Biosystems Design to Accelerate C 3 -to-CAM Progression

Yuan, Guoliang; Hassan, Md. Mahmudul; Liu, Degao; Lim, Sung Don; Yim, Won Cheol; Cushman, John C.; Markel, Kasey; Shih, Patrick M.; Lu, Haiwei; Weston, David J.; Chen, Jin-Gui; Tschaplinski, Timothy J.; Tuskan, Gerald A.; Yang, Xiaohan

doi:10.34133/2020/3686791

Title: Biosystems Design to Accelerate C ₃ -to-CAM Progression

Journal Article · 11 October 2020 · BioDesign Research

DOI: https://doi.org/10.34133/2020/3686791 · OSTI ID:1909316

^[1]; Hassan, Md. Mahmudul ^[2]; Liu, Degao ^[3]; Lim, Sung Don ^[4]; Yim, Won Cheol ^[5]; Cushman, John C. ^[5]; Markel, Kasey ^[6];

^[7];

^[8]; Weston, David J. ^[1];

^[1]; Tschaplinski, Timothy J. ^[1]; Tuskan, Gerald A. ^[1];

^[1]

Biosciences Division, Oak Ridge National Laboratory, Oak Ridge, TN 37831, USA, The Center for Bioenergy Innovation, Oak Ridge National Laboratory, Oak Ridge, TN 37831, USA
Biosciences Division, Oak Ridge National Laboratory, Oak Ridge, TN 37831, USA, The Center for Bioenergy Innovation, Oak Ridge National Laboratory, Oak Ridge, TN 37831, USA, Department of Genetics and Plant Breeding, Patuakhali Science and Technology University, Dumki, Patuakhali 8602, Bangladesh
Department of Genetics, Cell Biology and Development, Center for Precision Plant Genomics, and Center for Genome Engineering, University of Minnesota, Saint Paul, MN 55108, USA
Department of Applied Plant Sciences, Kangwon National University, Chuncheon 24341, Republic of Korea
Department of Biochemistry and Molecular Biology, University of Nevada, Reno, NV, USA
Department of Plant Biology, University of California, Davis, Davis, CA, USA
Department of Plant Biology, University of California, Davis, Davis, CA, USA, Feedstocks Division, Joint BioEnergy Institute, Emeryville, CA, USA
Biosciences Division, Oak Ridge National Laboratory, Oak Ridge, TN 37831, USA

Global demand for food and bioenergy production has increased rapidly, while the area of arable land has been declining for decades due to damage caused by erosion, pollution, sea level rise, urban development, soil salinization, and water scarcity driven by global climate change. In order to overcome this conflict, there is an urgent need to adapt conventional agriculture to water-limited and hotter conditions with plant crop systems that display higher water-use efficiency (WUE). Crassulacean acid metabolism (CAM) species have substantially higher WUE than species performing C ₃ or C ₄ photosynthesis. CAM plants are derived from C ₃ photosynthesis ancestors. However, it is extremely unlikely that the C ₃ or C ₄ crop plants would evolve rapidly into CAM photosynthesis without human intervention. Currently, there is growing interest in improving WUE through transferring CAM into C ₃ crops. However, engineering a major metabolic plant pathway, like CAM, is challenging and requires a comprehensive deep understanding of the enzymatic reactions and regulatory networks in both C ₃ and CAM photosynthesis, as well as overcoming physiometabolic limitations such as diurnal stomatal regulation. Recent advances in CAM evolutionary genomics research, genome editing, and synthetic biology have increased the likelihood of successful acceleration of C ₃ -to-CAM progression. Here, we first summarize the systems biology-level understanding of the molecular processes in the CAM pathway. Then, we review the principles of CAM engineering in an evolutionary context. Lastly, we discuss the technical approaches to accelerate the C ₃ -to-CAM transition in plants using synthetic biology toolboxes.

