Effects of proton and oxygen ion irradiation on cardiovascular function and structure in a rabbit model

Nemec-Bakk, Ashley S.; Sridharan, Vijayalakshmi; Seawright, John W.; Nelson, Gregory A.; Cao, Maohua; Singh, Preeti; Cheema, Amrita K.; Singh, Bhaldev; Li, Yaoxiang; Koturbash, Igor; Miousse, Isabelle R.; Ewing, Laura E.; Skinner, Charles M.; Landes, Reid D.; Lowery, John D.; Mao, Xiao-Wen; Singh, Sharda P.; Boerma, Marjan

doi:10.1016/j.lssr.2023.03.008

Title: Effects of proton and oxygen ion irradiation on cardiovascular function and structure in a rabbit model

Journal Article · 01 May 2023 · Life Sciences in Space Research

DOI: https://doi.org/10.1016/j.lssr.2023.03.008 · OSTI ID:1968947

;

; Seawright, John W.; Nelson, Gregory A.; Cao, Maohua;

; Cheema, Amrita K.; Singh, Bhaldev;

; Koturbash, Igor;

;

; Skinner, Charles M.;

; Lowery, John D.; Mao, Xiao-Wen; Singh, Sharda P.;

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Sponsoring Organization:: USDOE

OSTI ID:: 1968947

Journal Information:: Life Sciences in Space Research, Journal Name: Life Sciences in Space Research Vol. 37 Journal Issue: C; ISSN 2214-5524

Publisher:: ElsevierCopyright Statement

Country of Publication:: Netherlands

Language:: English

References (58)

