Development of an mRNA vaccine against a panel of heterologous H1N1 seasonal influenza viruses using a consensus hemagglutinin sequence

Ma, Ning; Xia, Zhi-Wu; Zhang, Zhe-Gang; Nian, Xuan-Xuan; Li, Xue-Dan; Gong, Zheng; Zhang, Guo-Mei; Le, Yang; Zhou, Rong; Zhang, Jia-You; Yang, Xiao-Ming

doi:10.1080/22221751.2023.2202278

Title: Development of an mRNA vaccine against a panel of heterologous H1N1 seasonal influenza viruses using a consensus hemagglutinin sequence

Journal Article · 30 December 2023 · Emerging Microbes & Infections

DOI: https://doi.org/10.1080/22221751.2023.2202278 · OSTI ID:1972261

Ma, Ning; Xia, Zhi-Wu; Zhang, Zhe-Gang; Nian, Xuan-Xuan; Li, Xue-Dan; Gong, Zheng; Zhang, Guo-Mei; Le, Yang; Zhou, Rong; Zhang, Jia-You; Yang, Xiao-Ming

Not Available

View Journal Article

Cite

Export

Save

Sponsoring Organization:: USDOE Office of Electricity (OE), Advanced Grid Research & Development. Power Systems Engineering Research

OSTI ID:: 1972261

Journal Information:: Emerging Microbes & Infections, Journal Name: Emerging Microbes & Infections Journal Issue: 1 Vol. 12; ISSN 2222-1751

Publisher:: Informa UK LimitedCopyright Statement

Country of Publication:: United Kingdom

Language:: English

References (34)

