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Title: The importance and future of biochemical engineering

Journal Article · · Biotechnology and Bioengineering
DOI: https://doi.org/10.1002/bit.27364 · OSTI ID:2298965
ORCiD logo [1]; ORCiD logo [2]; ORCiD logo [3]; ORCiD logo [4];  [5];  [6];  [7];  [8];  [9]; ORCiD logo [10];  [11];  [12];  [4]; ORCiD logo [13];  [14]; ORCiD logo [15];  [16];  [17]; ORCiD logo [18]
  1. University of Colorado, Boulder, CO (United States)
  2. Columbia University, New York, NY (United States)
  3. University of Maryland, College Park, MD (United States)
  4. Johns Hopkins University, Baltimore, MD (United States)
  5. Michigan State University, East Lansing, MI (United States)
  6. University of California, Berkeley, CA (United States)
  7. McGill University, Montreal, QC (Canada)
  8. Northwestern University, Evanston, IL (United States)
  9. BioProcess Advantage LLC Middesex New Jersey
  10. Rensselaer Polytechnic Institute, Troy, NY (United States)
  11. Rubius Therapeutics, Cambridge, MA (United States)
  12. Bristol Myers Squibb, Devens, MA (United States)
  13. Pennsylvania State University, University Park, PA (United States)
  14. University of Delaware, Newark, DE (United States)
  15. Massachusetts Institute of Technology (MIT), Cambridge, MA (United States)
  16. Evonik Industries AG, Marl (Germany)
  17. Rice University, Houston, TX (United States)
  18. University of California, Riverside, CA (United States)

Abstract Today's Biochemical Engineer may contribute to advances in a wide range of technical areas. The recent Biochemical and Molecular Engineering XXI conference focused on “The Next Generation of Biochemical and Molecular Engineering: The role of emerging technologies in tomorrow's products and processes”. On the basis of topical discussions at this conference, this perspective synthesizes one vision on where investment in research areas is needed for biotechnology to continue contributing to some of the world's grand challenges.

Research Organization:
Northwestern Univ., Evanston, IL (United States)
Sponsoring Organization:
USDOE
Grant/Contract Number:
SC0018249; DE‐AC05‐000R22725; DE‐SC0018249
OSTI ID:
2298965
Alternate ID(s):
OSTI ID: 1631194
Journal Information:
Biotechnology and Bioengineering, Vol. 117, Issue 8; ISSN 0006-3592
Publisher:
WileyCopyright Statement
Country of Publication:
United States
Language:
English
Citation Metrics:
Cited by: 10 works
Citation information provided by
Web of Science

References (69)

