Lignin-based carbon quantum dots with high fluorescence performance prepared by supercritical catalysis and solvothermal treatment for tumor-targeted labeling

Zhao, Siyu; Yue, Guihua; Liu, Xiaoli; Qin, Shiru; Wang, Baosu; Zhao, Peitao; Ragauskas, Arthur J.; Wu, Min; Song, Xueping

doi:10.1007/s42114-023-00645-0

Title: Lignin-based carbon quantum dots with high fluorescence performance prepared by supercritical catalysis and solvothermal treatment for tumor-targeted labeling

Journal Article · 22 March 2023 · Advanced Composites and Hybrid Materials

DOI: https://doi.org/10.1007/s42114-023-00645-0 · OSTI ID:1971027

Zhao, Siyu ^[1]; Yue, Guihua ^[2]; Liu, Xiaoli ^[1]; Qin, Shiru ^[3]; Wang, Baosu ^[3]; Zhao, Peitao ^[3];

^[4]; Wu, Min ^[1]; Song, Xueping ^[1]

Guangxi Univ., Nanning (China)
Guangxi International Zhuang Medicine Hospital (China)
China Univ. of Mining and Technology, Xuzhou, Jiangsu (China)
Univ. of Tennessee, Knoxville, TN (United States); Oak Ridge National Lab. (ORNL), Oak Ridge, TN (United States). Joint Institute for Biological Sciences (JIBS)

The poor fluorescence performance of lignin-based carbon quantum dots (L-CQDs) prepared using the bottom-up method has hindered their development. Here, in this study, a two-step strategy was proposed to efficiently enhance the fluorescence properties of L-CQDs. Lignin was first cracked using an ethanol supercritical/noble metal catalyst; then, the L-CQDs were prepared with the cracked lignin fragments as carbon precursors without adding any modified reagents. Compared with the OL-CQDs prepared by the traditional one-pot hydrothermal method, the L-CQDs-1 prepared from CL-1 containing much low molecular weight compounds, and have photoluminescence (increased from 63 to 975) and excellent up-conversion photoluminescence (enhanced by 16.3 to 963), which significantly enhanced by about 15 times and 60 times, respectively. They can emit bright blue fluorescence under both ultraviolet and near-infrared light irradiation owing to a large amount of surface defects caused by the rich compound composition. When L-CQDs-1 were combined with, and quenched by folic acid (FA), the prepared FA@L-CQDs-1 show the ability to target and label tumor cells. This study opens new avenues for the preparation of L-CQDs with high fluorescence performance using lignocellulosic material without heteroatom additives.

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Research Organization:: Oak Ridge National Laboratory (ORNL), Oak Ridge, TN (United States)

Sponsoring Organization:: USDOE; National Natural Science Foundation of China; National Key Research and Development Program of China; Guangxi Science and Technology Major Program; Foundation of Guangxi Key Laboratory of Clean Pulp & Papermaking and Pollution Control

Grant/Contract Number:: AC05-00OR22725

OSTI ID:: 1971027

Journal Information:: Advanced Composites and Hybrid Materials, Journal Name: Advanced Composites and Hybrid Materials Journal Issue: 2 Vol. 6; ISSN 2522-0128

Publisher:: SpringerCopyright Statement

Country of Publication:: United States

Language:: English

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