The pathways and the mechanisms by which Cryptococcus enters the brain

Zhou, Yangyu; Huang, Yemei; Yang, Chen; Zang, Xuelei; Deng, Hengyu; Liu, Jing; Zhao, Enqi; Tian, Tingyue; Pan, Lei; Xue, Xinying

doi:10.1080/21501203.2023.2295409

Title: The pathways and the mechanisms by which Cryptococcus enters the brain

Journal Article · 13 February 2024 · Mycology

DOI: https://doi.org/10.1080/21501203.2023.2295409 · OSTI ID:2305408

Zhou, Yangyu ^[1]; Huang, Yemei ^[1]; Yang, Chen ^[2]; Zang, Xuelei ^[1]; Deng, Hengyu ^[3]; Liu, Jing ^[3]; Zhao, Enqi ^[1]; Tian, Tingyue ^[1]; Pan, Lei ^[1]; Xue, Xinying ^[4]

Department of Respiratory and Critical Care, Emergency and Critical Care Medical Center, Beijing Shijitan Hospital, Capital Medical University, Beijing, China
Department of Laboratory Medicine, Chinese PLA General Hospital, the First Medical Centre, Beijing, China
Department of Respiratory and Critical Care, Weifang Medical College, Weifang, China
Department of Respiratory and Critical Care, Emergency and Critical Care Medical Center, Beijing Shijitan Hospital, Capital Medical University, Beijing, China, Department of Respiratory and Critical Care, Weifang Medical College, Weifang, China

Not Available

View Journal Article

Cite

Export

Save

Sponsoring Organization:: USDOE Office of Electricity (OE), Advanced Grid Research & Development. Power Systems Engineering Research

OSTI ID:: 2305408

Journal Information:: Mycology, Journal Name: Mycology Journal Issue: 3 Vol. 15; ISSN 2150-1203

Publisher:: Informa UK LimitedCopyright Statement

Country of Publication:: United Kingdom

Language:: English

References (105)

