The importance of ion kinetic energy for interference removal in ICP-MS/MS

French, Amanda D.; Melby, Kali M.; Hobbs, Kirby P.; Cox, Richard M.; Eiden, Greg; Hoppe, Eric W.; Arnquist, Isaac J.; Harouaka, Khadouja

doi:10.1016/j.talanta.2024.125799

Title: The importance of ion kinetic energy for interference removal in ICP-MS/MS

Journal Article · 20 February 2024 · Talanta

DOI: https://doi.org/10.1016/j.talanta.2024.125799 · OSTI ID:2322387

^[1];

^[1]; Eiden, Greg ^[2];

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^[1]; Harouaka, Khadouja ^[1]

Pacific Northwest National Laboratory (PNNL), Richland, WA (United States)
Pacific Northwest National Laboratory (PNNL), Richland, WA (United States); Idaho National Laboratory (INL), Idaho Falls, ID (United States)

Here, the effect of ion kinetic energy on gas phase ion reactivity with ICP-MS/MS was investigated in order to explore tuning strategies for interference removal. The collision/reaction gases CO₂, N₂O and O₂ were used to observe the ion product distribution for 48 elements using an Agilent tandem ICP-MS (ICP-MS/MS) as a function of reaction gas flow rate (pressure) and ion kinetic energy. The kinetic energy of the incident ion was varied by adjusting the octopole bias (V_oct). The three gases all form oxides (MO⁺) as the primary product with differing reaction enthalpies that result in distinct differences in the ion energies required for reaction with product ion distributions that vary with Voct. Consequently, by varying the ion kinetic energy (i.e., V_oct), differences in interference reactivity can be used to achieve maximum separation. Three practical application examples were reported to demonstrate how the ion kinetic energy can be varied to achieve the ideal ion product distribution for interference resolution: CO₂ for the removal of ²³⁸U in Pu analyses, CO₂ for the removal of ⁴⁰Ar¹⁶O vs. ⁵⁶Fe, and O₂ for the removal of Sm in Eu analyses, analogous to Pu/Am. The results demonstrate how the starting ion energy defined by V_oct is an important factor to fully leverage the utility of any given reaction gas to remove interferences in the mass spectrum using ICP-MS/MS.

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Research Organization:: Pacific Northwest National Laboratory (PNNL), Richland, WA (United States); Idaho National Laboratory (INL), Idaho Falls, ID (United States)

Sponsoring Organization:: USDOE Laboratory Directed Research and Development (LDRD) Program

Grant/Contract Number:: AC05-76RL01830; AC07-05ID14517

OSTI ID:: 2322387

Alternate ID(s):: OSTI ID: 2369068; OSTI ID: 2396698

Report Number(s):: PNNL-SA-190989; INL/JOU-24-77514-Rev000; TRN: US2409609

Journal Information:: Talanta, Vol. 272; ISSN 0039-9140

Publisher:: ElsevierCopyright Statement

Country of Publication:: United States

Language:: English

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Title: The importance of ion kinetic energy for interference removal in ICP-MS/MS

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