DOE PAGES title logo U.S. Department of Energy
Office of Scientific and Technical Information

Title: Biochemical and biophysical characterization of natural polyreactivity in antibodies

Journal Article · · Cell Reports

Not Available

Sponsoring Organization:
USDOE
Grant/Contract Number:
AC02-06CH11357
OSTI ID:
2202511
Journal Information:
Cell Reports, Journal Name: Cell Reports Journal Issue: 10 Vol. 42; ISSN 2211-1247
Publisher:
ElsevierCopyright Statement
Country of Publication:
Netherlands
Language:
English

References (56)

Scarcity of autoreactive human blood IgA+ memory B cells journal August 2016
CHARMM-GUI: A web-based graphical user interface for CHARMM journal March 2008
A naturally occurring peptide recognized by alloreactive CD8+ cytotoxic T lymphocytes in association with a class I MHC protein journal June 1992
Molecular mimicry in T cell-mediated autoimmunity: Viral peptides activate human T cell clones specific for myelin basic protein journal March 1995
VMD: Visual molecular dynamics journal February 1996
Thermodynamic Analysis of Degenerate Recognition by the NKG2D Immunoreceptor journal December 2003
A model T-cell receptor system for studying memory T-cell development journal March 2003
MDTraj: A Modern Open Library for the Analysis of Molecular Dynamics Trajectories journal October 2015
Conformational Plasticity in Broadly Neutralizing HIV-1 Antibodies Triggers Polyreactivity journal May 2018
Polyreactive Broadly Neutralizing B cells Are Selected to Provide Defense against Pandemic Threat Influenza Viruses journal December 2020
Efficient generation of monoclonal antibodies from single human B cells by single cell RT-PCR and expression vector cloning journal January 2008
Inference of Macromolecular Assemblies from Crystalline State journal September 2007
The Intrinsic Contributions of Tyrosine, Serine, Glycine and Arginine to the Affinity and Specificity of Antibodies journal April 2008
Reduction of Nonspecificity Motifs in Synthetic Antibody Libraries journal January 2018
Sequence features of variable region determining physicochemical properties and polyreactivity of therapeutic antibodies journal August 2019
Harnessing the Therapeutic Potential of ‘Rogue’ Antibodies journal June 2020
OPUS-Rota3: Improving Protein Side-Chain Modeling by Deep Neural Networks and Ensemble Methods journal November 2020
PyEMMA 2: A Software Package for Estimation, Validation, and Analysis of Markov Models journal October 2015
CHARMM-GUI Input Generator for NAMD, GROMACS, AMBER, OpenMM, and CHARMM/OpenMM Simulations Using the CHARMM36 Additive Force Field journal December 2015
T-cell-receptor affinity and thymocyte positive selection journal June 1996
Polyreactivity increases the apparent affinity of anti-HIV antibodies by heteroligation journal September 2010
Promiscuity and the single receptor: NKG2D journal August 2007
An in silico method to assess antibody fragment polyreactivity journal December 2022
Autoreactivity profiles of influenza hemagglutinin broadly neutralizing antibodies journal March 2019
Fast on-rates allow short dwell time ligands to activate T cells journal April 2010
Preconfiguration of the antigen-binding site during affinity maturation of a broadly neutralizing influenza virus antibody journal November 2012
Both protein dynamics and ligand concentration can shift the binding mechanism between conformational selection and induced fit journal June 2014
Biophysical properties of the clinical-stage antibody landscape journal January 2017
Five computational developability guidelines for therapeutic antibody profiling journal February 2019
Conformational diversity facilitates antibody mutation trajectories and discrimination between foreign and self-antigens journal August 2020
Surface patches induce nonspecific binding and phase separation of antibodies journal April 2023
Structural requirements for binding of an immunodominant myelin basic protein peptide to DR2 isotypes and for its recognition by human T cell clones. journal January 1994
Net charge of antibody complementarity-determining regions is a key predictor of specificity journal November 2018
PHENIX: a comprehensive Python-based system for macromolecular structure solution journal January 2010
Features and development of Coot journal March 2010
iMOSFLM : a new graphical interface for diffraction-image processing with MOSFLM journal March 2011
Structure of the apo anti-influenza CH65 Fab journal January 2015
Predominant Autoantibody Production by Early Human B Cell Precursors journal September 2003
Cardiolipin Polyspecific Autoreactivity in Two Broadly Neutralizing HIV-1 Antibodies journal June 2005
A Neutralizing Antibody Selected from Plasma Cells That Binds to Group 1 and Group 2 Influenza A Hemagglutinins journal July 2011
Highly Conserved Protective Epitopes on Influenza B Viruses journal August 2012
T Cell Receptor-MHC Class I Peptide Interactions: Affinity, Kinetics, and Specificity journal August 1994
Natural polyreactive IgA antibodies coat the intestinal microbiota journal September 2017
Conservation and diversity in the ultralong third heavy-chain complementarity-determining region of bovine antibodies journal June 2016
Immune history profoundly affects broadly protective B cell responses to influenza journal December 2015
Broadly Reactive Human Monoclonal Antibodies Elicited following Pandemic H1N1 Influenza Virus Exposure Protect Mice against Highly Pathogenic H5N1 Challenge journal June 2018
Nonneutralizing HIV-1 gp41 Envelope Cluster II Human Monoclonal Antibodies Show Polyreactivity for Binding to Phospholipids and Protein Autoantigens journal November 2010
Mechanism of HIV-1 Neutralization by Antibodies Targeting a Membrane-Proximal Region of gp41 journal November 2013
Mature B cells class switched to IgD are autoreactive in healthy individuals journal June 2007
Prediction of polyreactive and nonspecific single-chain fragment variables through structural biochemical features and protein language-based descriptors journal December 2022
Automated Builder and Database of Protein/Membrane Complexes for Molecular Dynamics Simulations journal September 2007
Repertoire Analysis of Antibody CDR-H3 Loops Suggests Affinity Maturation Does Not Typically Result in Rigidification journal March 2018
The Hypervariable Loops of Free TCRs Sample Multiple Distinct Metastable Conformations in Solution journal November 2018
Local and Global Rigidification Upon Antibody Affinity Maturation journal August 2020
Conformational Melding Permits a Conserved Binding Geometry in TCR Recognition of Foreign and Self Molecular Mimics journal January 2011
Biochemical patterns of antibody polyreactivity revealed through a bioinformatics-based analysis of CDR loops journal November 2020

Related Subjects