Qi-Long-Tian formula extract alleviates symptoms of acute high-altitude diseases via suppressing the inflammation responses in rat Fu, Xing; Yang, Chunyan; Chen, Bing Respiratory Research, Vol. 22, Issue 1 https://doi.org/10.1186/s12931-021-01645-8	journal	February 2021
Neutral Amino Acid Transport Characterization of Isolated Luminal and Abluminal Membranes of the Blood-Brain Barrier del Pino, Manuel M. Sánchez; Peterson, Darryl R.; Hawkins, Richard A. Journal of Biological Chemistry, Vol. 270, Issue 25 https://doi.org/10.1074/jbc.270.25.14913	journal	June 1995
Phagocytosis Inhibits F-Actin-Enriched Membrane Protrusions Stimulated by Fractalkine (CX3CL1) and Colony-Stimulating Factor 1 Luo, Yong; Isaac, Beth M.; Casadevall, Arturo Infection and Immunity, Vol. 77, Issue 10 https://doi.org/10.1128/IAI.00530-09	journal	October 2009
Real-timein vivoimaging of fungal migration to the central nervous system Shi, Meiqing; Calaruso, Pina; Mody, Christopher H. Cellular Microbiology, Vol. 14, Issue 12 https://doi.org/10.1111/cmi.12027	journal	October 2012
Spores as Infectious Propagules of Cryptococcus neoformans Velagapudi, Rajesh; Hsueh, Yen-Ping; Geunes-Boyer, Scarlett Infection and Immunity, Vol. 77, Issue 10 https://doi.org/10.1128/IAI.00542-09	journal	July 2009
Targeting pericytes for neurovascular regeneration Geranmayeh, Mohammad Hossein; Rahbarghazi, Reza; Farhoudi, Mehdi Cell Communication and Signaling, Vol. 17, Issue 1 https://doi.org/10.1186/s12964-019-0340-8	journal	March 2019
Odontogenic Sinusitis Resulting in Abscess Formation Within the Optic Chiasm and Tract: Case Report and Review Ghobrial, George M.; Pisculli, Mary L.; Evans, James J. Journal of Neuro-Ophthalmology, Vol. 36, Issue 4 https://doi.org/10.1097/WNO.0000000000000430	journal	December 2016
When is a multidisciplinary approach required in management of intracranial complications of sinonasal inflammatory disorders? De Vita, Carla; Sollini, Giacomo; Zoli, Matteo Acta Otorhinolaryngologica Italica, Vol. 41, Issue Suppl. 1 https://doi.org/10.14639/0392-100X-suppl.1-41-2021-07	journal	April 2021
Fc Gamma Receptor 3A Polymorphism and Risk for HIV-Associated Cryptococcal Disease Rohatgi, Soma; Gohil, Shruti; Kuniholm, Mark H. mBio, Vol. 4, Issue 5 https://doi.org/10.1128/mBio.00573-13	journal	November 2013
Elucidating the Pathogenesis of Spores from the Human Fungal Pathogen Cryptococcus neoformans Giles, Steven S.; Dagenais, Taylor R. T.; Botts, Michael R. Infection and Immunity, Vol. 77, Issue 8 https://doi.org/10.1128/IAI.00334-09	journal	May 2009
Capsule Structure Changes Associated with Cryptococcus neoformans Crossing of the Blood-Brain Barrier Charlier, Caroline; Chrétien, Fabrice; Baudrimont, Marielle The American Journal of Pathology, Vol. 166, Issue 2 https://doi.org/10.1016/S0002-9440(10)62265-1	journal	February 2005
Astrocyte–Endotheliocyte Axis in the Regulation of the Blood–Brain Barrier Pivoriūnas, Augustas; Verkhratsky, Alexei Neurochemical Research, Vol. 46, Issue 10 https://doi.org/10.1007/s11064-021-03338-6	journal	May 2021
Ascorbate reverses high glucose- and RAGE-induced leak of the endothelial permeability barrier Meredith, M. Elizabeth; Qu, Zhi-Chao; May, James M. Biochemical and Biophysical Research Communications, Vol. 445, Issue 1 https://doi.org/10.1016/j.bbrc.2014.01.078	journal	February 2014
HIV-1 gp41 ectodomain enhances Cryptococcus neoformans binding to human brain microvascular endothelial cells via gp41 core-induced membrane activities Huang, Sheng-He; Wu, Chu-Hua; Jiang, Shibo Biochemical Journal, Vol. 438, Issue 3 https://doi.org/10.1042/BJ20110218	journal	August 2011
Cryptococcus neoformans Host Adaptation: Toward Biological Evidence of Dormancy Alanio, Alexandre; Vernel-Pauillac, Frédérique; Sturny-Leclère, Aude mBio, Vol. 6, Issue 2 https://doi.org/10.1128/mBio.02580-14	journal	May 2015