Non-Targeted Effects Models Predict Significantly Higher Mars Mission Cancer Risk than Targeted Effects Models Cucinotta, Francis A.; Cacao, Eliedonna Scientific Reports, Vol. 7, Issue 1 https://doi.org/10.1038/s41598-017-02087-3	journal	May 2017
Heavy ion contributions to organ dose equivalent for the 1977 galactic cosmic ray spectrum Walker, Steven A.; Townsend, Lawrence W.; Norbury, John W. Advances in Space Research, Vol. 51, Issue 9 https://doi.org/10.1016/j.asr.2012.12.011	journal	May 2013
Factor Xa and thrombin evoke additive calcium and proinflammatory responses in endothelial cells subjected to coagulation Daubie, Valéry; Cauwenberghs, Sandra; Senden, Nicole H. M. Biochimica et Biophysica Acta (BBA) - Molecular Cell Research, Vol. 1763, Issue 8 https://doi.org/10.1016/j.bbamcr.2006.04.010	journal	August 2006
Sex-dependent differences in behavior and hippocampal neurogenesis after irradiation to the young mouse brain: Gender differences after IR to the rodent brain Roughton, Karolina; Kalm, Marie; Blomgren, Klas European Journal of Neuroscience, Vol. 36, Issue 6 https://doi.org/10.1111/j.1460-9568.2012.08197.x	journal	July 2012
Suppression of B lymphopoiesis at a lymphoid progenitor stage in adult rabbits Kalis, S. L.; Zhai, S. -K.; Yam, P. -C. International Immunology, Vol. 19, Issue 6 https://doi.org/10.1093/intimm/dxm048	journal	May 2007
Persistence of apoptosis and inflammatory responses in the heart and bone marrow of mice following whole-body exposure to 28Silicon (28Si) ions Tungjai, Montree; Whorton, Elbert B.; Rithidech, Kanokporn Noy Radiation and Environmental Biophysics, Vol. 52, Issue 3 https://doi.org/10.1007/s00411-013-0479-4	journal	June 2013
The risk of Radiation-Induced Cerebrovascular Disease in Chernobyl Emergency Workers Ivanov, V. K.; Maksioutov, M. A.; Chekin, S. Yu. Health Physics, Vol. 90, Issue 3 https://doi.org/10.1097/01.HP.0000175835.31663.ea	journal	January 2006
Kinetics of B-type natriuretic peptide plasma levels in patients with left-sided breast cancer treated with radiation therapy: Results after one-year follow-up D’Errico, Maria Patrizia; Petruzzelli, Maria Fonte; Gianicolo, Emilio A. L. International Journal of Radiation Biology, Vol. 91, Issue 10 https://doi.org/10.3109/09553002.2015.1027421	journal	May 2015
HZE ⁵⁶ Fe-Ion Irradiation Induces Endothelial Dysfunction in Rat Aorta: Role of Xanthine Oxidase Soucy, Kevin G.; Lim, Hyun Kyo; Kim, Jae Hyung Radiation Research, Vol. 176, Issue 4 https://doi.org/10.1667/RR2598.1	journal	October 2011
Human cardiac fibroblasts express B-type natriuretic peptide: fluvastatin ameliorates its up-regulation by interleukin-1α, tumour necrosis factor-α and transforming growth factor-β Jarai, Rudolf; Kaun, Christoph; Weiss, Thomas W. Journal of Cellular and Molecular Medicine, Vol. 13, Issue 11-12 https://doi.org/10.1111/j.1582-4934.2009.00704.x	journal	November 2009
Effects of low-dose oxygen ions on cardiac function and structure in female C57BL/6J mice Nemec-Bakk, Ashley S.; Sridharan, Vijayalakshmi; Landes, Reid D. Life Sciences in Space Research, Vol. 32 https://doi.org/10.1016/j.lssr.2021.12.004	journal	February 2022
Roles of the WHHL Rabbit in Translational Research on Hypercholesterolemia and Cardiovascular Diseases Kobayashi, Tsutomu; Ito, Takashi; Shiomi, Masashi Journal of Biomedicine and Biotechnology, Vol. 2011 https://doi.org/10.1155/2011/406473	journal	January 2011
The positive false discovery rate: a Bayesian interpretation and the q -value Storey, John D. The Annals of Statistics, Vol. 31, Issue 6 https://doi.org/10.1214/aos/1074290335	journal	December 2003
An improved approximation to the precision of fixed effects from restricted maximum likelihood Kenward, Michael G.; Roger, James H. Computational Statistics & Data Analysis, Vol. 53, Issue 7 https://doi.org/10.1016/j.csda.2008.12.013	journal	May 2009
