Divide and conquer towards synthetic autotrophy

Xiong, Wei; Ma, Yanhe

doi:10.1038/s41929-023-01084-2

Title: Divide and conquer towards synthetic autotrophy

Journal Article · 20 December 2023 · Nature Catalysis

DOI: https://doi.org/10.1038/s41929-023-01084-2 · OSTI ID:2282709

^[1]; Ma, Yanhe ^[2]

National Renewable Energy Laboratory (NREL), Golden, CO (United States)
Chinese Academy of Sciences (CAS), Beijing (China). Tianjin Inst. of Industrial Biotechnology

With climate change concerns deepening, CO₂ fixation pathways to produce value-added chemicals are currently of interest. In this work, synthetic biology and machine learning help developing such a pathway across modules that have been tested in vivo in Escherichia coli for the production of acetyl coenzyme A.

View Accepted Manuscript (DOE)

Cite

Export

Save

Research Organization:: National Renewable Energy Laboratory (NREL), Golden, CO (United States)

Sponsoring Organization:: USDOE Laboratory Directed Research and Development (LDRD) Program

Grant/Contract Number:: AC36-08GO28308

OSTI ID:: 2282709

Report Number(s):: NREL/JA-2700-88094; MainId:88869; UUID:2e13259d-9159-4923-bfca-8a330e41dd55; MainAdminID:71238

Journal Information:: Nature Catalysis, Vol. 6, Issue 12; ISSN 2520-1158

Publisher:: Springer NatureCopyright Statement

Country of Publication:: United States

Language:: English

References (9)

Acetogenesis and the Wood–Ljungdahl pathway of CO₂ fixation Ragsdale, Stephen W.; Pierce, Elizabeth Biochimica et Biophysica Acta (BBA) - Proteins and Proteomics, Vol. 1784, Issue 12, p. 1873-1898 https://doi.org/10.1016/j.bbapap.2008.08.012	journal	December 2008
Construction and modular implementation of the THETA cycle for synthetic CO2 fixation Luo, Shanshan; Diehl, Christoph; He, Hai Nature Catalysis, Vol. 6, Issue 12 https://doi.org/10.1038/s41929-023-01079-z	journal	December 2023
The plasticity of cyanobacterial metabolism supports direct CO2 conversion to ethylene Xiong, Wei; Morgan, John A.; Ungerer, Justin Nature Plants, Vol. 1, Issue 5 https://doi.org/10.1038/nplants.2015.53	journal	April 2015
Conversion of Escherichia coli to Generate All Biomass Carbon from CO2 Gleizer, Shmuel; Ben-Nissan, Roee; Bar-On, Yinon M. Cell, Vol. 179, Issue 6 https://doi.org/10.1016/j.cell.2019.11.009	journal	November 2019
Acetyl-CoA synthesis through a bicyclic carbon-fixing pathway in gas-fermenting bacteria Wu, Chao; Lo, Jonathan; Urban, Chris Nature Synthesis, Vol. 1, Issue 8 https://doi.org/10.1038/s44160-022-00095-4	journal	June 2022
Converting Escherichia coli to a Synthetic Methylotroph Growing Solely on Methanol Chen, Frederic Y. -H.; Jung, Hsin-Wei; Tsuei, Chao-Yin Cell, Vol. 182, Issue 4 https://doi.org/10.1016/j.cell.2020.07.010	journal	August 2020
Cell-free chemoenzymatic starch synthesis from carbon dioxide Cai, Tao; Sun, Hongbing; Qiao, Jing Science, Vol. 373, Issue 6562 https://doi.org/10.1126/science.abh4049	journal	September 2021
Biological carbon fixation: From natural to synthetic Gong, Fuyu; Zhu, Huawei; Zhang, Yanping Journal of CO2 Utilization, Vol. 28 https://doi.org/10.1016/j.jcou.2018.09.014	journal	December 2018
The Path of Carbon in Photosynthesis: The carbon cycle is a tool for exploring chemical biodynamics and the mechanism of quantum conversion Calvin, M. Science, Vol. 135, Issue 3507 https://doi.org/10.1126/science.135.3507.879	journal	March 1962

Similar Records

Establishing a versatile toolkit of flux enhanced strains and cell extracts for pathway prototyping

Journal Article · 2023 · Metabolic Engineering · OSTI ID:2499761

Yi, Xiunan; Rasor, Blake J.; Boadi, Nathalie; +5 more

Ancillary contributions of heterologous biotin protein ligase and carbonic anhydrase for CO₂ incorporation into 3-hydroxypropionate by metabolically engineered Pyrococcus furiosus

Journal Article · 2016 · Biotechnology and Bioengineering · OSTI ID:1422399

Lian, Hong; Zeldes, Benjamin M.; Lipscomb, Gina L.; +6 more

Acetyl-CoA Synthesis Through a Bicyclic Carbon-Fixing Pathway in Gas-Fermenting Bacteria

Journal Article · 2022 · Nature Synthesis · OSTI ID:2477747

Wu, Chao; Lo, Jonathan; Urban, Chris; +10 more

Related Subjects

59 BASIC BIOLOGICAL SCIENCES
29 ENERGY PLANNING, POLICY, AND ECONOMY
CO2 fixation pathway
metabolic engineering

Title: Divide and conquer towards synthetic autotrophy

Citation Formats

References (9)

Similar Records

Related Subjects