Electromechanics of lipid-modulated gating of potassium channels

Thomas, Nidhin; Mandadapu, Kranthi K.; Agrawal, Ashutosh

doi:10.1177/10812865211060071

Title: Electromechanics of lipid-modulated gating of potassium channels

Journal Article · 29 December 2021 · Mathematics and Mechanics of Solids

DOI: https://doi.org/10.1177/10812865211060071 · OSTI ID:1960403

Thomas, Nidhin ^[1]; Mandadapu, Kranthi K. ^[2];

^[1]

Univ. of Houston, TX (United States)
Univ. of California, Berkeley, CA (United States); Lawrence Berkeley National Lab. (LBNL), Berkeley, CA (United States)

Experimental studies reveal that the anionic lipid phosphatidic acid (POPA), non-phospholipid cholesterol, and cationic lipid DOTAP inhibit the gating of voltage-sensitive potassium (Kv) channels. In this work, we develop a continuum electromechanical model to investigate the interaction of these lipids with the ion channel. Our model suggests that: (i) POPA lipids may restrict the vertical motion of the voltage-sensor domain through direct electrostatic interactions; (ii) cholesterol may oppose the radial motion of the pore domain of the channel by increasing the mechanical rigidity of the membrane; and (iii) DOTAP can reduce the effect of electrostatic forces by regulating the dielectric constant at the channel–lipid interface. The electromechanical model predictions for the three lipid types match well with the experimental observations and provide mechanistic insights into lipid-dependent gating of Kv channels.

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Research Organization:: Lawrence Berkeley National Laboratory (LBNL), Berkeley, CA (United States)

Sponsoring Organization:: USDOE Office of Science (SC), Basic Energy Sciences (BES). Chemical Sciences, Geosciences & Biosciences Division; National Science Foundation (NSF)

Grant/Contract Number:: AC02-05CH11231

OSTI ID:: 1960403

Journal Information:: Mathematics and Mechanics of Solids, Journal Name: Mathematics and Mechanics of Solids Journal Issue: 7 Vol. 27; ISSN 1081-2865

Publisher:: SAGECopyright Statement

Country of Publication:: United States

Language:: English

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