Three major reasons why transgenerational effects of radiation are difficult to detect in humans

Nakamura, Nori; Yoshida, Noriaki; Suwa, Tatsuya

doi:10.1080/09553002.2023.2187478

Title: Three major reasons why transgenerational effects of radiation are difficult to detect in humans

Journal Article · 14 March 2023 · International Journal of Radiation Biology

DOI: https://doi.org/10.1080/09553002.2023.2187478 · OSTI ID:1961680

^[1];

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Department of Molecular Biosciences, Radiation Effects Research Foundation, Hiroshima, Japan
Department of Clinical Studies, Radiation Effects Research Foundation, Hiroshima, Japan
Department of Genome Dynamics, Radiation Biology Center, Graduate School of Biostudies, Kyoto University, Kyoto, Japan

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Sponsoring Organization:: USDOE

OSTI ID:: 1961680

Journal Information:: International Journal of Radiation Biology, Journal Name: International Journal of Radiation Biology Journal Issue: 9 Vol. 100; ISSN 0955-3002

Publisher:: Informa UK LimitedCopyright Statement

Country of Publication:: United Kingdom

Language:: English

References (87)

Frequency and nature of specific-locus mutations induced in female mice by radiations and chemicals: a review Russell, L. B.; Russell, W. L. Mutation Research/Reviews in Genetic Toxicology, Vol. 296, Issue 1-2 https://doi.org/10.1016/0165-1110(92)90035-8	journal	December 1992
Why Genetic Effects of Radiation are Observed in Mice but not in Humans Nakamura, Nori Radiation Research, Vol. 189, Issue 2 https://doi.org/10.1667/RR14947.1	journal	February 2018
Environmental Causes of Human Congenital Malformations: The Pediatrician’s Role in Dealing With These Complex Clinical Problems Caused by a Multiplicity of Environmental and Genetic Factors Brent, Robert L. Pediatrics, Vol. 113, Issue Supplement_3 https://doi.org/10.1542/peds.113.S3.957	journal	April 2004
EPAS1 Is Required for Spermatogenesis in the Postnatal Mouse Testis1 Gruber, Michaela; Mathew, Lijoy K.; Runge, Anja C. Biology of Reproduction, Vol. 82, Issue 6 https://doi.org/10.1095/biolreprod.109.079202	journal	June 2010
Hypoxia induces the dormant state in oocytes through expression of Foxo3 Shimamoto, So; Nishimura, Yohei; Nagamatsu, Go Proceedings of the National Academy of Sciences, Vol. 116, Issue 25 https://doi.org/10.1073/pnas.1817223116	journal	May 2019
The genome-wide effects of ionizing radiation on mutation induction in the mammalian germline Adewoye, Adeolu B.; Lindsay, Sarah J.; Dubrova, Yuri E. Nature Communications, Vol. 6, Issue 1 https://doi.org/10.1038/ncomms7684	journal	March 2015
Ovarian Organogenesis in Mammals: Mice Cannot Tell Us Everything Jiménez, R. Sexual Development, Vol. 3, Issue 6 https://doi.org/10.1159/000280584	journal	January 2009
Estimates of the genetic risks from ionizing irradiation Lüning, K. G.; Searle, A. G. Mutation Research/Fundamental and Molecular Mechanisms of Mutagenesis, Vol. 12, Issue 3 https://doi.org/10.1016/0027-5107(71)90017-0	journal	July 1971
Specific-locus experiments show that female mice exposed near the time of birth to low-LET ionizing radiation exhibit both a low mutational response and a dose-rate effect Selby, P. B.; Lee, S. S.; Kelley, E. M. Mutation Research/Fundamental and Molecular Mechanisms of Mutagenesis, Vol. 249, Issue 2 https://doi.org/10.1016/0027-5107(91)90010-L	journal	August 1991
Spermatogonial stem cells and spermatogenesis in mice, monkeys and men Fayomi, Adetunji P.; Orwig, Kyle E. Stem Cell Research, Vol. 29 https://doi.org/10.1016/j.scr.2018.04.009	journal	May 2018
