Title: Lipoprotein(a) is associated with the onset but not the progression of aortic valve calcification

Abstract

Abstract Aim Lipoprotein(a) [Lp(a)] is a potential causal factor in the pathogenesis of aortic valve disease. However, the relationship of Lp(a) with new onset and progression of aortic valve calcium (AVC) has not been studied. The purpose of the study was to assess whether high serum levels of Lp(a) are associated with AVC incidence and progression. Methods and results A total of 922 individuals from the population-based Rotterdam Study (mean age 66.0±4.2 years, 47.7% men), whose Lp(a) measurements were available, underwent non-enhanced cardiac computed tomography imaging at baseline and after a median follow-up of 14.0 [interquartile range (IQR) 13.9–14.2] years. New-onset AVC was defined as an AVC score >0 on the follow-up scan in the absence of AVC on the first scan. Progression was defined as the absolute difference in AVC score between the baseline and follow-up scan. Logistic and linear regression analyses were performed to evaluate the relationship of Lp(a) with baseline, new onset, and progression of AVC. All analyses were corrected for age, sex, body mass index, smoking, hypertension, dyslipidaemia, and creatinine. AVC progression was analysed conditional on baseline AVC score expressed as restricted cubic splines. Of the 702 individuals without AVC at baseline, 415 (59.1%) developed new-onsetmore » AVC on the follow-up scan. In those with baseline AVC, median annual progression was 13.5 (IQR = 5.2–37.8) Agatston units (AU). Lipoprotein(a) concentration was independently associated with baseline AVC [odds ratio (OR) 1.43 for each 50 mg/dL higher Lp(a); 95% confidence interval (CI) 1.15–1.79] and new-onset AVC (OR 1.30 for each 50 mg/dL higher Lp(a); 95% CI 1.02–1.65), but not with AVC progression (β: −71 AU for each 50 mg/dL higher Lp(a); 95% CI −117; 35). Only baseline AVC score was significantly associated with AVC progression (P < 0.001). Conclusion In the population-based Rotterdam Study, Lp(a) is robustly associated with baseline and new-onset AVC but not with AVC progression, suggesting that Lp(a)-lowering interventions may be most effective in pre-calcific stages of aortic valve disease.« less

Authors:

Kaiser, Yannick ;

• Search DOE PAGES for author "Kaiser, Yannick"
• Search DOE PAGES for ORCID "0000-0001-6869-0042"

van der Toorn, Janine E.; Singh, Sunny S.; Zheng, Kang H.; Kavousi, Maryam ;

• Search DOE PAGES for author "Kavousi, Maryam"
• Search DOE PAGES for ORCID "0000-0001-5976-6519"

Sijbrands, Eric J. G.; Stroes, Erik S. G. ;

• Search DOE PAGES for author "Stroes, Erik S. G."
• Search DOE PAGES for ORCID "0000-0001-9555-6260"

Vernooij, Meike W.; de Rijke, Yolanda B.; Boekholdt, S. Matthijs; Bos, Daniel

Publication Date:

Sat Jul 23 00:00:00 EDT 2022

Sponsoring Org.:

USDOE Office of Electricity (OE), Advanced Grid Research & Development. Power Systems Engineering Research

OSTI Identifier:

1877715

Resource Type:

Published Article

Journal Name:

European Heart Journal

Additional Journal Information:

Journal Name: European Heart Journal Journal Volume: 43 Journal Issue: 39; Journal ID: ISSN 0195-668X

Publisher:

Oxford University Press

Country of Publication:

Country unknown/Code not available

Language:

English