Herbal supplement Spirulina stimulates inflammatory cytokine production in patients with dermatomyositis in vitro

Bax, Christina E.; Diaz, DeAnna; Li, Yubin; Vazquez, Thomas; Patel, Jay; Grinnell, Madison; Ravishankar, Adarsh; Maddukuri, Spandana; Keyes, Emily; Yan, Daisy; Bashir, Muhammad; Werth, Victoria P.

doi:10.1016/j.isci.2023.108355

Title: Herbal supplement Spirulina stimulates inflammatory cytokine production in patients with dermatomyositis in vitro

Journal Article · 01 November 2023 · iScience

DOI: https://doi.org/10.1016/j.isci.2023.108355 · OSTI ID:2204777

;

; Li, Yubin;

; Patel, Jay; Grinnell, Madison; Ravishankar, Adarsh; Maddukuri, Spandana; Keyes, Emily; Yan, Daisy; Bashir, Muhammad; Werth, Victoria P.

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Sponsoring Organization:: USDOE Office of Electricity (OE), Advanced Grid Research & Development. Power Systems Engineering Research

OSTI ID:: 2204777

Journal Information:: iScience, Journal Name: iScience Vol. 26 Journal Issue: 11; ISSN 2589-0042

Publisher:: ElsevierCopyright Statement

Country of Publication:: Netherlands

Language:: English

References (50)

