Synthesis and Characterization of Carbon-Based Quantum Dots and Doped Derivatives for Improved Andrographolide’s Hydrophilicity in Drug Delivery Platforms

Medina-Berríos, Nataniel; Pantoja-Romero, Wenndy; Flores, Alexis Lavín; Díaz Vélez, Sebastián C.; Martínez Guadalupe, Anna C.; Torres Mulero, Mariana T.; Kisslinger, Kim; Martínez-Ferrer, Magaly; Morell, Gerardo; Weiner, Brad R.

doi:10.1021/acsomega.3c06252

Title: Synthesis and Characterization of Carbon-Based Quantum Dots and Doped Derivatives for Improved Andrographolide’s Hydrophilicity in Drug Delivery Platforms

Journal Article · 06 March 2024 · ACS Omega

DOI: https://doi.org/10.1021/acsomega.3c06252 · OSTI ID:2320305

^[1]; Pantoja-Romero, Wenndy ^[1]; Flores, Alexis Lavín ^[1]; Díaz Vélez, Sebastián C. ^[1]; Martínez Guadalupe, Anna C. ^[1]; Torres Mulero, Mariana T. ^[1]; Kisslinger, Kim ^[2]; Martínez-Ferrer, Magaly ^[1]; Morell, Gerardo ^[1]; Weiner, Brad R. ^[1]

Univ. of Puerto Rico, San Juan, PR (United States)
Brookhaven National Laboratory (BNL), Upton, NY (United States)

Carbon-based quantum dots (CBQDs), sulfur-doped carbon-based quantum dots (S-CBQDs), and nitrogen-doped carbon-based quantum dots (N-CBQDs) have strong potential for drug delivery platforms. They were conjugated with andrographolide, a well-known hydrophobic drug, to study the concomitant changes in hydrophilicity. The interactions between these nanomaterials and the drug were studied by characterizing the optical and structural properties of the nanoparticles before and after coupling with the drug. It was found that the interaction of the drug with these nanomaterials produced noticeable changes in their optical and structural properties. Moreover, the partition coefficient for the nanocomposites was determined by NMR. The results indicate that conjugating the drug with the nanoparticles significantly enhanced its affinity for the aqueous phase, from 2.632 to 0.1117, thereby opening the possibility of using this approach for developing an effective drug delivery platform for this hydrophobic drug.

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Research Organization:: Brookhaven National Laboratory (BNL), Upton, NY (United States)

Sponsoring Organization:: USDOE Office of Science (SC), Basic Energy Sciences (BES). Scientific User Facilities (SUF); National Aeronautics and Space Administration (NASA); National Science Foundation (NSF); USDOE

Grant/Contract Number:: SC0012704; 307656; 308523; 80NSSC22M0025; 1626103

OSTI ID:: 2320305

Alternate ID(s):: OSTI ID: 2338128

Report Number(s):: BNL-225501-2024-JAAM

Journal Information:: ACS Omega, Vol. 9, Issue 11; ISSN 2470-1343

Publisher:: American Chemical Society (ACS)Copyright Statement

Country of Publication:: United States

Language:: English

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