On-Demand Aligned DNA Hydrogel Via Light Scanning

Kim, Juri; Choi, Yun-Seok; Park, Geonhyeong; Kim, Mingeun; Myung, Jin Suk; Choi, Woo Jin; Park, Soon Mo; Yoon, Dong Ki

doi:10.1021/acsnano.3c07493

Title: On-Demand Aligned DNA Hydrogel Via Light Scanning

Journal Article · 10 November 2023 · ACS Nano

DOI: https://doi.org/10.1021/acsnano.3c07493 · OSTI ID:2217515

Kim, Juri ^[1];

^[2]; Park, Geonhyeong ^[1]; Kim, Mingeun ^[3]; Myung, Jin Suk ^[3];

^[3]; Park, Soon Mo ^[4];

^[1]

Korea Advanced Institute of Science and Technology (KAIST), Daejeon (Korea, Republic of)
Los Alamos National Laboratory (LANL), Los Alamos, NM (United States). Center for Integrated Nanotechnologies (CINT)
Korea Research Institute of Chemical Technology (KRICT), Daejeon (Korea, Republic of)
Korea Advanced Institute of Science and Technology (KAIST), Daejeon (Korea, Republic of); Cornell University, Ithaca, NY (United States)

DNA is an anisotropic, water-attracting, and biocompatible material, an ideal building block for hydrogel. The alignment of the anisotropic DNA chains is essential to maximize hydrogel properties, which has been little explored. Here, we present a method to fabricate the anisotropic DNA hydrogel that allows precise control for the polymerization process of photoreactive cationic monomers. Scanning ultraviolet light enables the uniaxial alignment of DNA chains through the polymerization-induced diffusive mass flow using a concentration gradient. In conclusion, while studying anisotropic mechanical properties and orientation recovery according to the DNA chain alignment direction, we demonstrate the potential of directionally controlled DNA hydrogels as smart materials.

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Research Organization:: Los Alamos National Laboratory (LANL), Los Alamos, NM (United States)

Sponsoring Organization:: USDOE Laboratory Directed Research and Development (LDRD) Program; USDOE National Nuclear Security Administration (NNSA); USDOE Office of Science (SC), Basic Energy Sciences (BES). Scientific User Facilities (SUF); Ministry of Science and ICT (MSIT); National Research Foundation of Korea (NRF)

Grant/Contract Number:: 89233218CNA000001; 2021M3C1C3097646l; 2018R1A5A1025208

OSTI ID:: 2217515

Report Number(s):: LA-UR-23-27477

Journal Information:: ACS Nano, Vol. 17, Issue 22; ISSN 1936-0851

Publisher:: American Chemical Society (ACS)Copyright Statement

Country of Publication:: United States

Language:: English

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36 MATERIALS SCIENCE
Material Science
DNA
hydrogel
liquid crystal
alignment
light scanning
mechanical property

Title: On-Demand Aligned DNA Hydrogel Via Light Scanning

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References (61)

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