Production of zirconium-88 via proton irradiation of metallic yttrium and preparation of target for neutron transmission measurements at DICER

Matyskin, Artem V.; Stamatopoulos, Athanasios; O’Brien, Ellen M.; DiGiovine, Brad J.; Mocko, Veronika; Fassbender, Michael E.; Vermeulen, C. Etienne; Koehler, Paul E.

doi:10.1038/s41598-023-27993-7

Title: Production of zirconium-88 via proton irradiation of metallic yttrium and preparation of target for neutron transmission measurements at DICER

Journal Article · Tue Jan 31 00:00:00 UTC 2023 · Scientific Reports

DOI: https://doi.org/10.1038/s41598-023-27993-7 · OSTI ID:1922678

Matyskin, Artem V.; Stamatopoulos, Athanasios; O’Brien, Ellen M.; DiGiovine, Brad J.; Mocko, Veronika; Fassbender, Michael E.; Vermeulen, C. Etienne; Koehler, Paul E.

Abstract A process for the production of tens to hundreds of GBq amounts of zirconium-88 ( ⁸⁸ Zr) using proton beams on yttrium was developed. For this purpose, yttrium metal targets (≈20 g) were irradiated in a ~16 to 34 MeV proton beam at a beam current of 100–200 µA at the Los Alamos Isotope Production Facility (IPF). The ⁸⁸ Zr radionuclide was produced and separated from the yttrium targets using hydroxamate resin with an elution yield of 94(5)% (1σ). Liquid DCl solution in D ₂ O was selected as a suitable ⁸⁸ Zr sample matrix due to the high neutron transmission of deuterium compared to hydrogen and an even distribution of ⁸⁸ Zr in the sample matrix. The separated ⁸⁸ Zr was dissolved in DCl and 8 µL of the obtained solution was transferred to a tungsten sample can with a 1.2 mm diameter hole using a syringe and automated filling station inside a hot cell. Neutron transmission of the obtained ⁸⁸ Zr sample was measured at the Device for Indirect Capture Experiments on Radionuclides (DICER).

View Journal Article

Cite

Export

Save

Research Organization:: Los Alamos National Laboratory (LANL), Los Alamos, NM (United States)

Sponsoring Organization:: USDOE; USDOE Laboratory Directed Research and Development (LDRD) Program; USDOE National Nuclear Security Administration (NNSA)

Grant/Contract Number:: 89233218CNA000001

OSTI ID:: 1922678

Report Number(s):: LA-UR-22-28588; 1736; PII: 27993

Journal Information:: Scientific Reports, Journal Name: Scientific Reports Journal Issue: 1 Vol. 13; ISSN 2045-2322

Publisher:: Nature Publishing GroupCopyright Statement

Country of Publication:: United Kingdom

Language:: English

References (58)

