High-Frequency 3D Photoacoustic Computed Tomography Using an Optical Microring Resonator
[1];
[6];
[1]
- Department of Biomedical Engineering, Duke University, Durham, NC, USA, 27708
- Department of Biomedical Engineering, Northwestern University, Evanston, IL 60208, USA, Department of Mechanical Engineering, Northwestern University, Evanston, IL 60208, USA
- Optical &, Ultrasonic Imaging Laboratory, University at Buffalo, North Campus Buffalo, NY 14260, USA
- Center for Nanoscale Materials, Argonne National Laboratory, Argonne, IL 60439, USA
- Department of Biomedical Engineering, Northwestern University, Evanston, IL 60208, USA
- Department of Mechanical Engineering, Northwestern University, Evanston, IL 60208, USA
3D photoacoustic computed tomography (3D-PACT) has made great advances in volumetric imaging of biological tissues, with high spatial-temporal resolutions and large penetration depth. The development of 3D-PACT requires high-performance acoustic sensors with a small size, large detection bandwidth, and high sensitivity. In this work, we present a new high-frequency 3D-PACT system that uses a microring resonator (MRR) as the acoustic sensor. The MRR sensor has a size of 80 μ m in diameter and was fabricated using the nanoimprint lithography technology. Using the MRR sensor, we have developed a transmission-mode 3D-PACT system that has achieved a detection bandwidth of ~23 MHz, an imaging depth of ~8 mm, a lateral resolution of 114 μ m, and an axial resolution of 57 μ m. We have demonstrated the 3D PACT’s performance on in vitro phantoms, ex vivo mouse brain, and in vivo mouse ear and tadpole. The MRR-based 3D-PACT system can be a promising tool for structural, functional, and molecular imaging of biological tissues at depths.
- Research Organization:
- Argonne National Laboratory (ANL), Argonne, IL (United States)
- Sponsoring Organization:
- American Heart Association; Chan Zuckerberg Initiative Grant; National Institutes of Health (NIH); USDOE; USDOE Office of Science (SC)
- Grant/Contract Number:
- AC02-06CH11357
- OSTI ID:
- 1879256
- Journal Information:
- BME Frontiers, Journal Name: BME Frontiers Vol. 2022; ISSN 2765-8031
- Publisher:
- American Association for the Advancement of Science (AAAS)Copyright Statement
- Country of Publication:
- United States
- Language:
- English
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