Screening the complex biological behavior of late lanthanides through genome-wide interactions

Pallares, Roger M.; An, Dahlia D.; Hebert, Solene; Loguinov, Alex; Proctor, Michael; Villalobos, Jonathan A.; Bjornstad, Kathleen A.; Rosen, Chris J.; Vulpe, Christopher; Abergel, Rebecca J.

doi:10.1093/mtomcs/mfad039

Title: Screening the complex biological behavior of late lanthanides through genome-wide interactions

Journal Article · 18 June 2023 · Metallomics (Online)

DOI: https://doi.org/10.1093/mtomcs/mfad039 · OSTI ID:1993627

;

; Hebert, Solene; Loguinov, Alex; Proctor, Michael; Villalobos, Jonathan A.; Bjornstad, Kathleen A.; Rosen, Chris J.;

;

Abstract Despite their similar physicochemical properties, recent studies have demonstrated that lanthanides can display different biological behaviors. Hence, the lanthanide series can be divided into three parts, namely early, mid, and late lanthanides, based on their interactions with biological systems. In particular, the late lanthanides demonstrate distinct, but poorly understood biological activity. In the current study, we employed genome-wide functional screening to help understand biological effects of exposure to Yb(III) and Lu(III), which were selected as representatives of the late lanthanides. As a model organism, we used Saccharomyces cerevisiae, since it shares many biological functions with humans. Analysis of the functional screening results indicated toxicity of late lanthanides is consistent with disruption of vesicle-mediated transport, and further supported a role for calcium transport processes and mitophagy in mitigating toxicity. Unexpectedly, our analysis suggested that late lanthanides target proteins with SH3 domains, which may underlie the observed toxicity. This study provides fundamental insights into the unique biological chemistry of late lanthanides, which may help devise new avenues toward the development of decorporation strategies and bio-inspired separation processes.

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Sponsoring Organization:: USDOE

Grant/Contract Number:: AC02-05CH11231

OSTI ID:: 1993627

Journal Information:: Metallomics (Online), Journal Name: Metallomics (Online) Journal Issue: 8 Vol. 15; ISSN 1756-591X

Publisher:: Oxford University PressCopyright Statement

Country of Publication:: United Kingdom

Language:: English

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