LFA-1 regulated by IL-2/STAT5 pathway boosts antitumor function of intratumoral CD8 + T cells for improving anti-PD-1 antibody therapy

Shan, Jiqi; Jing, Wei; Ping, Yu; Shen, Chunyi; Han, Dong; Liu, Fengsen; Liu, Yaqing; Li, Congcong; Zhang, Yi

doi:10.1080/2162402X.2023.2293511

Title: LFA-1 regulated by IL-2/STAT5 pathway boosts antitumor function of intratumoral CD8 ⁺ T cells for improving anti-PD-1 antibody therapy

Journal Article · 13 December 2023 · OncoImmunology (Online)

DOI: https://doi.org/10.1080/2162402X.2023.2293511 · OSTI ID:2229957

Shan, Jiqi ^[1]; Jing, Wei ^[1]; Ping, Yu ^[1]; Shen, Chunyi ^[1]; Han, Dong ^[1]; Liu, Fengsen ^[1]; Liu, Yaqing ^[1]; Li, Congcong ^[1];

^[2]

Biotherapy Center, The First Affiliated Hospital of Zhengzhou University, Zhengzhou, Henan, China, Academy of Medical Science, Zhengzhou University, Zhengzhou, Henan, China
Biotherapy Center, The First Affiliated Hospital of Zhengzhou University, Zhengzhou, Henan, China, Academy of Medical Science, Zhengzhou University, Zhengzhou, Henan, China, College of Life Science, Zhengzhou University, Zhengzhou, Henan, China, Department of Oncology, The First Affiliated Hospital of Zhengzhou University, Zhengzhou, Henan, China, State Key Laboratory of Esophageal Cancer Prevention and Treatment, Zhengzhou University, Zhengzhou, Henan, China

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Sponsoring Organization:: USDOE Office of Electricity (OE), Advanced Grid Research & Development. Power Systems Engineering Research

OSTI ID:: 2229957

Journal Information:: OncoImmunology (Online), Journal Name: OncoImmunology (Online) Journal Issue: 1 Vol. 13; ISSN 2162-402X

Publisher:: Informa UK LimitedCopyright Statement

Country of Publication:: United Kingdom

Language:: English

References (41)

