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Intermittent HIV-1 Viremia (Blips) and Drug Resistance in Patients Receiving HAART
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February 2005 |
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HIV-1 replication is controlled at the level of T cell activation and proviral integration.
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May 1990 |
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Measuring the Frequency of Latent HIV-1 in Resting CD4+ T Cells Using a Limiting Dilution Coculture Assay
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January 2016 |
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Immunologic Control of HIV-1: What Have We Learned and Can We Induce It?
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March 2021 |
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HIV-1 Integration in the Human Genome Favors Active Genes and Local Hotspots
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August 2002 |
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The T Cell Activation Factor NF-ATc Positively Regulates HIV-1 Replication and Gene Expression in T Cells
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March 1997 |
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Replication-Competent Noninduced Proviruses in the Latent Reservoir Increase Barrier to HIV-1 Cure
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October 2013 |
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HIV-1 Integration Landscape during Latent and Active Infection
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January 2015 |
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Parallel analysis of transcription, integration, and sequence of single HIV-1 proviruses
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January 2022 |
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Extensive characterization of HIV-1 reservoirs reveals links to plasma viremia before and during analytical treatment interruption
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April 2022 |
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Progressive transformation of the HIV-1 reservoir cell profile over two decades of antiviral therapy
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January 2023 |
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Antiretroviral therapy reveals triphasic decay of intact SIV genomes and persistence of ancestral variants
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March 2023 |
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Single-cell multiomics reveals persistence of HIV-1 in expanded cytotoxic T cell clones
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June 2022 |
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New insights into transcription elongation control of HIV-1 latency and rebound
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January 2023 |
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An inducible transcription factor activates expression of human immunodeficiency virus in T cells
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April 1987 |
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Quantification of latent tissue reservoirs and total body viral load in HIV-1 infection
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May 1997 |
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Decay characteristics of HIV-1-infected compartments during combination therapy
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May 1997 |
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Latent infection of CD4+ T cells provides a mechanism for lifelong persistence of HIV-1, even in patients on effective combination therapy
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May 1999 |
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Administration of vorinostat disrupts HIV-1 latency in patients on antiretroviral therapy
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July 2012 |
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Rapid seeding of the viral reservoir prior to SIV viraemia in rhesus monkeys
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July 2014 |
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Ad26/MVA therapeutic vaccination with TLR7 stimulation in SIV-infected rhesus monkeys
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November 2016 |
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HIV reservoir size and persistence are driven by T cell survival and homeostatic proliferation
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June 2009 |
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Defective proviruses rapidly accumulate during acute HIV-1 infection
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August 2016 |
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In vivo fate of HIV-1-infected T cells: Quantitative analysis of the transition to stable latency
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December 1995 |
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Long-term follow-up studies confirm the stability of the latent reservoir for HIV-1 in resting CD4+ T cells
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journal
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May 2003 |
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A majority of HIV persistence during antiretroviral therapy is due to infected cell proliferation
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November 2018 |
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Longitudinal HIV sequencing reveals reservoir expression leading to decay which is obscured by clonal expansion
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February 2019 |
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The role of CD32 during HIV-1 infection
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September 2018 |
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Combination therapy with anti-HIV-1 antibodies maintains viral suppression
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September 2018 |
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A quantitative approach for measuring the reservoir of latent HIV-1 proviruses
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January 2019 |
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Systemic HIV and SIV latency reversal via non-canonical NF-κB signalling in vivo
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January 2020 |
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Distinct viral reservoirs in individuals with spontaneous control of HIV-1
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August 2020 |
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Rapid HIV RNA rebound after antiretroviral treatment interruption in persons durably suppressed in Fiebig I acute HIV infection
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June 2018 |
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Early intervention with 3BNC117 and romidepsin at antiretroviral treatment initiation in people with HIV-1: a phase 1b/2a, randomized trial
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October 2022 |
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A Controlled Trial of Two Nucleoside Analogues plus Indinavir in Persons with Human Immunodeficiency Virus Infection and CD4 Cell Counts of 200 per Cubic Millimeter or Less
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September 1997 |
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Treatment with Indinavir, Zidovudine, and Lamivudine in Adults with Human Immunodeficiency Virus Infection and Prior Antiretroviral Therapy
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September 1997 |
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Large number of rebounding/founder HIV variants emerge from multifocal infection in lymphatic tissues after treatment interruption
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February 2015 |
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Clonally expanded CD4 + T cells can produce infectious HIV-1 in vivo
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February 2016 |
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Paired quantitative and qualitative assessment of the replication-competent HIV-1 reservoir and comparison with integrated proviral DNA
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November 2016 |
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Strain-induced accelerated asymmetric spatial degradation of polymeric vascular scaffolds
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February 2018 |
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Defective HIV-1 proviruses produce viral proteins
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February 2020 |
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Intact proviral DNA assay analysis of large cohorts of people with HIV provides a benchmark for the frequency and composition of persistent proviral DNA
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July 2020 |
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Autologous IgG antibodies block outgrowth of a substantial but variable fraction of viruses in the latent reservoir for HIV-1
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journal
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November 2020 |
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Complex decay dynamics of HIV virions, intact and defective proviruses, and 2LTR circles following initiation of antiretroviral therapy
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journal
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February 2022 |
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Identification of T cell-signaling pathways that stimulate latent HIV in primary cells
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October 2003 |
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Tumor necrosis factor alpha activates human immunodeficiency virus type 1 through induction of nuclear factor binding to the NF-kappa B sites in the long terminal repeat.
