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Title: A tipping point in cancer epidemiology: embracing a life course exposomic framework

Journal Article · · Trends in Cancer
 [1];  [2]
  1. Dept. of Environmental Medicine and Public Health, New York, NY (United States); Institute for Exposomic Research, New York, NY (United States); Icahn School of Medicine at Mount Sinai, New York, NY (United States)
  2. Oak Ridge National Lab. (ORNL), Oak Ridge, TN (United States); Univ. of Utah, Salt Lake City, UT (United States)
+ Show Author Affiliations

In this work, we show how the pathogenesis of multifactorial malignant diseases, with variable onset, severity, and natural history, reflects development-specific exposures and individual responses to these exposures influenced by underlying genetic predisposition. Embedded in life course theory, exposomics provides a framework to more fully elucidate how environmental factors alter cancer risk, disease course, and response to treatment across the lifespan.

Research Organization:
Oak Ridge National Laboratory (ORNL), Oak Ridge, TN (United States)
Sponsoring Organization:
USDOE; National Institutes of Health (NIH)
Grant/Contract Number:
AC05-00OR22725
OSTI ID:
1883932
Journal Information:
Trends in Cancer, Journal Name: Trends in Cancer Journal Issue: 4 Vol. 8; ISSN 2405-8033
Publisher:
ElsevierCopyright Statement
Country of Publication:
United States
Language:
English

References (14)

Association of Untargeted Urinary Metabolomics and Lung Cancer Risk Among Never-Smoking Women in China journal September 2019
Using primary teeth and archived dried spots for exposomic studies in children: Exploring new paths in the environmental epidemiology of pediatric cancer journal June 2021
Minimally Invasive Biospecimen Collection for Exposome Research in Children’s Health journal June 2020
The carcinogenicity of outdoor air pollution journal December 2013
Toenails as a biomarker of exposure to arsenic: A review journal April 2021
Untargeted adductomics of newborn dried blood spots identifies modifications to human serum albumin associated with childhood leukemia journal January 2020
Estimation of toluene exposure in air from BMA (S-benzylmercapturic acid) urinary measures using a reverse dosimetry approach based on physiologically pharmacokinetic modeling journal March 2021
Sex disparities matter in cancer development and therapy journal April 2021
Epidemiological challenges in studying the fetal origins of adult chronic disease journal April 2002
The last two decades of life course epidemiology, and its relevance for research on ageing journal August 2016
The Exposome: Molecules to Populations journal January 2019
Cardiovascular Disease and Breast Cancer: Where These Entities Intersect: A Scientific Statement From the American Heart Association journal February 2018
An overview of methods to address distinct research questions on environmental mixtures: an application to persistent organic pollutants and leukocyte telomere length journal August 2019
Why We Will Continue to Lose Our Battle with Cancers If We Do Not Stop Their Triggers from Environmental Pollution journal June 2021

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Related Subjects

60 APPLIED LIFE SCIENCES