Astroglia support, regulate and reinforce brain barriers Verkhratsky, Alexei; Pivoriūnas, Augustas Neurobiology of Disease, Vol. 179 https://doi.org/10.1016/j.nbd.2023.106054	journal	April 2023
Induction of Brain Microvascular Endothelial Cell Urokinase Expression by Cryptococcus neoformans Facilitates Blood-Brain Barrier Invasion Stie, Jamal; Fox, Deborah PLoS ONE, Vol. 7, Issue 11 https://doi.org/10.1371/journal.pone.0049402	journal	November 2012
The Metalloprotease, Mpr1, Engages AnnexinA2 to Promote the Transcytosis of Fungal Cells across the Blood-Brain Barrier Na Pombejra, Sarisa; Salemi, Michelle; Phinney, Brett S. Frontiers in Cellular and Infection Microbiology, Vol. 7 https://doi.org/10.3389/fcimb.2017.00296	journal	June 2017
Clinical Manifestations of Cryptococcus gattii Infection: Determinants of Neurological Sequelae and Death Chen, Sharon C-A.; Slavin, Monica A.; Heath, Christopher H. Clinical Infectious Diseases, Vol. 55, Issue 6 https://doi.org/10.1093/cid/cis529	journal	June 2012
Mechanisms of Blood-Brain Barrier Disruption in Herpes Simplex Encephalitis Liu, Hui; Qiu, Ke; He, Qiang Journal of Neuroimmune Pharmacology, Vol. 14, Issue 2 https://doi.org/10.1007/s11481-018-9821-6	journal	November 2018
Paranasal sinus development and implications for imaging Goldman-Yassen, Adam E.; Meda, Karthik; Kadom, Nadja Pediatric Radiology, Vol. 51, Issue 7 https://doi.org/10.1007/s00247-020-04859-y	journal	May 2021
Lipid raft/caveolae signaling is required for Cryptococcus neoformans invasion into human brain microvascular endothelial cells Long, Min; Huang, Sheng-He; Wu, Chun-Hua Journal of Biomedical Science, Vol. 19, Issue 1 https://doi.org/10.1186/1423-0127-19-19	journal	February 2012
Leukocytes Breach Endothelial Barriers by Insertion of Nuclear Lobes and Disassembly of Endothelial Actin Filaments Barzilai, Sagi; Yadav, Sandeep Kumar; Morrell, Steven Cell Reports, Vol. 18, Issue 3 https://doi.org/10.1016/j.celrep.2016.12.076	journal	January 2017
Human Immunodeficiency Virus Type 1 Infection Increases the In Vivo Capacity of Peripheral Monocytes To Cross the Blood-Brain Barrier into the Brain and the In Vivo Sensitivity of the Blood-Brain Barrier to Disruption by Lipopolysaccharide Wang, Hongwei; Sun, Jinglin; Goldstein, Harris Journal of Virology, Vol. 82, Issue 15 https://doi.org/10.1128/JVI.00768-08	journal	August 2008
Invasion of brain microvascular endothelial cells by group B streptococci Nizet, V.; Kim, K. S.; Stins, M. Infection and Immunity, Vol. 65, Issue 12 https://doi.org/10.1128/iai.65.12.5074-5081.1997	journal	December 1997
Imaging Features of Invasive and Noninvasive Fungal Sinusitis: A Review Aribandi, Manohar; McCoy, Victor A.; Bazan, Carlos RadioGraphics, Vol. 27, Issue 5 https://doi.org/10.1148/rg.275065189	journal	September 2007
Evolving paradigms in the pathogenesis of HIV-1-associated dementia Fischer-Smith, Tracy; Rappaport, Jay Expert Reviews in Molecular Medicine, Vol. 7, Issue 27 https://doi.org/10.1017/S1462399405010239	journal	December 2005
Inositol and higher inositol phosphates in neural tissues: homeostasis, metabolism and functional significance Fisher, Stephen K.; Novak, James E.; Agranoff, Bernard W. Journal of Neurochemistry, Vol. 82, Issue 4 https://doi.org/10.1046/j.1471-4159.2002.01041.x	journal	August 2002
Targeting of the central nervous system byListeria monocytogenes Disson, Olivier; Lecuit, Marc Virulence, Vol. 3, Issue 2 https://doi.org/10.4161/viru.19586	journal	March 2012
Isolated Cryptococcal Sphenoid Sinusitis with Septicemia, Meningitis, and Subsequent Skull Base Osteomyelitis in an Immunocompetent Patient Prendiville, Stephen; Bielamowicz, Steven A.; Hawrych, Andrew Otolaryngology–Head and Neck Surgery, Vol. 123, Issue 3 https://doi.org/10.1067/mhn.2000.104777	journal	September 2000
