Elimination of human rabies in Goa, India through an integrated One Health approach

Gibson, A. D.; Yale, G.; Corfmat, J.; Appupillai, M.; Gigante, C. M.; Lopes, M.; Betodkar, U.; Costa, N. C.; Fernandes, K. A.; Mathapati, P.; Suryawanshi, P. M.; Otter, N.; Thomas, G.; Ohal, P.; Airikkala-Otter, I.; Lohr, F.; Rupprecht, C. E.; King, A.; Sutton, D.; Deuzeman, I.; Li, Y.; Wallace, R. M.; Mani, R. S.; Gongal, G.; Handel, I. G.; Bronsvoort, M.; Naik, V.; Desai, S.; Mazeri, S.; Gamble, L.; Mellanby, R. J.

doi:10.1038/s41467-022-30371-y

Title: Elimination of human rabies in Goa, India through an integrated One Health approach

Journal Article · 19 May 2022 · Nature Communications

DOI: https://doi.org/10.1038/s41467-022-30371-y · OSTI ID:1905002

^[1]; Yale, G. ^[2]; Corfmat, J. ^[2]; Appupillai, M. ^[2]; Gigante, C. M. ^[3]; Lopes, M. ^[4]; Betodkar, U. ^[4]; Costa, N. C. ^[4]; Fernandes, K. A. ^[5]; Mathapati, P. ^[2]; Suryawanshi, P. M. ^[4]; Otter, N. ^[6]; Thomas, G. ^[7]; Ohal, P. ^[2]; Airikkala-Otter, I. ^[5];

^[7]; Rupprecht, C. E. ^[8]; King, A. ^[9]; Sutton, D. ^[10]; Deuzeman, I. ^[9] more »

Mission Rabies (United Kingdom); Univ. of Edinburgh, Scotland (United Kingdom); OSTI
Mission Rabies (India)
Centers for Disease Control and Prevention (CDC), Atlanta, GA (United States)
Government of Goa (India)
Worldwide Veterinary Service India (India)
Mission Rabies (India); Worldwide Veterinary Service India (India)
Mission Rabies (United Kingdom)
LYSSA LLC, Atlanta, GA (United States)
Merck Animal Health, Madison, NJ (United States)
MSD Animal Health (United Kingdom)
National Institute of Mental Health and Neurosciences (India)
World Health Organization (WHO) South-East Asia (India)
Univ. of Edinburgh, Scotland (United Kingdom)
Mission Rabies (United Kingdom); Univ. of Edinburgh, Scotland (United Kingdom)

Dog-mediated rabies kills tens of thousands of people each year in India, representing one third of the estimated global rabies burden. Whilst the World Health Organization (WHO), World Organization for Animal Health (OIE) and the Food and Agriculture Organization of the United Nations (FAO) have set a target for global dog-mediated human rabies elimination by 2030, examples of large-scale dog vaccination programs demonstrating elimination remain limited in Africa and Asia. We describe the development of a data-driven rabies elimination program from 2013 to 2019 in Goa State, India, culminating in human rabies elimination and a 92% reduction in monthly canine rabies cases. Smartphone technology enabled systematic spatial direction of remote teams to vaccinate over 95,000 dogs at 70% vaccination coverage, and rabies education teams to reach 150,000 children annually. An estimated 2249 disability-adjusted life years (DALYs) were averted over the program period at 526 USD per DALY, making the intervention ‘very cost-effective’ by WHO definitions. This One Health program demonstrates that human rabies elimination is achievable at the state level in India.

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Research Organization:: Oak Ridge Institute for Science and Education (ORISE), Oak Ridge, TN (United States)

Sponsoring Organization:: USDOE Office of Science (SC); Government of Goa

Contributing Organization:: Centers for Disease Control and Prevention (CDC)

Grant/Contract Number:: SC0014664

OSTI ID:: 1905002

Journal Information:: Nature Communications, Journal Name: Nature Communications Journal Issue: 1 Vol. 13; ISSN 2041-1723

Publisher:: Nature Publishing GroupCopyright Statement

Country of Publication:: United States

Language:: English

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