Towards prevention and prediction of infectious diseases with virus sterilization using ultraviolet light and low-temperature plasma and bio-sensing devices for health and hygiene care

Kumagai, Shinya; Nishigori, Chikako; Takeuchi, Tetsuya; Bruggeman, Peter; Takashima, Keisuke; Takahashi, Hideki; Kaneko, Toshiro; Choi, Eun Ha; Nakazato, Kazuo; Kambara, Makoto; Ishikawa, Kenji

doi:10.35848/1347-4065/ac1c3d

Title: Towards prevention and prediction of infectious diseases with virus sterilization using ultraviolet light and low-temperature plasma and bio-sensing devices for health and hygiene care

Journal Article · Wed Dec 15 00:00:00 UTC 2021 · Japanese Journal of Applied Physics

DOI: https://doi.org/10.35848/1347-4065/ac1c3d · OSTI ID:1981209

^[1]; Nishigori, Chikako ^[2]; Takeuchi, Tetsuya ^[3];

^[4];

^[5]; Takahashi, Hideki ^[5];

^[5];

^[6]; Nakazato, Kazuo ^[7]; Kambara, Makoto ^[8];

^[9]

Meijo University (Japan); Nagoya University, Japan
Kobe University (Japan)
Meijo University (Japan)
University of Minnesota, Minneapolis, MN (United States)
Tohoku University (Japan)
Kwangwoon University (Republic of Korea)
BioCMOS (Japan); Nagoya University (Japan)
University of Tokyo (Japan)
Nagoya University (Japan)

Inspired by the ideas of many authors, we provide insight on state-of-the-art potential technologies for the prevention and prediction of infectious diseases before they spread. This review also surveys virus sterilization with ultraviolet light and low temperature plasma technologies. Researchers in the various fields of medicine, materials, electronics, and plasma sciences have addressed increasingly challenging demands and the discussion encompasses the major challenges in societies that are faced with the threat of infectious diseases. In addition, technologies that use nanomaterials are evaluated for infection prevention and hygiene purposes. Advances in biomedical diagnostics for health care in terms of complementary metal-oxide-semiconductor transistors-based devices and telemetry for health monitoring are also reviewed.

View Accepted Manuscript (DOE)

Cite

Export

Save

Research Organization:: Univ. of Minnesota, Minneapolis, MN (United States)

Sponsoring Organization:: JSPS KAKENHI; National Research Foundation of Korea (NRF); National Science Foundation (NSF); US Dept. of Agriculture (USDA); USDOE Office of Science (SC), Fusion Energy Sciences (FES)

Grant/Contract Number:: SC0016053

OSTI ID:: 1981209

Journal Information:: Japanese Journal of Applied Physics, Journal Name: Japanese Journal of Applied Physics Journal Issue: SA Vol. 61; ISSN 0021-4922

Publisher:: Japan Society of Applied PhysicsCopyright Statement

Country of Publication:: United States

Language:: English

References (133)

