A multi-organ maize metabolic model connects temperature stress with energy production and reducing power generation

Chowdhury, Niaz Bahar; Simons-Senftle, Margaret; Decouard, Berengere; Quillere, Isabelle; Rigault, Martine; Sajeevan, Karuna Anna; Acharya, Bibek; Chowdhury, Ratul; Hirel, Bertrand; Dellagi, Alia; Maranas, Costas; Saha, Rajib

doi:10.1016/j.isci.2023.108400

Title: A multi-organ maize metabolic model connects temperature stress with energy production and reducing power generation

Journal Article · 07 November 2023 · iScience

DOI: https://doi.org/10.1016/j.isci.2023.108400 · OSTI ID:2205528

Chowdhury, Niaz Bahar ^[1]; Simons-Senftle, Margaret ^[2]; Decouard, Berengere ^[3]; Quillere, Isabelle ^[3]; Rigault, Martine ^[3];

^[4]; Acharya, Bibek ^[4]; Chowdhury, Ratul ^[4]; Hirel, Bertrand ^[5]; Dellagi, Alia ^[3];

^[2];

^[1]

University of Nebraska, Lincoln, NE (United States)
The Pennsylvania State University, University Park, PA (United States)
Université Paris-Saclay, Versailles (France)
Iowa State University, Ames, IA (United States)
Institut National de Recherche pour l’Agriculture, Versailles (France)

Climate change has adversely affected maize productivity. Thereby, a holistic understanding of metabolic crosstalk among its organs is important to address this issue. Thus, we reconstructed the first multi-organ maize metabolic model, iZMA6517, and contextualized it with heat and cold stress transcriptomics data using expression distributed reaction flux measurement (EXTREAM) algorithm. Furthermore, implementing metabolic bottleneck analysis on contextualized models revealed differences between these stresses. While both stresses had reducing power bottlenecks, heat stress had additional energy generation bottlenecks. We also performed thermodynamic driving force analysis, revealing thermodynamics-reducing power-energy generation axis dictating the nature of temperature stress responses. Thus, a temperature-tolerant maize ideotype can be engineered by leveraging the proposed thermodynamics-reducing power-energy generation axis. We experimentally inoculated maize root with a beneficial mycorrhizal fungus, Rhizophagus irregularis, and as a proof-of-concept demonstrated its efficacy in alleviating temperature stress. Overall, this study will guide the engineering effort of temperature stress-tolerant maize ideotypes.

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Research Organization:: Oak Ridge National Laboratory (ORNL), Oak Ridge, TN (United States). Center for Bioenergy Innovation (CBI)

Sponsoring Organization:: USDOE Office of Science (SC), Biological and Environmental Research (BER); National Science Foundation (NSF); Nebraska Collaboration Initiative Grant; French National Agency for Research (ANR); French National Research Institute for Agriculture, Food and the Environment (INRAE); USDOE

Grant/Contract Number:: AC05-00OR22725; 1943310; 21-1106-6011; 2242763; 18-CARN-024-01 – 2018; IB BAP 2021

OSTI ID:: 2205528

Alternate ID(s):: OSTI ID: 2471499

Journal Information:: iScience, Vol. 26, Issue 12; ISSN 2589-0042

Publisher:: ElsevierCopyright Statement

Country of Publication:: United States

Language:: English

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