An Antivirulence Approach for Preventing Cryptococcus neoformans from Crossing the Blood-Brain Barrier via Novel Natural Product Inhibitors of a Fungal Metalloprotease Aaron, Phylicia A.; Vu, Kiem; Gelli, Angie mBio, Vol. 11, Issue 4 https://doi.org/10.1128/mBio.01249-20	journal	August 2020
Comparative miRNA transcriptomics of macaques and mice reveals MYOC is an inhibitor for Cryptococcus neoformans invasion into the brain Li, Hailong; Han, Xiaoxu; Du, Wei Emerging Microbes & Infections, Vol. 11, Issue 1 https://doi.org/10.1080/22221751.2022.2081619	journal	June 2022
Methods for Manipulating Cryptococcus Spores Frerichs, Anna B.; Huang, Mingwei; Ortiz, Sébastien C. Journal of Fungi, Vol. 8, Issue 1 https://doi.org/10.3390/jof8010004	journal	December 2021
Infectious particle identity determines dissemination and disease outcome for the inhaled human fungal pathogen Cryptococcus Walsh, Naomi M.; Botts, Michael R.; McDermott, Andrew J. PLOS Pathogens, Vol. 15, Issue 6 https://doi.org/10.1371/journal.ppat.1007777	journal	June 2019
Invasion of the Central Nervous System by Cryptococcus neoformans Requires a Secreted Fungal Metalloprotease Vu, Kiem; Tham, Rick; Uhrig, John P. mBio, Vol. 5, Issue 3 https://doi.org/10.1128/mBio.01101-14	journal	July 2014
Blood‐brain barrier‐specific properties of a human adult brain endothelial cell line Weksler, B. B.; Subileau, E. A.; Perrière, N. The FASEB Journal, Vol. 19, Issue 13 https://doi.org/10.1096/fj.04-3458fje	journal	September 2005
Strategies for Intranasal Delivery of Therapeutics for the Prevention and Treatment of NeuroAIDS Hanson, Leah R.; Frey, William H. Journal of Neuroimmune Pharmacology, Vol. 2, Issue 1 https://doi.org/10.1007/s11481-006-9039-x	journal	September 2006
Cordycepin ameliorates acute hypobaric hypoxia induced blood-brain barrier disruption, and cognitive impairment partly by suppressing the TLR4/NF-κB/MMP-9 pathway in the adult rats Liu, Pengfei; Pan, Lei; Cui, Lei European Journal of Pharmacology, Vol. 924 https://doi.org/10.1016/j.ejphar.2022.174952	journal	June 2022
Trojan Horse Transit Contributes to Blood-Brain Barrier Crossing of a Eukaryotic Pathogen Santiago-Tirado, Felipe H.; Onken, Michael D.; Cooper, John A. mBio, Vol. 8, Issue 1 https://doi.org/10.1128/mBio.02183-16	journal	March 2017
Glycosaminoglycan Binding Facilitates Entry of a Bacterial Pathogen into Central Nervous Systems Chang, Yung-Chi; Wang, Zhipeng; Flax, Lindsay A. PLoS Pathogens, Vol. 7, Issue 6 https://doi.org/10.1371/journal.ppat.1002082	journal	June 2011
Involvement of human CD44 during Cryptococcus neoformans infection of brain microvascular endothelial cells Jong, Ambrose; Wu, Chun-Hua; Shackleford, Gregory M. Cellular Microbiology, Vol. 10, Issue 6 https://doi.org/10.1111/j.1462-5822.2008.01128.x	journal	June 2008
Identification and Characterization ofCPS1as a Hyaluronic Acid Synthase Contributing to the Pathogenesis ofCryptococcus neoformansInfection Jong, Ambrose; Wu, Chun-Hua; Chen, Han-Min Eukaryotic Cell, Vol. 6, Issue 8 https://doi.org/10.1128/EC.00120-07	journal	August 2007
Blood–brain barrier invasion by Cryptococcus neoformans is enhanced by functional interactions with plasmin Stie, Jamal; Fox, Deborah Microbiology, Vol. 158, Issue 1 https://doi.org/10.1099/mic.0.051524-0	journal	January 2012
Cryptococcus neoformans Activates RhoGTPase Proteins Followed by Protein Kinase C, Focal Adhesion Kinase, and Ezrin to Promote Traversal across the Blood-Brain Barrier Kim, Jong-Chul; Crary, Benjamin; Chang, Yun C. Journal of Biological Chemistry, Vol. 287, Issue 43 https://doi.org/10.1074/jbc.M112.389676	journal	October 2012
Lipopolysaccharide-Induced Increase in Intestinal Permeability Is Mediated by TAK-1 Activation of IKK and MLCK/MYLK Gene Nighot, Meghali; Rawat, Manmeet; Al-Sadi, Rana The American Journal of Pathology, Vol. 189, Issue 4 https://doi.org/10.1016/j.ajpath.2018.12.016	journal	April 2019