The Radiopharmaceutical Chemistry of Zirconium-89 Marquez-Nostra, Bernadette V.; Viola, Nerissa Radiopharmaceutical Chemistry https://doi.org/10.1007/978-3-319-98947-1_21	book	January 2019
Decomposition of oxalic acid with nitric acid Kubota, M. Journal of Radioanalytical Chemistry, Vol. 75, Issue 1-2 https://doi.org/10.1007/BF02519972	journal	March 1982
The Decomposition of Oxalic Acid in Nitric Acid Mason, C.; Brown, T. L.; Buchanan, D. Journal of Solution Chemistry, Vol. 45, Issue 3 https://doi.org/10.1007/s10953-016-0437-2	journal	February 2016
Radiopharmaceutical Studies and Nuclear Medicine; Simultaneous 68Ge and 88Zr recovery from proton irradiated Ga/Nb capsules (LA-UR #03-2319) Fassbender, M.; Jamriska, D. J.; Hamilton, V. T. Journal of Radioanalytical and Nuclear Chemistry, Vol. 263, Issue 2 https://doi.org/10.1007/s10967-005-0082-5	journal	January 2005
A comparative study on the separation of radiozirconium via ion-exchange and solvent extraction techniques, with particular reference to the production of 88Zr and 89Zr in proton induced reactions on yttrium Kandil, S. A.; Scholten, B.; Saleh, Z. A. Journal of Radioanalytical and Nuclear Chemistry, Vol. 274, Issue 1 https://doi.org/10.1007/s10967-006-6892-2	journal	October 2007
Production of 88,89Zr by proton induced activation of natY and separation by SLX and LLX Dutta, Binita; Maiti, Moumita; Lahiri, Susanta Journal of Radioanalytical and Nuclear Chemistry, Vol. 281, Issue 3 https://doi.org/10.1007/s10967-009-0051-5	journal	June 2009
Separation of 89Zr from irradiated yttrium targets by extraction chromatography Kazakov, Andrey G.; Aliev, Ramiz A.; Ostapenko, Valentina S. Journal of Radioanalytical and Nuclear Chemistry, Vol. 317, Issue 1 https://doi.org/10.1007/s10967-018-5888-z	journal	May 2018
The first generation of γ-rays from hot nuclei Guttormsen, M.; Ramsøy, T.; Rekstad, J. Nuclear Instruments and Methods in Physics Research Section A: Accelerators, Spectrometers, Detectors and Associated Equipment, Vol. 255, Issue 3 https://doi.org/10.1016/0168-9002(87)91221-6	journal	April 1987
The unfolding of continuum γ-ray spectra Guttormsen, M.; Tveter, T. S.; Bergholt, L. Nuclear Instruments and Methods in Physics Research Section A: Accelerators, Spectrometers, Detectors and Associated Equipment, Vol. 374, Issue 3 https://doi.org/10.1016/0168-9002(96)00197-0	journal	June 1996
Production of highly pure no-carrier added 89Zr for the labelling of antibodies with a positron emitter Meijs, Wilma E.; Herscheid, Jacobus D. M.; Haisma, Hidde J. Applied Radiation and Isotopes, Vol. 45, Issue 12 https://doi.org/10.1016/0969-8043(94)90029-9	journal	December 1994
Studies on the extraction of zirconium with organophosphorus compounds Umezawa, Hirokazu; Hara, Reinosuke Analytica Chimica Acta, Vol. 25, Issue 1 https://doi.org/10.1016/S0003-2670(01)81577-4	journal	January 1961
Investigation of the natMo(p,x) nuclear reaction to monitor proton beams: New measurements and consequences on the earlier reported data Takács, S.; Tárkányi, F.; Sonck, M. Nuclear Instruments and Methods in Physics Research Section B: Beam Interactions with Materials and Atoms, Vol. 198, Issue 3-4 https://doi.org/10.1016/S0168-583X(02)01528-8	journal	December 2002
Cross sections for the production of residual nuclides by low- and medium-energy protons from the target elements C, N, O, Mg, Al, Si, Ca, Ti, V, Mn, Fe, Co, Ni, Cu, Sr, Y, Zr, Nb, Ba and Au Michel, R.; Bodemann, R.; Busemann, H. Nuclear Instruments and Methods in Physics Research Section B: Beam Interactions with Materials and Atoms, Vol. 129, Issue 2 https://doi.org/10.1016/S0168-583X(97)00213-9	journal	July 1997
Extraction of level density and γ strength function from primary γ spectra Schiller, A.; Bergholt, L.; Guttormsen, M. Nuclear Instruments and Methods in Physics Research Section A: Accelerators, Spectrometers, Detectors and Associated Equipment, Vol. 447, Issue 3 https://doi.org/10.1016/S0168-9002(99)01187-0	journal	June 2000
Experimental studies on excitation functions of the proton-induced activation reactions on yttrium Uddin, M. S.; Hagiwara, M.; Baba, M. Applied Radiation and Isotopes, Vol. 63, Issue 3 https://doi.org/10.1016/j.apradiso.2005.04.006	journal	September 2005
Evaluation of excitation functions of 100Mo(p,d+pn)99Mo and 100Mo (p,2n)99mTc reactions: Estimation of long-lived Tc-impurity and its implication on the specific activity of cyclotron-produced 99mTc Qaim, S. M.; Sudár, S.; Scholten, B. Applied Radiation and Isotopes, Vol. 85 https://doi.org/10.1016/j.apradiso.2013.10.004	journal	February 2014
Evaluation of nuclear reaction cross section data for the production of 87Y and 88Y via proton, deuteron and alpha-particle induced transmutations Zaneb, H.; Hussain, M.; Amjad, N. Applied Radiation and Isotopes, Vol. 112 https://doi.org/10.1016/j.apradiso.2016.03.016	journal	June 2016
A simple and convenient method for production of 89Zr with high purity Tang, Yu; Li, Shuntao; Yang, Yuanyou Applied Radiation and Isotopes, Vol. 118 https://doi.org/10.1016/j.apradiso.2016.09.024	journal	December 2016