Sec‐Eliminating the SARS‐CoV‐2 by AlGaN Based High Power Deep Ultraviolet Light Source Liu, Shangfeng; Luo, Wei; Li, Dan Advanced Functional Materials, Vol. 31, Issue 7 https://doi.org/10.1002/adfm.202008452	journal	November 2020
Plasma‐on‐Chip : device for non‐thermal atmospheric pressure plasma irradiation to single cells Kumagai, Shinya; Kobayashi, Mime; Shimizu, Tetsuji Electronics and Communications in Japan, Vol. 103, Issue 9 https://doi.org/10.1002/ecj.12263	journal	July 2020
Reactive species responsible for the inactivation of feline calicivirus by a two-dimensional array of integrated coaxial microhollow dielectric barrier discharges in air Nayak, Gaurav; Aboubakr, Hamada A.; Goyal, Sagar M. Plasma Processes and Polymers, Vol. 15, Issue 1 https://doi.org/10.1002/ppap.201700119	journal	September 2017
Humidification effect of air plasma effluent gas on suppressing conidium germination of a plant pathogenic fungus in the liquid phase Shimada, Keisuke; Takashima, Keisuke; Kimura, Yutaka Plasma Processes and Polymers, Vol. 17, Issue 1 https://doi.org/10.1002/ppap.201900004	journal	September 2019
Comparative evaluation of the virucidal effect of remote and direct cold air plasmas with UV‐C Moldgy, Ankit; Aboubakr, Hamada; Nayak, Gaurav Plasma Processes and Polymers, Vol. 17, Issue 4 https://doi.org/10.1002/ppap.201900234	journal	January 2020
Rapid inactivation of airborne porcine reproductive and respiratory syndrome virus using an atmospheric pressure air plasma Nayak, Gaurav; Andrews, Austin J.; Marabella, Ian Plasma Processes and Polymers, Vol. 17, Issue 10 https://doi.org/10.1002/ppap.201900269	journal	February 2020
Measurement of nitrogen dioxide and nitric oxide densities by using CEAS (cavity‐enhanced absorption spectroscopy) in nonthermal atmospheric pressure air plasma Hong, Young J.; Lim, Junsup; Choi, Jin S. Plasma Processes and Polymers, Vol. 18, Issue 1 https://doi.org/10.1002/ppap.202000168	journal	October 2020
State of the art in nonthermal plasma processing for biomedical applications: Can it help fight viral pandemics like COVID‐19? Misra, Nilanjal; Bhatt, Sudhir; Arefi‐Khonsari, Farzaneh Plasma Processes and Polymers, Vol. 18, Issue 7 https://doi.org/10.1002/ppap.202000215	journal	May 2021
Development of sensor-probe system with function of measuring flow and pressure for evaluating breathing property at airway in lungs Kawamoto, Yuji; Maeda, Yoshifumi; Hasegawa, Yoshihiro Microsystem Technologies, Vol. 27, Issue 10 https://doi.org/10.1007/s00542-020-05201-0	journal	January 2021
Atmospheric-pressure plasma irradiation can disrupt tobacco mosaic virus particles and RNAs to inactivate their infectivity Hanbal, Sara E.; Takashima, Keisuke; Miyashita, Shuhei Archives of Virology, Vol. 163, Issue 10 https://doi.org/10.1007/s00705-018-3909-4	journal	June 2018
Design and electrochemical measurement of a current-mode analog-to-time converter with short-pulse output capability using local intra-cell activation for high-speed time-domain biosensor array Ikeda, Kei; Kobayashi, Atsuki; Nakazato, Kazuo Analog Integrated Circuits and Signal Processing, Vol. 92, Issue 3 https://doi.org/10.1007/s10470-017-1003-6	journal	June 2017
Design and analysis of a three-dimensional millimeter-wave frequency-shift based CMOS biosensor using vertically stacked spiral inductors in LC oscillators Matsunaga, Maya; Nakanishi, Taiki; Kobayashi, Atsuki Analog Integrated Circuits and Signal Processing, Vol. 98, Issue 3 https://doi.org/10.1007/s10470-018-1267-5	journal	July 2018
Nanotechnology: an emerging approach to combat COVID-19 Chintagunta, Anjani Devi; M., Sai Krishna; Nalluru, Sanjana Emergent Materials, Vol. 4, Issue 1 https://doi.org/10.1007/s42247-021-00178-6	journal	February 2021
Plasma-on-chip device for stable irradiation of cells cultured in media with a low-temperature atmospheric pressure plasma Okada, Tomohiro; Chang, Chun-Yao; Kobayashi, Mime Archives of Biochemistry and Biophysics, Vol. 605 https://doi.org/10.1016/j.abb.2016.04.001	journal	September 2016
Effectiveness of 222-nm ultraviolet light on disinfecting SARS-CoV-2 surface contamination Kitagawa, Hiroki; Nomura, Toshihito; Nazmul, Tanuza American Journal of Infection Control, Vol. 49, Issue 3 https://doi.org/10.1016/j.ajic.2020.08.022	journal	March 2021
Potent antiviral effect of silver nanoparticles on SARS-CoV-2 Jeremiah, Sundararaj S.; Miyakawa, Kei; Morita, Takeshi Biochemical and Biophysical Research Communications, Vol. 533, Issue 1 https://doi.org/10.1016/j.bbrc.2020.09.018	journal	November 2020
Extended-gate FET-based enzyme sensor with ferrocenyl-alkanethiol modified gold sensing electrode Ishige, Yu; Shimoda, Maki; Kamahori, Masao Biosensors and Bioelectronics, Vol. 24, Issue 5 https://doi.org/10.1016/j.bios.2008.06.012	journal	January 2009
Electrochemical immunosensor for botulinum neurotoxin type-E using covalently ordered graphene nanosheets modified electrodes and gold nanoparticles-enzyme conjugate Narayanan, J.; Sharma, Mukesh K.; Ponmariappan, S. Biosensors and Bioelectronics, Vol. 69 https://doi.org/10.1016/j.bios.2015.02.039	journal	July 2015