Influenza vaccines: Past, present, and future Kim, Yun‐Hee; Hong, Kee‐Jong; Kim, Hun Reviews in Medical Virology, Vol. 32, Issue 1 https://doi.org/10.1002/rmv.2243	journal	May 2021
Estimates of global seasonal influenza-associated respiratory mortality: a modelling study Iuliano, A. Danielle; Roguski, Katherine M.; Chang, Howard H. The Lancet, Vol. 391, Issue 10127 https://doi.org/10.1016/S0140-6736(17)33293-2	journal	March 2018
Modified mRNA Vaccines Protect against Zika Virus Infection Richner, Justin M.; Himansu, Sunny; Dowd, Kimberly A. Cell, Vol. 168, Issue 6 https://doi.org/10.1016/j.cell.2017.02.017	journal	March 2017
A Thermostable mRNA Vaccine against COVID-19 Zhang, Na-Na; Li, Xiao-Feng; Deng, Yong-Qiang Cell, Vol. 182, Issue 5 https://doi.org/10.1016/j.cell.2020.07.024	journal	September 2020
Recent advances in mRNA vaccine technology Pardi, Norbert; Hogan, Michael J.; Weissman, Drew Current Opinion in Immunology, Vol. 65 https://doi.org/10.1016/j.coi.2020.01.008	journal	August 2020
Immunologic Basis of Vaccine Vectors Liu, Margaret A. Immunity, Vol. 33, Issue 4 https://doi.org/10.1016/j.immuni.2010.10.004	journal	October 2010
The Pathway to a Universal Influenza Vaccine Paules, Catharine I.; Marston, Hilary D.; Eisinger, Robert W. Immunity, Vol. 47, Issue 4 https://doi.org/10.1016/j.immuni.2017.09.007	journal	October 2017
Lipid nanoparticles enhance the efficacy of mRNA and protein subunit vaccines by inducing robust T follicular helper cell and humoral responses Alameh, Mohamad-Gabriel; Tombácz, István; Bettini, Emily Immunity, Vol. 54, Issue 12 https://doi.org/10.1016/j.immuni.2021.11.001	journal	December 2021
Generation of a broadly reactive influenza H1 antigen using a consensus HA sequence Ping, Xianqiang; Hu, Weibin; Xiong, Rui Vaccine, Vol. 36, Issue 32 https://doi.org/10.1016/j.vaccine.2018.06.048	journal	August 2018
A Multi-Targeting, Nucleoside-Modified mRNA Influenza Virus Vaccine Provides Broad Protection in Mice Freyn, Alec W.; Ramos da Silva, Jamile; Rosado, Victoria C. Molecular Therapy, Vol. 28, Issue 7 https://doi.org/10.1016/j.ymthe.2020.04.018	journal	July 2020
The evolution of seasonal influenza viruses Petrova, Velislava N.; Russell, Colin A. Nature Reviews Microbiology, Vol. 16, Issue 1 https://doi.org/10.1038/nrmicro.2017.118	journal	October 2017
Modified mRNA/lipid nanoparticle-based vaccines expressing respiratory syncytial virus F protein variants are immunogenic and protective in rodent models of RSV infection Espeseth, Amy S.; Cejas, Pedro J.; Citron, Michael P. npj Vaccines, Vol. 5, Issue 1 https://doi.org/10.1038/s41541-020-0163-z	journal	February 2020
Emergence of a Novel Swine-Origin Influenza A (H1N1) Virus in Humans New England Journal of Medicine, Vol. 360, Issue 25, p. 2605-2615 https://doi.org/10.1056/NEJMoa0903810	journal	June 2009
Safety and Efficacy of the BNT162b2 mRNA Covid-19 Vaccine Polack, Fernando P.; Thomas, Stephen J.; Kitchin, Nicholas New England Journal of Medicine, Vol. 383, Issue 27 https://doi.org/10.1056/NEJMoa2034577	journal	December 2020
Potent CD8+ T-Cell Immunogenicity in Humans of a Novel Heterosubtypic Influenza A Vaccine, MVA-NP+M1 Berthoud, T. K.; Hamill, M.; Lillie, P. J. Clinical Infectious Diseases, Vol. 52, Issue 1 https://doi.org/10.1093/cid/ciq015	journal	January 2011
Message in a bottle: mRNA vaccination for influenza Shartouny, Jessica R.; Lowen, Anice C. Journal of General Virology, Vol. 103, Issue 7 https://doi.org/10.1099/jgv.0.001765	journal	July 2022
Influenza Hemagglutinin Structures and Antibody Recognition Wu, Nicholas C.; Wilson, Ian A. Cold Spring Harbor Perspectives in Medicine, Vol. 10, Issue 8 https://doi.org/10.1101/cshperspect.a038778	journal	December 2019
Interferon-γ and B Cell Stimulatory Factor-1 Reciprocally Regulate Ig Isotype Production Snapper, Clifford M.; Paul, William E. Science, Vol. 236, Issue 4804 https://doi.org/10.1126/science.3107127	journal	May 1987
Broad neutralization of H1 and H3 viruses by adjuvanted influenza HA stem vaccines in nonhuman primates Darricarrère, Nicole; Qiu, Yu; Kanekiyo, Masaru Science Translational Medicine, Vol. 13, Issue 583 https://doi.org/10.1126/scitranslmed.abe5449	journal	March 2021
Broadly Reactive H2 Hemagglutinin Vaccines Elicit Cross-Reactive Antibodies in Ferrets Preimmune to Seasonal Influenza A Viruses Reneer, Z. Beau; Skarlupka, Amanda L.; Jamieson, Parker J. mSphere, Vol. 6, Issue 2 https://doi.org/10.1128/mSphere.00052-21	journal	April 2021