Survival and Renewal of Murine Stem Spermatogonia Following 60 Co g Radiation Erickson, B. H. Radiation Research, Vol. 86, Issue 1 https://doi.org/10.2307/3575597	journal	April 1981
Ovarian Failure and Reproductive Outcomes After Childhood Cancer Treatment: Results From the Childhood Cancer Survivor Study Green, Daniel M.; Sklar, Charles A.; Boice, John D. Journal of Clinical Oncology, Vol. 27, Issue 14 https://doi.org/10.1200/JCO.2008.21.1839	journal	May 2009
Human testicular peritubular cells secrete pigment epithelium-derived factor (PEDF), which may be responsible for the avascularity of the seminiferous tubules Windschüttl, S.; Kampfer, C.; Mayer, C. Scientific Reports, Vol. 5, Issue 1 https://doi.org/10.1038/srep12820	journal	September 2015
The Effect of Testicular X-irradiation on Spermatogenesis in Man Clifton, Donald K.; Bremner, William J. Journal of Andrology, Vol. 4, Issue 6 https://doi.org/10.1002/j.1939-4640.1983.tb00765.x	journal	November 1983
Defying DNA Double-Strand Break-Induced Death during Prophase I Meiosis by Temporal TAp63α Phosphorylation Regulation in Developing Mouse Oocytes Kim, Dal-Ah; Suh, Eun-Kyung Molecular and Cellular Biology, Vol. 34, Issue 8 https://doi.org/10.1128/MCB.01223-13	journal	April 2014
Male Fertility After Cancer Sabanegh, Edmund S.; Ragheb, Ahmed M. Urology, Vol. 73, Issue 2 https://doi.org/10.1016/j.urology.2008.08.474	journal	February 2009
Apoptotic spermatogenic cells can be energy sources for Sertoli cells Xiong, Weipeng; Wang, Haikun; Wu, Hui REPRODUCTION, Vol. 137, Issue 3 https://doi.org/10.1530/REP-08-0343	journal	March 2009
Role of the testis interstitial compartment in spermatogonial stem cell function Potter, Sarah J.; DeFalco, Tony Reproduction, Vol. 153, Issue 4 https://doi.org/10.1530/REP-16-0588	journal	April 2017
Morphometric study of the human neonatal ovary Forabosco, Antonino; Sforza, Chiarella; De Pol, Anto The Anatomical Record, Vol. 231, Issue 2 https://doi.org/10.1002/ar.1092310208	journal	October 1991
Concise Review: The Role of Oxygen in Hematopoietic Stem Cell Physiology Jež, Mojca; Rožman, Primož; Ivanović, Zoran Journal of Cellular Physiology, Vol. 230, Issue 9 https://doi.org/10.1002/jcp.24953	journal	May 2015
Lack of transgenerational effects of ionizing radiation exposure from the Chernobyl accident Yeager, Meredith; Machiela, Mitchell J.; Kothiyal, Prachi Science, Vol. 372, Issue 6543 https://doi.org/10.1126/science.abg2365	journal	April 2021
Congenital Malformations and Perinatal Deaths Among the Children of Atomic Bomb Survivors: A Reappraisal Yamada, Michiko; Furukawa, Kyoji; Tatsukawa, Yoshimi American Journal of Epidemiology, Vol. 190, Issue 11 https://doi.org/10.1093/aje/kwab099	journal	April 2021
Radiation Effects on Human Heredity Nakamura, Nori; Suyama, Akihiko; Noda, Asao Annual Review of Genetics, Vol. 47, Issue 1 https://doi.org/10.1146/annurev-genet-111212-133501	journal	November 2013
Spermatogenesis and Cycle of the Seminiferous Epithelium Hess, Rex A.; de Franca, Luiz Renato Advances in Experimental Medicine and Biology https://doi.org/10.1007/978-0-387-09597-4_1	book	January 2009
Studies on the Human Oocyte and its Follicle Hertig, Arthur T.; Adams, Eleanor C. Journal of Cell Biology, Vol. 34, Issue 2 https://doi.org/10.1083/jcb.34.2.647	journal	August 1967
p63 protects the female germ line during meiotic arrest Suh, Eun-Kyung; Yang, Annie; Kettenbach, Arminja Nature, Vol. 444, Issue 7119 https://doi.org/10.1038/nature05337	journal	November 2006
Hypoxia Signaling Pathway in Stem Cell Regulation: Good and Evil Huang, Xinxin; Trinh, Thao; Aljoufi, Arafat Current Stem Cell Reports, Vol. 4, Issue 2 https://doi.org/10.1007/s40778-018-0127-7	journal	April 2018
