfeeding, and age at menopause) and GBC risk. We observed that a later age at menarche was associated with an increased risk of GBC (HR 1.4, 95% CI 1.16–1.70 for 17 years and older vs. 13–14 years), especially among the cohort born in 1940 and later (HR 2.5, 95% CI 1.50–4.35). Among the cohort born before 1940, women with a later age at first delivery showed an increased risk of GBC (HR 1.56, 95% CI 1.08–2.24 for 31 years of age and older vs. 20 years of age and younger). Other reproductive factors did not show a clear association with GBC risk. Later ages at menarche and at first delivery were associated with a higher risk of GBC, and these associations varied by birth cohort.

Sponsoring Organization:
USDOE
OSTI ID:
2323596
Journal Information:
International Journal of Cancer, Journal Name: International Journal of Cancer Vol. 155 Journal Issue: 2; ISSN 0020-7136
Publisher:
Wiley Blackwell (John Wiley & Sons)Copyright Statement
Country of Publication:
United States
Language:
English

References (27)

Five-year Relative Survival Rate of Gallbladder Cancer in the USA, Europe and Japan journal June 2014
Gallbladder cancer worldwide: Geographical distribution and risk factors journal January 2006
Estrogen and progesterone receptors in human gallbladder journal July 1986
Epidemiology of Gallbladder Disease: Cholelithiasis and Cancer journal April 2012
Trends in Gallbladder Cancer Incidence and Survival in Korea journal October 2018
Gallbladder cancer: epidemiology and genetic risk associations journal August 2019
Age of menopause and impact of climacteric symptoms by geographical region journal August 2010
Secular trends and associated factors of age at natural menopause in Taiwanese women journal May 2019
Association between Body-Mass Index and Risk of Death in More Than 1 Million Asians journal February 2011
Familial assimilation in transmission of raw-freshwater fish-eating practice leading to clonorchiasis journal April 2020
Secular trend in age at menarche for South Korean women born between 1920 and 1986: the Ansan Study journal January 2003
The Asian Menopause Survey: Knowledge, perceptions, hormone treatment and sexual function journal March 2010
Reproductive hormone concentrations in pregnancy and neonates: a systematic review journal July 2013
Socioeconomic position, lifestyle factors and age at natural menopause: a systematic review and meta-analyses of studies across six continents journal April 2014
Gallbladder Cancer in the 21st Century journal January 2015
A Secular Trend in Age at Menarche in Japan journal January 1980
Associations between reproductive factors and biliary tract cancers in women from the Biliary Tract Cancers Pooling Project journal October 2020
Reproductive factors and risks of biliary tract cancers and stones: a population-based study in Shanghai, China journal March 2010
Menopausal hormone therapy and risk of biliary tract cancers journal January 2022
The spectrum of sex differences in cancer journal April 2022
Age at natural menopause in Koreans: secular trends and influences thereon journal April 2018
Descriptive Epidemiology of Cholangiocarcinoma and Clonorchiasis in Korea journal January 2010
Menstrual factors and cancer risk among Korean women journal August 2011
Racial Differences in Physician Recommendation of Hormone Replacement Therapy journal December 2001
Secular Trend in age at Menarche in China: a case Study of two Rural Counties in Anhui Province journal April 1999
Complementary and Alternative Medicine for Menopause journal January 2019
Global Cancer Statistics 2020: GLOBOCAN Estimates of Incidence and Mortality Worldwide for 36 Cancers in 185 Countries journal February 2021

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