Gene Expression of Diverse Cryptococcus Isolates during Infection of the Human Central Nervous System Yu, Chen-Hsin; Sephton-Clark, Poppy; Tenor, Jennifer L. mBio, Vol. 12, Issue 6 https://doi.org/10.1128/mBio.02313-21	journal	December 2021
The blood-brain barrier internalisesCryptococcus neoformansvia the EphA2-tyrosine kinase receptor Aaron, Phylicia A.; Jamklang, Mantana; Uhrig, John P. Cellular Microbiology, Vol. 20, Issue 3 https://doi.org/10.1111/cmi.12811	journal	January 2018
Invasion of Cryptococcus neoformans into Human Brain Microvascular Endothelial Cells Is Mediated through the Lipid Rafts-Endocytic Pathway via the Dual Specificity Tyrosine Phosphorylation-regulated Kinase 3 (DYRK3) Huang, Sheng-He; Long, Min; Wu, Chun-Hua Journal of Biological Chemistry, Vol. 286, Issue 40 https://doi.org/10.1074/jbc.M111.219378	journal	October 2011
Hyaluronic Acid Receptor CD44 Deficiency Is Associated with Decreased Cryptococcus neoformans Brain Infection Jong, Ambrose; Wu, Chun-Hua; Gonzales-Gomez, Ignacio Journal of Biological Chemistry, Vol. 287, Issue 19 https://doi.org/10.1074/jbc.M112.353375	journal	May 2012
Intracranial Complications of Sinusitis: A 15-Year Review of 39 Cases Younis, Ramzi T.; Lazar, Rande H.; Anand, Vinod K. Ear, Nose & Throat Journal, Vol. 81, Issue 9 https://doi.org/10.1177/014556130208100911	journal	September 2002
S100A10 downregulation inhibits the phagocytosis of Cryptococcus neoformans by murine brain microvascular endothelial cells Chen, Yuchong; Chen, Jianghan; Wen, Hai Microbial Pathogenesis, Vol. 51, Issue 3 https://doi.org/10.1016/j.micpath.2011.05.003	journal	September 2011
Complications of Sinusitis Carr, Tara F. American Journal of Rhinology & Allergy, Vol. 30, Issue 4 https://doi.org/10.2500/ajra.2016.30.4322	journal	July 2016
Invasion of the Central Nervous System by Intracellular Bacteria Drevets, Douglas A.; Leenen, Pieter J. M.; Greenfield, Ronald A. Clinical Microbiology Reviews, Vol. 17, Issue 2 https://doi.org/10.1128/CMR.17.2.323-347.2004	journal	April 2004
Cryptococcosis and Cryptococcus Francisco, Elaine Cristina; de Jong, Auke W.; Hagen, Ferry Mycopathologia, Vol. 186, Issue 5 https://doi.org/10.1007/s11046-021-00577-7	journal	July 2021
Cryptococcal Endophthalmitis: Case Report and Review Crump, J. R. C.; Elner, S. G.; Elner, V. M. Clinical Infectious Diseases, Vol. 14, Issue 5 https://doi.org/10.1093/clinids/14.5.1069	journal	May 1992
Real-time imaging of trapping and urease-dependent transmigration of Cryptococcus neoformans in mouse brain Shi, Meiqing; Li, Shu Shun; Zheng, Chunfu Journal of Clinical Investigation, Vol. 120, Issue 5 https://doi.org/10.1172/JCI41963	journal	May 2010
Evidence of a Role for Monocytes in Dissemination and Brain Invasion by Cryptococcus neoformans Charlier, Caroline; Nielsen, Kirsten; Daou, Samira Infection and Immunity, Vol. 77, Issue 1 https://doi.org/10.1128/IAI.01065-08	journal	October 2008
Cryptococcus neoformans Promotes Its Transmigration into the Central Nervous System by Inducing Molecular and Cellular Changes in Brain Endothelial Cells Vu, Kiem; Eigenheer, Richard A.; Phinney, Brett S. Infection and Immunity, Vol. 81, Issue 9 https://doi.org/10.1128/IAI.00554-13	journal	September 2013
Two Major Inositol Transporters and Their Role in Cryptococcal Virulence Wang, Yina; Liu, Tong-bao; Delmas, Guillaume Eukaryotic Cell, Vol. 10, Issue 5 https://doi.org/10.1128/EC.00327-10	journal	March 2011
Osmotic regulation ofmyo-inositol uptake in primary astrocyte cultures Isaacks, Russell E.; Bender, Alexander S.; Kim, Chang Y. Neurochemical Research, Vol. 19, Issue 3 https://doi.org/10.1007/BF00971582	journal	March 1994
Innate immune evasion strategies against Cryptococcal meningitis caused by Cryptococcus?neoformans (Review) Yang, Cheng‑Liang; Wang, Jun; Zou, Li‑Li Experimental and Therapeutic Medicine https://doi.org/10.3892/etm.2017.5220	journal	September 2017