Microvasculature of the human testis in correlation to Leydig cells and seminiferous tubules Ergün, S.; Stingl, J.; Holstein, A. F. Andrologia, Vol. 26, Issue 5 https://doi.org/10.1111/j.1439-0272.1994.tb00799.x	journal	April 2009
Hypoxia-Inducible Factor-1 Is Constitutively Expressed in Murine Leydig Cells and Regulates 3 -Hydroxysteroid Dehydrogenase Type 1 Promoter Activity Lysiak, J. J.; Kirby, J. L.; Tremblay, J. J. Journal of Andrology, Vol. 30, Issue 2 https://doi.org/10.2164/jandrol.108.006155	journal	October 2008
Artificial Transmutation of the gene Muller, H. J. Science, Vol. 66, Issue 1699 https://doi.org/10.1126/science.66.1699.84	journal	July 1927
Linking a mutation to survival in wild mice Barrett, Rowan D. H.; Laurent, Stefan; Mallarino, Ricardo Science, Vol. 363, Issue 6426 https://doi.org/10.1126/science.aav3824	journal	January 2019
History of radiation genetics: light and darkness Nakamura, Nori International Journal of Radiation Biology, Vol. 95, Issue 7 https://doi.org/10.1080/09553002.2019.1572251	journal	February 2019
Two classes of ovarian primordial follicles exhibit distinct developmental dynamics and physiological functions Zheng, Wenjing; Zhang, Hua; Gorre, Nagaraju Human Molecular Genetics, Vol. 23, Issue 4 https://doi.org/10.1093/hmg/ddt486	journal	October 2013
The HIF-1-active microenvironment: An environmental target for cancer therapy Kizaka-Kondoh, Shinae; Tanaka, Shotaro; Harada, Hiroshi Advanced Drug Delivery Reviews, Vol. 61, Issue 7-8 https://doi.org/10.1016/j.addr.2009.01.006	journal	July 2009
Oocytes maintain ROS-free mitochondrial metabolism by suppressing complex I Rodríguez-Nuevo, Aida; Torres-Sanchez, Ariadna; Duran, Juan M. Nature, Vol. 607, Issue 7920 https://doi.org/10.1038/s41586-022-04979-5	journal	July 2022
Dynamics of follicular growth in the human: a model from preliminary results Gougeon, A. Human Reproduction, Vol. 1, Issue 2 https://doi.org/10.1093/oxfordjournals.humrep.a136365	journal	February 1986
Reproduction following treatment for childhood leukemia: A population-based prospective cohort study of fertility and offspring Nygaard, Randi; Clausen, Niels; Siimes, Martti A. Medical and Pediatric Oncology, Vol. 19, Issue 6 https://doi.org/10.1002/mpo.2950190603	journal	January 1991
Is there a proportionality between the spontaneous and the X-ray induction rates of mutations? Shukla, P. T.; Sankaranarayanan, K.; Sobels, F. H. Mutation Research/Fundamental and Molecular Mechanisms of Mutagenesis, Vol. 61, Issue 2 https://doi.org/10.1016/0027-5107(79)90130-1	journal	July 1979
The Cycle of the Seminiferous Epithelium in Humans: A Need to Revisit? Amann, R. P. Journal of Andrology, Vol. 29, Issue 5 https://doi.org/10.2164/jandrol.107.004655	journal	April 2008
Brain Damage among the Prenatally Exposed Otake, Masanori; Schull, William J.; Yoshimaru, Hiroshi Journal of Radiation Research, Vol. 32, Issue SUPPLEMENT https://doi.org/10.1269/jrr.32.SUPPLEMENT_249	journal	January 1991
Germ Cell-Specific Transcriptional Regulator Sohlh2 Is Essential for Early Mouse Folliculogenesis and Oocyte-Specific Gene Expression1 Choi, Youngsok; Yuan, Daniel; Rajkovic, Aleksandar Biology of Reproduction, Vol. 79, Issue 6 https://doi.org/10.1095/biolreprod.108.071217	journal	December 2008
Partial loss of contractile marker proteins in human testicular peritubular cells in infertility patients Welter, H.; Kampfer, C.; Lauf, S. Andrology, Vol. 1, Issue 2 https://doi.org/10.1111/j.2047-2927.2012.00030.x	journal	November 2012
Comparative aspects of the effects of radiation during oogenesis Baker, T. G. Mutation Research/Fundamental and Molecular Mechanisms of Mutagenesis, Vol. 11, Issue 1 https://doi.org/10.1016/0027-5107(71)90028-5	journal	January 1971