Essential role for TIRAP in activation of the signalling cascade shared by TLR2 and TLR4 Yamamoto, Masahiro; Sato, Shintaro; Hemmi, Hiroaki Nature, Vol. 420, Issue 6913 https://doi.org/10.1038/nature01182	journal	November 2002
429 Spirulina use and its temporal association with dermatomyositis exacerbation Ravishankar, A.; Bax, C.; Grinnell, M. Journal of Investigative Dermatology, Vol. 141, Issue 5 https://doi.org/10.1016/j.jid.2021.02.452	journal	May 2021
Expression of TLR2, TLR4, and TLR9 in dermatomyositis and polymyositis Kim, Geun-Tae; Cho, Mi-La; Park, Young-Eun Clinical Rheumatology, Vol. 29, Issue 3 https://doi.org/10.1007/s10067-009-1316-7	journal	December 2009
Taking the STING out of TLR-driven autoimmune diseases: good, bad, or indifferent? Pawaria, Sudesh; Sharma, Shruti; Baum, Rebecca Journal of Leukocyte Biology, Vol. 101, Issue 1 https://doi.org/10.1189/jlb.3MR0316-115R	journal	August 2016
The efficacy of dietary Spirulina as an adjunct to chemotherapy to improve immune function and reduce myelosuppression in patients with malignant tumors Ge, Yang; Kang, Yi-Kun; Dong, Li Translational Cancer Research, Vol. 8, Issue 4 https://doi.org/10.21037/tcr.2019.06.13	journal	August 2019
Spirulina is an effective dietary source of zeaxanthin to humans Yu, Bolan; Wang, Jie; Suter, Paolo M. British Journal of Nutrition, Vol. 108, Issue 4 https://doi.org/10.1017/S0007114511005885	journal	February 2012
A mixed immunoblistering disorder exhibiting features of bullous pemphigoid and pemphigus foliaceus associated with Spirulina algae intake Kraigher, Oliver; Wohl, Yonit; Gat, Andrea International Journal of Dermatology, Vol. 47, Issue 1 https://doi.org/10.1111/j.1365-4632.2007.03388.x	journal	December 2007
Monocyte Subsets: Phenotypes and Function in Tuberculosis Infection Sampath, Pavithra; Moideen, Kadar; Ranganathan, Uma Devi Frontiers in Immunology, Vol. 9 https://doi.org/10.3389/fimmu.2018.01726	journal	July 2018
Antigen gene transfer to cultured human dendritic cells using recombinant avipoxvirus vectors Brown, M.; Davies, D. H.; Skinner, M. A. Cancer Gene Therapy, Vol. 6, Issue 3 https://doi.org/10.1038/sj.cgt.7700014	journal	May 1999
Improvement of vitamin B ₁₂ status with Spirulina supplementation in Wistar rats validated through functional and circulatory markers Madhubalaji, Chegu Krishnamurthi; Rashmi, Venkatasubbaiah; Chauhan, Vikas Singh Journal of Food Biochemistry, Vol. 43, Issue 11 https://doi.org/10.1111/jfbc.13038	journal	September 2019
Enhancement of antitumor natural killer cell activation by orally administered Spirulina extract in mice Akao, Yuusuke; Ebihara, Takashi; Masuda, Hisayo Cancer Science, Vol. 100, Issue 8 https://doi.org/10.1111/j.1349-7006.2009.01188.x	journal	July 2009
DNA sensing by the cGAS–STING pathway in health and disease Motwani, Mona; Pesiridis, Scott; Fitzgerald, Katherine A. Nature Reviews Genetics, Vol. 20, Issue 11 https://doi.org/10.1038/s41576-019-0151-1	journal	July 2019
The Heterogeneity of Ly6Chi Monocytes Controls Their Differentiation into iNOS+ Macrophages or Monocyte-Derived Dendritic Cells Menezes, Shinelle; Melandri, Daisy; Anselmi, Giorgio Immunity, Vol. 45, Issue 6 https://doi.org/10.1016/j.immuni.2016.12.001	journal	December 2016
Potential ofSpirulina Platensisas a Nutritional Supplement in Malnourished HIV-Infected Adults in Sub-Saharan Africa: A Randomised, Single-Blind Study Azabji-Kenfack, M.; Dikosso, S. Edie; Loni, E. G. Nutrition and Metabolic Insights, Vol. 4 https://doi.org/10.4137/NMI.S5862	journal	January 2011
Highly Multiplexed Mass Cytometry Identifies the Immunophenotype in the Skin of Dermatomyositis Patel, Jay; Maddukuri, Spandana; Li, Yubin Journal of Investigative Dermatology, Vol. 141, Issue 9 https://doi.org/10.1016/j.jid.2021.02.748	journal	September 2021
TRAM is specifically involved in the Toll-like receptor 4–mediated MyD88-independent signaling pathway Yamamoto, Masahiro; Sato, Shintaro; Hemmi, Hiroaki Nature Immunology, Vol. 4, Issue 11 https://doi.org/10.1038/ni986	journal	October 2003
Cellular Differentiation of Human Monocytes Is Regulated by Time-Dependent Interleukin-4 Signaling and the Transcriptional Regulator NCOR2 Sander, Jil; Schmidt, Susanne V.; Cirovic, Branko Immunity, Vol. 47, Issue 6 https://doi.org/10.1016/j.immuni.2017.11.024	journal	December 2017
Long-Term Trends in the Use of Complementary and Alternative Medical Therapies in the United States Kessler, Ronald C.; Davis, Roger B.; Foster, David F. Annals of Internal Medicine, Vol. 135, Issue 4 https://doi.org/10.7326/0003-4819-135-4-200108210-00011	journal	August 2001
