An Electrochemical Electrode to Detect Theophylline Based on Copper Oxide Nanoparticles Composited with Graphene Oxide

Patil, Vinoda B.; Malode, Shweta J.; Mangasuli, Sumitra N.; Tuwar, Suresh M.; Mondal, Kunal; Shetti, Nagaraj P.

doi:10.3390/mi13081166

Title: An Electrochemical Electrode to Detect Theophylline Based on Copper Oxide Nanoparticles Composited with Graphene Oxide

Journal Article · 23 July 2022 · Micromachines

DOI: https://doi.org/10.3390/mi13081166 · OSTI ID:1895430

Patil, Vinoda B. ^[1]; Malode, Shweta J. ^[2]; Mangasuli, Sumitra N. ^[1]; Tuwar, Suresh M. ^[1];

^[3]; Shetti, Nagaraj P. ^[2]

Karnatak Science College, Karnataka (India)
KLE Technological University, Hubli (India)
Idaho National Lab. (INL), Idaho Falls, ID (United States)

The electrochemical analysis of theophylline (THP) was investigated by fabricating a carbon paste electrode (CPE) modified with graphene oxide (GO) along with copper oxide (CuO) nanoparticles (CuO-GO/CPE). The impact of electro-kinetic parameters such as the heterogeneous rate constant, the scan rate, the accumulation time, the pH, the transfer coefficient, and the number of electrons and protons transferred into the electro-oxidation mechanism of THP has been studied utilizing electrochemical methods such as cyclic voltammetry (CV) and differential pulse voltammetry (DPV). The differential pulse voltammetry technique was employed to investigate THP in pharmaceutical and biological samples, confirming the limit of detection (LOD) and quantification (LOQ) of the THP. X-ray diffraction (XRD) and scanning electron microscopy (SEM) analysis were performed to characterize the CuO nanoparticles. The CuO-GO/CPE was more sensitive in THP detection because its electrocatalytic characteristics displayed an enhanced peak current in the 0.2 M supporting electrolyte of pH 6.0, proving the excellent sensing functioning of the modified electrode.

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Research Organization:: Idaho National Laboratory (INL), Idaho Falls, ID (United States)

Sponsoring Organization:: USDOE Office of Nuclear Energy (NE)

Grant/Contract Number:: AC07-05ID14517

OSTI ID:: 1895430

Report Number(s):: INL/JOU-22-68013-Rev000

Journal Information:: Micromachines, Journal Name: Micromachines Journal Issue: 8 Vol. 13; ISSN 2072-666X

Publisher:: MDPICopyright Statement

Country of Publication:: United States

Language:: English

References (47)