Cryptococcal Laryngitis: Case Report and Review of the Literature Nadrous, Hassan F.; Lewis, Jean E.; Ryu, Jay H. Annals of Otology, Rhinology & Laryngology, Vol. 113, Issue 2 https://doi.org/10.1177/000348940411300207	journal	February 2004
HIV-1 gp41 ectodomain enhances Cryptococcus neoformans binding to HBMEC Jong, Ambrose Y.; Wu, Chu-Hua; Jiang, Shibo Biochemical and Biophysical Research Communications, Vol. 356, Issue 4 https://doi.org/10.1016/j.bbrc.2007.03.100	journal	May 2007
Cryptococcal transmigration across a model brain blood-barrier: evidence of the Trojan horse mechanism and differences between Cryptococcus neoformans var. grubii strain H99 and Cryptococcus gattii strain R265 Sorrell, Tania C.; Juillard, Pierre-Georges; Djordjevic, Julianne T. Microbes and Infection, Vol. 18, Issue 1 https://doi.org/10.1016/j.micinf.2015.08.017	journal	January 2016
Methamphetamine and diazepam suppress antigen-specific cytokine expression and antibody production in ovalbumin-sensitized BALB/c mice Wey, Shiaw-Pyng; Wu, Hsin-Ying; Chang, Fang-Chia Toxicology Letters, Vol. 181, Issue 3 https://doi.org/10.1016/j.toxlet.2008.07.015	journal	October 2008
Dancing cheek to cheek: Cryptococcus neoformans and phagocytes Zhang, Mingshun; Sun, Donglei; Shi, Meiqing SpringerPlus, Vol. 4, Issue 1 https://doi.org/10.1186/s40064-015-1192-3	journal	August 2015
Invasion ofCryptococcus neoformansinto human brain microvascular endothelial cells requires protein kinase C-α activation Jong, Ambrose; Wu, Chun-Hua; Prasadarao, Nemani V. Cellular Microbiology, Vol. 10, Issue 9 https://doi.org/10.1111/j.1462-5822.2008.01172.x	journal	September 2008
Atypical clinical and radiological presentation of cryptococcal choroid plexitis in an immunocompetent woman Dubbioso, Raffaele; Pappatà, Sabina; Quarantelli, Mario Journal of the Neurological Sciences, Vol. 334, Issue 1-2 https://doi.org/10.1016/j.jns.2013.08.010	journal	November 2013
Basic principles of the virulence ofCryptococcus Zaragoza, Oscar Virulence, Vol. 10, Issue 1 https://doi.org/10.1080/21505594.2019.1614383	journal	January 2019
Cryptococcus neoformans induces alterations in the cytoskeleton of human brain microvascular endothelial cells Chen, Steven H. M.; Stins, Monique F.; Huang, Sheng-He Journal of Medical Microbiology, Vol. 52, Issue 11 https://doi.org/10.1099/jmm.0.05230-0	journal	November 2003
Lactate Alters Metabolism in Human Macrophages and Improves Their Ability to Kill Mycobacterium tuberculosis Ó Maoldomhnaigh, Cilian; Cox, Donal J.; Phelan, James J. Frontiers in Immunology, Vol. 12 https://doi.org/10.3389/fimmu.2021.663695	journal	October 2021
Microbial translocation of the blood–brain barrier Kim, Kwang Sik International Journal for Parasitology, Vol. 36, Issue 5 https://doi.org/10.1016/j.ijpara.2006.01.013	journal	May 2006
Fungal brain infection modelled in a human-neurovascular-unit-on-a-chip with a functional blood–brain barrier Kim, Jin; Lee, Kyung-Tae; Lee, Jong Seung Nature Biomedical Engineering, Vol. 5, Issue 8 https://doi.org/10.1038/s41551-021-00743-8	journal	June 2021
A critical role of farnesol in the modulation of Amphotericin B and Aureobasidin A antifungal drug susceptibility Mahendrarajan, Venkatramanan; Bari, Vinay Kumar Mycology, Vol. 13, Issue 4 https://doi.org/10.1080/21501203.2022.2138599	journal	October 2022
Role of Extracellular Phospholipases and Mononuclear Phagocytes in Dissemination of Cryptococcosis in a Murine Model Santangelo, R.; Zoellner, H.; Sorrell, T. Infection and Immunity, Vol. 72, Issue 4 https://doi.org/10.1128/IAI.72.4.2229-2239.2004	journal	March 2004
Mitochondrial transplantation strategies in multifaceted induction of cancer cell death Cruz-Gregorio, Alfredo; Aranda-Rivera, Ana Karina; Amador-Martinez, Isabel Life Sciences, Vol. 332 https://doi.org/10.1016/j.lfs.2023.122098	journal	November 2023
Astrocyte–endothelial interactions at the blood–brain barrier Abbott, N. Joan; Rönnbäck, Lars; Hansson, Elisabeth Nature Reviews Neuroscience, Vol. 7, Issue 1 https://doi.org/10.1038/nrn1824	journal	January 2006
