Mechanisms of Biomolecular Self–Assembly Investigated Through In Situ Observations of Structures and Dynamics

Schmid, Sakshi Yadav; Lachowski, Kacper; Chiang, Huat Thart; Pozzo, Lilo; De Yoreo, Jim; Zhang, Shuai

doi:10.1002/anie.202309725

Title: Mechanisms of Biomolecular Self–Assembly Investigated Through In Situ Observations of Structures and Dynamics

Journal Article · 12 September 2023 · Angewandte Chemie (International Edition)

DOI: https://doi.org/10.1002/anie.202309725 · OSTI ID:2274873

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^[3]; De Yoreo, Jim ^[4]; Zhang, Shuai ^[4]

Pacific Northwest National Laboratory (PNNL), Richland, WA (United States); University of Washington
University of Washington, Seattle, WA (United States)
University of Washington, Seattle, WA (United States)
Pacific Northwest National Laboratory (PNNL), Richland, WA (United States); University of Washington, Seattle, WA (United States)

Biomolecular self-assembly of hierarchical materials is a precise and adaptable bottom-up approach to synthesizing across scales with considerable energy, health, environment, sustainability, and information technology applications. To achieve desired functions in biomaterials, it is essential to directly observe assembly dynamics and structural evolutions that reflect the underlying energy landscape and the assembly mechanism. This review will summarize the current understanding of biomolecular assembly mechanisms based on in situ characterization and discuss the broader significance and achievements of newly gained insights. In addition, we will also introduce how emerging deep learning/machine learning-based approaches, multiparametric characterization, and high-throughput methods can boost the development of biomolecular self-assembly. Furthermore, the objective of this review is to accelerate the development of in situ characterization approaches for biomolecular self-assembly and to inspire the next generation of biomimetic materials.

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Research Organization:: University of Washington, Seattle, WA (United States)

Sponsoring Organization:: USDOE Office of Science (SC), Basic Energy Sciences (BES)

Grant/Contract Number:: SC0019288; AC05-76RL01830

OSTI ID:: 2274873

Alternate ID(s):: OSTI ID: 1999963

Journal Information:: Angewandte Chemie (International Edition), Journal Name: Angewandte Chemie (International Edition) Journal Issue: 48 Vol. 62; ISSN 1433-7851

Publisher:: WileyCopyright Statement

Country of Publication:: United States

Language:: English

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