Structural Analysis of Cholesterol Binding and Sterol Selectivity by ABCG5/G8

Farhat, Danny; Rezaei, Fatemeh; Ristovski, Milica; Yang, Yidai; Stancescu, Albert; Dzimkova, Lucia; Samnani, Sabrina; Couture, Jean-François; Lee, Jyh-Yeuan

doi:10.1016/j.jmb.2022.167795

Title: Structural Analysis of Cholesterol Binding and Sterol Selectivity by ABCG5/G8

Journal Article · 01 October 2022 · Journal of Molecular Biology

DOI: https://doi.org/10.1016/j.jmb.2022.167795 · OSTI ID:1885856

;

; Ristovski, Milica; Yang, Yidai; Stancescu, Albert; Dzimkova, Lucia; Samnani, Sabrina; Couture, Jean-François; Lee, Jyh-Yeuan

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Sponsoring Organization:: USDOE

Grant/Contract Number:: AC02-06CH11357

OSTI ID:: 1885856

Journal Information:: Journal of Molecular Biology, Journal Name: Journal of Molecular Biology Vol. 434 Journal Issue: 20; ISSN 0022-2836

Publisher:: ElsevierCopyright Statement

Country of Publication:: United Kingdom

Language:: English

References (66)

ABCG1 as a potential oncogene in lung cancer Tian, Chunyan; Huang, Di; Yu, Yanli Experimental and Therapeutic Medicine, Vol. 13, Issue 6 https://doi.org/10.3892/etm.2017.4393	journal	April 2017
Accumulation of Dietary Cholesterol in Sitosterolemia Caused by Mutations in Adjacent ABC Transporters Berge, K. E. Science, Vol. 290, Issue 5497 https://doi.org/10.1126/science.290.5497.1771	journal	December 2000
A Smoothed Backbone-Dependent Rotamer Library for Proteins Derived from Adaptive Kernel Density Estimates and Regressions Shapovalov, Maxim V.; Dunbrack, Roland L. Structure, Vol. 19, Issue 6 https://doi.org/10.1016/j.str.2011.03.019	journal	June 2011
The transport pathway in the ABCG2 protein and its regulation revealed by molecular dynamics simulations Nagy, Tamás; Tóth, Ágota; Telbisz, Ágnes Cellular and Molecular Life Sciences, Vol. 78, Issue 5 https://doi.org/10.1007/s00018-020-03651-3	journal	September 2020
The ATP Binding Cassette Transporters Pdr5 and Snq2 of Saccharomyces cerevisiae Can Mediate Transport of Steroids in Vivo Mahé, Yannick; Lemoine, Yves; Kuchler, Karl Journal of Biological Chemistry, Vol. 271, Issue 41 https://doi.org/10.1074/jbc.271.41.25167	journal	October 1996
ABCA1, ABCG1, and ABCG4 Are Distributed to Distinct Membrane Meso-Domains and Disturb Detergent-Resistant Domains on the Plasma Membrane Sano, Osamu; Ito, Shiho; Kato, Reiko PLoS ONE, Vol. 9, Issue 10 https://doi.org/10.1371/journal.pone.0109886	journal	October 2014
Collaboration gets the most out of software Morin, Andrew; Eisenbraun, Ben; Key, Jason eLife, Vol. 2 https://doi.org/10.7554/eLife.01456	journal	September 2013
CLUSTAL W: improving the sensitivity of progressive multiple sequence alignment through sequence weighting, position-specific gap penalties and weight matrix choice Thompson, Julie D.; Higgins, Desmond G.; Gibson, Toby J. Nucleic Acids Research, Vol. 22, Issue 22, p. 4673-4680 https://doi.org/10.1093/nar/22.22.4673	journal	January 1994
ABCG5 and ABCG8 Are Obligate Heterodimers for Protein Trafficking and Biliary Cholesterol Excretion Graf, Gregory A.; Yu, Liqing; Li, Wei-Ping Journal of Biological Chemistry, Vol. 278, Issue 48 https://doi.org/10.1074/jbc.M310223200	journal	September 2003