Developmental Relationships of Four Exhausted CD8+ T Cell Subsets Reveals Underlying Transcriptional and Epigenetic Landscape Control Mechanisms Beltra, Jean-Christophe; Manne, Sasikanth; Abdel-Hakeem, Mohamed S. Immunity, Vol. 52, Issue 5 https://doi.org/10.1016/j.immuni.2020.04.014	journal	May 2020
Dysfunctional CD8 T Cells Form a Proliferative, Dynamically Regulated Compartment within Human Melanoma Li, Hanjie; van der Leun, Anne M.; Yofe, Ido Cell, Vol. 176, Issue 4 https://doi.org/10.1016/j.cell.2018.11.043	journal	February 2019
CXCL13 shapes immunoactive tumor microenvironment and enhances the efficacy of PD-1 checkpoint blockade in high-grade serous ovarian cancer Yang, Moran; Lu, Jiaqi; Zhang, Guodong Journal for ImmunoTherapy of Cancer, Vol. 9, Issue 1 https://doi.org/10.1136/jitc-2020-001136	journal	January 2021
Actin cytoskeletal dynamics in T lymphocyte activation and migration Samstag, Yvonne; Eibert, Sybille M.; Klemke, Martin Journal of Leukocyte Biology, Vol. 73, Issue 1 https://doi.org/10.1189/jlb.0602272	journal	January 2003
Efficacy and safety of immune checkpoint inhibitors in non-small cell lung cancer Wang, Shuai; Hao, Jiatao; Wang, Hao OncoImmunology https://doi.org/10.1080/2162402X.2018.1457600	journal	April 2018
The role of the integrin LFA‐1 in T‐lymphocyte migration Smith, Andrew; Stanley, Paula; Jones, Kristian Immunological Reviews, Vol. 218, Issue 1 https://doi.org/10.1111/j.1600-065X.2007.00537.x	journal	July 2007
Cannabis suppresses antitumor immunity by inhibiting JAK/STAT signaling in T cells through CNR2 Xiong, Xinxin; Chen, Siyu; Shen, Jianfei Signal Transduction and Targeted Therapy, Vol. 7, Issue 1 https://doi.org/10.1038/s41392-022-00918-y	journal	April 2022
Induction of T cell exhaustion by JAK1/3 inhibition in the treatment of alopecia areata Dai, Zhenpeng; Sezin, Tanya; Chang, Yuqian Frontiers in Immunology, Vol. 13 https://doi.org/10.3389/fimmu.2022.955038	journal	September 2022
BD750, a benzothiazole derivative, inhibits T cell proliferation by affecting the JAK3/STAT5 signalling pathway Liu, Y.; Yang, T.; Li, H. British Journal of Pharmacology, Vol. 168, Issue 3 https://doi.org/10.1111/j.1476-5381.2012.02172.x	journal	January 2013
IL-2 regulates tumor-reactive CD8+ T cell exhaustion by activating the aryl hydrocarbon receptor Liu, Yuying; Zhou, Nannan; Zhou, Li Nature Immunology, Vol. 22, Issue 3 https://doi.org/10.1038/s41590-020-00850-9	journal	January 2021
NgR1 is an NK cell inhibitory receptor that destabilizes the immunological synapse Oh, Se-Chan; Kim, Seong-Eun; Jang, In-Hwan Nature Immunology, Vol. 24, Issue 3 https://doi.org/10.1038/s41590-022-01394-w	journal	January 2023
Epigenetic stability of exhausted T cells limits durability of reinvigoration by PD-1 blockade Pauken, Kristen E.; Sammons, Morgan A.; Odorizzi, Pamela M. Science, Vol. 354, Issue 6316 https://doi.org/10.1126/science.aaf2807	journal	December 2016
Capping the hydroxyl groups (-OH) of α-cellulose to reduce Hy-groscopicity for accurate 18O/16O measurement by EA/Py/IRMS Yan, Qiulin; Zhao, Yu; Ma, Ran Talanta, Vol. 262 https://doi.org/10.1016/j.talanta.2023.124698	journal	September 2023
Intracellular signalling controlling integrin activation in lymphocytes Kinashi, Tatsuo Nature Reviews Immunology, Vol. 5, Issue 7 https://doi.org/10.1038/nri1646	journal	June 2005
LFA-1 activation enriches tumor-specific T cells in a cold tumor model and synergizes with CTLA-4 blockade Hickman, Amber; Koetsier, Joost; Kurtanich, Trevin Journal of Clinical Investigation, Vol. 132, Issue 13 https://doi.org/10.1172/JCI154152	journal	July 2022
IL-2 is inactivated by the acidic pH environment of tumors enabling engineering of a pH-selective mutein Gaggero, Silvia; Martinez-Fabregas, Jonathan; Cozzani, Adeline Science Immunology, Vol. 7, Issue 78 https://doi.org/10.1126/sciimmunol.ade5686	journal	December 2022
IL-2 delivery by engineered mesenchymal stem cells re-invigorates CD8+ T cells to overcome immunotherapy resistance in cancer Bae, Joonbeom; Liu, Longchao; Moore, Casey Nature Cell Biology, Vol. 24, Issue 12 https://doi.org/10.1038/s41556-022-01024-5	journal	December 2022
First-line serplulimab or placebo plus chemotherapy in PD-L1-positive esophageal squamous cell carcinoma: a randomized, double-blind phase 3 trial Song, Yan; Zhang, Bo; Xin, Dao Nature Medicine, Vol. 29, Issue 2 https://doi.org/10.1038/s41591-022-02179-2	journal	February 2023
IL-2 and IL-7 Induce Heterodimerization of STAT5 Isoforms in Human Peripheral Blood T Lymphoblasts Rosenthal, Louis A.; Winestock, Karen D.; Finbloom, David S. Cellular Immunology, Vol. 181, Issue 2 https://doi.org/10.1006/cimm.1997.1208	journal	November 1997
Magnesium sensing via LFA-1 regulates CD8+ T cell effector function Lötscher, Jonas; Martí i. Líndez, Adrià-Arnau; Kirchhammer, Nicole Cell, Vol. 185, Issue 4 https://doi.org/10.1016/j.cell.2021.12.039	journal	February 2022
Role of LFA-1 integrin in the control of a lymphocytic choriomeningitis virus (LCMV) infection Perro, Mario; Iannacone, Matteo; von Andrian, Ulrich H. Virulence, Vol. 11, Issue 1 https://doi.org/10.1080/21505594.2020.1845506	journal	November 2020