Impedimetric immunosensor for the label-free and direct detection of botulinum neurotoxin serotype A using Au nanoparticles/graphene-chitosan composite Afkhami, Abbas; Hashemi, Pegah; Bagheri, Hasan Biosensors and Bioelectronics, Vol. 93 https://doi.org/10.1016/j.bios.2016.09.059	journal	July 2017
Function improvement of wool fabric based on surface assembly of silica and silver nanoparticles Tang, Bin; Wang, Jinfeng; Xu, Shuping Chemical Engineering Journal, Vol. 185-186 https://doi.org/10.1016/j.cej.2012.01.082	journal	March 2012
Organ/body-on-a-chip based on microfluidic technology for drug discovery Kimura, Hiroshi; Sakai, Yasuyuki; Fujii, Teruo Drug Metabolism and Pharmacokinetics, Vol. 33, Issue 1 https://doi.org/10.1016/j.dmpk.2017.11.003	journal	February 2018
Ìn situ inactivation of human norovirus GII.4 by cold plasma: Ethidium monoazide (EMA)-coupled RT-qPCR underestimates virus reduction and fecal material suppresses inactivation Aboubakr, Hamada A.; Sampedro Parra, Fernando; Collins, James Food Microbiology, Vol. 85 https://doi.org/10.1016/j.fm.2019.103307	journal	February 2020
Copper for the Prevention of Outbreaks of Health Care–Associated Infections in a Long-term Care Facility for Older Adults Zerbib, Sarah; Vallet, Lydie; Muggeo, Anaëlle Journal of the American Medical Directors Association, Vol. 21, Issue 1 https://doi.org/10.1016/j.jamda.2019.02.003	journal	January 2020
Investigation of the antiviral properties of copper iodide nanoparticles against feline calicivirus Shionoiri, Nozomi; Sato, Tetsuya; Fujimori, Yoshie Journal of Bioscience and Bioengineering, Vol. 113, Issue 5 https://doi.org/10.1016/j.jbiosc.2011.12.006	journal	May 2012
Credibility of polymeric and ceramic membrane filtration in the removal of bacteria and virus from water: A review Goswami, Kakali Priyam; Pugazhenthi, G. Journal of Environmental Management, Vol. 268 https://doi.org/10.1016/j.jenvman.2020.110583	journal	August 2020
730 Long-term effect of 222-nm ultraviolet lamp on mice highly susceptible to developing ultraviolet-induced skin tumors Yamano, N.; Kunisada, M.; Kaizu, S. Journal of Investigative Dermatology, Vol. 139, Issue 5 https://doi.org/10.1016/j.jid.2019.03.806	journal	May 2019
Sars-CoV-2 (COVID-19) inactivation capability of copper-coated touch surface fabricated by cold-spray technology Hutasoit, Novana; Kennedy, Byron; Hamilton, Stephanie Manufacturing Letters, Vol. 25 https://doi.org/10.1016/j.mfglet.2020.08.007	journal	August 2020
Transcutaneous plasma stress: From soft-matter models to living tissues Lu, X.; Keidar, M.; Laroussi, M. Materials Science and Engineering: R: Reports, Vol. 138 https://doi.org/10.1016/j.mser.2019.04.002	journal	October 2019
Measurement of electron density in transient spark discharge by simple interferometry Lim, Jun Sup; Hong, Young June; Ghimire, Bhagirath Results in Physics, Vol. 20 https://doi.org/10.1016/j.rinp.2020.103693	journal	January 2021
Challenges and solutions for addressing critical shortage of supply chain for personal and protective equipment (PPE) arising from Coronavirus disease (COVID19) pandemic – Case study from the Republic of Ireland Rowan, Neil J.; Laffey, John G. Science of The Total Environment, Vol. 725 https://doi.org/10.1016/j.scitotenv.2020.138532	journal	July 2020
Redox-potential sensor array based on extended-gate field-effect transistors with ω-ferrocenylalkanethiol-modified gold electrodes Anan, Hiroo; Kamahori, Masao; Ishige, Yu Sensors and Actuators B: Chemical, Vol. 187 https://doi.org/10.1016/j.snb.2012.11.016	journal	October 2013
Multifunctional Ti-O coatings on polyethylene terephthalate fabric produced by using roll-to-roll high power impulse magnetron sputtering system Nguyen, Thi-Thuy-Nga; Chen, Ying-Hung; Chen, Min-Yi Surface and Coatings Technology, Vol. 324 https://doi.org/10.1016/j.surfcoat.2017.05.082	journal	September 2017
TiO2 photocatalysis and related surface phenomena Fujishima, A.; Zhang, X.; Tryk, D. Surface Science Reports, Vol. 63, Issue 12 https://doi.org/10.1016/j.surfrep.2008.10.001	journal	December 2008
Microstructure, near infrared reflectance, and surface temperature of Ti-O coated polyethylene terephthalate fabrics prepared by roll-to-roll high power impulse magnetron sputtering system Nguyen, Thi-Thuy-Nga; Chen, Ying-Hung; Chen, Zih-Min Thin Solid Films, Vol. 663 https://doi.org/10.1016/j.tsf.2018.08.003	journal	October 2018
Portable Plasma Device for Electric N₂O₅ Production from Air Sasaki, Shota; Takashima, Keisuke; Kaneko, Toshiro Industrial & Engineering Chemistry Research, Vol. 60, Issue 1 https://doi.org/10.1021/acs.iecr.0c04915	journal	December 2020
Visible-Light-Sensitive Photocatalysts: Nanocluster-Grafted Titanium Dioxide for Indoor Environmental Remediation Miyauchi, Masahiro; Irie, Hiroshi; Liu, Min The Journal of Physical Chemistry Letters, Vol. 7, Issue 1 https://doi.org/10.1021/acs.jpclett.5b02041	journal	December 2015
Nanoscience-Led Antimicrobial Surface Engineering to Prevent Infections Zare, Mina; Zare, Mohamad; Butler, Jonathan A. ACS Applied Nano Materials, Vol. 4, Issue 5 https://doi.org/10.1021/acsanm.1c00466	journal	May 2021
