Metal–Organic Framework as a New Type of Magnetothermally‐Triggered On‐Demand Release Carrier

Ge, Xueying; Mohapatra, Jeotikanta; Silva, Enya; He, Guihua; Gong, Lingshan; Lyu, Tengteng; Madhogaria, Richa P.; Zhao, Xin; Cheng, Yuchuan; Al‐Enizi, Abdullah M.; Nafady, Ayman; Tian, Jian; Liu, J. Ping; Phan, Manh‐Huong; Taraballi, Francesca; Pettigrew, Roderic I.; Ma, Shengqian

doi:10.1002/smll.202306940

Title: Metal–Organic Framework as a New Type of Magnetothermally‐Triggered On‐Demand Release Carrier

Journal Article · 20 December 2023 · Small

DOI: https://doi.org/10.1002/smll.202306940 · OSTI ID:2263318

Ge, Xueying ^[1]; Mohapatra, Jeotikanta ^[2]; Silva, Enya ^[3]; He, Guihua ^[4]; Gong, Lingshan ^[5]; Lyu, Tengteng ^[5]; Madhogaria, Richa P. ^[3]; Zhao, Xin ^[6]; Cheng, Yuchuan ^[7]; Al‐Enizi, Abdullah M. ^[8]; Nafady, Ayman ^[8]; Tian, Jian ^[4]; Liu, J. Ping ^[2]; Phan, Manh‐Huong ^[3]; Taraballi, Francesca ^[9]; Pettigrew, Roderic I. ^[10];

^[5]

Department of Chemistry University of North Texas Denton Texas 76201 USA, Engineering Medicine (EnMed) Texas A&,M University and Houston Methodist Hospital Houston Texas 77030 USA
Department of Physics The University of Texas at Arlington Arlington Texas 76019 USA
Department of Physics University of South Florida Tampa Florida 33620 USA
Key Laboratory of Combinatorial Biosynthesis and Drug Discovery (MOE) Hubei Province Engineering and Technology Research Center for Fluorinated Pharmaceuticals School of Pharmaceutical Sciences Wuhan University Wuhan 430071 P. R. China
Department of Chemistry University of North Texas Denton Texas 76201 USA
J. Mike Walker ‘66 Department of Mechanical Engineering Texas A&,M University College Station TX 77843 USA
Zhejiang Key Laboratory of Additive Manufacturing Materials Ningbo Institute of Material Technology and Engineering Chinese Academy of Sciences Ningbo 315201 P. R. China
Department of Chemistry College of Science King Saud University Riyadh 11451 Saudi Arabia
Center for Musculoskeletal Regeneration Orthopedics and Sports Medicine Houston Methodist Hospital Houston Methodist Academic Institute Houston Texas 77030 USA
Engineering Medicine (EnMed) Texas A&,M University and Houston Methodist Hospital Houston Texas 77030 USA

Abstract The development of external stimuli‐controlled payload systems has been sought after with increasing interest toward magnetothermally‐triggered drug release (MTDR) carriers due to their non‐invasive features. However, current MTDR carriers present several limitations, such as poor heating efficiency caused by the aggregation of iron oxide nanoparticles (IONPs) or the presence of antiferromagnetic phases which affect their efficiency. Herein, a novel MTDR carrier is developed using a controlled encapsulation method that fully fixes and confines IONPs of various sizes within the metal–organic frameworks (MOFs). This novel carrier preserves the MOF's morphology, porosity, and IONP segregation, while enhances heating efficiency through the oxidation of antiferromagnetic phases in IONPs during encapsulation. It also features a magnetothermally‐responsive nanobrush that is stimulated by an alternating magnetic field to enable on‐demand drug release. The novel carrier shows improved heating, which has potential applications as contrast agents and for combined chemo and magnetic hyperthermia therapy. It holds a great promise for magneto‐thermally modulated drug dosing at tumor sites, making it an exciting avenue for cancer treatment.

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Sponsoring Organization:: USDOE

Grant/Contract Number:: NONE; FG02-07ER46438

OSTI ID:: 2263318

Journal Information:: Small, Journal Name: Small; ISSN 1613-6810

Publisher:: Wiley Blackwell (John Wiley & Sons)Copyright Statement

Country of Publication:: Germany

Language:: English

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