DOE PAGES title logo U.S. Department of Energy
Office of Scientific and Technical Information

Title: Structural Analysis of Cholesterol Binding and Sterol Selectivity by ABCG5/G8

Journal Article · · Journal of Molecular Biology

Not Available

Sponsoring Organization:
USDOE
Grant/Contract Number:
AC02-06CH11357
OSTI ID:
1885856
Journal Information:
Journal of Molecular Biology, Journal Name: Journal of Molecular Biology Journal Issue: 20 Vol. 434; ISSN 0022-2836
Publisher:
ElsevierCopyright Statement
Country of Publication:
United Kingdom
Language:
English

References (68)

Picky ABCG5/G8 and promiscuous ABCG2 ‐ a tale of fatty diets and drug toxicity journal October 2020
UCSF Chimera?A visualization system for exploratory research and analysis journal January 2004
DOCK 6: Impact of new features and current docking performance journal April 2015
MolProbity: More and better reference data for improved all-atom structure validation: PROTEIN SCIENCE.ORG journal November 2017
The transport pathway in the ABCG2 protein and its regulation revealed by molecular dynamics simulations journal September 2020
Molecular cloning of a mammalian ABC transporter homologous to Drosophila white gene journal September 1996
Sitosterolemia: exclusion of genes involved in reduced cholesterol biosynthesis journal May 1998
The effect of ABCG1 deficiency on atherosclerotic lesion development in LDL receptor knockout mice depends on the stage of atherogenesis journal March 2012
Structure of the Human Lipid Exporter ABCA1 journal June 2017
Structure and transport mechanism of the human cholesterol transporter ABCG1 journal January 2022
Partial molecular volumes of lipids and cholesterol journal September 2006
Interaction of G protein coupled receptors and cholesterol journal September 2016
Structure of the Human Cholesterol Transporter ABCG1 journal October 2021
Automatic atom type and bond type perception in molecular mechanical calculations journal October 2006
Direct Binding of Cholesterol to the Purified Membrane Region of SCAP journal July 2004
A Smoothed Backbone-Dependent Rotamer Library for Proteins Derived from Adaptive Kernel Density Estimates and Regressions journal June 2011
Identification of a gene, ABCG5, important in the regulation of dietary cholesterol absorption journal January 2001
Crystal structure of the human sterol transporter ABCG5/ABCG8 journal May 2016
Structure of the human multidrug transporter ABCG2 journal May 2017
The cholesterol transporter ABCG1 links cholesterol homeostasis and tumour immunity journal February 2015
The ABCG2 multidrug transporter is a pump gated by a valve and an extracellular lid journal November 2019
Structural basis for itraconazole-mediated NPC1 inhibition journal January 2020
ABCG2 transports anticancer drugs via a closed-to-open switch journal May 2020
Structures of ABCG2 under turnover conditions reveal a key step in the drug transport mechanism journal July 2021
Structure and efflux mechanism of the yeast pleiotropic drug resistance transporter Pdr5 journal September 2021
Structures of human Patched and its complex with native palmitoylated sonic hedgehog journal July 2018
Cryo-EM structures of a human ABCG2 mutant trapped in ATP-bound and substrate-bound states journal November 2018
Highly accurate protein structure prediction with AlphaFold journal July 2021
Structural basis of small-molecule inhibition of human multidrug transporter ABCG2 journal April 2018
Cryo-EM structure of ABCG5/G8 in complex with modulating antibodies journal May 2021
The ATP binding cassette transporter, ABCG1, localizes to cortical actin filaments journal February 2017
Cholesterol in phospholipid bilayers: positions and orientations inside membranes with different unsaturation degrees journal January 2019
Effects of the lipid environment, cholesterol and bile acids on the function of the purified and reconstituted human ABCG2 protein journal February 2013
ABCG5/G8: a structural view to pathophysiology of the hepatobiliary cholesterol secretion journal October 2019
ATP-binding cassette transporters G1 and G4 mediate cellular cholesterol efflux to high-density lipoproteins journal June 2004
Molecular basis of cholesterol efflux via ABCG subfamily transporters journal August 2021
Disruption of Abcg5 and Abcg8 in mice reveals their crucial role in biliary cholesterol secretion journal November 2002
Amino acid substitution matrices from protein blocks. journal November 1992
A multidrug resistance transporter from human MCF-7 breast cancer cells journal December 1998
The ATP Binding Cassette Transporters Pdr5 and Snq2 of Saccharomyces cerevisiae Can Mediate Transport of Steroids in Vivo journal October 1996
ABCG5 and ABCG8 Are Obligate Heterodimers for Protein Trafficking and Biliary Cholesterol Excretion journal September 2003
Expression of ABCG5 and ABCG8 Is Required for Regulation of Biliary Cholesterol Secretion journal March 2005
ABCG1 Redistributes Cell Cholesterol to Domains Removable by High Density Lipoprotein but Not by Lipid-depleted Apolipoproteins journal August 2005
Protein sequence alignments: a strategy for the hierarchical analysis of residue conservation journal January 1993
Biopython: freely available Python tools for computational molecular biology and bioinformatics journal March 2009
CLUSTAL W: improving the sensitivity of progressive multiple sequence alignment through sequence weighting, position-specific gap penalties and weight matrix choice journal January 1994
MUSCLE: multiple sequence alignment with high accuracy and high throughput journal March 2004
PROMALS3D: a tool for multiple protein sequence and structure alignments journal February 2008
ABCG2 requires a single aromatic amino acid to “clamp” substrates and inhibitors into the binding pocket journal February 2020
Coot model-building tools for molecular graphics journal November 2004
MolProbity : all-atom structure validation for macromolecular crystallography journal December 2009
PHENIX: a comprehensive Python-based system for macromolecular structure solution journal January 2010
Accumulation of Dietary Cholesterol in Sitosterolemia Caused by Mutations in Adjacent ABC Transporters journal December 2000
Disruption of cholesterol homeostasis by plant sterols journal September 2004
MOLE 2.0: advanced approach for analysis of biomacromolecular channels journal August 2013
ABCG1 regulates pulmonary surfactant metabolism in mice and men journal May 2017
Selective sterol accumulation in ABCG5/ABCG8-deficient mice journal February 2004
Sphingomyelin-dependence of cholesterol efflux mediated by ABCG1 journal November 2007
Differential expression and function of ABCG1 and ABCG4 during development and aging journal January 2010
ABCA1, ABCG1, and ABCG4 Are Distributed to Distinct Membrane Meso-Domains and Disturb Detergent-Resistant Domains on the Plasma Membrane journal October 2014
ABCG2- and ABCG4-Mediated Efflux of Amyloid-β Peptide 1-40 at the Mouse Blood-Brain Barrier journal May 2012
phaseR: An R Package for Phase Plane Analysis of Autonomous ODE Systems journal January 2014
Drosophila melanogaster White Mutant w1118 Undergo Retinal Degeneration journal January 2018
Depletion of Lipid Efflux Pump ABCG1 Triggers the Intracellular Accumulation of Extracellular Vesicles and Reduces Aggregation and Tumorigenesis of Metastatic Cancer Cells journal October 2018
Transmembrane Polar Relay Drives the Allosteric Regulation for ABCG5/G8 Sterol Transporter journal November 2020
Lipid Transporters Beam Signals from Cell Membranes journal July 2021
ABCG1 as a potential oncogene in lung cancer journal April 2017
Collaboration gets the most out of software journal September 2013