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August 1989 |
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Presence of an inducible HIV-1 latent reservoir during highly active antiretroviral therapy
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November 1997 |
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Early establishment of a pool of latently infected, resting CD4+ T cells during primary HIV-1 infection
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July 1998 |
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HIV-1 and T cell dynamics after interruption of highly active antiretroviral therapy (HAART) in patients with a history of sustained viral suppression
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December 1999 |
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Proliferation of latently infected CD4 + T cells carrying replication-competent HIV-1: Potential role in latent reservoir dynamics
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March 2017 |
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Relationship between latent and rebound viruses in a clinical trial of anti–HIV-1 antibody 3BNC117
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August 2018 |
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Antigen-responsive CD4+ T cell clones contribute to the HIV-1 latent reservoir
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April 2020 |
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Integration features of intact latent HIV-1 in CD4+ T cell clones contribute to viral persistence
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October 2021 |
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Establishment of a CCR5-Expressing T-Lymphoblastoid Cell Line Highly Susceptible to R5 HIV Type 1
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July 2000 |
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Selective Decay of Intact HIV-1 Proviral DNA on Antiretroviral Therapy
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August 2020 |
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Varied Patterns of Decay of Intact Human Immunodeficiency Virus Type 1 Proviruses Over 2 Decades of Antiretroviral Therapy
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February 2023 |
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Longitudinal Genetic Characterization Reveals That Cell Proliferation Maintains a Persistent HIV Type 1 DNA Pool During Effective HIV Therapy
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February 2015 |
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Precise Quantitation of the Latent HIV-1 Reservoir: Implications for Eradication Strategies
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April 2015 |
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Human Immunodeficiency Virus Type 1 Persistence Following Systemic Chemotherapy for Malignancy
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June 2017 |
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Designing and Interpreting Limiting Dilution Assays: General Principles and Applications to the Latent Reservoir for Human Immunodeficiency Virus-1
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January 2015 |
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Transcription elongation factor P-TEFb is required for HIV-1 Tat transactivation in vitro
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October 1997 |
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Specific HIV integration sites are linked to clonal expansion and persistence of infected cells
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June 2014 |
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Proliferation of cells with HIV integrated into cancer genes contributes to persistent infection
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July 2014 |
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Recovery of Replication-Competent HIV Despite Prolonged Suppression of Plasma Viremia
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November 1997 |
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Identification of a Reservoir for HIV-1 in Patients on Highly Active Antiretroviral Therapy
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November 1997 |
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Different human resting memory CD4 + T cell subsets show similar low inducibility of latent HIV-1 proviruses
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January 2020 |
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Signatures of immune selection in intact and defective proviruses distinguish HIV-1 elite controllers
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December 2021 |
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Residual Human Immunodeficiency Virus Type 1 Viremia in Some Patients on Antiretroviral Therapy Is Dominated by a Small Number of Invariant Clones Rarely Found in Circulating CD4+ T Cells
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June 2006 |
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An Increasing Proportion of Monotypic HIV-1 DNA Sequences during Antiretroviral Treatment Suggests Proliferation of HIV-Infected Cells
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November 2012 |
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Cyclin T1 and CDK9 T-Loop Phosphorylation Are Downregulated during Establishment of HIV-1 Latency in Primary Resting Memory CD4+ T Cells
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November 2012 |
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Resting CD4+ T Cells from Human Immunodeficiency Virus Type 1 (HIV-1)-Infected Individuals Carry Integrated HIV-1 Genomes within Actively Transcribed Host Genes
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June 2004 |
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Evidence that Low-Level Viremias during Effective Highly Active Antiretroviral Therapy Result from Two Processes: Expression of Archival Virus and Replication of Virus
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July 2005 |
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The Molecular Basis for Human Immunodeficiency Virus Latency
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September 2017 |
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HIV-1 latent reservoir size and diversity are stable following brief treatment interruption
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June 2018 |
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Longitudinal study reveals HIV-1–infected CD4+ T cell dynamics during long-term antiretroviral therapy
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journal
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June 2020 |
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HIV-1 viremia not suppressible by antiretroviral therapy can originate from large T cell clones producing infectious virus
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journal
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October 2020 |
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Antigen-driven clonal selection shapes the persistence of HIV-1–infected CD4+ T cells in vivo
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February 2021 |
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Differential decay of intact and defective proviral DNA in HIV-1–infected individuals on suppressive antiretroviral therapy
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February 2020 |
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Regulation of nuclear factor of activated T cells by phosphotyrosyl-specific phosphatase activity: a positive effect on HIV-1 long terminal repeat–driven transcription and a possible implication of SHP-1
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April 2001 |
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ART Suppresses Plasma HIV-1 RNA to a Stable Set Point Predicted by Pretherapy Viremia
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January 2007 |
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Absence of HIV-1 Evolution in the Gut-Associated Lymphoid Tissue from Patients on Combination Antiviral Therapy Initiated during Primary Infection
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February 2012 |
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Comparative Analysis of Measures of Viral Reservoirs in HIV-1 Eradication Studies
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February 2013 |
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Rapid Quantification of the Latent Reservoir for HIV-1 Using a Viral Outgrowth Assay
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journal
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May 2013 |
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Proviruses with identical sequences comprise a large fraction of the replication-competent HIV reservoir
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journal
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March 2017 |
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Integration in oncogenes plays only a minor role in determining the in vivo distribution of HIV integration sites before or during suppressive antiretroviral therapy
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journal
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April 2021 |
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Biogenesis of P-TEFb in CD4+ T cells to reverse HIV latency is mediated by protein kinase C (PKC)-independent signaling pathways
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journal
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September 2021 |
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HIV infected CD4+ T cell clones are more stable than uninfected clones during long-term antiretroviral therapy
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journal
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August 2022 |