Electroanalysis of Carbendazim using MWCNT/Ca‐ZnO Modified Electrode Malode, Shweta J.; Keerthi, Prabhu K.; Shetti, Nagaraj P. Electroanalysis, Vol. 32, Issue 7 https://doi.org/10.1002/elan.201900776	journal	April 2020
Glucose‐based carbon electrode for trace‐level detection of acetaminophen Patil, Vinoda B.; Sawkar, Rakesh R.; Ilager, Davalasab Electrochemical Science Advances, Vol. 2, Issue 5 https://doi.org/10.1002/elsa.202100117	journal	October 2021
Rapid analysis of traditional Chinese medicinePinellia ternataby microchip electrophoresis with electrochemical detection Shih, Tsung-Ting; Lee, Hui-Ling; Chen, Show-Chuen Journal of Separation Science, Vol. 41, Issue 3 https://doi.org/10.1002/jssc.201700901	journal	December 2017
Xanthines and Phosphodiesterase Inhibitors Spina, D.; Page, C. P. Handbook of Experimental Pharmacology https://doi.org/10.1007/164_2016_71	book	January 2016
General expression of the linear potential sweep voltammogram in the case of diffusionless electrochemical systems Laviron, E. Journal of Electroanalytical Chemistry and Interfacial Electrochemistry, Vol. 101, Issue 1 https://doi.org/10.1016/S0022-0728(79)80075-3	journal	July 1979
A study on the photoelectrochemical properties of copper oxide thin films Chaudhary, Y. International Journal of Hydrogen Energy, Vol. 29, Issue 2 https://doi.org/10.1016/S0360-3199(03)00109-5	journal	February 2004
A highly sensitive gold nanoparticle-based electrochemical aptasensor for theophylline detection Chen, Xifeng; Guo, Zhenzhen; Tang, Yuguo Analytica Chimica Acta, Vol. 999 https://doi.org/10.1016/j.aca.2017.10.039	journal	January 2018
Theophylline toxicity: Successful management of a patient with distributive shock secondary to drug overdose Chandrasekaran, V. P.; Parthasarathy, Anand; Muruga, Balaji The American Journal of Emergency Medicine, Vol. 38, Issue 11 https://doi.org/10.1016/j.ajem.2020.05.112	journal	November 2020
Detection of ketorolac drug using pencil graphite electrode Sawkar, Rakesh R.; Patil, Vinoda B.; Shanbhag, Mahesh M. Biomedical Engineering Advances, Vol. 2 https://doi.org/10.1016/j.bea.2021.100009	journal	December 2021
A review on various electrochemical techniques for heavy metal ions detection with different sensing platforms Bansod, BabanKumar; Kumar, Tejinder; Thakur, Ritula Biosensors and Bioelectronics, Vol. 94 https://doi.org/10.1016/j.bios.2017.03.031	journal	August 2017
Fabrication of 3D carbon microstructures using glassy carbon microspheres and organic precursors Ruiz-Morales, J. C.; Canales-Vázquez, J.; Marrero-López, D. Carbon, Vol. 48, Issue 13 https://doi.org/10.1016/j.carbon.2010.06.012	journal	November 2010
Analysis of herbicide and its applications through a sensitive electrochemical technique based on MWCNTs/ZnO/CPE fabricated sensor Prabhu, Keerthi; Malode, Shweta J.; Shetti, Nagaraj P. Chemosphere, Vol. 287 https://doi.org/10.1016/j.chemosphere.2021.132086	journal	January 2022
Nanostructuring electrodes with carbon nanotubes: A review on electrochemistry and applications for sensing Gooding, J. Justin Electrochimica Acta, Vol. 50, Issue 15 https://doi.org/10.1016/j.electacta.2004.08.052	journal	May 2005
Fabrication of anchored copper oxide nanoparticles on graphene oxide nanosheets via an electrostatic coprecipitation and its application as supercapacitor Pendashteh, Afshin; Mousavi, Mir Fazlollah; Rahmanifar, Mohammad Safi Electrochimica Acta, Vol. 88 https://doi.org/10.1016/j.electacta.2012.10.088	journal	January 2013
Electrochemical determination of theophylline in foodstuff, tea and soft drinks based on urchin-like CdSe microparticles modified glassy carbon electrode Yin, Huanshun; Meng, Xiaomeng; Su, Haichao Food Chemistry, Vol. 134, Issue 2 https://doi.org/10.1016/j.foodchem.2012.02.197	journal	September 2012
Electrochemical methods as a tool for determining the antioxidant capacity of food and beverages: A review Hoyos-Arbeláez, Jorge; Vázquez, Mario; Contreras-Calderón, José Food Chemistry, Vol. 221 https://doi.org/10.1016/j.foodchem.2016.11.017	journal	April 2017
