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Title: Association Between Prevalence of Peripheral Artery Disease and Radiation Exposure in the Atomic Bomb Survivors

Journal Article · · Journal of the American Heart Association
 [1];  [2];  [2];  [2];  [3];  [2];  [4];  [5];  [3];  [2];  [2]
  1. Radiation Effects Research Foundation (RERF), Hiroshima (Japan); OSTI
  2. Radiation Effects Research Foundation (RERF), Hiroshima (Japan)
  3. Hiroshima University (Japan)
  4. Radiation Effects Research Foundation (RERF), Hiroshima (Japan); Hiroshima Atomic‐bomb Casualty Council, Hiroshima (Japan)
  5. University Hiroshima (Japan); Hoshigaoka Medical Center, Osaka (Japan)
+ Show Author Affiliations

Past reports suggested that total-body irradiation at 0.5 to 1.0 Gy could be responsible for atherosclerosis. Peripheral artery disease (PAD) is a manifestation of systematic atherosclerosis. Whether the consequences of a low-to-moderate dose of radiation include increased risk of PAD remains to be determined. The purpose of this study was to examine the association between radiation exposure and prevalence of PAD among Japanese atomic bomb survivors. Radiation exposure from the atomic bombing was assessed in 3476 participants (41.1% men, mean age 74.8 years with SD 6.4 years) with a cross-sectional survey in 2010 to 2014. Left- and right-side ankle-brachial indexes and upstroke time (UT) were obtained using oscillometric VP-2000. PAD was defined as an ankle-brachial index of 1.0 or less or a prior history related to revascularization. UT was considered a sensitive marker of early-stage PAD. Association between radiation exposure and PAD or UT was assessed using multivariable regression analyses with adjustment for potential confounding factors. Of 3476 participants, 79 (2.3%) were identified as having prevalent PAD. Multivariate logistic regression analysis indicated that radiation dose was unrelated to PAD prevalence (odds ratio, 0.83; 95% confidence interval [0.57-1.21]). UT appeared to increase with radiation dose, but the increase was not statistically significant (1.09 ms/Gy; 95% confidence interval [-0.17 to 2.36]). We found no clear association of radiation dose with PAD, but it remains to be determined whether UT is associated with radiation dose.

Research Organization:
Radiation Effects Research Foundation (RERF), Hiroshima (Japan)
Sponsoring Organization:
Japanese Ministry of Health, Labour and Welfare (MHLW); USDOE
OSTI ID:
1903947
Journal Information:
Journal of the American Heart Association, Journal Name: Journal of the American Heart Association Journal Issue: 23 Vol. 7; ISSN 2047-9980
Publisher:
American Heart Association, Inc.Copyright Statement
Country of Publication:
United States
Language:
English

References (51)