Translation of Diverse Aramid- and 1,3-Dicarbonyl-peptides by Wild Type Ribosomes in Vitro journal June 2019
AlphaFold at CASP13 journal May 2019
Bacterial outer membrane vesicles: New insights and applications journal November 2016
Integration of chemical catalysis with extractive fermentation to produce fuels journal November 2012
Rational engineering of synthetic microbial systems: from single cells to consortia journal October 2018
Biochemical Pathways of Caspase Activation During Apoptosis journal November 1999
Generation of an atlas for commodity chemical production in Escherichia coli and a novel pathway prediction algorithm, GEM-Path journal September 2014
Estimating the biotech sector's contribution to the US economy journal March 2016
Enzyme clustering accelerates processing of intermediates through metabolic channeling journal September 2014
Intrinsic Structural Features of the Human IRE1α Transmembrane Domain Sense Membrane Lipid Saturation journal April 2019
Report of the National Heart, Lung, and Blood Institute Working Group on Epigenetics and Hypertension journal May 2012
Industrial brewing yeast engineered for the production of primary flavor determinants in hopped beer journal March 2018
Epic $12 billion deal and FDA's approval raise CAR-T to new heights journal October 2017
Bags versus flasks: a comparison of cell culture systems for the production of dendritic cell–based immunotherapies journal April 2018
Improving catalytic function by ProSAR-driven enzyme evolution journal February 2007
Extreme thermophiles: moving beyond single-enzyme biocatalysis journal November 2012
Top-Down Enrichment Guides in Formation of Synthetic Microbial Consortia for Biomass Degradation journal August 2019
Nutrient-Gene Interaction: Metabolic Genotype-Phenotype Relationship journal December 2005
Thresholds and ultrasensitivity from negative cooperativity journal May 2016
A parts list for fungal cellulosomes revealed by comparative genomics journal May 2017
Decentralized manufacturing of cell and gene therapies: Overcoming challenges and identifying opportunities journal October 2017
Discovery and analysis of novel metabolic pathways for the biosynthesis of industrial chemicals: 3-hydroxypropanoate journal January 2010
Epigenetics and cancer: towards an evaluation of the impact of environmental and dietary factors journal January 2007
Industrializing Autologous Adoptive Immunotherapies: Manufacturing Advances and Challenges journal May 2018
A systems-level model reveals that 1,2-Propanediol utilization microcompartments enhance pathway flux through intermediate sequestration journal May 2017
How do megakaryocytic microparticles target and deliver cargo to alter the fate of hematopoietic stem cells? journal February 2017
Experimental and computational optimization of an Escherichia coli co-culture for the efficient production of flavonoids journal May 2016
Extracellular vesicles: exosomes, microparticles, their parts, and their targets to enable their biomanufacturing and clinical applications journal December 2019
Renewable acrylonitrile production journal December 2017
Bacterial microcompartments journal March 2018
Deciphering the human microbiome using next-generation sequencing data and bioinformatics approaches journal June 2015
Efficient Syntheses of Diverse, Medicinally Relevant Targets Planned by Computer and Executed in the Laboratory journal March 2018
High-Resolution Sequence-Function Mapping of Full-Length Proteins journal March 2015
Anomalous diffusion along metal/ceramic interfaces journal December 2018
Expanding the limits of the second genetic code with ribozymes journal November 2019
Next-generation biocontainment systems for engineered organisms journal May 2018
Inflammation, Antibiotics, and Diet as Environmental Stressors of the Gut Microbiome in Pediatric Crohn’s Disease journal October 2015
Retrosynthetic design of metabolic pathways to chemicals not found in nature journal April 2019
Engineering microbial consortia for controllable outputs journal March 2016
Using a Redox Modality to Connect Synthetic Biology to Electronics: Hydrogel-Based Chemo-Electro Signal Transduction for Molecular Communication journal November 2016
Challenges of up-scaling lentivirus production and processing journal December 2016
Brazzein, a new high-potency thermostable sweet protein from Pentadiplandra brazzeana B journal November 1994
Direct-coupling analysis of residue coevolution captures native contacts across many protein families journal November 2011
Anti-CRISPR-mediated control of gene editing and synthetic circuits in eukaryotic cells journal January 2019
High-level semi-synthetic production of the potent antimalarial artemisinin journal April 2013
Engineering Epigenetic Regulation Using Synthetic Read-Write Modules journal January 2019
Cultured meat from stem cells: Challenges and prospects journal November 2012
Validation and Stabilization of a Prophage Lysin of Clostridium perfringens by Using Yeast Surface Display and Coevolutionary Models journal March 2019
High-Fat Diets Alter the Modulatory Effects of Xenobiotics on Cytochrome P450 Activities journal March 2018
Microalgae metabolites: A rich source for food and medicine journal May 2019
Synthetic RNA Polymerase III Promoters Facilitate High-Efficiency CRISPR–Cas9-Mediated Genome Editing in Yarrowia lipolytica journal January 2016
Towards synthetic microbial consortia for bioprocessing journal October 2012
Single Cell Protein journal January 1983
Early-branching gut fungi possess a large, comprehensive array of biomass-degrading enzymes journal February 2016
Opportunities for applying biomedical production and manufacturing methods to the development of the clean meat industry journal April 2018
Application of metabolic flux analysis to identify the mechanisms of free fatty acid toxicity to human hepatoma cell line journal February 2008
Bacterial co-culture with cell signaling translator and growth controller modules for autonomously regulated culture composition journal September 2019
Transforming biochemical engineering with cell-free biology journal December 2011
Stress-tolerant non-conventional microbes enable next-generation chemical biosynthesis journal January 2020
Electronic control of gene expression and cell behaviour in Escherichia coli through redox signalling journal January 2017
Valorization of Biomass: Deriving More Value from Waste journal August 2012
Redox-Based Synthetic Biology Enables Electrochemical Detection of the Herbicides Dicamba and Roundup via Rewired Escherichia coli journal April 2019
ProtaBank: A repository for protein design and engineering data: ProtaBank: A Protein Engineering Database journal April 2018
Integration of heterogeneous and biochemical catalysis for production of fuels and chemicals from biomass journal June 2017
Substrate channelling as an approach to cascade reactions journal March 2016
A CRISPR–dCas Toolbox for Genetic Engineering and Synthetic Biology journal January 2019
Repression of PKR mediates palmitate-induced apoptosis in HepG2 cells through regulation of Bcl-2 journal March 2009
A bacterium that degrades and assimilates poly(ethylene terephthalate) journal March 2016
Environmental stimuli drive a transition from cooperation to competition in synthetic phototrophic communities journal October 2019