Emerging Telemedicine Tools for Remote COVID-19 Diagnosis, Monitoring, and Management Lukas, Heather; Xu, Changhao; Yu, You ACS Nano, Vol. 14, Issue 12 https://doi.org/10.1021/acsnano.0c08494	journal	December 2020
Understanding TiO ₂ Photocatalysis: Mechanisms and Materials Schneider, Jenny; Matsuoka, Masaya; Takeuchi, Masato Chemical Reviews, Vol. 114, Issue 19 https://doi.org/10.1021/cr5001892	journal	May 2014
Electrochemical Photolysis of Water at a Semiconductor Electrode Fujishima, Akira; Honda, Kenichi Nature, Vol. 238, Issue 5358, p. 37-38 https://doi.org/10.1038/238037a0	journal	July 1972
High incidence of ultraviolet-B-or chemical-carcinogen-induced skin tumours in mice lacking the xeroderma pigmentosum group A gene Nakane, Hironobu; Takeuchi, Seiji; Yuba, Shunsuke Nature, Vol. 377, Issue 6545 https://doi.org/10.1038/377165a0	journal	September 1995
The lasting misery of coronavirus long-haulers Marshall, Michael Nature, Vol. 585, Issue 7825 https://doi.org/10.1038/d41586-020-02598-6	journal	September 2020
An integrated semiconductor device enabling non-optical genome sequencing Rothberg, Jonathan M.; Hinz, Wolfgang; Rearick, Todd M. Nature, Vol. 475, Issue 7356 https://doi.org/10.1038/nature10242	journal	July 2011
Post-acute COVID-19 syndrome Nalbandian, Ani; Sehgal, Kartik; Gupta, Aakriti Nature Medicine, Vol. 27, Issue 4 https://doi.org/10.1038/s41591-021-01283-z	journal	March 2021
Far-UVC light (222 nm) efficiently and safely inactivates airborne human coronaviruses Buonanno, Manuela; Welch, David; Shuryak, Igor Scientific Reports, Vol. 10, Issue 1 https://doi.org/10.1038/s41598-020-67211-2	journal	June 2020
Co-continuous structural effect of size-controlled macro-porous glass membrane on extracellular vesicle collection for the analysis of miRNA Yukawa, Hiroshi; Yamazaki, Shuji; Aoki, Keita Scientific Reports, Vol. 11, Issue 1 https://doi.org/10.1038/s41598-021-87986-2	journal	April 2021
Generation mechanism of hydroxyl radical species and its lifetime prediction during the plasma-initiated ultraviolet (UV) photolysis Attri, Pankaj; Kim, Yong Hee; Park, Dae Hoon Scientific Reports, Vol. 5, Issue 1 https://doi.org/10.1038/srep09332	journal	March 2015
Integrated heart/cancer on a chip to reproduce the side effects of anti-cancer drugs in vitro Kamei, Ken-ichiro; Kato, Yoshiki; Hirai, Yoshikazu RSC Advances, Vol. 7, Issue 58 https://doi.org/10.1039/C7RA07716E	journal	January 2017
Metal complexes as a promising source for new antibiotics Frei, Angelo; Zuegg, Johannes; Elliott, Alysha G. Chemical Science, Vol. 11, Issue 10 https://doi.org/10.1039/C9SC06460E	journal	January 2020
Graphene-based biosensors for detection of bacteria and their metabolic activities Huang, Yinxi; Dong, Xiaochen; Liu, Yuxin Journal of Materials Chemistry, Vol. 21, Issue 33, 12358-12362 https://doi.org/10.1039/c1jm11436k	journal	January 2011
Aerosol and Surface Stability of SARS-CoV-2 as Compared with SARS-CoV-1 van Doremalen, Neeltje; Bushmaker, Trenton; Morris, Dylan H. New England Journal of Medicine, Vol. 382, Issue 16 https://doi.org/10.1056/NEJMc2004973	journal	April 2020
High performance thin-film flip-chip InGaN–GaN light-emitting diodes Shchekin, O. B.; Epler, J. E.; Trottier, T. A. Applied Physics Letters, Vol. 89, Issue 7 https://doi.org/10.1063/1.2337007	journal	August 2006
Botulinum toxin detection using AlGaN∕GaN high electron mobility transistors Wang, Yu-Lin; Chu, B. H.; Chen, K. H. Applied Physics Letters, Vol. 93, Issue 26 https://doi.org/10.1063/1.3056612	journal	December 2008
Separative extended-gate AlGaAs/GaAs HEMT biosensors based on capacitance change strategy Yu, Jiahuan; Xu, Mengke; Liang, Lingyan Applied Physics Letters, Vol. 116, Issue 12 https://doi.org/10.1063/5.0001786	journal	March 2020
Cold atmospheric plasma for SARS-CoV-2 inactivation Chen, Zhitong; Garcia, Gustavo; Arumugaswami, Vaithilingaraja Physics of Fluids, Vol. 32, Issue 11 https://doi.org/10.1063/5.0031332	journal	November 2020
White light emitting diodes with super-high luminous efficacy Narukawa, Yukio; Ichikawa, Masatsugu; Sanga, Daisuke Journal of Physics D: Applied Physics, Vol. 43, Issue 35 https://doi.org/10.1088/0022-3727/43/35/354002	journal	August 2010
Inactivation of virus in solution by cold atmospheric pressure plasma: identification of chemical inactivation pathways Aboubakr, Hamada A.; Gangal, Urvashi; Youssef, Mohammed M. Journal of Physics D: Applied Physics, Vol. 49, Issue 20 https://doi.org/10.1088/0022-3727/49/20/204001	journal	April 2016
Micro-machined stent flow sensor for detecting breathing and heartbeat from airflow in airway of rat Noma, Hayato; Hasegawa, Yoshihiro; Matsushima, Miyoko Journal of Micromechanics and Microengineering, Vol. 31, Issue 2 https://doi.org/10.1088/1361-6439/abd07a	journal	December 2020
Effects of •OH and •NO radicals in the aqueous phase on H ₂ O ₂ and $\text{NO}_{2}^{-}$ generated in plasma-activated medium Kurake, Naoyuki; Tanaka, Hiromasa; Ishikawa, Kenji Journal of Physics D: Applied Physics, Vol. 50, Issue 15 https://doi.org/10.1088/1361-6463/aa5f1d	journal	March 2017