Unifying theory of adult resting follicle recruitment and fetal oocyte arrest Silber, Sherman Reproductive BioMedicine Online, Vol. 31, Issue 4 https://doi.org/10.1016/j.rbmo.2015.06.022	journal	October 2015
Prevalence and architecture of de novo mutations in developmental disorders Nature, Vol. 542, Issue 7642, p. 433-438 https://doi.org/10.1038/nature21062	journal	January 2017
Germ-line mitochondria exhibit suppressed respiratory activity to support their accurate transmission to the next generation Kogo, Naomi; Tazaki, Akira; Kashino, Yasuhiro Developmental Biology, Vol. 349, Issue 2 https://doi.org/10.1016/j.ydbio.2010.11.021	journal	January 2011
Hormonal regulation of pigment epithelium-derived factor (PEDF) in granulosa cells Chuderland, Dana; Ben-Ami, Ido; Kaplan-Kraicer, Ruth MHR: Basic science of reproductive medicine, Vol. 19, Issue 2 https://doi.org/10.1093/molehr/gas046	journal	October 2012
Ethical, legal and social implications of human genome studies in radiation research: a workshop report for studies on atomic bomb survivors at the Radiation Effects Research Foundation Noda, Asao; Kato, Kazuto; Tamura, Chieko Journal of Radiation Research, Vol. 62, Issue 4 https://doi.org/10.1093/jrr/rrab043	journal	May 2021
Genetic Effects of X-Rays in Maize Stadler, L. J. Proceedings of the National Academy of Sciences, Vol. 14, Issue 1 https://doi.org/10.1073/pnas.14.1.69	journal	January 1928
Uterine Selection of Human Embryos at Implantation Brosens, Jan J.; Salker, Madhuri S.; Teklenburg, Gijs Scientific Reports, Vol. 4, Issue 1 https://doi.org/10.1038/srep03894	journal	February 2014
Dominant cataract and recessive specific locus mutations in offspring of X-irradiated male mice Graw, Jochen; Favor, Jack; Neuhäuser-Klaus, Angelika Mutation Research/Fundamental and Molecular Mechanisms of Mutagenesis, Vol. 159, Issue 1-2 https://doi.org/10.1016/0027-5107(86)90111-9	journal	January 1986
Two distinct pathways of pregranulosa cell differentiation support follicle formation in the mouse ovary Niu, Wanbao; Spradling, Allan C. Proceedings of the National Academy of Sciences, Vol. 117, Issue 33 https://doi.org/10.1073/pnas.2005570117	journal	August 2020
A Genome Scanning Approach to Assess the Genetic Effects of Radiation in Mice and Humans Asakawa, Jun-ichi; Kuick, Rork; Kodaira, Mieko Radiation Research, Vol. 161, Issue 4 https://doi.org/10.1667/RR3146	journal	April 2004
A life‐table analysis of the intrauterine fate of malformed human embryos and fetuses Shiota, Kohei Birth Defects Research, Vol. 113, Issue 8 https://doi.org/10.1002/bdr2.1888	journal	March 2021
Risk of death among children of atomic bomb survivors after 62 years of follow-up: a cohort study Grant, Eric J.; Furukawa, Kyoji; Sakata, Ritsu The Lancet Oncology, Vol. 16, Issue 13 https://doi.org/10.1016/S1470-2045(15)00209-0	journal	October 2015
Untapped Reserves: Controlling Primordial Follicle Growth Activation Kallen, Amanda; Polotsky, Alex J.; Johnson, Joshua Trends in Molecular Medicine, Vol. 24, Issue 3 https://doi.org/10.1016/j.molmed.2018.01.008	journal	March 2018
New insights into mechanisms behind miscarriage Larsen, Elisabeth Clare; Christiansen, Ole Bjarne; Kolte, Astrid Marie BMC Medicine, Vol. 11, Issue 1 https://doi.org/10.1186/1741-7015-11-154	journal	June 2013
Genetic Effects of Radiation in Atomic-bomb Survivors and Their Children: Past, Present and Future Nakamura, Nori Journal of Radiation Research, Vol. 47, Issue SupplementB https://doi.org/10.1269/jrr.47.B67	journal	January 2006
