Cyclotron production of 43Sc and 44gSc from enriched 42CaO, 43CaO, and 44CaO targets

Becker, Kaelyn V.; Aluicio-Sarduy, Eduardo; Bradshaw, Tyler; Hurley, Samuel A.; Olson, Aeli P.; Barrett, Kendall E.; Batterton, Jeanine; Ellison, Paul A.; Barnhart, Todd E.; Pirasteh, Ali; Engle, Jonathan W.

doi:10.3389/fchem.2023.1167783

Title: Cyclotron production of 43Sc and 44gSc from enriched 42CaO, 43CaO, and 44CaO targets

Journal Article · 25 April 2023 · Frontiers in Chemistry

DOI: https://doi.org/10.3389/fchem.2023.1167783 · OSTI ID:1971555

Becker, Kaelyn V.; Aluicio-Sarduy, Eduardo; Bradshaw, Tyler; Hurley, Samuel A.; Olson, Aeli P.; Barrett, Kendall E.; Batterton, Jeanine; Ellison, Paul A.; Barnhart, Todd E.; Pirasteh, Ali; Engle, Jonathan W.

Introduction: ⁴³ Sc and ^44g Sc are both positron-emitting radioisotopes of scandium with suitable half-lives and favorable positron energies for clinical positron emission tomography (PET) imaging. Irradiation of isotopically enriched calcium targets has higher cross sections compared to titanium targets and higher radionuclidic purity and cross sections than natural calcium targets for reaction routes possible on small cyclotrons capable of accelerating protons and deuterons. Methods: In this work, we investigate the following production routes via proton and deuteron bombardment on CaCO ₃ and CaO target materials: ⁴² Ca(d,n) ⁴³ Sc, ⁴³ Ca(p,n) ⁴³ Sc, ⁴³ Ca(d,n) ^44g Sc, ⁴⁴ Ca(p,n) ^44g Sc, and ⁴⁴ Ca(p,2n) ⁴³ Sc. Radiochemical isolation of the produced radioscandium was performed with extraction chromatography using branched DGA resin and apparent molar activity was measured with the chelator DOTA. The imaging performance of ⁴³ Sc and ^44g Sc was compared with ¹⁸ F, ⁶⁸ Ga, and ⁶⁴ Cu on two clinical PET/CT scanners. Discussion: The results of this work demonstrate that proton and deuteron bombardment of isotopically enriched CaO targets produce high yield and high radionuclidic purity ⁴³ Sc and ^44g Sc. Laboratory capabilities, circumstances, and budgets are likely to dictate which reaction route and radioisotope of scandium is chosen.

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Research Organization:: USDOE Office of Science (SC), Office of Isotope R&D and Production (IRP); Univ. of Wisconsin, Madison, WI (United States)

Sponsoring Organization:: National Institutes of Health (NIH); USDOE

OSTI ID:: 1971555

Journal Information:: Frontiers in Chemistry, Journal Name: Frontiers in Chemistry Vol. 11; ISSN 2296-2646

Publisher:: Frontiers Media SACopyright Statement

Country of Publication:: Switzerland

Language:: English

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cyclotron
phantom imaging
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radionuclide production
scandium

Title: Cyclotron production of 43Sc and 44gSc from enriched 42CaO, 43CaO, and 44CaO targets

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