Free radical generation by non-equilibrium atmospheric pressure plasma in alcohol–water mixtures: an EPR-spin trapping study Uchiyama, Hidefumi; Ishikawa, Kenji; Zhao, Qing-Li Journal of Physics D: Applied Physics, Vol. 51, Issue 9 https://doi.org/10.1088/1361-6463/aaa885	journal	February 2018
Investigation on dinitrogen pentoxide roles on air plasma effluent exposure to liquid water solution Kimura, Yutaka; Takashima, Keisuke; Sasaki, Shota Journal of Physics D: Applied Physics, Vol. 52, Issue 6 https://doi.org/10.1088/1361-6463/aaf15a	journal	December 2018
Systematic diagnostics of the electrical, optical, and physicochemical characteristics of low-temperature atmospheric-pressure helium plasma sources Takeda, Keigo; Yamada, Hiromasa; Ishikawa, Kenji Journal of Physics D: Applied Physics, Vol. 52, Issue 16 https://doi.org/10.1088/1361-6463/aaff44	journal	February 2019
Liquid spray transport of air–plasma-generated reactive species toward plant disease management Takashima, Keisuke; Hu, Yue; Goto, Tsubasa Journal of Physics D: Applied Physics, Vol. 53, Issue 35 https://doi.org/10.1088/1361-6463/ab87bd	journal	June 2020
Inactivation of virus and bacteria using cold atmospheric pressure air plasmas and the role of reactive nitrogen species Moldgy, Ankit; Nayak, Gaurav; Aboubakr, Hamada A. Journal of Physics D: Applied Physics, Vol. 53, Issue 43 https://doi.org/10.1088/1361-6463/aba066	journal	August 2020
The 2020 UV emitter roadmap Amano, Hiroshi; Collazo, Ramón; Santi, Carlo De Journal of Physics D: Applied Physics, Vol. 53, Issue 50 https://doi.org/10.1088/1361-6463/aba64c	journal	September 2020
Cocktail of reactive species generated by cold atmospheric plasma: oral administration induces non-small cell lung cancer cell death Song, Chang-Hyun; Attri, Pankaj; Ku, Sae-Kwang Journal of Physics D: Applied Physics, Vol. 54, Issue 18 https://doi.org/10.1088/1361-6463/abdff2	journal	February 2021
Spatially resolved density measurements of singlet delta oxygen in a non-equilibrium atmospheric pressure plasma jet by molecular beam mass spectrometry Jiang, Jingkai; Gonzalvo, Yolanda Aranda; Bruggeman, Peter J. Plasma Sources Science and Technology, Vol. 29, Issue 4 https://doi.org/10.1088/1361-6595/ab7f4b	journal	April 2020
GaN-based tunnel junctions and optoelectronic devices grown by metal-organic vapor-phase epitaxy Takeuchi, Tetsuya; Kamiyama, Satoshi; Iwaya, Motoaki Semiconductor Science and Technology, Vol. 36, Issue 6 https://doi.org/10.1088/1361-6641/abeb82	journal	April 2021
Bactericidal Efficacy of a Two-Dimensional Array of Integrated, Coaxial, Microhollow, Dielectric Barrier Discharge Plasma Against Salmonella enterica Serovar Heidelberg Aboubakr, Hamada A.; Nisar, Muhammad; Nayak, Gaurav Foodborne Pathogens and Disease, Vol. 17, Issue 3 https://doi.org/10.1089/fpd.2019.2698	journal	March 2020
Predictive coding under the free-energy principle Friston, Karl; Kiebel, Stefan Philosophical Transactions of the Royal Society B: Biological Sciences, Vol. 364, Issue 1521 https://doi.org/10.1098/rstb.2008.0300	journal	May 2009
BioCMOS LSIs for portable gene-based diagnostic inspection system Nakazato, Kazuo 2012 IEEE International Symposium on Circuits and Systems https://doi.org/10.1109/ISCAS.2012.6271750	conference	May 2012
Design and Experimental Verification of a 0.19 V 53 μW 65 nm CMOS Integrated Supply-Sensing Sensor With a Supply-Insensitive Temperature Sensor and an Inductive-Coupling Transmitter for a Self-Powered Bio-sensing System Using a Biofuel Cell Kobayashi, Atsuki; Ikeda, Kei; Ogawa, Yudai IEEE Transactions on Biomedical Circuits and Systems, Vol. 11, Issue 6 https://doi.org/10.1109/TBCAS.2017.2735447	journal	December 2017
A 65-nm CMOS Fully Integrated Analysis Platform Using an On-Chip Vector Network Analyzer and a Transmission-Line-Based Detection Window for Analyzing Circulating Tumor Cell and Exosome Niitsu, Kiichi; Nakanishi, Taiki; Murakami, Shunya IEEE Transactions on Biomedical Circuits and Systems, Vol. 13, Issue 2 https://doi.org/10.1109/TBCAS.2018.2882472	journal	April 2019
Development of an Ion-Sensitive Solid-State Device for Neurophysiological Measurements Bergveld, P. IEEE Transactions on Biomedical Engineering, Vol. BME-17, Issue 1 https://doi.org/10.1109/TBME.1970.4502688	journal	January 1970
A Self-Powered Supply-Sensing Biosensor Platform Using Bio Fuel Cell and Low-Voltage, Low-Cost CMOS Supply-Controlled Ring Oscillator With Inductive-Coupling Transmitter for Healthcare IoT Niitsu, Kiichi; Kobayashi, Atsuki; Nishio, Yuya IEEE Transactions on Circuits and Systems I: Regular Papers, Vol. 65, Issue 9 https://doi.org/10.1109/TCSI.2018.2791516	journal	September 2018
Microfluidic Transport Through Microsized Holes Treated by Nonequilibrium Atmospheric-Pressure Plasma Ito, Takumi; Ishikawa, Kenji; Onoshima, Daisuke IEEE Transactions on Plasma Science, Vol. 44, Issue 12 https://doi.org/10.1109/TPS.2016.2571721	journal	December 2016