Tissue-resident memory features are linked to the magnitude of cytotoxic T cell responses in human lung cancer Ganesan, Anusha-Preethi; Clarke, James; Wood, Oliver Nature Immunology, Vol. 18, Issue 8 https://doi.org/10.1038/ni.3775	journal	June 2017
IL-2: The First Effective Immunotherapy for Human Cancer Rosenberg, Steven A. The Journal of Immunology, Vol. 192, Issue 12 https://doi.org/10.4049/jimmunol.1490019	journal	June 2014
Chemokines and integrins independently tune actin flow and substrate friction during intranodal migration of T cells Hons, Miroslav; Kopf, Aglaja; Hauschild, Robert Nature Immunology, Vol. 19, Issue 6 https://doi.org/10.1038/s41590-018-0109-z	journal	May 2018
LFA-1 in T cell priming, differentiation, and effector functions Gérard, Audrey; Cope, Andrew P.; Kemper, Claudia Trends in Immunology, Vol. 42, Issue 8 https://doi.org/10.1016/j.it.2021.06.004	journal	August 2021
The JAK/STAT signaling pathway: from bench to clinic Hu, Xiaoyi; li, Jing; Fu, Maorong Signal Transduction and Targeted Therapy, Vol. 6, Issue 1 https://doi.org/10.1038/s41392-021-00791-1	journal	November 2021
‘Stem-like’ precursors are the fount to sustain persistent CD8+ T cell responses Zehn, Dietmar; Thimme, Robert; Lugli, Enrico Nature Immunology, Vol. 23, Issue 6 https://doi.org/10.1038/s41590-022-01219-w	journal	May 2022
Interleukin-2: Inception, Impact, and Implications Smith, Kendall A. Science, Vol. 240, Issue 4856 https://doi.org/10.1126/science.3131876	journal	May 1988
Immune synapse formation determines interaction forces between T cells and antigen-presenting cells measured by atomic force microscopy Hosseini, Babak H.; Louban, Ilia; Djandji, Dominik Proceedings of the National Academy of Sciences, Vol. 106, Issue 42 https://doi.org/10.1073/pnas.0905384106	journal	October 2009
Ectocytosis renders T cell receptor signaling self-limiting at the immune synapse Stinchcombe, Jane C.; Asano, Yukako; Kaufman, Christopher J. G. Science, Vol. 380, Issue 6647 https://doi.org/10.1126/science.abp8933	journal	May 2023
IL18 Receptor Signaling Regulates Tumor-Reactive CD8+ T-cell Exhaustion via Activation of the IL2/STAT5/mTOR Pathway in a Pancreatic Cancer Model Lutz, Veronika; Hellmund, Veronique M.; Picard, Felix S. R. Cancer Immunology Research, Vol. 11, Issue 4 https://doi.org/10.1158/2326-6066.CIR-22-0398	journal	February 2023
Circulating mucosal-associated invariant T cells identify patients responding to anti-PD-1 therapy De Biasi, Sara; Gibellini, Lara; Lo Tartaro, Domenico Nature Communications, Vol. 12, Issue 1 https://doi.org/10.1038/s41467-021-21928-4	journal	March 2021
Mechanically active integrins target lytic secretion at the immune synapse to facilitate cellular cytotoxicity Wang, Mitchell S.; Hu, Yuesong; Sanchez, Elisa E. Nature Communications, Vol. 13, Issue 1 https://doi.org/10.1038/s41467-022-30809-3	journal	June 2022
A transcriptionally and functionally distinct PD-1+ CD8+ T cell pool with predictive potential in non-small-cell lung cancer treated with PD-1 blockade Thommen, Daniela S.; Koelzer, Viktor H.; Herzig, Petra Nature Medicine, Vol. 24, Issue 7 https://doi.org/10.1038/s41591-018-0057-z	journal	June 2018
Recent Advancements in the Mechanisms Underlying Resistance to PD-1/PD-L1 Blockade Immunotherapy Yuan, Yu; Adam, Abdalla; Zhao, Chen Cancers, Vol. 13, Issue 4 https://doi.org/10.3390/cancers13040663	journal	February 2021
Tumour-Infiltrating Lymphocytes and Interleukin-2 in Treatment of Advanced Cancer Kradin, RichardL.; Lazarus, DavidS.; Dubinett, StevenM. The Lancet, Vol. 333, Issue 8638 https://doi.org/10.1016/S0140-6736(89)91609-7	journal	March 1989
STAT5-mediated chromatin interactions in superenhancers activate IL-2 highly inducible genes: Functional dissection of the Il2ra gene locus Li, Peng; Mitra, Suman; Spolski, Rosanne Proceedings of the National Academy of Sciences, Vol. 114, Issue 46 https://doi.org/10.1073/pnas.1714019114	journal	October 2017
Molecular Pathways of Colon Inflammation Induced by Cancer Immunotherapy Luoma, Adrienne M.; Suo, Shengbao; Williams, Hannah L. Cell, Vol. 182, Issue 3 https://doi.org/10.1016/j.cell.2020.06.001	journal	August 2020
Signaling and Function of Interleukin-2 in T Lymphocytes Ross, Sarah H.; Cantrell, Doreen A. Annual Review of Immunology, Vol. 36, Issue 1 https://doi.org/10.1146/annurev-immunol-042617-053352	journal	April 2018
Exhaustion of tumor-specific CD8+ T cells in metastases from melanoma patients Baitsch, Lukas; Baumgaertner, Petra; Devêvre, Estelle Journal of Clinical Investigation, Vol. 121, Issue 6 https://doi.org/10.1172/JCI46102	journal	June 2011
Bispecific PD1-IL2v and anti-PD-L1 break tumor immunity resistance by enhancing stem-like tumor-reactive CD8+ T cells and reprogramming macrophages Tichet, Mélanie; Wullschleger, Stephan; Chryplewicz, Agnieszka Immunity, Vol. 56, Issue 1 https://doi.org/10.1016/j.immuni.2022.12.006	journal	January 2023

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Title: LFA-1 regulated by IL-2/STAT5 pathway boosts antitumor function of intratumoral CD8 + T cells for improving anti-PD-1 antibody therapy

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Title: LFA-1 regulated by IL-2/STAT5 pathway boosts antitumor function of intratumoral CD8 ⁺ T cells for improving anti-PD-1 antibody therapy