Large-scale production of 88Y and 88Zr/88Y generators: A proof of concept study for a 70 MeV H− cyclotron Steyn, G. F.; van der Walt, T. N.; Szelecsényi, F. Applied Radiation and Isotopes, Vol. 168 https://doi.org/10.1016/j.apradiso.2020.109469	journal	February 2021
Optimized anion exchange column isolation of zirconium-89 (89Zr) from yttrium cyclotron target: Method development and implementation on an automated fluidic platform O’Hara, Matthew J.; Murray, Nathaniel J.; Carter, Jennifer C. Journal of Chromatography A, Vol. 1545 https://doi.org/10.1016/j.chroma.2018.02.053	journal	April 2018
Evaluated Iridium, Yttrium, and Thulium Cross Sections and Integral Validation Against Critical Assembly and Bethe Sphere Measurements Chadwick, M. B.; Frankle, S.; Trellue, H. Nuclear Data Sheets, Vol. 108, Issue 12 https://doi.org/10.1016/j.nds.2007.11.005	journal	December 2007
ENDF/B-VIII.0: The 8 th Major Release of the Nuclear Reaction Data Library with CIELO-project Cross Sections, New Standards and Thermal Scattering Data Brown, D. A.; Chadwick, M. B.; Capote, R. Nuclear Data Sheets, Vol. 148 https://doi.org/10.1016/j.nds.2018.02.001	journal	February 2018
TENDL: Complete Nuclear Data Library for Innovative Nuclear Science and Technology Koning, A. J.; Rochman, D.; Sublet, J. -Ch. Nuclear Data Sheets, Vol. 155 https://doi.org/10.1016/j.nds.2019.01.002	journal	January 2019
Novel design and diagnostics improvements for increased production capacity and improved reliability at the Los Alamos Isotope Production Facility O’Brien, E. M.; Baily, S. A.; Birnbaum, E. R. Nuclear Instruments and Methods in Physics Research Section A: Accelerators, Spectrometers, Detectors and Associated Equipment, Vol. 956 https://doi.org/10.1016/j.nima.2019.163316	journal	March 2020
Investigations of 89Y(p,x)86,88,89gZr, 86m+g,87g,87m,88gY, 85gSr, and 84gRb nuclear processes up to 42MeV Khandaker, Mayeen Uddin; Kim, Kwangsoo; Lee, Man-Woo Nuclear Instruments and Methods in Physics Research Section B: Beam Interactions with Materials and Atoms, Vol. 271 https://doi.org/10.1016/j.nimb.2011.11.009	journal	January 2012
Production cross sections of proton-induced reactions on yttrium Yang, Sung-Chul; Song, Tae-Yung; Lee, Young-Ouk Nuclear Instruments and Methods in Physics Research Section B: Beam Interactions with Materials and Atoms, Vol. 398 https://doi.org/10.1016/j.nimb.2017.03.021	journal	May 2017
Standardized methods for the production of high specific-activity zirconium-89 Holland, Jason P.; Sheh, Yiauchung; Lewis, Jason S. Nuclear Medicine and Biology, Vol. 36, Issue 7 https://doi.org/10.1016/j.nucmedbio.2009.05.007	journal	October 2009
Production of Zr-89 using sputtered yttrium coin targets Queern, Stacy Lee; Aweda, Tolulope Aramide; Massicano, Adriana Vidal Fernandes Nuclear Medicine and Biology, Vol. 50 https://doi.org/10.1016/j.nucmedbio.2017.03.004	journal	July 2017
Proton-induced production and radiochemical isolation of 44Ti from scandium metal targets for 44Ti/44Sc generator development Radchenko, Valery; Engle, Jonathan W.; Medvedev, Dmitri G. Nuclear Medicine and Biology, Vol. 50 https://doi.org/10.1016/j.nucmedbio.2017.03.006	journal	July 2017
89 Zr for antibody labeling and in vivo studies – A comparison between liquid and solid target production Dias, Gemma M.; Ramogida, Caterina F.; Rousseau, Julie Nuclear Medicine and Biology, Vol. 58 https://doi.org/10.1016/j.nucmedbio.2017.11.005	journal	March 2018
A radiopharmaceutical [89Zr]Zr-DFO-nimotuzumab for immunoPET with epidermal growth factor receptor expression in vivo Tang, Yu; Hu, Yingjiang; Liu, Weihao Nuclear Medicine and Biology, Vol. 70 https://doi.org/10.1016/j.nucmedbio.2019.01.007	journal	March 2019
Anion Exchange Separation of Zirconium, Titanium, Niobium, Tantalum, Tungsten, and Molybdenum Bandi, W. R.; Buyok, E. G.; Lewis, L. L. Analytical Chemistry, Vol. 33, Issue 9 https://doi.org/10.1021/ac60177a045	journal	August 1961
⁸⁹ Zr-Immuno-Positron Emission Tomography in Oncology: State-of-the-Art ⁸⁹ Zr Radiochemistry Heskamp, Sandra; Raavé, René; Boerman, Otto Bioconjugate Chemistry, Vol. 28, Issue 9 https://doi.org/10.1021/acs.bioconjchem.7b00325	journal	August 2017
Thermodynamic Stability and Speciation of Ga(III) and Zr(IV) Complexes with High-Denticity Hydroxamate Chelators Toporivska, Yuliya; Mular, Andrzej; Piasta, Karolina Inorganic Chemistry, Vol. 60, Issue 17 https://doi.org/10.1021/acs.inorgchem.1c01622	journal	August 2021
Predicting the Thermodynamic Stability of Zirconium Radiotracers Holland, Jason P. Inorganic Chemistry, Vol. 59, Issue 3 https://doi.org/10.1021/acs.inorgchem.9b03515	journal	January 2020
Evaluation of the in Vivo Biodistribution of Indium-111 and Yttrium-88 Labeled Dendrimer-1B4M-DTPA and Its Conjugation with Anti-Tac Monoclonal Antibody ^† Kobayashi, Hisataka; Wu, Chuanchu; Kim, Meyoung-Kon Bioconjugate Chemistry, Vol. 10, Issue 1 https://doi.org/10.1021/bc980091d	journal	January 1999