Prevalence of asymptomatic arteriosclerosis obliterans and its relationship with risk factors in inhabitants of rural communities in Japan: Tanno-Sobetsu study journal November 2004
Ankle-arm blood pressure index as a correlate of preclinical carotid atherosclerosis in elderly Japanese men journal February 2006
Understanding Radiation-induced Cardiovascular Damage and Strategies for Intervention journal October 2013
The Ankle-Brachial Index and Incident Cardiovascular Events in the MESA (Multi-Ethnic Study of Atherosclerosis) journal October 2010
Can low-dose radiation increase risk of cardiovascular disease? journal August 2008
The effects of aging and radiation exposure on blood pressure levels of atomic bomb survivors journal October 2002
Validation of automated oscillometric versus manual measurement of the ankle–brachial index journal September 2009
Prevalence of atherosclerosis in relation to atomic bomb radiation exposure: An RERF Adult Health Study journal January 2005
Trends in the Utilization of Medical Procedures that use Ionizing Radiation journal November 2008
Blood pressure and ageing journal February 2007
Peripheral Arterial Disease in the Elderly journal February 1998
Epidemiology of Peripheral Artery Disease journal April 2015
ACC/AHA 2005 Practice Guidelines for the Management of Patients With Peripheral Arterial Disease (Lower Extremity, Renal, Mesenteric, and Abdominal Aortic): A Collaborative Report from the American Association for Vascular Surgery/Society for Vascular Surgery,* Society for Cardiovascular Angiography and Interventions, Society for Vascular Medicine and Biology, Society of Interventional Radiology, and the ACC/AHA Task Force on Practice Guidelines (Writing Committee to Develop Guidelines for the Management of Patients With Peripheral Arterial Disease): Endorsed by the American Association of Cardiovascular and Pulmonary Rehabilitation; National Heart, Lung, and Blood Institute; Society for Vascular Nursing; TransAtlantic Inter-Society Consensus; and Vascular Disease Foundation journal March 2006
Immune Mechanisms in Atherosclerosis journal December 2001
Pulse Waves in the Lower Extremities as a Diagnostic Tool of Peripheral Arterial Disease and Predictor of Mortality in Elderly Chinese journal March 2016
Sensitivity and Specificity of Ankle-Brachial Index for Detecting Angiographic Stenosis of Peripheral Arteries journal January 2007
Accounting for Neutron Exposure in the Japanese Atomic Bomb Survivors journal December 2014
Mortality from Circulatory Diseases and other Non-Cancer Outcomes among Nuclear Workers in France, the United Kingdom and the United States (INWORKS) journal July 2017
Comparison between oscillometric- and Doppler-ABI in elderly individuals journal March 2013
The 1997 American Diabetes Association and 1999 World Health Organization criteria for hyperglycemia in the diagnosis and prediction of diabetes. journal August 2000
Multiple imputation by chained equations: what is it and how does it work?: Multiple imputation by chained equations
  • Azur, Melissa J.; Stuart, Elizabeth A.; Frangakis, Constantine
  • International Journal of Methods in Psychiatric Research, Vol. 20, Issue 1 https://doi.org/10.1002/mpr.329
journal February 2011
Can low-dose radiation increase risk of cardiovascular disease? journal August 2008
The effects of aging and radiation exposure on blood pressure levels of atomic bomb survivors journal October 2002
Prevalence of asymptomatic arteriosclerosis obliterans and its relationship with risk factors in inhabitants of rural communities in Japan: Tanno-Sobetsu study journal November 2004
Ankle-arm blood pressure index as a correlate of preclinical carotid atherosclerosis in elderly Japanese men journal February 2006
Understanding Radiation-induced Cardiovascular Damage and Strategies for Intervention journal October 2013
The Ankle-Brachial Index and Incident Cardiovascular Events in the MESA (Multi-Ethnic Study of Atherosclerosis) journal October 2010
Inter-Society Consensus for the Management of Peripheral Arterial Disease (TASC II) journal January 2007
Validation of automated oscillometric versus manual measurement of the ankle–brachial index journal September 2009
Revised Equations for Estimated GFR From Serum Creatinine in Japan journal June 2009
Prevalence and clinical correlates of peripheral arterial disease in the Framingham Offspring Study journal June 2002
Radiation dose-dependent increases in inflammatory response markers in A-bomb survivors journal January 2003
Prevalence of atherosclerosis in relation to atomic bomb radiation exposure: An RERF Adult Health Study journal January 2005
Long-lasting alterations of the immune system by ionizing radiation exposure: Implications for disease development among atomic bomb survivors journal January 2008
Trends in the Utilization of Medical Procedures that use Ionizing Radiation journal November 2008
Radiation exposure and circulatory disease risk: Hiroshima and Nagasaki atomic bomb survivor data, 1950-2003 journal January 2010
Blood pressure and ageing journal February 2007
2016 AHA/ACC Guideline on the Management of Patients With Lower Extremity Peripheral Artery Disease: Executive Summary: A Report of the American College of Cardiology/American Heart Association Task Force on Clinical Practice Guidelines journal March 2017
Pulse Waves in the Lower Extremities as a Diagnostic Tool of Peripheral Arterial Disease and Predictor of Mortality in Elderly Chinese journal March 2016
Epidemiology of Peripheral Artery Disease journal April 2015
Sensitivity and Specificity of Ankle-Brachial Index for Detecting Angiographic Stenosis of Peripheral Arteries journal January 2007
Arterial stiffness journal September 2012
Systematic Review and Meta-analysis of Circulatory Disease from Exposure to Low-Level Ionizing Radiation and Estimates of Potential Population Mortality Risks journal November 2012
Accounting for Neutron Exposure in the Japanese Atomic Bomb Survivors journal December 2014
Heart Disease Mortality in the Life Span Study, 1950–2008 journal February 2017
Mortality from Circulatory Diseases and other Non-Cancer Outcomes among Nuclear Workers in France, the United Kingdom and the United States (INWORKS) journal July 2017
Noncancer Disease Incidence in Atomic Bomb Survivors, 1958–1998 journal June 2004
Dose Estimation for Atomic Bomb Survivor Studies: Its Evolution and Present Status journal July 2006
Comparison between oscillometric- and Doppler-ABI in elderly individuals journal March 2013
The 1997 American Diabetes Association and 1999 World Health Organization criteria for hyperglycemia in the diagnosis and prediction of diabetes. journal August 2000
Risk Factors for and the Prevalence of Peripheral Arterial Disease and its Relationship to Carotid Atherosclerosis: The Kyushu and Okinawa Population Study (KOPS) journal January 2010

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