Electrochemical oxidation of theophylline at multi-wall carbon nanotube modified glassy carbon electrodes Zhu, Yuan-Hai; Zhang, Zhi-Ling; Pang, Dai-Wen Journal of Electroanalytical Chemistry, Vol. 581, Issue 2 https://doi.org/10.1016/j.jelechem.2005.05.004	journal	August 2005
The electropolymerization of CTAB on glassy carbon electrode for simultaneous determination of dopamine, uric acid, tryptophan and theophylline Yang, Yu Jun; Guo, Lili; Zhang, Wanqiang Journal of Electroanalytical Chemistry, Vol. 768 https://doi.org/10.1016/j.jelechem.2016.02.043	journal	May 2016
Preparation and supercapacitance of CuO nanosheet arrays grown on nickel foam Wang, Guiling; Huang, Jichun; Chen, Shuli Journal of Power Sources, Vol. 196, Issue 13 https://doi.org/10.1016/j.jpowsour.2011.02.049	journal	July 2011
Clay-based carbon sensor for electro-oxidation of nimesulide Prabhu, Keerthi; Malode, Shweta J.; Veerapur, Ravindra S. Materials Chemistry and Physics, Vol. 272 https://doi.org/10.1016/j.matchemphys.2021.124992	journal	November 2021
A simple and flexible enzymatic glucose biosensor using chitosan entrapped mesoporous carbon nanocomposite Barathi, Palani; Thirumalraj, Balamurugan; Chen, Shen-Ming Microchemical Journal, Vol. 147 https://doi.org/10.1016/j.microc.2019.03.083	journal	June 2019
Direct electrochemical determination of methotrexate using functionalized carbon nanotube paste electrode as biosensor for in-vitro analysis of urine and dilute serum samples Kummari, Shekher; Kumar, V. Sunil; Satyanarayana, M. Microchemical Journal, Vol. 148 https://doi.org/10.1016/j.microc.2019.05.054	journal	July 2019
Electrochemical sensing of parabens in solubilized ionic liquid system at polyaniline decorated gold nanoparticles constructed interface Ahmad Rather, Jahangir; Al Abri, Asma; Kannan, Palanisamy Microchemical Journal, Vol. 159 https://doi.org/10.1016/j.microc.2020.105379	journal	December 2020
Novel layered structured bentonite clay-based electrodes for electrochemical sensor applications Vernekar, Pramod R.; Shetti, Nagaraj P.; Shanbhag, Mahesh M. Microchemical Journal, Vol. 159 https://doi.org/10.1016/j.microc.2020.105441	journal	December 2020
Molecularly imprinted poly(4-amino-5-hydroxy-2,7-naphthalenedisulfonic acid) modified glassy carbon electrode as an electrochemical theophylline sensor Aswini, K. K.; Vinu Mohan, A. M.; Biju, V. M. Materials Science and Engineering: C, Vol. 65 https://doi.org/10.1016/j.msec.2016.03.098	journal	August 2016
Poly(eriochrome black T) modified electrode for electrosensing of methdilazine Shetti, Nagaraj P.; Ilager, Davalasab; Malode, Shweta J. Materials Science in Semiconductor Processing, Vol. 120 https://doi.org/10.1016/j.mssp.2020.105261	journal	December 2020
Simultaneous determination of caffeine and theophylline using square wave voltammetry at poly( l -aspartic acid)/functionalized multi-walled carbon nanotubes composite modified electrode Mekassa, Birhanu; Tessema, Merid; Chandravanshi, Bhagwan Singh Sensing and Bio-Sensing Research, Vol. 16 https://doi.org/10.1016/j.sbsr.2017.11.002	journal	November 2017
Silica gel-based electrochemical sensor for tinidazole Sawkar, Rakesh R.; Shanbhag, Mahesh M.; Tuwar, Suresh M. Sensors International, Vol. 3 https://doi.org/10.1016/j.sintl.2022.100192	journal	January 2022
Manganese dioxide nanosheet-decorated ionic liquid-functionalized graphene for electrochemical theophylline biosensing Zhuang, Xuming; Chen, Dandan; Wang, Shengnan Sensors and Actuators B: Chemical, Vol. 251 https://doi.org/10.1016/j.snb.2017.05.049	journal	November 2017
Sensitive voltammetric determination of Morin in leaf extract at Nickel (II) phthalocyanine modified carbon paste electrode Erady, Veera; Mascarenhas, Ronald J.; Satpati, Ashis K. Surfaces and Interfaces, Vol. 19 https://doi.org/10.1016/j.surfin.2020.100517	journal	June 2020