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Research Organization:: Oak Ridge National Laboratory (ORNL), Oak Ridge, TN (United States)

Sponsoring Organization:: National Research Foundation of Korea (NRF); National Science Foundation (NSF); USDOE; USDOE Office of Science (SC), Biological and Environmental Research (BER)

Grant/Contract Number:: AC02-05CH11231; AC05-00OR22725; SC0008834

OSTI ID:: 1909316

Journal Information:: BioDesign Research, Journal Name: BioDesign Research Vol. 2020; ISSN 2693-1257

Publisher:: ElsevierCopyright Statement

Country of Publication:: India

Language:: English

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Transgene stacking in potato using the GAANTRY system McCue, Kent F.; Gardner, Ethan; Chan, Ronald BMC Research Notes, Vol. 12, Issue 1 https://doi.org/10.1186/s13104-019-4493-8	journal	July 2019
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The gypsy Insulator of Drosophila melanogaster , Together With Its Binding Protein Suppressor of Hairy-Wing, Facilitate High and Precise Expression of Transgenes in Arabidopsis thaliana She, Wenjing; Lin, Weiqiang; Zhu, Yubin Genetics, Vol. 185, Issue 4 https://doi.org/10.1534/genetics.110.117960	journal	June 2010
Elimination of Transcriptional Interference between Tandem Genes in Plant Cells Padidam, Malla; Cao, Yajuan BioTechniques, Vol. 31, Issue 2 https://doi.org/10.2144/01312st04	journal	August 2001
Small RNAs in plants: recent development and application for crop improvement Kamthan, Ayushi; Chaudhuri, Abira; Kamthan, Mohan Frontiers in Plant Science, Vol. 06 https://doi.org/10.3389/fpls.2015.00208	journal	April 2015
Laying the Foundation for Crassulacean Acid Metabolism (CAM) Biodesign: Expression of the C4 Metabolism Cycle Genes of CAM in Arabidopsis Lim, Sung Don; Lee, Sojeong; Choi, Won-Gyu Frontiers in Plant Science, Vol. 10 https://doi.org/10.3389/fpls.2019.00101	journal	February 2019
Water-Use Efficiency: Advances and Challenges in a Changing Climate Hatfield, Jerry L.; Dold, Christian Frontiers in Plant Science, Vol. 10 https://doi.org/10.3389/fpls.2019.00103	journal	February 2019
Crassulacean Acid Metabolism Abiotic Stress-Responsive Transcription Factors: a Potential Genetic Engineering Approach for Improving Crop Tolerance to Abiotic Stress Amin, Atia B.; Rathnayake, Kumudu N.; Yim, Won C. Frontiers in Plant Science, Vol. 10 https://doi.org/10.3389/fpls.2019.00129	journal	February 2019
Comparative Genomics Analysis Provides New Insight Into Molecular Basis of Stomatal Movement in Kalanchoë fedtschenkoi Moseley, Robert C.; Tuskan, Gerald A.; Yang, Xiaohan Frontiers in Plant Science, Vol. 10 https://doi.org/10.3389/fpls.2019.00292	journal	March 2019
Maltose Processing and Not β-Amylase Activity Curtails Hydrolytic Starch Degradation in the CAM Orchid Phalaenopsis Ceusters, Nathalie; Frans, Mario; Van den Ende, Wim Frontiers in Plant Science, Vol. 10 https://doi.org/10.3389/fpls.2019.01386	journal	November 2019
Biodesign Research to Advance the Principles and Applications of Biosystems Design Yang, Xiaohan; Qi, Lei S.; Jaramillo, Alfonso BioDesign Research, Vol. 2019 https://doi.org/10.34133/2019/9680853	journal	January 2019
Prime Editing Technology and Its Prospects for Future Applications in Plant Biology Research Hassan, Md. Mahmudul; Yuan, Guoliang; Chen, Jin-Gui BioDesign Research, Vol. 2020 https://doi.org/10.34133/2020/9350905	journal	June 2020

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