Pathophysiological Integration of Metabolic Reprogramming in Breast Cancer

Corchado-Cobos, Roberto; García-Sancha, Natalia; Mendiburu-Eliçabe, Marina; Gómez-Vecino, Aurora; Jiménez-Navas, Alejandro; Pérez-Baena, Manuel Jesús; Holgado-Madruga, Marina; Mao, Jian-Hua; Cañueto, Javier; Castillo-Lluva, Sonia; Pérez-Losada, Jesús

doi:10.3390/cancers14020322

Title: Pathophysiological Integration of Metabolic Reprogramming in Breast Cancer

Journal Article · 10 January 2022 · Cancers (Basel)

DOI: https://doi.org/10.3390/cancers14020322 · OSTI ID:1896679

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^[1]; Mendiburu-Eliçabe, Marina ^[1]; Gómez-Vecino, Aurora ^[1];

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^[1]; Holgado-Madruga, Marina ^[2];

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University of Salamanca (Spain); Instituto de Investigación Biosanitaria de Salamanca (IBSAL) (Spain)
Instituto de Investigación Biosanitaria de Salamanca (IBSAL) (Spain); University of Salamanca (Spain)
Lawrence Berkeley National Lab. (LBNL), Berkeley, CA (United States)
University of Salamanca (Spain); Instituto de Investigación Biosanitaria de Salamanca (IBSAL) (Spain); Salamanca University Hospital (Spain); Complejo Asistencial Univesitario de Salamanca (CAUSA) (Spain)
Complutense Univ. of Madrid (Spain); Instituto de Investigaciones Sanitarias San Carlos (IdISSC) (Spain)

Metabolic changes that facilitate tumor growth are one of the hallmarks of cancer. The triggers of these metabolic changes are located in the tumor parenchymal cells, where oncogenic mutations induce an imperative need to proliferate and cause tumor initiation and progression. Cancer cells undergo significant metabolic reorganization during disease progression that is tailored to their energy demands and fluctuating environmental conditions. Oxidative stress plays an essential role as a trigger under such conditions. These metabolic changes are the consequence of the interaction between tumor cells and stromal myofibroblasts. The metabolic changes in tumor cells include protein anabolism and the synthesis of cell membranes and nucleic acids, which all facilitate cell proliferation. They are linked to catabolism and autophagy in stromal myofibroblasts, causing the release of nutrients for the cells of the tumor parenchyma. Metabolic changes lead to an interstitium deficient in nutrients, such as glucose and amino acids, and acidification by lactic acid. Together with hypoxia, they produce functional changes in other cells of the tumor stroma, such as many immune subpopulations and endothelial cells, which lead to tumor growth. Thus, immune cells favor tissue growth through changes in immunosuppression. This review considers some of the metabolic changes described in breast cancer.

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Research Organization:: Lawrence Berkeley National Laboratory (LBNL), Berkeley, CA (United States)

Sponsoring Organization:: USDOE Office of Science (SC), Biological and Environmental Research (BER); European Regional Development Fund (ERDF); European Union (EU); Instituto de Salud Carlos III; Ministry of Science (MCIN)

Grant/Contract Number:: AC02-05CH11231; SAF2017-88854R; PID2020-118527RB-I00; PDC2021-121735-I00; RTI2018-094130-B-100; GRS2139/A/20; PI18/00587; PI21/01207; INT20/00074

OSTI ID:: 1896679

Journal Information:: Cancers (Basel), Vol. 14, Issue 2; ISSN 2072-6694

Publisher:: MDPICopyright Statement

Country of Publication:: United States

Language:: English

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