Long‐Range Electron Transport Rates Depend on Wire Dimensions in Cytochrome Nanowires

Kulke, Martin; Olson, Dayna M.; Huang, Jingcheng; Kramer, David M.; Vermaas, Josh V.

doi:10.1002/smll.202304013

Title: Long‐Range Electron Transport Rates Depend on Wire Dimensions in Cytochrome Nanowires

Journal Article · 30 August 2023 · Small

DOI: https://doi.org/10.1002/smll.202304013 · OSTI ID:1997869

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MSU‐DOE Plant Research Laboratory and Department of Biochemistry and Molecular Biology Michigan State University 612 Wilson Rd East Lansing MI 48824 United States of America

Abstract The ability to redirect electron transport to new reactions in living systems opens possibilities to store energy, generate new products, or probe physiological processes. Recent work by Huang et al. showed that 3D crystals of small tetraheme cytochromes (STC) can transport electrons over nanoscopic to mesoscopic distances by an electron hopping mechanism, making them promising materials for nanowires. However, fluctuations at room temperature may distort the nanostructure, hindering efficient electron transport. Classical molecular dynamics simulations of these fluctuations at the nano‐ and mesoscopic scales allowed us to develop a graph network representation to estimate maximum electron flow that can be driven through STC wires. In longer nanowires, transient structural fluctuations at protein‐protein interfaces tended to obstruct efficient electron transfer, but these blockages are ameliorated in thicker crystals where alternative electron transfer pathways become more efficient. The model implies that more flexible proteinprotein interfaces limit the required minimum diameter to carry currents commensurate with conventional electronics.

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Research Organization:: Michigan State Univ., East Lansing, MI (United States)

Sponsoring Organization:: USDOE; USDOE Office of Science (SC)

Grant/Contract Number:: FG02-91ER20021

OSTI ID:: 1997869

Journal Information:: Small, Journal Name: Small Journal Issue: 52 Vol. 19; ISSN 1613-6810

Publisher:: Wiley Blackwell (John Wiley & Sons)Copyright Statement

Country of Publication:: Germany

Language:: English

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