The surprisingly large neutron capture cross-section of 88Zr Shusterman, Jennifer A.; Scielzo, Nicholas D.; Thomas, Keenan J. Nature, Vol. 565, Issue 7739 https://doi.org/10.1038/s41586-018-0838-z	journal	January 2019
Excitation Functions for Production of 88Zr and 88Y by Proton and Deuteron Irradiation of Mo, Nb, Zr, and Y Tárkányi, F. INTERNATIONAL CONFERENCE ON NUCLEAR DATA FOR SCIENCE AND TECHNOLOGY, AIP Conference Proceedings https://doi.org/10.1063/1.1945326	conference	January 2005
A peristaltic pump driven [sup 89]Zr separation module Siikanen, J.; Peterson, M.; Tran, T. A. 14TH INTERNATIONAL WORKSHOP ON TARGETRY AND TARGET CHEMISTRY, AIP Conference Proceedings https://doi.org/10.1063/1.4773969	conference	January 2012
Effect of Diluents on the Extraction of Zirconium from Nitrate Medium by Thenoyltrifluoroacetone El‐Hefny, N. E.; El‐Nadi, Y. A.; Daoud, J. A. Solvent Extraction and Ion Exchange, Vol. 24, Issue 5 https://doi.org/10.1080/07366290600762306	journal	October 2006
Solvent Extraction for the Separation of Zr and Hf from Aqueous Solutions Banda, Raju; Lee, Man Seung Separation & Purification Reviews, Vol. 44, Issue 3 https://doi.org/10.1080/15422119.2014.920876	journal	September 2014
Zirconium Solubility in Ternary Aqueous System of Zr(IV)-OH-Carboxylates Kobayashi, Taishi; Sasaki, Takayuki; Takagi, Ikuji Journal of Nuclear Science and Technology, Vol. 46, Issue 2 https://doi.org/10.1080/18811248.2007.9711515	journal	February 2009
( p , xn ) and ( p , pxn ) Reactions of Yttrium-89 with 5-85-MeV Protons Saha, G. B.; Porile, N. T.; Yaffe, L. Physical Review, Vol. 144, Issue 3 https://doi.org/10.1103/PhysRev.144.962	journal	April 1966
Aqueous harvesting of Zr 88 at a radioactive-ion-beam facility for cross-section measurements Shusterman, Jennifer A.; Scielzo, Nicholas D.; Abel, E. Paige Physical Review C, Vol. 103, Issue 2 https://doi.org/10.1103/PhysRevC.103.024614	journal	February 2021
Measurement of 14-MeV neutron cross sections for Zr 88 and Y 88 Prestwood, René J.; Thomas, Kimberly W.; Nethaway, David R. Physical Review C, Vol. 29, Issue 3 https://doi.org/10.1103/PhysRevC.29.805	journal	March 1984
Measurements and a direct-reaction – plus – Hauser-Feshbach analysis of Y 89 ( p , n ) 89 Zr, Y 89 ( p ,2 n ) 88 , and Y 89 ( p , pn ) 88 Y reactions up to 40 MeV Mustafa, M. G.; West, H. I.; O’Brien, H. Physical Review C, Vol. 38, Issue 4 https://doi.org/10.1103/PhysRevC.38.1624	journal	October 1988
γ -ray strength function method and its application to Pd 107 Utsunomiya, H.; Goriely, S.; Akimune, H. Physical Review C, Vol. 82, Issue 6 https://doi.org/10.1103/PhysRevC.82.064610	journal	December 2010
Analysis of possible systematic errors in the Oslo method Larsen, A. C.; Guttormsen, M.; Krtička, M. Physical Review C, Vol. 83, Issue 3 https://doi.org/10.1103/PhysRevC.83.034315	journal	March 2011
Photoneutron cross sections for Mo isotopes: A step toward a unified understanding of ( γ , n ) and ( n , γ ) reactions Utsunomiya, H.; Goriely, S.; Kondo, T. Physical Review C, Vol. 88, Issue 1 https://doi.org/10.1103/PhysRevC.88.015805	journal	July 2013
Novel technique for Constraining r -Process ( n , γ ) Reaction Rates Spyrou, A.; Liddick, S. N.; Larsen, A. C. Physical Review Letters, Vol. 113, Issue 23 https://doi.org/10.1103/PhysRevLett.113.232502	journal	December 2014
Constraining Neutron Capture Cross Sections for Unstable Nuclei with Surrogate Reaction Data and Theory Escher, J. E.; Burke, J. T.; Hughes, R. O. Physical Review Letters, Vol. 121, Issue 5 https://doi.org/10.1103/PhysRevLett.121.052501	journal	July 2018
Revised effective ionic radii and systematic studies of interatomic distances in halides and chalcogenides Shannon, R. D. Acta Crystallographica Section A, Vol. 32, Issue 5, p. 751-767 https://doi.org/10.1107/S0567739476001551	journal	September 1976
Proton induced reactions on 89Y with particular reference to the production of the medically interesting radionuclide 89Zr Omara, H. M.; Hassan, K. F.; Kandil, S. A. Radiochimica Acta, Vol. 97, Issue 9 https://doi.org/10.1524/ract.2009.1645	journal	January 2009
Some nuclear chemical aspects of medical generator nuclide production at the Los Alamos hot cell facility Faßbender, M.; Nortier, F. M.; Phillips, D. R. Radiochimica Acta, Vol. 92, Issue 4-6 https://doi.org/10.1524/ract.92.4.237.35596	journal	January 2004
The Radiochemistry of the Rare Earths, Scandium, Yttrium, and Actinium Stevenson, P.; Nervik, W. https://doi.org/10.2172/4061656	report	February 1961
Updated User's Guide for Sammy: Multilevel R-Matrix Fits to Neutron Data Using Bayes' Equations Larson, Nancy M. https://doi.org/10.2172/941054	report	October 2008
89Zr Radiochemistry for Positron Emission Tomography W. Severin, Gregory; W. Engle, Jonathan; E. Barnhart, Todd Medicinal Chemistry, Vol. 7, Issue 5 https://doi.org/10.2174/157340611796799186	journal	September 2011
Excitation Functions of Proton Induced Reactions on 89Y and 93Nb with Emphasis on the Production of Selected Radio-Zirconiums Steyn, G. F.; Vermeulen, C.; Szelecsenyi, F. Journal of the Korean Physical Society, Vol. 59, Issue 2(3) https://doi.org/10.3938/jkps.59.1991	journal	August 2011

