Cyclotron production of 43Sc and 44gSc from enriched 42CaO, 43CaO, and 44CaO targets

Becker, Kaelyn V.; Aluicio-Sarduy, Eduardo; Bradshaw, Tyler; Hurley, Samuel A.; Olson, Aeli P.; Barrett, Kendall E.; Batterton, Jeanine; Ellison, Paul A.; Barnhart, Todd E.; Pirasteh, Ali; Engle, Jonathan W.

doi:10.3389/fchem.2023.1167783

Title: Cyclotron production of ⁴³Sc and ⁴⁴gSc from enriched ⁴²CaO, ⁴³CaO, and ⁴⁴CaO targets

Journal Article · 26 April 2023 · Frontiers in Chemistry

DOI: https://doi.org/10.3389/fchem.2023.1167783 · OSTI ID:1971555

Becker, Kaelyn V. ^[1]; Aluicio-Sarduy, Eduardo ^[1]; Bradshaw, Tyler ^[1]; Hurley, Samuel A. ^[1]; Olson, Aeli P. ^[1]; Barrett, Kendall E. ^[1]; Batterton, Jeanine ^[1]; Ellison, Paul A. ^[1]; Barnhart, Todd E. ^[1]; Pirasteh, Ali ^[1]; Engle, Jonathan W. ^[1]

Univ. of Wisconsin, Madison, WI (United States)

⁴³Sc and ⁴⁴gSc are both positron-emitting radioisotopes of scandium with suitable half-lives and favorable positron energies for clinical positron emission tomography (PET) imaging. Irradiation of isotopically enriched calcium targets has higher cross sections compared to titanium targets and higher radionuclidic purity and cross sections than natural calcium targets for reaction routes possible on small cyclotrons capable of accelerating protons and deuterons. In this work, we investigate the following production routes via proton and deuteron bombardment on CaCO₃ and CaO target materials: ⁴²Ca(d,n)⁴³Sc, ⁴³Ca(p,n)⁴³Sc, ⁴³Ca(d,n)⁴⁴gSc, ⁴⁴Ca(p,n)⁴⁴gSc, and ⁴⁴Ca(p,2n)⁴³Sc. Radiochemical isolation of the produced radioscandium was performed with extraction chromatography using branched DGA resin and apparent molar activity was measured with the chelator DOTA. The imaging performance of ⁴³Sc and ^44gSc was compared with ¹⁸F, ⁶⁸Ga, and ⁶⁴Cu on two clinical PET/CT scanners. The results of this work demonstrate that proton and deuteron bombardment of isotopically enriched CaO targets produce high yield and high radionuclidic purity ⁴³Sc and ^44gSc. Laboratory capabilities, circumstances, and budgets are likely to dictate which reaction route and radioisotope of scandium is chosen.

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Research Organization:: USDOE Office of Science (SC), Office of Isotope R&D and Production (IRP); Univ. of Wisconsin, Madison, WI (United States)

Sponsoring Organization:: USDOE; National Institutes of Health (NIH)

Grant/Contract Number:: T32CA009206; F31CA239617

OSTI ID:: 1971555

Alternate ID(s):: OSTI ID: 2424945

Journal Information:: Frontiers in Chemistry, Vol. 11; ISSN 2296-2646

Publisher:: Frontiers Research FoundationCopyright Statement

Country of Publication:: United States

Language:: English

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Title: Cyclotron production of 43Sc and 44gSc from enriched 42CaO, 43CaO, and 44CaO targets

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Title: Cyclotron production of ⁴³Sc and ⁴⁴gSc from enriched ⁴²CaO, ⁴³CaO, and ⁴⁴CaO targets