Protection against Radiation-Induced Mutagenesis in V79 Cells by 2-[(Aminopropyl)amino] Ethanethiol under Conditions of Acute Hypoxia Grdina, David J.; Nagy, Biserka; Hill, Colin K. Radiation Research, Vol. 117, Issue 2 https://doi.org/10.2307/3577326	journal	February 1989
Embryoscopic and cytogenetic analysis of 233 missed abortions: factors involved in the pathogenesis of developmental defects of early failed pregnancies Philipp, T. Human Reproduction, Vol. 18, Issue 8 https://doi.org/10.1093/humrep/deg309	journal	August 2003
The two classes of primordial follicles in the mouse ovary: their development, physiological functions and implications for future research Zheng, W.; Zhang, H.; Liu, K. Molecular Human Reproduction, Vol. 20, Issue 4 https://doi.org/10.1093/molehr/gau007	journal	January 2014
Reduced Expression of the Endothelin Receptor Type B Gene in Piebald Mice Caused by Insertion of a Retroposon-like Element in Intron 1 Yamada, Takahisa; Ohtani, Shin; Sakurai, Takeshi Journal of Biological Chemistry, Vol. 281, Issue 16 https://doi.org/10.1074/jbc.M512618200	journal	April 2006
Novel Role for p110β PI 3-Kinase in Male Fertility through Regulation of Androgen Receptor Activity in Sertoli Cells Guillermet-Guibert, Julie; Smith, Lee B.; Halet, Guillaume PLOS Genetics, Vol. 11, Issue 7 https://doi.org/10.1371/journal.pgen.1005304	journal	July 2015
Radiation risk of individual multifactorial diseases in offspring of the atomic-bomb survivors: a clinical health study Tatsukawa, Yoshimi; Cologne, John B.; Hsu, Wan-Ling Journal of Radiological Protection, Vol. 33, Issue 2 https://doi.org/10.1088/0952-4746/33/2/281	journal	March 2013
Environmental factors for establishment of the dormant state in oocytes Hayashi, Katsuhiko; Shimamoto, So; Nagamatsu, Go Development, Growth & Differentiation, Vol. 62, Issue 3 https://doi.org/10.1111/dgd.12653	journal	February 2020
Mutation frequencies in female mice and the estimation of genetic hazards of radiation in women. Russell, W. L. Proceedings of the National Academy of Sciences, Vol. 74, Issue 8 https://doi.org/10.1073/pnas.74.8.3523	journal	August 1977
Functional and molecular features of the Id4⁺ germline stem cell population in mouse testes Chan, Frieda; Oatley, Melissa J.; Kaucher, Amy V. Genes & Development, Vol. 28, Issue 12 https://doi.org/10.1101/gad.240465.114	journal	June 2014
The Genetic Risk in Mice from Radiation: An Estimate of the Mutation Induction Rate per Genome Asakawa, Jun-ichi; Kodaira, Mieko; Cullings, Harry M. Radiation Research, Vol. 179, Issue 3 https://doi.org/10.1667/RR3095.1	journal	March 2013
The radiosensitivity of the human oocyte Wallace, W. H. B.; Thomson, A. B.; Kelsey, T. W. Human Reproduction, Vol. 18, Issue 1 https://doi.org/10.1093/humrep/deg016	journal	January 2003
Histological study of proportion of cortex and medulla of the ovary in Bangladeshi women Perven, Hosna Ara; Nurunnabi, Abu Sadat Mohammad; Siddiqua, Dilruba Bangladesh Medical Journal, Vol. 44, Issue 1 https://doi.org/10.3329/bmj.v44i1.26337	journal	January 2016
Oxygen Sensitization of Mammalian Cells under Different Irradiation Conditions Ling, C. Clifton; Michaels, Howard B.; Gerweck, Leo E. Radiation Research, Vol. 86, Issue 2 https://doi.org/10.2307/3575509	journal	May 1981
Pregnancy Outcome After Treatment for Wilms Tumor: A Report From the National Wilms Tumor Long-Term Follow-Up Study Green, Daniel M.; Lange, Jane M.; Peabody, Eve M. Journal of Clinical Oncology, Vol. 28, Issue 17 https://doi.org/10.1200/JCO.2009.27.2922	journal	June 2010
Cancer cells that survive radiation therapy acquire HIF-1 activity and translocate towards tumour blood vessels Harada, Hiroshi; Inoue, Masahiro; Itasaka, Satoshi Nature Communications, Vol. 3, Issue 1 https://doi.org/10.1038/ncomms1786	journal	April 2012