Gas Plasma Technology—An Asset to Healthcare During Viral Pandemics Such as the COVID-19 Crisis? Bekeschus, Sander; Kramer, Axel; Suffredini, Elisabetta IEEE Transactions on Radiation and Plasma Medical Sciences, Vol. 4, Issue 4 https://doi.org/10.1109/TRPMS.2020.3002658	journal	July 2020
WAVELENGTH DEPENDENT FORMATION OF THYMINE DIMERS AND (6-4)PHOTOPRODUCTS IN DNA BY MONOCHROMATIC ULTRAVIOLET LIGHT RANGING FROM 150 TO 365 nm Matsunaga, Tsukasa; Hieda, Kotaro; Nikaido, Osamu Photochemistry and Photobiology, Vol. 54, Issue 3 https://doi.org/10.1111/j.1751-1097.1991.tb02034.x	journal	September 1991
Long‐term Effects of 222‐nm ultraviolet radiation C Sterilizing Lamps on Mice Susceptible to Ultraviolet Radiation Yamano, Nozomi; Kunisada, Makoto; Kaidzu, Sachiko Photochemistry and Photobiology, Vol. 96, Issue 4 https://doi.org/10.1111/php.13269	journal	May 2020
Exposure of Human Skin Models to KrCl Excimer Lamps: The Impact of Optical Filtering ^† Buonanno, Manuela; Welch, David; Brenner, David J. Photochemistry and Photobiology, Vol. 97, Issue 3 https://doi.org/10.1111/php.13383	journal	February 2021
Evaluation of Acute Reactions on Mouse Skin Irradiated with 222 and 235 nm UV‐C Yamano, Nozomi; Kunisada, Makoto; Nishiaki‐Sawada, Aiko Photochemistry and Photobiology https://doi.org/10.1111/php.13384	journal	February 2021
Extreme Exposure to Filtered Far‐UVC: A Case Study ^† Eadie, Ewan; Barnard, Isla M. R.; Ibbotson, Sally H. Photochemistry and Photobiology, Vol. 97, Issue 3 https://doi.org/10.1111/php.13385	journal	February 2021
Management of bakanae and bacterial seedling blight diseases in nurseries by irradiating rice seeds with atmospheric plasma Ochi, A.; Konishi, H.; Ando, S. Plant Pathology, Vol. 66, Issue 1 https://doi.org/10.1111/ppa.12555	journal	June 2016
Polarization-Induced Hole Doping in Wide-Band-Gap Uniaxial Semiconductor Heterostructures Simon, J.; Protasenko, V.; Lian, C. Science, Vol. 327, Issue 5961 https://doi.org/10.1126/science.1183226	journal	December 2009
Virucidal Effect of Cold Atmospheric Gaseous Plasma on Feline Calicivirus, a Surrogate for Human Norovirus Aboubakr, Hamada A.; Williams, Paul; Gangal, Urvashi Applied and Environmental Microbiology, Vol. 81, Issue 11 https://doi.org/10.1128/AEM.00054-15	journal	March 2015
Novel Antiviral Characteristics of Nanosized Copper(I) Iodide Particles Showing Inactivation Activity against 2009 Pandemic H1N1 Influenza Virus Fujimori, Yoshie; Sato, Tetsuya; Hayata, Taishi Applied and Environmental Microbiology, Vol. 78, Issue 4 https://doi.org/10.1128/AEM.06284-11	journal	February 2012
Cancer and neurologic degeneration in xeroderma pigmentosum: long term follow-up characterises the role of DNA repair Bradford, P. T.; Goldstein, A. M.; Tamura, D. Journal of Medical Genetics, Vol. 48, Issue 3 https://doi.org/10.1136/jmg.2010.083022	journal	November 2010
Label-Free Aptamer-Based Immunoglobulin Sensors Using Graphene Field-Effect Transistors Ohno, Yasuhide; Maehashi, Kenzo; Inoue, Koichi Japanese Journal of Applied Physics, Vol. 50, Issue 7R https://doi.org/10.1143/JJAP.50.070120	journal	July 2011
Cell Deposition Microchip with Micropipette Control over Liquid Interface Motion Onoshima, Daisuke; Hattori, Yuya; Yukawa, Hiroshi Cell Medicine, Vol. 10 https://doi.org/10.1177/2155179017733152	journal	January 2018
Antiviral activity of silver nanoparticle/chitosan composites against H1N1 influenza A virus Mori, Yasutaka; Ono, Takeshi; Miyahira, Yasushi Nanoscale Research Letters, Vol. 8, Issue 1 https://doi.org/10.1186/1556-276X-8-93	journal	February 2013
Inactivation of Norovirus on Dry Copper Alloy Surfaces Warnes, Sarah L.; Keevil, C. William PLoS ONE, Vol. 8, Issue 9 https://doi.org/10.1371/journal.pone.0075017	journal	September 2013
Strategic Focus on 3R Principles Reveals Major Reductions in the Use of Animals in Pharmaceutical Toxicity Testing Törnqvist, Elin; Annas, Anita; Granath, Britta PLoS ONE, Vol. 9, Issue 7 https://doi.org/10.1371/journal.pone.0101638	journal	July 2014
Cold argon-oxygen plasma species oxidize and disintegrate capsid protein of feline calicivirus Aboubakr, Hamada A.; Mor, Sunil K.; Higgins, LeeAnn PLOS ONE, Vol. 13, Issue 3 https://doi.org/10.1371/journal.pone.0194618	journal	March 2018
Chronic irradiation with 222-nm UVC light induces neither DNA damage nor epidermal lesions in mouse skin, even at high doses Narita, Kouji; Asano, Krisana; Morimoto, Yukihiro PLOS ONE, Vol. 13, Issue 7 https://doi.org/10.1371/journal.pone.0201259	journal	July 2018
Exploratory clinical trial on the safety and bactericidal effect of 222-nm ultraviolet C irradiation in healthy humans Fukui, Tomoaki; Niikura, Takahiro; Oda, Takahiro PLOS ONE, Vol. 15, Issue 8 https://doi.org/10.1371/journal.pone.0235948	journal	August 2020
Membrane and Virus Filter Trends in the Processes of Biopharmaceutical Production Choi, Tae Hwan; Park, Ho Bum Membrane Journal, Vol. 30, Issue 1 https://doi.org/10.14579/MEMBRANE_JOURNAL.2020.30.1.9	journal	February 2020