Protein sequence alignments: a strategy for the hierarchical analysis of residue conservation Livingstone, Craig D.; Barton, Geoffrey J. Bioinformatics, Vol. 9, Issue 6 https://doi.org/10.1093/bioinformatics/9.6.745	journal	January 1993
Expression of ABCG5 and ABCG8 Is Required for Regulation of Biliary Cholesterol Secretion Yu, Liqing; Gupta, Sarita; Xu, Fang Journal of Biological Chemistry, Vol. 280, Issue 10 https://doi.org/10.1074/jbc.M411080200	journal	March 2005
The effect of ABCG1 deficiency on atherosclerotic lesion development in LDL receptor knockout mice depends on the stage of atherogenesis Meurs, Illiana; Lammers, Bart; Zhao, Ying Atherosclerosis, Vol. 221, Issue 1 https://doi.org/10.1016/j.atherosclerosis.2011.11.024	journal	March 2012
Structure of the Human Cholesterol Transporter ABCG1 Skarda, Liga; Kowal, Julia; Locher, Kaspar P. Journal of Molecular Biology, Vol. 433, Issue 21 https://doi.org/10.1016/j.jmb.2021.167218	journal	October 2021
MOLE 2.0: advanced approach for analysis of biomacromolecular channels Sehnal, David; Svobodová Vařeková, Radka; Berka, Karel Journal of Cheminformatics, Vol. 5, Issue 1 https://doi.org/10.1186/1758-2946-5-39	journal	August 2013
Interaction of G protein coupled receptors and cholesterol Gimpl, Gerald Chemistry and Physics of Lipids, Vol. 199 https://doi.org/10.1016/j.chemphyslip.2016.04.006	journal	September 2016
Automatic atom type and bond type perception in molecular mechanical calculations Wang, Junmei; Wang, Wei; Kollman, Peter A. Journal of Molecular Graphics and Modelling, Vol. 25, Issue 2 https://doi.org/10.1016/j.jmgm.2005.12.005	journal	October 2006
MolProbity: More and better reference data for improved all-atom structure validation: PROTEIN SCIENCE.ORG Williams, Christopher J.; Headd, Jeffrey J.; Moriarty, Nigel W. Protein Science, Vol. 27, Issue 1 https://doi.org/10.1002/pro.3330	journal	November 2017
Picky ABCG5/G8 and promiscuous ABCG2 ‐ a tale of fatty diets and drug toxicity Khunweeraphong, Narakorn; Mitchell‐White, James; Szöllősi, Dániel FEBS Letters, Vol. 594, Issue 23 https://doi.org/10.1002/1873-3468.13938	journal	October 2020
Biopython: freely available Python tools for computational molecular biology and bioinformatics Cock, P. J. A.; Antao, T.; Chang, J. T. Bioinformatics, Vol. 25, Issue 11 https://doi.org/10.1093/bioinformatics/btp163	journal	March 2009
The cholesterol transporter ABCG1 links cholesterol homeostasis and tumour immunity Sag, Duygu; Cekic, Caglar; Wu, Runpei Nature Communications, Vol. 6, Issue 1 https://doi.org/10.1038/ncomms7354	journal	February 2015
Structural basis for itraconazole-mediated NPC1 inhibition Long, Tao; Qi, Xiaofeng; Hassan, Abdirahman Nature Communications, Vol. 11, Issue 1 https://doi.org/10.1038/s41467-019-13917-5	journal	January 2020
DOCK 6: Impact of new features and current docking performance Allen, William J.; Balius, Trent E.; Mukherjee, Sudipto Journal of Computational Chemistry, Vol. 36, Issue 15 https://doi.org/10.1002/jcc.23905	journal	April 2015
ABCG1 Redistributes Cell Cholesterol to Domains Removable by High Density Lipoprotein but Not by Lipid-depleted Apolipoproteins Vaughan, Ashley M.; Oram, John F. Journal of Biological Chemistry, Vol. 280, Issue 34 https://doi.org/10.1074/jbc.M505368200	journal	August 2005
