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Title: Data-driven and physics informed modeling of Chinese Hamster Ovary cell bioreactors

Journal Article · · Computers and Chemical Engineering

Not Available

Sponsoring Organization:
USDOE Office of Science (SC), Biological and Environmental Research (BER)
Grant/Contract Number:
SC0018260
OSTI ID:
2283783
Journal Information:
Computers and Chemical Engineering, Journal Name: Computers and Chemical Engineering Journal Issue: C Vol. 183; ISSN 0098-1354
Publisher:
ElsevierCopyright Statement
Country of Publication:
United Kingdom
Language:
English

References (27)

Dynamic Flux Balance Analysis of Diauxic Growth in Escherichia coli journal September 2002
Metabolic flux analysis and pharmaceutical production journal March 2010
Sloppiness, robustness, and evolvability in systems biology journal August 2008
Learning emergent partial differential equations in a learned emergent space journal June 2022
Dynamic modeling of the central carbon metabolism ofEscherichia coli journal May 2002
Physics-informed machine learning journal May 2021
Modeling, simulation, sensitivity analysis, and optimization of hybrid systems journal October 2002
Recent advances in constraint and machine learning-based metabolic modeling by leveraging stoichiometric balances, thermodynamic feasibility and kinetic law formalisms journal January 2021
Living With Heterogeneities in Bioreactors: Understanding the Effects of Environmental Gradients on Cells journal January 2006
Systems biology informed deep learning for inferring parameters and hidden dynamics journal November 2020
DISCRETE- vs. CONTINUOUS-TIME NONLINEAR SIGNAL PROCESSING OF Cu ELECTRODISSOLUTION DATA journal November 1992
Animal cell cultures: recent achievements and perspectives in the production of biopharmaceuticals journal April 2005
Metabolic flux analysis of CHO cells in perfusion culture by metabolite balancing and 2D [13C, 1H] COSY NMR spectroscopy journal March 2010
DeepXDE: A Deep Learning Library for Solving Differential Equations journal January 2021
Limits of entrainment of circadian neuronal networks
  • Psarellis, Yorgos M.; Kavousanakis, Michail; Henson, Michael A.
  • Chaos: An Interdisciplinary Journal of Nonlinear Science, Vol. 33, Issue 1 https://doi.org/10.1063/5.0122744
journal January 2023
Metabolic flux analysis in mammalian cell culture journal March 2010
Multi-Scale Modeling of Heterogeneities in Mammalian Cell Culture Processes journal July 2010
A rewriting system for convex optimization problems journal November 2017
Dynamic model of CHO cell metabolism journal January 2011
Dimension reduction in heterogeneous neural networks: Generalized Polynomial Chaos (gPC) and ANalysis-Of-VAriance (ANOVA) journal September 2016
Manifold learning for parameter reduction journal September 2019
Computational Modeling of Fed-Batch Cell Culture Bioreactor: Hybrid Agent-Based Approach journal January 2015
Engineering challenges in high density cell culture systems journal January 1996
Global and local reduced models for interacting, heterogeneous agents journal July 2021
Nonlinear signal processing and system identification: applications to time series from electrochemical reactions journal January 1990
Physics-informed neural networks: A deep learning framework for solving forward and inverse problems involving nonlinear partial differential equations journal February 2019
A single nutrient feed supports both chemically defined NS0 and CHO fed‐batch processes: Improved productivity and lactate metabolism journal September 2009