Effects of single-dose protons or oxygen ions on function and structure of the cardiovascular system in male Long Evans rats Sridharan, Vijayalakshmi; Seawright, John W.; Landes, Reid D. Life Sciences in Space Research, Vol. 26 https://doi.org/10.1016/j.lssr.2020.04.002	journal	August 2020
Thematic review series: The Pathogenesis of Atherosclerosis. An interpretive history of the cholesterol controversy: part I Steinberg, Daniel Journal of Lipid Research, Vol. 45, Issue 9 https://doi.org/10.1194/jlr.R400003-JLR200	journal	September 2004
Analysis of the metabolomic profile in serum of irradiated nonhuman primates treated with Ex-Rad, a radiation countermeasure Li, Yaoxiang; Girgis, Michael; Wise, Stephen Y. Scientific Reports, Vol. 11, Issue 1 https://doi.org/10.1038/s41598-021-91067-9	journal	June 2021
Effects of Solar Particle Event-Like Proton Radiation and/or Simulated Microgravity on Circulating Mouse Blood Cells Romero-Weaver, Ana L.; Lin, Liyong; Carabe-Fernandez, Alejandro Gravitational and Space Research, Vol. 2, Issue 1 https://doi.org/10.2478/gsr-2014-0004	journal	July 2014
Effects of ionizing radiation on the heart Boerma, Marjan; Sridharan, Vijayalakshmi; Mao, Xiao-Wen Mutation Research/Reviews in Mutation Research, Vol. 770 https://doi.org/10.1016/j.mrrev.2016.07.003	journal	October 2016
Sex Difference of Radiation Response in Occupational and Accidental Exposure Narendran, Nadia; Luzhna, Lidia; Kovalchuk, Olga Frontiers in Genetics, Vol. 10 https://doi.org/10.3389/fgene.2019.00260	journal	May 2019
Cardiovascular disease among atomic bomb survivors Ozasa, Kotaro; Takahashi, Ikuno; Grant, Eric J. International Journal of Radiation Biology, Vol. 93, Issue 10 https://doi.org/10.1080/09553002.2017.1290849	journal	January 2017
Characterization of Thrombin-Induced Leukocyte Rolling and Adherence: A Potential Proinflammatory Role for Proteinase-Activated Receptor-4 Vergnolle, Nathalie; Derian, Claudia K.; D’Andrea, Michael R. The Journal of Immunology, Vol. 169, Issue 3 https://doi.org/10.4049/jimmunol.169.3.1467	journal	August 2002
Combined Effects of Low-Dose Proton Radiation and Simulated Microgravity on the Mouse Retina and the Hematopoietic System Mao, X. W.; Boerma, M.; Rodriguez, D. Radiation Research, Vol. 192, Issue 3 https://doi.org/10.1667/RR15219.1	journal	November 2018
Principles and Applications of Rabbit Models for Atherosclerosis Research Fan, Jianglin; Chen, Yajie; Yan, Haizhao Journal of Atherosclerosis and Thrombosis, Vol. 25, Issue 3 https://doi.org/10.5551/jat.RV17018	journal	January 2018
Different Effects of Thrombin Receptor Activation on Endothelium and Smooth Muscle Cells of Human Coronary Bypass Vessels Yang, Zhihong; Ruschitzka, Frank; Rabelink, Ton J. Circulation, Vol. 95, Issue 7 https://doi.org/10.1161/01.CIR.95.7.1870	journal	April 1997
Can Animal Models of Disease Reliably Inform Human Studies? van der Worp, H. Bart; Howells, David W.; Sena, Emily S. PLoS Medicine, Vol. 7, Issue 3 https://doi.org/10.1371/journal.pmed.1000245	journal	March 2010
Effects of 40Ar and 56Fe ions on retinal photoreceptor cells of the rabbit: Implications for manned missions to Mars Williams, G. R.; Lett, J. T. Advances in Space Research, Vol. 14, Issue 10 https://doi.org/10.1016/0273-1177(94)90471-5	journal	October 1994
Cancer risk from exposure to galactic cosmic rays: implications for space exploration by human beings Cucinotta, Francis A.; Durante, Marco The Lancet Oncology, Vol. 7, Issue 5 https://doi.org/10.1016/S1470-2045(06)70695-7	journal	May 2006
Radiation–Induced Signaling Results in Mitochondrial Impairment in Mouse Heart at 4 Weeks after Exposure to X-Rays Barjaktarovic, Zarko; Schmaltz, Dominik; Shyla, Alena PLoS ONE, Vol. 6, Issue 12 https://doi.org/10.1371/journal.pone.0027811	journal	December 2011