Sub-1-V CMOS-Based Electrophoresis Using Electroless Gold Plating for Small-Form-Factor Biomolecule Manipulation Yamaji, Yuuki; Nakazato, Kazuo; Niitsu, Kiichi IEICE Transactions on Electronics, Vol. E100.C, Issue 6 https://doi.org/10.1587/transele.E100.C.592	journal	January 2017
Design and Analysis of Scalability in Current-Mode Analog-to-Time Converter for an Energy-Efficient and High-Resolution CMOS Biosensor Array Ikeda, Kei; Kobayashi, Atsuki; Nakazato, Kazuo IEICE Transactions on Electronics, Vol. E100.C, Issue 6 https://doi.org/10.1587/transele.E100.C.597	journal	January 2017
A Current-Integration-Based CMOS Amperometric Sensor with 1024 × 1024 Bacteria-Sized Microelectrode Array for High-Sensitivity Bacteria Counting Gamo, Kohei; Nakazato, Kazuo; Niitsu, Kiichi IEICE Transactions on Electronics, Vol. E100.C, Issue 6 https://doi.org/10.1587/transele.E100.C.602	journal	January 2017
The impact of far-UVC radiation (200–230 nm) on pathogens, cells, skin, and eyes – a collection and analysis of a hundred years of data Hessling, Martin; Haag, Robin; Sieber, Nicole German Medical Science GMS Publishing House https://doi.org/10.3205/dgkh000378	text	January 2021
Non-Thermal Plasma as a Novel Strategy for Treating or Preventing Viral Infection and Associated Disease Mohamed, Hager; Nayak, Gaurav; Rendine, Nicole Frontiers in Physics, Vol. 9 https://doi.org/10.3389/fphy.2021.683118	journal	June 2021
Ultraviolet Irradiation Enhances the Microbicidal Activity of Silver Nanoparticles by Hydroxyl Radicals Nakamura, Shingo; Ando, Naoko; Sato, Masahiro International Journal of Molecular Sciences, Vol. 21, Issue 9 https://doi.org/10.3390/ijms21093204	journal	April 2020
Respiratory Motion Sensor Measuring Capacitance Constructed across Skin in Daily Activities Terazawa, Makie; Karita, Momoko; Kumagai, Shinya Micromachines, Vol. 9, Issue 11 https://doi.org/10.3390/mi9110543	journal	October 2018
Near-UV plasmon resonances for enhanced TiO₂ photocatalysis Honda, Mitsuhiro; Hizumi, Kohki; Devi, Rajkumari Irena Japanese Journal of Applied Physics, Vol. 59, Issue 4 https://doi.org/10.35848/1347-4065/ab809b	journal	April 2020
All-electrochemical fabrication of α-Fe₂O₃ nanotube array/Cu₂O composites toward visible-light-responsive photocatalysis Masegi, Hikaru; Imai, Sakiko; Sadale, Shivaji B. Japanese Journal of Applied Physics, Vol. 59, Issue 6 https://doi.org/10.35848/1347-4065/ab9279	journal	June 2020
Fabrication of nanostructured Ti thin film with Ti deposition in He plasmas Miyaguchi, Kazuya; Kajita, Shin; Tanaka, Hirohiko Japanese Journal of Applied Physics, Vol. 60, Issue 3 https://doi.org/10.35848/1347-4065/abe3a5	journal	February 2021
Fabrication of ZnS/ZnO composite photocatalysts by spin-coating ZnS nanoparticles on ZnO thin film Zhang, Qiyan; Honda, Mitsuhiro; Ichikawa, Yo Japanese Journal of Applied Physics, Vol. 60, Issue 3 https://doi.org/10.35848/1347-4065/abe8a6	journal	March 2021
Junctionless gate-all-around nanowire field-effect transistors with an extended gate in biomolecule detection Chen, Chih-Wei; Lin, Ru-Zheng; Chiang, Li-Chuan Japanese Journal of Applied Physics, Vol. 58, Issue 2 https://doi.org/10.7567/1347-4065/aaf46b	journal	January 2019
Deposition of TiO₂ photocatalyst on polyethylene terephthalate or polyimide polymer films by reactive sputtering for flexible photocatalytic sheets Kitazawa, Yuka; Jia, Junjun; Nakamura, Shin-ichi Japanese Journal of Applied Physics, Vol. 58, Issue 5 https://doi.org/10.7567/1347-4065/ab0517	journal	April 2019
Fabrication of a nanostructured TiO₂ photocatalyst using He plasma-irradiated tungsten and ethylene gas decomposition Tomita, Yudai; Kajita, Shin; Yasunaga, Eriko Japanese Journal of Applied Physics, Vol. 58, Issue SE https://doi.org/10.7567/1347-4065/ab09c8	journal	May 2019
A micro-machined flow sensor formed on copper on a polyimide substrate and its application to respiration measurement Kato, Ayami; Hasegawa, Yoshihiro; Taniguchi, Kazuhiro Japanese Journal of Applied Physics, Vol. 58, Issue SD https://doi.org/10.7567/1347-4065/ab0dec	journal	May 2019
Photocatalytic decomposition of ethylene using He plasma induced nano-TiO₂ Kajita, Shin; Tomita, Yudai; Yasunaga, Eriko Japanese Journal of Applied Physics, Vol. 58, Issue 7 https://doi.org/10.7567/1347-4065/ab2830	journal	June 2019
Photocatalytic application of helium plasma induced nanostructured tungsten oxides Feng, Shuangyuan; Kajita, Shin; Tomita, Yudai Japanese Journal of Applied Physics, Vol. 59, Issue SA https://doi.org/10.7567/1347-4065/ab4601	journal	November 2019
Measurement of hydroxyl radicals delivered into liquid through a micro gas–liquid interface Ishikawa, Koichi; Sasaki, Minoru; Kumagai, Shinya Japanese Journal of Applied Physics, Vol. 59, Issue SA https://doi.org/10.7567/1347-4065/ab5171	journal	November 2019
Evaluation of the crystalline structure of Ag⁺-doped ZnO thin film treated with selected annealing temperatures Abdullah, Nurul Afaah; Asib, Nur Amierah Mohd; Aziz, Noor Aadila Abd Japanese Journal of Applied Physics, Vol. 59, Issue SA https://doi.org/10.7567/1347-4065/ab56b5	journal	December 2019