Glial alterations in tuberculous and cryptococcal meningitis and their relation to HIV co-infection – A study on human brains Tripathi, Surya; Patro, Ishan; Mahadevan, Anita The Journal of Infection in Developing Countries, Vol. 8, Issue 11 https://doi.org/10.3855/jidc.3894	journal	November 2014
Cryptococcus neoformans–astrocyte interactions: effect on fungal blood brain barrier disruption, brain invasion, and meningitis progression Woo, Yeon Hwa; Martinez, Luis R. Critical Reviews in Microbiology, Vol. 47, Issue 2 https://doi.org/10.1080/1040841X.2020.1869178	journal	January 2021
Cryptococcal Yeast Cells Invade the Central Nervous System via Transcellular Penetration of the Blood-Brain Barrier Chang, Yun C.; Stins, Monique F.; McCaffery, Michael J. Infection and Immunity, Vol. 72, Issue 9 https://doi.org/10.1128/IAI.72.9.4985-4995.2004	journal	September 2004
Endogenous Cryptococcal Endophthalmitis in Immunocompetent Host: Case Report and Review of Multimodal Imaging Findings and Treatment Amphornphruet, Atchara; Silpa-archa, Sukhum; Preble, Janine M. Ocular Immunology and Inflammation https://doi.org/10.1080/09273948.2017.1298820	journal	April 2017
Mechanisms of microbial traversal of the blood–brain barrier Kim, Kwang Sik Nature Reviews Microbiology, Vol. 6, Issue 8 https://doi.org/10.1038/nrmicro1952	journal	July 2008
Brain Inositol Is a Novel Stimulator for Promoting Cryptococcus Penetration of the Blood-Brain Barrier Liu, Tong-Bao; Kim, Jong-Chul; Wang, Yina PLoS Pathogens, Vol. 9, Issue 4 https://doi.org/10.1371/journal.ppat.1003247	journal	April 2013
Updates in management of acute invasive fungal rhinosinusitis Craig, John R. Current Opinion in Otolaryngology & Head & Neck Surgery, Vol. 27, Issue 1 https://doi.org/10.1097/MOO.0000000000000507	journal	February 2019
Listeria monocytogenes : epidemiology, human disease, and mechanisms of brain invasion Drevets, Douglas A.; Bronze, Michael S. FEMS Immunology & Medical Microbiology, Vol. 53, Issue 2 https://doi.org/10.1111/j.1574-695X.2008.00404.x	journal	July 2008
The barrier and interface mechanisms of the brain barrier, and brain drug delivery Zhang, Shanshan; Gan, Lin; Cao, Fengye Brain Research Bulletin, Vol. 190 https://doi.org/10.1016/j.brainresbull.2022.09.017	journal	November 2022
Altered Immune Response Differentially Enhances Susceptibility to Cryptococcus neoformans and Cryptococcus gattii Infection in Mice Expressing the HIV-1 Transgene Leongson, Kassandre; Cousineau-Côté, Vincent; Goupil, Mathieu Infection and Immunity, Vol. 81, Issue 4 https://doi.org/10.1128/IAI.01339-12	journal	April 2013
Rhino-orbito-cerebral mucormycosis: an epidemic in a pandemic Sekaran, Anuradha; Patil, Nayana; Sabhapandit, Swapnali IJID Regions, Vol. 2 https://doi.org/10.1016/j.ijregi.2021.12.009	journal	March 2022
Mechanism of Cryptococcus Meningoencephalitis Miyazato, Akiko Medical Mycology Journal, Vol. 57, Issue 1 https://doi.org/10.3314/mmj.57.J27	journal	January 2016
Diagnostic and therapeutic strategies of acute invasive fungal rhinosinusitis Luo, Yang-tuo; Zhu, Cheng-rui; He, Bing Asian Journal of Surgery, Vol. 46, Issue 1 https://doi.org/10.1016/j.asjsur.2022.05.006	journal	January 2023
Is the Nickel-Dependent Urease Complex of Cryptococcus the Pathogen’s Achilles’ Heel? Morrow, Carl A.; Fraser, James A. mBio, Vol. 4, Issue 4 https://doi.org/10.1128/mBio.00408-13	journal	August 2013
Treatment strategies for cryptococcal infection: challenges, advances and future outlook Iyer, Kali R.; Revie, Nicole M.; Fu, Ci Nature Reviews Microbiology, Vol. 19, Issue 7 https://doi.org/10.1038/s41579-021-00511-0	journal	February 2021
The impact of hypoxia on blood-brain, blood-CSF, and CSF-brain barriers Dunn, Jeff F.; Isaacs, Albert M. Journal of Applied Physiology, Vol. 131, Issue 3 https://doi.org/10.1152/japplphysiol.00108.2020	journal	September 2021