Effects of low-dose oxygen ions and protons on cardiac function and structure in male C57BL/6J mice Seawright, John W.; Sridharan, Vijayalakshmi; Landes, Reid D. Life Sciences in Space Research, Vol. 20 https://doi.org/10.1016/j.lssr.2019.01.003	journal	February 2019
Systematic Review and Meta-analysis of Circulatory Disease from Exposure to Low-Level Ionizing Radiation and Estimates of Potential Population Mortality Risks Little, Mark P.; Azizova, Tamara V.; Bazyka, Dimitry Environmental Health Perspectives, Vol. 120, Issue 11 https://doi.org/10.1289/ehp.1204982	journal	November 2012
Effects of Radiation Therapy on Myocardial Cell Integrity and Pump Function: Which Role for Cardiac Biomarkers? Nellessen, Ulrich; Zingel, Manuela; Hecker, Hartmut Chemotherapy, Vol. 56, Issue 2 https://doi.org/10.1159/000313528	journal	January 2010
Brain natriuretic peptide as a cardiac marker of transient radiotherapy-related damage in left-sided breast cancer patients: A prospective study Palumbo, I.; Palumbo, B.; Fravolini, M. L. The Breast, Vol. 25 https://doi.org/10.1016/j.breast.2015.10.004	journal	February 2016
Late onset cardiovascular dysfunction in adult mice resulting from galactic cosmic ray exposure Bishawi, Muath; Lee, Franklin H.; Abraham, Dennis M. iScience, Vol. 25, Issue 4 https://doi.org/10.1016/j.isci.2022.104086	journal	April 2022
Late Administration of a Palladium Lipoic Acid Complex (POLY-MVA) Modifies Cardiac Mitochondria but Not Functional or Structural Manifestations of Radiation-Induced Heart Disease in a Rat Model Sridharan, Vijayalakshmi; Seawright, John W.; Antonawich, Francis J. Radiation Research, Vol. 187, Issue 3 https://doi.org/10.1667/RR14643.1	journal	February 2017
Cytoplasmic lipid droplets are translocated into the lumen of the Chlamydia trachomatis parasitophorous vacuole Cocchiaro, Jordan L.; Kumar, Yadunanda; Fischer, Elizabeth R. Proceedings of the National Academy of Sciences, Vol. 105, Issue 27 https://doi.org/10.1073/pnas.0712241105	journal	July 2008
Cardiac Troponin T and Troponin I in the General Population Welsh, Paul; Preiss, David; Hayward, Caroline Circulation, Vol. 139, Issue 24 https://doi.org/10.1161/CIRCULATIONAHA.118.038529	journal	June 2019
Coronary heart disease after radiotherapy for peptic ulcer disease Carr, Zhanat A.; Land, Charles E.; Kleinerman, Ruth A. International Journal of Radiation OncologyBiologyPhysics, Vol. 61, Issue 3 https://doi.org/10.1016/j.ijrobp.2004.07.708	journal	March 2005
How Similar Are the Mice to Men? Between-Species Comparison of Left Ventricular Mechanics Using Strain Imaging Kusunose, Kenya; Penn, Marc S.; Zhang, Youhua PLoS ONE, Vol. 7, Issue 6 https://doi.org/10.1371/journal.pone.0040061	journal	June 2012
Comparison between High-Sensitivity Cardiac Troponin T and Cardiac Troponin I in a Large General Population Cohort Welsh, Paul; Preiss, David; Shah, Anoop S. V. Clinical Chemistry, Vol. 64, Issue 11 https://doi.org/10.1373/clinchem.2018.292086	journal	November 2018
Low-dose radiation affects cardiac physiology: gene networks and molecular signaling in cardiomyocytes Coleman, Matthew A.; Sasi, Sharath P.; Onufrak, Jillian American Journal of Physiology-Heart and Circulatory Physiology, Vol. 309, Issue 11 https://doi.org/10.1152/ajpheart.00050.2015	journal	December 2015
Studies of Mortality of Atomic Bomb Survivors. Report 13: Solid Cancer and Noncancer Disease Mortality: 1950–1997 Preston, Dale L.; Shimizu, Yukiko; Pierce, Donald A. Radiation Research, Vol. 160, Issue 4 https://doi.org/10.1667/RR3049	journal	October 2003
Myocardial Injury and the Release of Troponins I and T in the Blood of Patients Katrukha, Ivan A.; Katrukha, Alexey G. Clinical Chemistry, Vol. 67, Issue 1 https://doi.org/10.1093/clinchem/hvaa281	journal	December 2020