Endometrial Stromal Cells of Women with Recurrent Miscarriage Fail to Discriminate between High- and Low-Quality Human Embryos Weimar, Charlotte H. E.; Kavelaars, Annemieke; Brosens, Jan J. PLoS ONE, Vol. 7, Issue 7 https://doi.org/10.1371/journal.pone.0041424	journal	July 2012
Superficial ovarian cortex vascularization is inversely related to the follicle reserve in normal cycling ovaries and is increased in polycystic ovary syndrome Delgado-Rosas, F.; Gaytan, M.; Morales, C. Human Reproduction, Vol. 24, Issue 5 https://doi.org/10.1093/humrep/dep008	journal	February 2009
Metabolic Changes Accompanying Spermatogonial Stem Cell Differentiation Lord, Tessa; Nixon, Brett Developmental Cell, Vol. 52, Issue 4 https://doi.org/10.1016/j.devcel.2020.01.014	journal	February 2020
Ovarian tissue cryopreservation and transplantation: scientific implications Silber, Sherman Journal of Assisted Reproduction and Genetics, Vol. 33, Issue 12 https://doi.org/10.1007/s10815-016-0814-1	journal	October 2016
Mutations in Barley Induced by X-Rays and Radium Stadler, L. J. Science, Vol. 68, Issue 1756 https://doi.org/10.1126/science.68.1756.186	journal	August 1928
Distribution of spermatogenesis in the testicles of azoospermic men: the presence or absence of spermatids in the testes of men with germinal failure Silber, S. J.; Nagy, Z.; Devroey, P. Human Reproduction, Vol. 12, Issue 11 https://doi.org/10.1093/humrep/12.11.2422	journal	November 1997
Quantification of healthy follicles in the neonatal and adult mouse ovary: evidence for maintenance of primordial follicle supply Kerr, J. B.; Duckett, R.; Myers, M. Reproduction, Vol. 132, Issue 1 https://doi.org/10.1530/rep.1.01128	journal	July 2006
Dilute (d) coat colour mutation of DBA/2J mice is associated with the site of integration of an ecotropic MuLV genome Jenkins, Nancy A.; Copeland, Neal G.; Taylor, Benjamin A. Nature, Vol. 293, Issue 5831 https://doi.org/10.1038/293370a0	journal	October 1981
SPINK1 as a plasma marker for tumor hypoxia and a therapeutic target for radiosensitization Suwa, Tatsuya; Kobayashi, Minoru; Shirai, Yukari JCI Insight, Vol. 6, Issue 21 https://doi.org/10.1172/jci.insight.148135	journal	November 2021
Detection of de novo single nucleotide variants in offspring of atomic-bomb survivors close to the hypocenter by whole-genome sequencing Horai, Makiko; Mishima, Hiroyuki; Hayashida, Chisa Journal of Human Genetics, Vol. 63, Issue 3 https://doi.org/10.1038/s10038-017-0392-9	journal	December 2017
Characteristics of induced mutations in offspring derived from irradiated mouse spermatogonia and mature oocytes Satoh, Yasunari; Asakawa, Jun-ichi; Nishimura, Mayumi Scientific Reports, Vol. 10, Issue 1 https://doi.org/10.1038/s41598-019-56881-2	journal	January 2020
Unified single-cell analysis of testis gene regulation and pathology in five mouse strains Jung, Min; Wells, Daniel; Rusch, Jannette eLife, Vol. 8 https://doi.org/10.7554/eLife.43966	journal	June 2019
Recent advances in the biology of tumour hypoxia with relevance to diagnostic practice and tissue‐based research Macklin, Philip S.; Yamamoto, Atsushi; Browning, Lisa The Journal of Pathology, Vol. 250, Issue 5 https://doi.org/10.1002/path.5402	journal	March 2020
Genome-Wide Deletion Screening with the Array CGH Method in Mouse Offspring Derived from Irradiated Spermatogonia Indicates that Mutagenic Responses are Highly Variable among Genes Asakawa, Jun-ichi; Kodaira, Mieko; Miura, Akiko Radiation Research, Vol. 186, Issue 6 https://doi.org/10.1667/RR14402.1	journal	November 2016

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