Similar Records

New capability for indirect neutron capture measurements: The DICER instrument at LANSCE

Journal Article · Thu Feb 24 00:00:00 UTC 2022 · EPJ Web of Conferences (Online) · OSTI ID:1853934

Stamatopoulos, Athanasios; Koehler, Paul E.; Matyskin, Artem; +11 more

A Large Area Picosecond Photodetector for Neutron Transmission Measurements at DICER at LANSCE

Journal Article · Fri Jun 09 00:00:00 UTC 2023 · IEEE Transactions on Nuclear Science · OSTI ID:1998127

Stamatopoulos, Athanasios; Couture, A.; DiGiovine, B.; +2 more

New capability for neutron transmission measurements at LANSCE: The DICER instrument

Journal Article · Mon Dec 13 00:00:00 UTC 2021 · Nuclear Instruments and Methods in Physics Research. Section A, Accelerators, Spectrometers, Detectors and Associated Equipment · OSTI ID:1994128

Stamatopoulos, Athanasios; Koehler, Paul E.; Couture, Aaron Joseph; +3 more

Related Subjects

73 NUCLEAR PHYSICS AND RADIATION PHYSICS
chromatography
cross section
deuterium target
isotope production
neutron capture
neutron resonance
yttrium-88

Title: Production of zirconium-88 via proton irradiation of metallic yttrium and preparation of target for neutron transmission measurements at DICER

Citation Formats

References (58)

Similar Records

Related Subjects