Integrative illustration of a JCVI-syn3A minimal cell

Goodsell, David S.

doi:10.1515/jib-2022-0013

Title: Integrative illustration of a JCVI-syn3A minimal cell

Journal Article · 26 June 2022 · Journal of Integrative Bioinformatics

DOI: https://doi.org/10.1515/jib-2022-0013 · OSTI ID:1967533

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Department of Integrative Structural and Computational Biology , The Scripps Research Institute , La Jolla , CA 92037 , USA, Research Collaboratory for Structural Bioinformatics Protein Data Bank , Rutgers, The State University of New Jersey , Piscataway , NJ 08854 , USA

Abstract Data from genomics, proteomics, structural biology and cryo-electron microscopy are integrated into a structural illustration of a cross section through an entire JCVI-syn3.0 minimal cell. The illustration is designed with several goals: to inspire excitement in science, to depict the underlying scientific results accurately, and to be feasible in traditional media. Design choices to achieve these goals include reduction of visual complexity with simplified representations, use of orthographic projection to retain scale relationships, and an approach to color that highlights functional compartments of the cell. Given that this simple cell provides an attractive laboratory for exploring the central processes needed for life, several functional narratives are included in the illustration, including division of the cell and the first depiction of an entire cellular proteome. The illustration lays the foundation for 3D molecular modeling of this cell.

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Sponsoring Organization:: USDOE

Grant/Contract Number:: SC0019749

OSTI ID:: 1967533

Journal Information:: Journal of Integrative Bioinformatics, Journal Name: Journal of Integrative Bioinformatics Journal Issue: 2 Vol. 19; ISSN 1613-4516

Publisher:: Walter de Gruyter GmbHCopyright Statement

Country of Publication:: Germany

Language:: English

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