Nitrogen-doped carbon nanotubes decorated poly (L-Cysteine) as a novel, ultrasensitive electrochemical sensor for simultaneous determination of theophylline and caffeine Wang, Yingzi; Ding, Yaping; Li, Li Talanta, Vol. 178 https://doi.org/10.1016/j.talanta.2017.08.076	journal	February 2018
A First Assessment on the Scale-Up Possibilities of Different Electrochemical Techniques for Lithium Isotopic Enrichment Acosta, Lautaro N.; Flexer, Victoria Industrial & Engineering Chemistry Research, Vol. 57, Issue 33 https://doi.org/10.1021/acs.iecr.8b01640	journal	July 2018
Biomedical Applications of Graphene and Graphene Oxide Chung, Chul; Kim, Young-Kwan; Shin, Dolly Accounts of Chemical Research, Vol. 46, Issue 10 https://doi.org/10.1021/ar300159f	journal	November 2012
Honeycomb Carbon: A Review of Graphene Allen, Matthew J.; Tung, Vincent C.; Kaner, Richard B. Chemical Reviews, Vol. 110, Issue 1, p. 132-145 https://doi.org/10.1021/cr900070d	journal	January 2010
CuO Nanostructures As Quartz Crystal Microbalance Sensing Layers for Detection of Trace Hydrogen Cyanide Gas Yang, Mingqing; He, Junhui; Hu, Xiaochun Environmental Science & Technology, Vol. 45, Issue 14 https://doi.org/10.1021/es201121w	journal	June 2011
Plasma-Enhanced Catalytic CuO Nanowires for CO Oxidation Feng, Yunzhe; Zheng, Xiaolin Nano Letters, Vol. 10, Issue 11 https://doi.org/10.1021/nl1034545	journal	November 2010
Graphene: Corrosion-Inhibiting Coating Prasai, Dhiraj; Tuberquia, Juan Carlos; Harl, Robert R. ACS Nano, Vol. 6, Issue 2 https://doi.org/10.1021/nn203507y	journal	January 2012
The rise of graphene Geim, A. K.; Novoselov, K. S. Nature Materials, Vol. 6, Issue 3, p. 183-191 https://doi.org/10.1038/nmat1849	journal	March 2007
Graphene nanodevices for DNA sequencing Heerema, Stephanie J.; Dekker, Cees Nature Nanotechnology, Vol. 11, Issue 2 https://doi.org/10.1038/nnano.2015.307	journal	February 2016
Advanced porous graphene materials: from in-plane pore generation to energy storage applications Tao, You; Sui, Zhu-Yin; Han, Bao-Hang Journal of Materials Chemistry A, Vol. 8, Issue 13 https://doi.org/10.1039/D0TA00154F	journal	January 2020
Graphene layer modified glassy carbon electrode for the determination of norepinephrine and theophylline in pharmaceutical formulations Amal Raj, M.; Abraham John, S. Analytical Methods, Vol. 6, Issue 7 https://doi.org/10.1039/c3ay42279h	journal	January 2014
Field emission from various CuO nanostructures Hsieh, Chien-Te; Chen, Jin-Ming; Lin, Hung-Hsiao Applied Physics Letters, Vol. 83, Issue 16 https://doi.org/10.1063/1.1619229	journal	October 2003
Novel heterostructured Ru-doped TiO₂/CNTs hybrids with enhanced electrochemical sensing performance for Cetirizine Shetti, Nagaraj P.; Malode, Shweta J.; Nayak, Deepti S. Materials Research Express, Vol. 6, Issue 11 https://doi.org/10.1088/2053-1591/ab4b92	journal	October 2019
Theophylline: a review of population pharmacokinetic analyses Ma, Y. J.; Jiang, D. Q.; Meng, J. X. Journal of Clinical Pharmacy and Therapeutics, Vol. 41, Issue 6 https://doi.org/10.1111/jcpt.12435	journal	August 2016
Electrochemical Determination of Theophylline Pharmacokinetic under the Effect of Roxithromycin in Rats by the MWNTs/Au/poly-L-lysine Modified Sensor Peng, Anlin International Journal of Electrochemical Science https://doi.org/10.20964/2017.01.03	journal	January 2017
Highly Sensitive Determination of Theophylline Based on Graphene Quantum Dots Modified Electrode Reza Ganjali, Mohammad International Journal of Electrochemical Science https://doi.org/10.20964/2018.03.09	journal	March 2018
Thermal Conductivity of Nanoparticle - Fluid Mixture Wang, Xinwei; Xu, Xianfan; Choi, Stephen U. S. Journal of Thermophysics and Heat Transfer, Vol. 13, Issue 4 https://doi.org/10.2514/2.6486	journal	October 1999

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36 MATERIALS SCIENCE
CuO nanoparticles
Graphene oxide
Limit of detection
Theophylline
Voltammetry techniques

Title: An Electrochemical Electrode to Detect Theophylline Based on Copper Oxide Nanoparticles Composited with Graphene Oxide

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