The Blood–Brain Barrier Daneman, Richard; Prat, Alexandre Cold Spring Harbor Perspectives in Biology, Vol. 7, Issue 1 https://doi.org/10.1101/cshperspect.a020412	journal	January 2015
Central Nervous System-Infecting Pathogens Escherichia coli and Cryptococcus neoformans Exploit the Host Pdlim2 for Intracellular Traversal and Exocytosis in the Blood-Brain Barrier Li, Zhongming; Bruno, Vincent M.; Kim, Kwang Sik Infection and Immunity, Vol. 89, Issue 10 https://doi.org/10.1128/IAI.00128-21	journal	September 2021
Blood-brain barrier transport machineries and targeted therapy of brain diseases Barar, Jaleh; Rafi, Mohammad A.; Pourseif, Mohammad M. BioImpacts, Vol. 6, Issue 4 https://doi.org/10.15171/bi.2016.30	journal	December 2016
The Intracranial Complications of Rhinosinusitis: Can They Be Prevented? Jones, N. S.; Walker, J. L.; Bassi, S. The Laryngoscope, Vol. 112, Issue 1 https://doi.org/10.1097/00005537-200201000-00011	journal	January 2002
Listeria monocytogenes-Infected Phagocytes Can Initiate Central Nervous System Infection in Mice Drevets, D. A.; Jelinek, T. A.; Freitag, N. E. Infection and Immunity, Vol. 69, Issue 3 https://doi.org/10.1128/IAI.69.3.1344-1350.2001	journal	March 2001
Fungal disease of the nose and paranasal sinuses Thompson, George R.; Patterson, Thomas F. Journal of Allergy and Clinical Immunology, Vol. 129, Issue 2 https://doi.org/10.1016/j.jaci.2011.11.039	journal	February 2012
Surface-Associated Plasminogen Binding of Cryptococcus neoformans Promotes Extracellular Matrix Invasion Stie, Jamal; Bruni, Gillian; Fox, Deborah PLoS ONE, Vol. 4, Issue 6 https://doi.org/10.1371/journal.pone.0005780	journal	June 2009
Burden of fungal infections in Kenya Ratemo, Stanley N.; Denning, David W. Mycology, Vol. 14, Issue 2 https://doi.org/10.1080/21501203.2023.2204112	journal	April 2023
A bioactive gypenoside (GP-14) alleviates neuroinflammation and blood brain barrier (BBB) disruption by inhibiting the NF-κB signaling pathway in a mouse high-altitude cerebral edema (HACE) model Geng, Yanan; Yang, Junli; Cheng, Xiang International Immunopharmacology, Vol. 107 https://doi.org/10.1016/j.intimp.2022.108675	journal	June 2022
Proteomic analysis of human umbilical vein endothelial cells incubated with Cryptococcus neoformans var. neoformans Wang, Xiao‐Jun; Zhu, Yuan‐Jie; Cui, Jian‐Guo Mycoses, Vol. 54, Issue 5 https://doi.org/10.1111/j.1439-0507.2010.01920.x	journal	September 2011
Intranasal delivery bypasses the blood-brain barrier to target therapeutic agents to the central nervous system and treat neurodegenerative disease Hanson, Leah R.; Frey, William H. BMC Neuroscience, Vol. 9, Issue S3 https://doi.org/10.1186/1471-2202-9-S3-S5	journal	December 2008
Urease Expression by Cryptococcus neoformans Promotes Microvascular Sequestration, Thereby Enhancing Central Nervous System Invasion Olszewski, Michal A.; Noverr, Mairi C.; Chen, Gwo-Hsiao The American Journal of Pathology, Vol. 164, Issue 5 https://doi.org/10.1016/S0002-9440(10)63734-0	journal	May 2004

Similar Records

FURTHER STUDIES OF THE MECHANISM BY WHICH HYDROGEN ENTERS METALS DURING CHEMICAL AND ELECTROCHEMICAL PROCESSING

Technical Report · 1954 · OSTI ID:4371530

McGraw, L D; Ditmars, W E; Snavely, C A; +1 more

A FUNDAMENTAL STUDY OF THE MECHANISM BY WHICH HYDROGEN ENTERS METALS DURING CHEMICAL AND ELECTROCHEMICAL PROCESSING

Technical Report · 1952 · OSTI ID:4405304

McGraw, L D; Snavely, C A; Moore, H L; +2 more

Molecular mechanisms by which tetrahydrofuran affects CO2 hydrate Growth: Implications for carbon storage

Journal Article · 2021 · Chemical Engineering Journal · OSTI ID:1772142

Phan, Anh; Schlösser, Henrik; Striolo, Alberto

Title: The pathways and the mechanisms by which Cryptococcus enters the brain

Citation Formats

References (105)

Similar Records

Related Subjects