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Title: CCL2 promotes lymphatic metastasis via activating RhoA and Rac1 pathway and predict prognosis to some extent in tongue cancer

Journal Article · · Cancer Biology & Therapy
 [1];  [1];  [2];  [2];  [2]; ORCiD logo [2];  [3]
  1. State Key Laboratory of Oral Disease &, National Clinical Research Center for Oral Diseases, West China Hospital of Stomatology, Sichuan University, Chengdu, China, Department of Pediatric Dentistry, West China Hospital of Stomatology, Sichuan University, Chengdu, China
  2. State Key Laboratory of Oral Disease &, National Clinical Research Center for Oral Diseases, West China Hospital of Stomatology, Sichuan University, Chengdu, China, Department of Head and Neck Oncology, West China Hospital of Stomatology, Sichuan University, Chengdu, China
  3. Yunnan Key Laboratory of Stomatology, The Affiliated Hospital of Stomatology, School of Stomatology, Kunming Medical University, Kunming, Yunnan, PR China

Sponsoring Organization:
USDOE Office of Electricity (OE), Advanced Grid Research & Development. Power Systems Engineering Research
OSTI ID:
1972414
Journal Information:
Cancer Biology & Therapy, Journal Name: Cancer Biology & Therapy Vol. 24 Journal Issue: 1; ISSN 1538-4047
Publisher:
Informa UK LimitedCopyright Statement
Country of Publication:
Country unknown/Code not available
Language:
English

References (32)

Chemokine (C-C Motif) Ligand 2 Mediates the Prometastatic Effect of Dysadherin in Human Breast Cancer Cells journal July 2006
COX-2 and CCR2 induced by CD40 ligand and MCP-1 are linked to VEGF production in endothelial cells journal February 2008
Resveratrol suppresses breast cancer cell invasion by inactivating a RhoA/YAP signaling axis journal February 2017
CCL2 recruits inflammatory monocytes to facilitate breast-tumour metastasis journal June 2011
Altered phenotype of lymphatic endothelial cells induced by highly metastatic OTSCC cells contributed to the lymphatic metastasis of OTSCC cells journal March 2010
Progression-Free Survival: Meaningful or Simply Measurable? journal April 2012
PLEK2 promotes gallbladder cancer invasion and metastasis through EGFR/CCL2 pathway journal June 2019
CCL2 Protects Prostate Cancer PC3 Cells from Autophagic Death via Phosphatidylinositol 3-Kinase/AKT-dependent Survivin Up-regulation journal September 2008
Human endothelial cells express CCR2 and respond to MCP-1: direct role of MCP-1 in angiogenesis and tumor progression journal July 2000
Inflammatory breast cancer biology: the tumour microenvironment is key journal April 2018
High Level of Plasma Matrix Metalloproteinase-11 Is Associated with Clinicopathological Characteristics in Patients with Oral Squamous Cell Carcinoma journal November 2014
PAR1-mediated RhoA activation facilitates CCL2-induced chemotaxis in PC-3 cells journal January 2007
Metastasis of squamous cell carcinoma of the oral tongue journal September 2007
Cancer statistics, 2019 journal October 2018
CCL2 is a Potent Regulator of Prostate Cancer Cell Migration and Proliferation journal July 2006
Pivotal function for cytoplasmic protein FROUNT in CCR2-mediated monocyte chemotaxis journal July 2005
RhoC GTPase is required for PC-3 prostate cancer cell invasion but not motility journal November 2005
Role of the CCL2‐CCR2 signalling axis in cancer: Mechanisms and therapeutic targeting journal August 2021
CCL2 induces prostate cancer transendothelial cell migration via activation of the small GTPase Rac journal August 2008
Oral cancer cells with different potential of lymphatic metastasis displayed distinct biologic behaviors and gene expression profiles journal February 2010
CCL2/CCR2 signaling in cancer pathogenesis journal May 2020
LNMAT1 promotes lymphatic metastasis of bladder cancer via CCL2 dependent macrophage recruitment journal September 2018
Epigenetic silencing of chemokine CCL2 represses macrophage infiltration to potentiate tumor development in small cell lung cancer journal February 2021
Type I Collagen Receptor (α2β1) Signaling Promotes the Growth of Human Prostate Cancer Cells within the Bone journal September 2006
Chemokines in the cancer microenvironment and their relevance in cancer immunotherapy journal May 2017
Phosphatidylinositol 3-kinase mutations identified in human cancer are oncogenic journal January 2005
Rho GTPases: Big Players in Breast Cancer Initiation, Metastasis and Therapeutic Responses journal September 2020
Oral Cancer Screening: Past, Present, and Future journal May 2021
B7-H3 Suppresses Antitumor Immunity via the CCL2–CCR2–M2 Macrophage Axis and Contributes to Ovarian Cancer Progression journal November 2021
Cancer Metastasis: Building a Framework journal November 2006
Association of CCL2 with Lymph Node Metastasis and Macrophage Infiltration in Oral Cavity and Lip Squamous Cell Carcinoma journal January 2008
Recommendations for the assessment of progression in randomised cancer treatment trials journal January 2009