A priming dose of protons alters the early cardiac cellular and molecular response to 56 Fe irradiation Ramadan, Samy S.; Sridharan, Vijayalakshmi; Koturbash, Igor Life Sciences in Space Research, Vol. 8 https://doi.org/10.1016/j.lssr.2015.12.001	journal	February 2016
Rabbit models for the study of human atherosclerosis: From pathophysiological mechanisms to translational medicine Fan, Jianglin; Kitajima, Shuji; Watanabe, Teruo Pharmacology & Therapeutics, Vol. 146 https://doi.org/10.1016/j.pharmthera.2014.09.009	journal	February 2015
Serum cardiac troponin T levels during treatment of early-stage breast cancer. Hughes-Davies, L.; Sacks, D.; Rescigno, J. Journal of Clinical Oncology, Vol. 13, Issue 10 https://doi.org/10.1200/JCO.1995.13.10.2582	journal	October 1995
Damage to the photoreceptor cells of the rabbit retina from 56Fe ions: Effect of age at exposure, 1 Williams, G. R.; Lett, J. T. Advances in Space Research, Vol. 18, Issue 1-2 https://doi.org/10.1016/0273-1177(95)00790-L	journal	January 1996
Nuclear interactions in heavy ion transport and event-based risk models Cucinotta, F. A.; Plante, I.; Ponomarev, A. L. Radiation Protection Dosimetry, Vol. 143, Issue 2-4 https://doi.org/10.1093/rpd/ncq512	journal	January 2011
Adriamycin Cardiomyopathy: Enhanced Cardiac Damage in Rabbits with Combined Drug and Cardiac Irradiation Eltringham, James R.; Fajardo, Luis F.; Robert Stewart, J. Radiology, Vol. 115, Issue 2 https://doi.org/10.1148/115.2.471	journal	May 1975
Limitations in predicting the space radiation health risk for exploration astronauts Chancellor, Jeffery C.; Blue, Rebecca S.; Cengel, Keith A. npj Microgravity, Vol. 4, Issue 1 https://doi.org/10.1038/s41526-018-0043-2	journal	April 2018
Subclinical Cardiotoxicity Detected by Strain Rate Imaging up to 14 months After Breast Radiation Therapy Erven, Katrien; Florian, Anca; Slagmolen, Pieter International Journal of Radiation OncologyBiologyPhysics, Vol. 85, Issue 5 https://doi.org/10.1016/j.ijrobp.2012.09.022	journal	April 2013
NT-ProBNP: The Mechanism Behind the Marker Hall, Christian Journal of Cardiac Failure, Vol. 11, Issue 5 https://doi.org/10.1016/j.cardfail.2005.04.019	journal	June 2005
Dose and dose rate effects of whole-body proton irradiation on leukocyte populations and lymphoid organs: Part I Gridley, Daila S.; Pecaut, Michael J.; Dutta-Roy, Radha Immunology Letters, Vol. 80, Issue 1 https://doi.org/10.1016/S0165-2478(01)00306-6	journal	January 2002
Cardiovascular Risks Associated with Low Dose Ionizing Particle Radiation Yan, Xinhua; Sasi, Sharath P.; Gee, Hannah PLoS ONE, Vol. 9, Issue 10 https://doi.org/10.1371/journal.pone.0110269	journal	October 2014
Predictions of cognitive detriments from galactic cosmic ray exposures to astronauts on exploration missions Cucinotta, Francis A.; Cacao, Eliedonna Life Sciences in Space Research, Vol. 25 https://doi.org/10.1016/j.lssr.2019.10.004	journal	May 2020
Analysis of White Blood Cell Counts in Mice after Gamma- or Proton-Radiation Exposure Maks, Casey J.; Wan, X. Steven; Ware, Jeffrey H. Radiation Research, Vol. 176, Issue 2 https://doi.org/10.1667/RR2413.1	journal	August 2011
Hypoxia induces B-type natriuretic peptide release in cell lines derived from human cardiomyocytes Casals, Gregori; Ros, Josefa; Sionis, Alessandro American Journal of Physiology-Heart and Circulatory Physiology, Vol. 297, Issue 2 https://doi.org/10.1152/ajpheart.00250.2009	journal	August 2009
Effects of High-LET Radiation Exposure and Hindlimb Unloading on Skeletal Muscle Resistance Artery Vasomotor Properties and Cancellous Bone Microarchitecture in Mice Ghosh, Payal; Behnke, Brad J.; Stabley, John N. Radiation Research, Vol. 185, Issue 3 https://doi.org/10.1667/RR4308.1	journal	March 2016

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