Highly accurate protein structure prediction with AlphaFold Jumper, John; Evans, Richard; Pritzel, Alexander Nature https://doi.org/10.1038/s41586-021-03819-2	journal	July 2021
A multidrug resistance transporter from human MCF-7 breast cancer cells Doyle, L. A.; Yang, W.; Abruzzo, L. V. Proceedings of the National Academy of Sciences, Vol. 95, Issue 26 https://doi.org/10.1073/pnas.95.26.15665	journal	December 1998
UCSF Chimera?A visualization system for exploratory research and analysis Pettersen, Eric F.; Goddard, Thomas D.; Huang, Conrad C. Journal of Computational Chemistry, Vol. 25, Issue 13 https://doi.org/10.1002/jcc.20084	journal	January 2004
Sphingomyelin-dependence of cholesterol efflux mediated by ABCG1 Sano, Osamu; Kobayashi, Aya; Nagao, Kohjiro Journal of Lipid Research, Vol. 48, Issue 11 https://doi.org/10.1194/jlr.M700139-JLR200	journal	November 2007
Cryo-EM structures of a human ABCG2 mutant trapped in ATP-bound and substrate-bound states Manolaridis, Ioannis; Jackson, Scott M.; Taylor, Nicholas M. I. Nature, Vol. 563, Issue 7731 https://doi.org/10.1038/s41586-018-0680-3	journal	November 2018
Structure and transport mechanism of the human cholesterol transporter ABCG1 Xu, Da; Li, Yanyan; Yang, Fengrui Cell Reports, Vol. 38, Issue 4 https://doi.org/10.1016/j.celrep.2022.110298	journal	January 2022
Disruption of Abcg5 and Abcg8 in mice reveals their crucial role in biliary cholesterol secretion Yu, L.; Hammer, R. E.; Li-Hawkins, J. Proceedings of the National Academy of Sciences, Vol. 99, Issue 25 https://doi.org/10.1073/pnas.252582399	journal	November 2002
Partial molecular volumes of lipids and cholesterol Greenwood, Alexander I.; Tristram-Nagle, Stephanie; Nagle, John F. Chemistry and Physics of Lipids, Vol. 143, Issue 1-2 https://doi.org/10.1016/j.chemphyslip.2006.04.002	journal	September 2006
phaseR: An R Package for Phase Plane Analysis of Autonomous ODE Systems Grayling, Michael,J. The R Journal, Vol. 6, Issue 2 https://doi.org/10.32614/RJ-2014-023	journal	January 2014
Crystal structure of the human sterol transporter ABCG5/ABCG8 Lee, Jyh-Yeuan; Kinch, Lisa N.; Borek, Dominika M. Nature, Vol. 533, Issue 7604 https://doi.org/10.1038/nature17666	journal	May 2016
Molecular basis of cholesterol efflux via ABCG subfamily transporters Sun, Yingyuan; Wang, Jin; Long, Tao Proceedings of the National Academy of Sciences, Vol. 118, Issue 34 https://doi.org/10.1073/pnas.2110483118	journal	August 2021
MolProbity : all-atom structure validation for macromolecular crystallography Chen, Vincent B.; Arendall, W. Bryan; Headd, Jeffrey J. Acta Crystallographica Section D Biological Crystallography, Vol. 66, Issue 1 https://doi.org/10.1107/S0907444909042073	journal	December 2009
Coot model-building tools for molecular graphics Emsley, Paul; Cowtan, Kevin Acta Crystallographica Section D Biological Crystallography, Vol. 60, Issue 12, p. 2126-2132 https://doi.org/10.1107/S0907444904019158	journal	November 2004
Structural basis of small-molecule inhibition of human multidrug transporter ABCG2 Jackson, Scott M.; Manolaridis, Ioannis; Kowal, Julia Nature Structural & Molecular Biology, Vol. 25, Issue 4 https://doi.org/10.1038/s41594-018-0049-1	journal	April 2018
Transmembrane Polar Relay Drives the Allosteric Regulation for ABCG5/G8 Sterol Transporter Xavier, Bala M.; Zein, Aiman A.; Venes, Angelica International Journal of Molecular Sciences, Vol. 21, Issue 22 https://doi.org/10.3390/ijms21228747	journal	November 2020