Isolation of Three High Molecular Weight Polysaccharide Preparations with Potent Immunostimulatory Activity fromSpirulina platensis,Aphanizomenon flos-aquaeandChlorella pyrenoidosa Pugh, Nirmal; Ross, Samir; ElSohly, Hala Planta Medica, Vol. 67, Issue 08 https://doi.org/10.1055/s-2001-18358	journal	November 2001
Human Monocyte Subsets and Phenotypes in Major Chronic Inflammatory Diseases Kapellos, Theodore S.; Bonaguro, Lorenzo; Gemünd, Ioanna Frontiers in Immunology, Vol. 10 https://doi.org/10.3389/fimmu.2019.02035	journal	August 2019
Oral administration of a Spirulina extract enriched for Braun-type lipoproteins protects mice against influenza A (H1N1) virus infection Pugh, Nirmal D.; Edwall, Dan; Lindmark, Lars Phytomedicine, Vol. 22, Issue 2 https://doi.org/10.1016/j.phymed.2014.12.006	journal	February 2015
Spirulina in Clinical Practice: Evidence-Based Human Applications Karkos, P. D.; Leong, S. C.; Karkos, C. D. Evidence-Based Complementary and Alternative Medicine, Vol. 2011 https://doi.org/10.1093/ecam/nen058	journal	January 2011
A case of inflammatory myopathy with widely skin rash following use of supplements containing Spirulina Konno, Takuya; Umeda, Yoshitaka; Umeda, Maiko Rinsho Shinkeigaku, Vol. 51, Issue 5 https://doi.org/10.5692/clinicalneurol.51.330	journal	January 2011
Plasma-derived DNA containing-extracellular vesicles induce STING-mediated proinflammatory responses in dermatomyositis Li, Yubin; Bax, Christina; Patel, Jay Theranostics, Vol. 11, Issue 15 https://doi.org/10.7150/thno.59152	journal	January 2021
Immolina, a High–Molecular-Weight Polysaccharide Fraction of Spirulina, Enhances Chemokine Expression in Human Monocytic THP-1 Cells Grzanna, Reinhard; Polotsky, Anna; Phan, Phong V. The Journal of Alternative and Complementary Medicine, Vol. 12, Issue 5 https://doi.org/10.1089/acm.2006.12.429	journal	June 2006
Antioxidant, Immunomodulating, and Microbial-Modulating Activities of the Sustainable and EcofriendlySpirulina Finamore, Alberto; Palmery, Maura; Bensehaila, Sarra Oxidative Medicine and Cellular Longevity, Vol. 2017 https://doi.org/10.1155/2017/3247528	journal	January 2017
Effect of Spirulina on the Secretion of Cytokines from Peripheral Blood Mononuclear Cells Mao, T. K.; Van De Water, J.; Gershwin, M. E. Journal of Medicinal Food, Vol. 3, Issue 3 https://doi.org/10.1089/jmf.2000.3.135	journal	January 2000
Lipid and lipopolysaccharide constituents of cyanobacterium Spirulina platensis (Cyanophyceae, Nostocales) Tornabene, Tg; Bourne, Tf; Raziuddin, S. Marine Ecology Progress Series, Vol. 22 https://doi.org/10.3354/meps022121	journal	January 1985
Frequency of immunostimulatory herbal supplement use among patients with autoimmune skin disease Ravishankar, Adarsh; Bax, Christina E.; Grinnell, Madison Journal of the American Academy of Dermatology, Vol. 87, Issue 5 https://doi.org/10.1016/j.jaad.2021.12.050	journal	November 2022
Regulating STING in health and disease Li, Yang; Wilson, Heather L.; Kiss-Toth, Endre Journal of Inflammation, Vol. 14, Issue 1 https://doi.org/10.1186/s12950-017-0159-2	journal	June 2017
Tank binding kinase 1 is a centrosome-associated kinase necessary for microtubule dynamics and mitosis Pillai, Smitha; Nguyen, Jonathan; Johnson, Joseph Nature Communications, Vol. 6, Issue 1 https://doi.org/10.1038/ncomms10072	journal	December 2015
Enhancement of Natural Killer Cell Activity in Healthy Subjects by Immulina®, aSpirulinaExtract Enriched for Braun-Type Lipoproteins Nielsen, Claus; Balachandran, Premalatha; Christensen, Ole Planta Medica, Vol. 76, Issue 16 https://doi.org/10.1055/s-0030-1250043	journal	June 2010
Hypolipidemic, Antioxidant, and Antiinflammatory Activities of Microalgae Spirulina: Hypolipidemic, Antioxidant, and Antiinflammatory Activities of Microalgae Spirulina Deng, Ruitang; Chow, Te-Jin Cardiovascular Therapeutics, Vol. 28, Issue 4 https://doi.org/10.1111/j.1755-5922.2010.00200.x	journal	July 2010
Pathogenesis of Dermatomyositis: Role of Cytokines and Interferon Kao, Lily; Chung, Lorinda; Fiorentino, David F. Current Rheumatology Reports, Vol. 13, Issue 3 https://doi.org/10.1007/s11926-011-0166-x	journal	February 2011
Evidence for licensing of IFN-γ-induced IFN regulatory factor 1 transcription factor by MyD88 in Toll-like receptor-dependent gene induction program Negishi, Hideo; Fujita, Yasuyuki; Yanai, Hideyuki Proceedings of the National Academy of Sciences, Vol. 103, Issue 41 https://doi.org/10.1073/pnas.0607181103	journal	October 2006
