Spiroligomer‐Based Macrocycles for Atomically Precise Membranes

Xie, Yihui; Luo, Danni; Wiener, Jesse A.; Koval, Alexander B.; Pfeiffer, Conrad T.; Schafmeister, Christian E.

doi:10.1002/anie.202302809

Title: Spiroligomer‐Based Macrocycles for Atomically Precise Membranes

Journal Article · 24 May 2023 · Angewandte Chemie (International Edition)

DOI: https://doi.org/10.1002/anie.202302809 · OSTI ID:1975167

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^[1]; Wiener, Jesse A. ^[1]; Koval, Alexander B. ^[1];

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Department of Chemistry Temple University 1901N. 13th St. Philadelphia PA-19122 USA

Abstract Here, we report a new class of peptidomimetic macrocycles with well‐defined three‐dimensional structures and low conformational flexibility. They are assembled from fused‐ring spiro‐ladder oligomers (spiroligomers) by modular solid‐phase synthesis. Two‐dimensional nuclear magnetic resonance confirms their shape persistency. Triangular macrocycles of tunable sizes assemble into membranes with atomically precise pores, which exhibit size and shape‐dependent molecular sieving towards a series of structurally similar compounds. The exceptional structural diversity and stability of spiroligomer‐based macrocycles will be explored for more applications.

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Research Organization:: Mainstream Engineering Corporation, Rockledge, FL (United States)

Sponsoring Organization:: USDOE; USDOE Office of Science (SC)

Grant/Contract Number:: SC0017037

OSTI ID:: 1975167

Journal Information:: Angewandte Chemie (International Edition), Journal Name: Angewandte Chemie (International Edition) Journal Issue: 27 Vol. 62; ISSN 1433-7851

Publisher:: Wiley Blackwell (John Wiley & Sons)Copyright Statement

Country of Publication:: Germany

Language:: English

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37 INORGANIC, ORGANIC, PHYSICAL, AND ANALYTICAL CHEMISTRY
Atomic Precision
Chemistry
Macrocycles
Membranes
Molecular Sieving
Spiroligomers

Title: Spiroligomer‐Based Macrocycles for Atomically Precise Membranes

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