Structures of human Patched and its complex with native palmitoylated sonic hedgehog Qi, Xiaofeng; Schmiege, Philip; Coutavas, Elias Nature, Vol. 560, Issue 7716 https://doi.org/10.1038/s41586-018-0308-7	journal	July 2018
ABCG2 requires a single aromatic amino acid to “clamp” substrates and inhibitors into the binding pocket Gose, Tomoka; Shafi, Talha; Fukuda, Yu The FASEB Journal, Vol. 34, Issue 4 https://doi.org/10.1096/fj.201902338RR	journal	February 2020
PROMALS3D: a tool for multiple protein sequence and structure alignments Pei, Jimin; Kim, Bong-Hyun; Grishin, Nick V. Nucleic Acids Research, Vol. 36, Issue 7 https://doi.org/10.1093/nar/gkn072	journal	February 2008
Cryo-EM structure of ABCG5/G8 in complex with modulating antibodies Zhang, Hanzhi; Huang, Ching-Shin; Yu, Xinchao Communications Biology, Vol. 4, Issue 1 https://doi.org/10.1038/s42003-021-02039-8	journal	May 2021
Lipid Transporters Beam Signals from Cell Membranes Ristovski, Miliça; Farhat, Danny; Bancud, Shelly Ellaine M. Membranes, Vol. 11, Issue 8 https://doi.org/10.3390/membranes11080562	journal	July 2021
Structure of the Human Lipid Exporter ABCA1 Qian, Hongwu; Zhao, Xin; Cao, Pingping Cell, Vol. 169, Issue 7 https://doi.org/10.1016/j.cell.2017.05.020	journal	June 2017
Structures of ABCG2 under turnover conditions reveal a key step in the drug transport mechanism Yu, Qin; Ni, Dongchun; Kowal, Julia Nature Communications, Vol. 12, Issue 1 https://doi.org/10.1038/s41467-021-24651-2	journal	July 2021
The ATP binding cassette transporter, ABCG1, localizes to cortical actin filaments Pandzic, Elvis; Gelissen, Ingrid C.; Whan, Renee Scientific Reports, Vol. 7, Issue 1 https://doi.org/10.1038/srep42025	journal	February 2017
PHENIX: a comprehensive Python-based system for macromolecular structure solution Adams, Paul D.; Afonine, Pavel V.; Bunkóczi, Gábor Acta Crystallographica Section D Biological Crystallography, Vol. 66, Issue 2, p. 213-221 https://doi.org/10.1107/S0907444909052925	journal	January 2010
ATP-binding cassette transporters G1 and G4 mediate cellular cholesterol efflux to high-density lipoproteins Wang, Nan; Lan, Debin; Chen, Wengen Proceedings of the National Academy of Sciences, Vol. 101, Issue 26 https://doi.org/10.1073/pnas.0403506101	journal	June 2004
Amino acid substitution matrices from protein blocks. Henikoff, S.; Henikoff, J. G. Proceedings of the National Academy of Sciences, Vol. 89, Issue 22, p. 10915-10919 https://doi.org/10.1073/pnas.89.22.10915	journal	November 1992
The ABCG2 multidrug transporter is a pump gated by a valve and an extracellular lid Khunweeraphong, Narakorn; Szöllősi, Daniel; Stockner, Thomas Nature Communications, Vol. 10, Issue 1 https://doi.org/10.1038/s41467-019-13302-2	journal	November 2019
ABCG2 transports anticancer drugs via a closed-to-open switch Orlando, Benjamin J.; Liao, Maofu Nature Communications, Vol. 11, Issue 1 https://doi.org/10.1038/s41467-020-16155-2	journal	May 2020
Depletion of Lipid Efflux Pump ABCG1 Triggers the Intracellular Accumulation of Extracellular Vesicles and Reduces Aggregation and Tumorigenesis of Metastatic Cancer Cells Namba, Yuri; Sogawa, Chiharu; Okusha, Yuka Frontiers in Oncology, Vol. 8 https://doi.org/10.3389/fonc.2018.00376	journal	October 2018
