DOE PAGES title logo U.S. Department of Energy
Office of Scientific and Technical Information

Title: Development of an mRNA vaccine against a panel of heterologous H1N1 seasonal influenza viruses using a consensus hemagglutinin sequence

Journal Article · · Emerging Microbes & Infections
 [1];  [2];  [1];  [1];  [1];  [1];  [1];  [1];  [1];  [1];  [3]
  1. National Engineering Technology Research Center for Combined Vaccines, Wuhan, People’s Republic of China, The Second Laboratory of Viral Vaccine Research, Wuhan Institute of Biological Products Co. Ltd., Wuhan, People’s Republic of China
  2. National Engineering Technology Research Center for Combined Vaccines, Wuhan, People’s Republic of China, School of Animal Science and Technology, School of Animal Medicine, Huazhong Agricultural University, Wuhan, People’s Republic of China
  3. National Engineering Technology Research Center for Combined Vaccines, Wuhan, People’s Republic of China, China National Biotec Group Company Limited, Beijing, People’s Republic of China

Sponsoring Organization:
USDOE Office of Electricity (OE), Advanced Grid Research & Development. Power Systems Engineering Research
OSTI ID:
1972261
Journal Information:
Emerging Microbes & Infections, Journal Name: Emerging Microbes & Infections Vol. 12 Journal Issue: 1; ISSN 2222-1751
Publisher:
Informa UK LimitedCopyright Statement
Country of Publication:
United Kingdom
Language:
English

References (34)

mRNA-Based Vaccines journal April 2021
Lipid nanoparticles enhance the efficacy of mRNA and protein subunit vaccines by inducing robust T follicular helper cell and humoral responses journal December 2021
Self-Amplifying mRNA Vaccines Expressing Multiple Conserved Influenza Antigens Confer Protection against Homologous and Heterosubtypic Viral Challenge journal August 2016
A Thermostable mRNA Vaccine against COVID-19 journal September 2020
Broadly Reactive H2 Hemagglutinin Vaccines Elicit Cross-Reactive Antibodies in Ferrets Preimmune to Seasonal Influenza A Viruses journal April 2021
Influenza Hemagglutinin Structures and Antibody Recognition journal December 2019
A Multi-Targeting, Nucleoside-Modified mRNA Influenza Virus Vaccine Provides Broad Protection in Mice journal July 2020
Lipid Nanoparticles as Delivery Systems for RNA-Based Vaccines journal February 2021
Intranasally administered protein coated chitosan nanoparticles encapsulating influenza H9N2 HA2 and M2e mRNA molecules elicit protective immunity against avian influenza viruses in chickens journal March 2020
Influenza Pandemics of the 20th Century journal January 2006
Human influenza vaccines and assessment of immunogenicity journal December 2010
Emergence of a Novel Swine-Origin Influenza A (H1N1) Virus in Humans journal June 2009
Elicitation of Broadly Protective Antibodies following Infection with Influenza Viruses Expressing H1N1 Computationally Optimized Broadly Reactive Hemagglutinin Antigens journal August 2018
Broad neutralization of H1 and H3 viruses by adjuvanted influenza HA stem vaccines in nonhuman primates journal March 2021
Generation of a broadly reactive influenza H1 antigen using a consensus HA sequence journal August 2018
Enhancement of the HIV-1-Specific Immune Response Induced by an mRNA Vaccine through Boosting with a Poxvirus MVA Vector Expressing the Same Antigen journal August 2021
mRNA Vaccines Encoding the HA Protein of Influenza A H1N1 Virus Delivered by Cationic Lipid Nanoparticles Induce Protective Immune Responses in Mice journal March 2020
Vaccination with Consensus H7 Elicits Broadly Reactive and Protective Antibodies against Eurasian and North American Lineage H7 Viruses journal March 2020
An Influenza A Vaccine Based on the Extracellular Domain of Matrix 2 Protein Protects BALB/C Mice Against H1N1 and H3N2 journal August 2019
The Pathway to a Universal Influenza Vaccine journal October 2017
Influenza vaccines: Past, present, and future journal May 2021
Modified mRNA Vaccines Protect against Zika Virus Infection journal March 2017
Construction and Immunogenicity of Modified mRNA-Vaccine Variants Encoding Influenza Virus Antigens journal May 2021
Modified mRNA/lipid nanoparticle-based vaccines expressing respiratory syncytial virus F protein variants are immunogenic and protective in rodent models of RSV infection journal February 2020
Interferon-γ and B Cell Stimulatory Factor-1 Reciprocally Regulate Ig Isotype Production journal May 1987
Safety and Efficacy of the BNT162b2 mRNA Covid-19 Vaccine journal December 2020
Recent advances in mRNA vaccine technology journal August 2020
The evolution of seasonal influenza viruses journal October 2017
Potent CD8+ T-Cell Immunogenicity in Humans of a Novel Heterosubtypic Influenza A Vaccine, MVA-NP+M1 journal January 2011
Immunologic Basis of Vaccine Vectors journal October 2010
Advances in RNA Vaccines for Preventive Indications: A Case Study of A Vaccine Against Rabies journal September 2019
Message in a bottle: mRNA vaccination for influenza journal July 2022
Estimates of global seasonal influenza-associated respiratory mortality: a modelling study journal March 2018
Nanomaterial Delivery Systems for mRNA Vaccines journal January 2021