Amperometric Electrochemical Sensor Array for On-Chip Simultaneous Imaging: Circuit and Microelectrode Design Considerations Hasegawa, Junichi; Uno, Shigeyasu; Nakazato, Kazuo Japanese Journal of Applied Physics, Vol. 50, Issue 4S https://doi.org/10.7567/JJAP.50.04DL03	journal	April 2011
Immunosensors Based on Graphene Field-Effect Transistors Fabricated Using Antigen-Binding Fragment Okamoto, Shogo; Ohno, Yasuhide; Maehashi, Kenzo Japanese Journal of Applied Physics, Vol. 51, Issue 6S https://doi.org/10.7567/JJAP.51.06FD08	journal	June 2012
A Wearable Capacitive Sensor for Monitoring Human Respiratory Rate Kundu, Subrata Kumar; Kumagai, Shinya; Sasaki, Minoru Japanese Journal of Applied Physics, Vol. 52, Issue 4S https://doi.org/10.7567/JJAP.52.04CL05	journal	April 2013
Direct Electrical Detection of DNA Hybridization Based on Electrolyte-Gated Graphene Field-Effect Transistor Ohno, Yasuhide; Okamoto, Shogo; Maehashi, Kenzo Japanese Journal of Applied Physics, Vol. 52, Issue 11R https://doi.org/10.7567/JJAP.52.110107	journal	October 2013
Development of plasma-on-chip: Plasma treatment for individual cells cultured in media Kumagai, Shinya; Chang, Chun-Yao; Jeong, Jonghyeon Japanese Journal of Applied Physics, Vol. 55, Issue 1S https://doi.org/10.7567/JJAP.55.01AF01	journal	October 2015
Frequency-response-based analysis of respiratory sensor measuring capacitance built across skin Terasawa, Makie; Kumagai, Shinya; Sasaki, Minoru Japanese Journal of Applied Physics, Vol. 55, Issue 4S https://doi.org/10.7567/JJAP.55.04EM13	journal	March 2016
Application of atmospheric solution precursor plasma spray to photocatalytic devices for small and medium industries in developing countries Kindole, Dickson; Ando, Yasutaka Japanese Journal of Applied Physics, Vol. 56, Issue 1S https://doi.org/10.7567/JJAP.56.01AB10	journal	December 2016
Energy-efficient and low-voltage design methodology for a supply-sensing CMOS biosensor using biofuel cells for energy-autonomous healthcare applications Kobayashi, Atsuki; Ikeda, Kei; Nakazato, Kazuo Japanese Journal of Applied Physics, Vol. 56, Issue 1S https://doi.org/10.7567/JJAP.56.01AH03	journal	November 2016
Enhancement in open-circuit voltage of implantable CMOS-compatible glucose fuel cell by improving the anodic catalyst Niitsu, Kiichi; Ando, Takashi; Kobayashi, Atsuki Japanese Journal of Applied Physics, Vol. 56, Issue 1S https://doi.org/10.7567/JJAP.56.01AH04	journal	November 2016
Design and experimental verification of CMOS magnetic-based microbead detection using an asynchronous intra-chip inductive-coupling transceiver Niitsu, Kiichi; Kobayashi, Atsuki; Yoshida, Kohei Japanese Journal of Applied Physics, Vol. 56, Issue 1S https://doi.org/10.7567/JJAP.56.01AH05	journal	November 2016
Design, experimental verification, and analysis of a 1.8-V-input-range voltage-to-current converter using source degeneration for low-noise multimodal CMOS biosensor array Niitsu, Kiichi; Ikeda, Kei; Muto, Keita Japanese Journal of Applied Physics, Vol. 56, Issue 1S https://doi.org/10.7567/JJAP.56.01AH06	journal	November 2016
Electrical conductance change of graphene-based devices upon surface modification for detecting botulinum neurotoxin Kim, Daehee; Kim, Ho-Jong; Shim, Seung-Bo Japanese Journal of Applied Physics, Vol. 56, Issue 6 https://doi.org/10.7567/JJAP.56.067001	journal	May 2017
Theoretical analysis and simulation study of low-power CMOS electrochemical impedance spectroscopy biosensor in 55 nm deeply depleted channel technology for cell-state monitoring Itakura, Keisuke; Kayano, Keisuke; Nakazato, Kazuo Japanese Journal of Applied Physics, Vol. 57, Issue 1S https://doi.org/10.7567/JJAP.57.01AG02	journal	November 2017
Facile fabrication of a poly(ethylene terephthalate) membrane filter with precise arrangement of through-holes Kihara, Naoto; Odaka, Hidefumi; Kuboyama, Daiki Japanese Journal of Applied Physics, Vol. 57, Issue 3 https://doi.org/10.7567/JJAP.57.037001	journal	January 2018
A 40 GHz fully integrated circuit with a vector network analyzer and a coplanar-line-based detection area for circulating tumor cell analysis using 65 nm CMOS technology Nakanishi, Taiki; Matsunaga, Maya; Kobayashi, Atsuki Japanese Journal of Applied Physics, Vol. 57, Issue 3S2 https://doi.org/10.7567/JJAP.57.03EC01	journal	January 2018
Design trade-off between spatial resolution and power consumption in CMOS biosensor circuit based on millimeter-wave LC oscillator array Matsunaga, Maya; Kobayashi, Atsuki; Nakazato, Kazuo Japanese Journal of Applied Physics, Vol. 57, Issue 3S2 https://doi.org/10.7567/JJAP.57.03EC02	journal	January 2018
Wafer-scale development and experimental verification of 0.36 mm²228 mV open-circuit-voltage solid-state CMOS-compatible glucose fuel cell Arata, Shigeki; Hayashi, Kenya; Nishio, Yuya Japanese Journal of Applied Physics, Vol. 57, Issue 4S https://doi.org/10.7567/JJAP.57.04FM04	journal	March 2018
Low-autofluorescence fluoropolymer membrane filters for cell filtration Kihara, Naoto; Kuboyama, Daiki; Onoshima, Daisuke Japanese Journal of Applied Physics, Vol. 57, Issue 6S2 https://doi.org/10.7567/JJAP.57.06JF03	journal	May 2018