Pharmacokinetics and relative bioavailability study of two cefquinome sulfate intramammary infusions in cow milk

Li, Shuang; Yu, Na; Tang, Yaoxin; Liu, Chunshuang; Zhang, Ying; Chen, Xiaojie; Wu, Hao; Li, Xiubo; Liu, Yiming

doi:10.3389/fvets.2024.1384076

Title: Pharmacokinetics and relative bioavailability study of two cefquinome sulfate intramammary infusions in cow milk

Journal Article · 10 March 2024 · Frontiers in Veterinary Science

DOI: https://doi.org/10.3389/fvets.2024.1384076 · OSTI ID:2322608

Li, Shuang; Yu, Na; Tang, Yaoxin; Liu, Chunshuang; Zhang, Ying; Chen, Xiaojie; Wu, Hao; Li, Xiubo; Liu, Yiming

In this study, two intramammary infusions of cefquinome sulfate were investigated for pharmacokinetics and bioavailability. Twelve lactating cows for each group were administered an effective dose of 75 mg/gland for cefquinome, with milk samples collected at various time intervals. The concentrations of cefquinome in milk at different times were determined by the UPLC-MS/MS method. Analyses of noncompartmental pharmacokinetics were conducted on the concentration of cefquinome in milk. Mean pharmacokinetic parameters of group A and group B following intramammary administration were as follows: AUC _last 300558.57 ± 25052.78 ng/mL and 266551.3 ± 50654.85 ng/mL, C _max 51786.35 ± 11948.4 ng/mL and 59763.7 ± 8403.2 ng/mL, T _1/2 5.69 ± 0.62 h and 5.25 ± 1.62 h, MRT 7.43 ± 0.79 h and 4.8 ± 0.78 h, respectively. Pharmacokinetic experiments showed that the relative bioavailability of group B was 88.69% that of group A. From our findings, group B (3 g: 75 mg) shows a quicker drug elimination process than group A (8 g: 75 mg), which suggests that the withdrawal period for the new formulation may be shorter.

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Sponsoring Organization:: USDOE Office of Electricity (OE), Advanced Grid Research & Development. Power Systems Engineering Research

OSTI ID:: 2322608

Journal Information:: Frontiers in Veterinary Science, Journal Name: Frontiers in Veterinary Science Vol. 11; ISSN 2297-1769

Publisher:: Frontiers Media SACopyright Statement

Country of Publication:: Switzerland

Language:: English

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