Intranasally administered protein coated chitosan nanoparticles encapsulating influenza H9N2 HA2 and M2e mRNA molecules elicit protective immunity against avian influenza viruses in chickens Hajam, Irshad Ahmed; Senevirathne, Amal; Hewawaduge, Chamit Veterinary Research, Vol. 51, Issue 1 https://doi.org/10.1186/s13567-020-00762-4	journal	March 2020
Self-Amplifying mRNA Vaccines Expressing Multiple Conserved Influenza Antigens Confer Protection against Homologous and Heterosubtypic Viral Challenge Magini, Diletta; Giovani, Cinzia; Mangiavacchi, Simona PLOS ONE, Vol. 11, Issue 8 https://doi.org/10.1371/journal.pone.0161193	journal	August 2016
Human influenza vaccines and assessment of immunogenicity Zakay-Rones, Zichria Expert Review of Vaccines, Vol. 9, Issue 12 https://doi.org/10.1586/erv.10.144	journal	December 2010
Influenza Pandemics of the 20th Century Kilbourne, Edwin D. Emerging Infectious Diseases, Vol. 12, Issue 1 https://doi.org/10.3201/eid1201.051254	journal	January 2006
Lipid Nanoparticles as Delivery Systems for RNA-Based Vaccines Aldosari, Basmah N.; Alfagih, Iman M.; Almurshedi, Alanood S. Pharmaceutics, Vol. 13, Issue 2 https://doi.org/10.3390/pharmaceutics13020206	journal	February 2021
An Influenza A Vaccine Based on the Extracellular Domain of Matrix 2 Protein Protects BALB/C Mice Against H1N1 and H3N2 Ong, Hui Kian; Yong, Chean Yeah; Tan, Wen Siang Vaccines, Vol. 7, Issue 3 https://doi.org/10.3390/vaccines7030091	journal	August 2019
Advances in RNA Vaccines for Preventive Indications: A Case Study of A Vaccine Against Rabies Vaccines, Vol. 7, Issue 4 https://doi.org/10.3390/vaccines7040132	journal	September 2019
mRNA Vaccines Encoding the HA Protein of Influenza A H1N1 Virus Delivered by Cationic Lipid Nanoparticles Induce Protective Immune Responses in Mice Zhuang, Xinyu; Qi, Yanxin; Wang, Maopeng Vaccines, Vol. 8, Issue 1 https://doi.org/10.3390/vaccines8010123	journal	March 2020
Vaccination with Consensus H7 Elicits Broadly Reactive and Protective Antibodies against Eurasian and North American Lineage H7 Viruses Fadlallah, Gendeal M.; Ma, Fuying; Zhang, Zherui Vaccines, Vol. 8, Issue 1 https://doi.org/10.3390/vaccines8010143	journal	March 2020
Nanomaterial Delivery Systems for mRNA Vaccines Buschmann, Michael D.; Carrasco, Manuel J.; Alishetty, Suman Vaccines, Vol. 9, Issue 1 https://doi.org/10.3390/vaccines9010065	journal	January 2021
mRNA-Based Vaccines Kowalzik, Frank; Schreiner, Daniel; Jensen, Christian Vaccines, Vol. 9, Issue 4 https://doi.org/10.3390/vaccines9040390	journal	April 2021
Construction and Immunogenicity of Modified mRNA-Vaccine Variants Encoding Influenza Virus Antigens Starostina, Ekaterina V.; Sharabrin, Sergei V.; Antropov, Denis N. Vaccines, Vol. 9, Issue 5 https://doi.org/10.3390/vaccines9050452	journal	May 2021
Enhancement of the HIV-1-Specific Immune Response Induced by an mRNA Vaccine through Boosting with a Poxvirus MVA Vector Expressing the Same Antigen Gómez, Carmen Elena; Perdiguero, Beatriz; Usero, Lorena Vaccines, Vol. 9, Issue 9 https://doi.org/10.3390/vaccines9090959	journal	August 2021
Elicitation of Broadly Protective Antibodies following Infection with Influenza Viruses Expressing H1N1 Computationally Optimized Broadly Reactive Hemagglutinin Antigens Sautto, Giuseppe A.; Kirchenbaum, Greg A.; Ecker, Jeffrey W. ImmunoHorizons, Vol. 2, Issue 7 https://doi.org/10.4049/immunohorizons.1800044	journal	August 2018

Similar Records

The hemagglutinin structure of an avian H1N1 influenza A virus

Journal Article · 2009 · Virology · OSTI ID:1005844

Lin, Tianwei; Wang, Gengyan; Li, Anzhang; +6 more

Structural insights into the broad protection against H1 influenza viruses by a computationally optimized hemagglutinin vaccine

Journal Article · 2023 · Communications Biology · OSTI ID:2423649

Dzimianski, John V.; Han, Julianna; Sautto, Giuseppe A.; +10 more

Structural Stability of Influenza A(H1N1)pdm09 Virus Hemagglutinins

Journal Article · 2014 · J. Virol. · OSTI ID:1140050

Yang, Hua; Chang, Jessie C.; Guo, Zhu; +7 more

Title: Development of an mRNA vaccine against a panel of heterologous H1N1 seasonal influenza viruses using a consensus hemagglutinin sequence

Citation Formats

References (34)

Similar Records

Related Subjects