Toll-like receptor 2-dependent activation of monocytes by Spirulina polysaccharide and its immune enhancing action in mice Balachandran, Premalatha; Pugh, Nirmal D.; Ma, Guoyi International Immunopharmacology, Vol. 6, Issue 12 https://doi.org/10.1016/j.intimp.2006.08.001	journal	December 2006
MyD88 Primes Macrophages for Full-Scale Activation by Interferon-γ yet Mediates Few Responses to Mycobacterium tuberculosis Shi, Shuangping; Nathan, Carl; Schnappinger, Dirk The Journal of Experimental Medicine, Vol. 198, Issue 7 https://doi.org/10.1084/jem.20030603	journal	September 2003
Lipopolysaccharide Stimulates the MyD88-Independent Pathway and Results in Activation of IFN-Regulatory Factor 3 and the Expression of a Subset of Lipopolysaccharide-Inducible Genes Kawai, Taro; Takeuchi, Osamu; Fujita, Takashi The Journal of Immunology, Vol. 167, Issue 10 https://doi.org/10.4049/jimmunol.167.10.5887	journal	November 2001
Enhancement of Human Adaptive Immune Responses by Administration of a High-Molecular-Weight Polysaccharide Extract from the Cyanobacterium Arthrospira platensis Løbner, Morten; Walsted, Anette; Larsen, Rune Journal of Medicinal Food, Vol. 11, Issue 2 https://doi.org/10.1089/jmf.2007.564	journal	June 2008
Acute onset/flares of dermatomyositis following ingestion of IsaLean herbal supplement: Clinical and immunostimulatory findings Zeidi, Majid; Chansky, Peter B.; Werth, Victoria P. Journal of the American Academy of Dermatology, Vol. 80, Issue 3 https://doi.org/10.1016/j.jaad.2018.08.019	journal	March 2019
IFN-γ selectively suppresses a subset of TLR4-activated genes and enhancers to potentiate macrophage activation Kang, Kyuho; Bachu, Mahesh; Park, Sung Ho Nature Communications, Vol. 10, Issue 1 https://doi.org/10.1038/s41467-019-11147-3	journal	July 2019
Stimulation of toll-like receptor 4 expression in human mononuclear phagocytes by interferon-γ: a molecular basis for priming and synergism with bacterial lipopolysaccharide Bosisio, Daniela; Polentarutti, Nadia; Sironi, Marina Blood, Vol. 99, Issue 9 https://doi.org/10.1182/blood.V99.9.3427	journal	May 2002
Activation of Autoimmunity Following Use of Immunostimulatory Herbal Supplements Lee, Alice N.; Werth, Victoria P. Archives of Dermatology, Vol. 140, Issue 6 https://doi.org/10.1001/archderm.140.6.723	journal	June 2004
Impact of daily supplementation of Spirulina platensis on the immune system of naïve HIV-1 patients in Cameroon: a 12-months single blind, randomized, multicenter trial Ngo-Matip, Marthe-Elise; Pieme, Constant Anatole; Azabji-Kenfack, Marcel Nutrition Journal, Vol. 14, Issue 1 https://doi.org/10.1186/s12937-015-0058-4	journal	July 2015
Cutting Edge: Toll-Like Receptor 4 (TLR4)-Deficient Mice Are Hyporesponsive to Lipopolysaccharide: Evidence for TLR4 as the Lps Gene Product Hoshino, Katsuaki; Takeuchi, Osamu; Kawai, Taro The Journal of Immunology, Vol. 162, Issue 7 https://doi.org/10.4049/jimmunol.162.7.3749	journal	April 1999
Toll like receptors and autoimmunity: A critical appraisal Papadimitraki, Eva D.; Bertsias, George K.; Boumpas, Dimitrios T. Journal of Autoimmunity, Vol. 29, Issue 4 https://doi.org/10.1016/j.jaut.2007.09.001	journal	December 2007
Activation of the human innate immune system by Spirulina: augmentation of interferon production and NK cytotoxicity by oral administration of hot water extract of Spirulina platensis Hirahashi, Tomohiro; Matsumoto, Misako; Hazeki, Kaoru International Immunopharmacology, Vol. 2, Issue 4 https://doi.org/10.1016/S1567-5769(01)00166-7	journal	March 2002
Comparison of copper and zinc in vitro bioaccessibility from cyanobacteria rich in proteins and a synthetic supplement containing gluconate complexes: LC–MS mapping of bioaccessible copper complexes Wojcieszek, Justyna; Witkoś, Katarzyna; Ruzik, Lena Analytical and Bioanalytical Chemistry, Vol. 408, Issue 3 https://doi.org/10.1007/s00216-015-9162-8	journal	November 2015
Characterization of Microalgal Carotenoids by Mass Spectrometry and Their Bioavailability and Antioxidant Properties Elucidated in Rat Model Ranga Rao, A.; Raghunath Reddy, R. L.; Baskaran, V. Journal of Agricultural and Food Chemistry, Vol. 58, Issue 15 https://doi.org/10.1021/jf101187k	journal	July 2010
TLR expression in peripheral monocyte subsets of patients with idiopathic inflammatory myopathies: association with clinical and immunological features Torres-Ruiz, Jiram; Carrillo-Vazquez, Daniel Alberto; Padilla-Ortiz, Diana Marcela Journal of Translational Medicine, Vol. 18, Issue 1 https://doi.org/10.1186/s12967-020-02290-3	journal	March 2020

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