Direct Binding of Cholesterol to the Purified Membrane Region of SCAP Radhakrishnan, Arun; Sun, Li-Ping; Kwon, Hyock Joo Molecular Cell, Vol. 15, Issue 2 https://doi.org/10.1016/j.molcel.2004.06.019	journal	July 2004
Identification of a gene, ABCG5, important in the regulation of dietary cholesterol absorption Lee, Mi-Hye; Lu, Kangmo; Hazard, Star Nature Genetics, Vol. 27, Issue 1 https://doi.org/10.1038/83799	journal	January 2001
Sitosterolemia: exclusion of genes involved in reduced cholesterol biosynthesis Patel, Shailendra B.; Honda, Akira; Salen, Gerald Journal of Lipid Research, Vol. 39, Issue 5 https://doi.org/10.1016/S0022-2275(20)33874-8	journal	May 1998
ABCG1 regulates pulmonary surfactant metabolism in mice and men de Aguiar Vallim, Thomas Q.; Lee, Elinor; Merriott, David J. Journal of Lipid Research, Vol. 58, Issue 5 https://doi.org/10.1194/jlr.M075101	journal	May 2017
ABCG2- and ABCG4-Mediated Efflux of Amyloid-β Peptide 1-40 at the Mouse Blood-Brain Barrier Do, Tuan Minh; Noel-Hudson, Marie-Sophie; Ribes, Sandy Journal of Alzheimer's Disease, Vol. 30, Issue 1 https://doi.org/10.3233/JAD-2012-112189	journal	May 2012
Structure and efflux mechanism of the yeast pleiotropic drug resistance transporter Pdr5 Harris, Andrzej; Wagner, Manuel; Du, Dijun Nature Communications, Vol. 12, Issue 1 https://doi.org/10.1038/s41467-021-25574-8	journal	September 2021
Molecular cloning of a mammalian ABC transporter homologous to Drosophila white gene Savary, S.; Denizot, F.; Luciani, M. -F. Mammalian Genome, Vol. 7, Issue 9 https://doi.org/10.1007/s003359900203	journal	September 1996
Drosophila melanogaster White Mutant w1118 Undergo Retinal Degeneration Ferreiro, María José; Pérez, Coralia; Marchesano, Mariana Frontiers in Neuroscience, Vol. 11 https://doi.org/10.3389/fnins.2017.00732	journal	January 2018
Differential expression and function of ABCG1 and ABCG4 during development and aging Bojanic, Dragana D.; Tarr, Paul T.; Gale, Greg D. Journal of Lipid Research, Vol. 51, Issue 1 https://doi.org/10.1194/jlr.M900250-JLR200	journal	January 2010
Selective sterol accumulation in ABCG5/ABCG8-deficient mice Yu, Liqing; von Bergmann, Klaus; Lutjohann, Dieter Journal of Lipid Research, Vol. 45, Issue 2 https://doi.org/10.1194/jlr.M300377-JLR200	journal	February 2004
MUSCLE: multiple sequence alignment with high accuracy and high throughput Edgar, R. C. Nucleic Acids Research, Vol. 32, Issue 5, p. 1792-1797 https://doi.org/10.1093/nar/gkh340	journal	March 2004
Effects of the lipid environment, cholesterol and bile acids on the function of the purified and reconstituted human ABCG2 protein Telbisz, Ágnes; Özvegy-Laczka, Csilla; Hegedűs, Tamás Biochemical Journal, Vol. 450, Issue 2 https://doi.org/10.1042/BJ20121485	journal	February 2013
Structure of the human multidrug transporter ABCG2 Taylor, Nicholas M. I.; Manolaridis, Ioannis; Jackson, Scott M. Nature, Vol. 546, Issue 7659 https://doi.org/10.1038/nature22345	journal	May 2017
Disruption of cholesterol homeostasis by plant sterols Yang, Chendong; Yu, Liqing; Li, Weiping Journal of Clinical Investigation, Vol. 114, Issue 6 https://doi.org/10.1172/JCI22186	journal	September 2004

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