Development of First-in-Class Dual Sirt2/HDAC6 Inhibitors as Molecular Tools for Dual Inhibition of Tubulin Deacetylation

Sinatra, Laura; Vogelmann, Anja; Friedrich, Florian; Tararina, Margarita A.; Neuwirt, Emilia; Colcerasa, Arianna; König, Philipp; Toy, Lara; Yesiloglu, Talha Z.; Hilscher, Sebastian; Gaitzsch, Lena; Papenkordt, Niklas; Zhai, Shiyang; Zhang, Lin; Romier, Christophe; Einsle, Oliver; Sippl, Wolfgang; Schutkowski, Mike; Gross, Olaf; Bendas, Gerd; Christianson, David W.; Hansen, Finn K.; Jung, Manfred; Schiedel, Matthias

doi:10.1021/acs.jmedchem.3c01385

Title: Development of First-in-Class Dual Sirt2/HDAC6 Inhibitors as Molecular Tools for Dual Inhibition of Tubulin Deacetylation

Journal Article · 29 October 2023 · Journal of Medicinal Chemistry

DOI: https://doi.org/10.1021/acs.jmedchem.3c01385 · OSTI ID:2204062

Sinatra, Laura ^[1]; Vogelmann, Anja ^[2]; Friedrich, Florian ^[2];

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^[4]; Colcerasa, Arianna ^[2]; König, Philipp ^[5];

^[6]; Yesiloglu, Talha Z. ^[7];

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^[11]; Gross, Olaf ^[12];

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Institute for Drug Discovery, Medical Faculty, Leipzig University, Brüderstraße 34, 04103 Leipzig, Germany
Institute of Pharmaceutical Sciences, University of Freiburg, Albertstraße 25, 79104 Freiburg, Germany
Roy and Diana Vagelos Laboratories, Department of Chemistry, University of Pennsylvania, 231 South 34th Street, Philadelphia, Pennsylvania 19104-6323, United States
Institute of Neuropathology, Medical Center−University of Freiburg, Faculty of Medicine, University of Freiburg, Breisacherstraße 64, 79106 Freiburg, Germany, CIBSS−Centre for Integrative Biological Signalling Studies, University of Freiburg, Schänzlestraße 18, 79104 Freiburg, Germany
Department of Pharmaceutical & Cell Biological Chemistry, Pharmaceutical Institute, University of Bonn, An der Immenburg 4, 53121 Bonn, Germany
Department of Chemistry and Pharmacy, Medicinal Chemistry, Friedrich-Alexander-University Erlangen-Nürnberg, Nikolaus-Fiebiger-Straße 10, 91058 Erlangen, Germany
Department of Medicinal Chemistry, Institute of Pharmacy, Martin-Luther University of Halle-Wittenberg, Wolfgang-Langenbeck-Straße 2-4, 06120 Halle (Saale), Germany
Department of Medicinal Chemistry, Institute of Pharmacy, Martin-Luther University of Halle-Wittenberg, Wolfgang-Langenbeck-Straße 2-4, 06120 Halle (Saale), Germany, Department of Enzymology, Charles Tanford Protein Center, Institute of Biochemistry and Biotechnology, Martin-Luther-University Halle-Wittenberg, 06120 Halle, Germany
Institute of Biochemistry, University of Freiburg, Albertstraße 21, 79104 Freiburg, Germany
Institut de Génétique et de Biologie Moléculaire et Cellulaire (IGBMC), Université de Strasbourg, CNRS UMR 7104, Inserm UMR-S 1258, 1 rue Laurent Fries, F-67400 Illkirch, France
Department of Enzymology, Charles Tanford Protein Center, Institute of Biochemistry and Biotechnology, Martin-Luther-University Halle-Wittenberg, 06120 Halle, Germany
Institute of Neuropathology, Medical Center−University of Freiburg, Faculty of Medicine, University of Freiburg, Breisacherstraße 64, 79106 Freiburg, Germany, CIBSS−Centre for Integrative Biological Signalling Studies, University of Freiburg, Schänzlestraße 18, 79104 Freiburg, Germany, Center for Basics in NeuroModulation (NeuroModulBasics), Faculty of Medicine, University of Freiburg, Breisacherstraße 64, 79106 Freiburg, Germany
Institute for Drug Discovery, Medical Faculty, Leipzig University, Brüderstraße 34, 04103 Leipzig, Germany, Department of Pharmaceutical & Cell Biological Chemistry, Pharmaceutical Institute, University of Bonn, An der Immenburg 4, 53121 Bonn, Germany
Department of Chemistry and Pharmacy, Medicinal Chemistry, Friedrich-Alexander-University Erlangen-Nürnberg, Nikolaus-Fiebiger-Straße 10, 91058 Erlangen, Germany, Institute of Medicinal and Pharmaceutical Chemistry, Technische Universität Braunschweig, Beethovenstraße 55, 38106 Braunschweig, Germany

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Sponsoring Organization:: USDOE Office of Science (SC), Biological and Environmental Research (BER)

OSTI ID:: 2204062

Alternate ID(s):: OSTI ID: 2470257

Journal Information:: Journal of Medicinal Chemistry, Journal Name: Journal of Medicinal Chemistry Journal Issue: 21 Vol. 66; ISSN 0022-2623

Publisher:: American Chemical SocietyCopyright Statement

Country of Publication:: United States

Language:: English

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