The Need for Biological Countermeasures to Mitigate the Risk of Space Radiation-Induced Carcinogenesis, Cardiovascular Disease, and Central Nervous System Deficiencies

Sishc, Brock J.; Zawaski, Janice; Saha, Janapriya; Carnell, Lisa S.; Fabre, Kristin M.; Elgart, S. Robin

doi:10.1016/j.lssr.2022.06.003

Title: The Need for Biological Countermeasures to Mitigate the Risk of Space Radiation-Induced Carcinogenesis, Cardiovascular Disease, and Central Nervous System Deficiencies

Journal Article · 31 October 2022 · Life Sciences in Space Research

DOI: https://doi.org/10.1016/j.lssr.2022.06.003 · OSTI ID:1876931

; Zawaski, Janice; Saha, Janapriya; Carnell, Lisa S.; Fabre, Kristin M.; Elgart, S. Robin

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Sponsoring Organization:: USDOE

OSTI ID:: 1876931

Alternate ID(s):: OSTI ID: 2424640

Journal Information:: Life Sciences in Space Research, Journal Name: Life Sciences in Space Research Journal Issue: C Vol. 35; ISSN 2214-5524

Publisher:: ElsevierCopyright Statement

Country of Publication:: Netherlands

Language:: English

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Elemental and Isotopic Composition of the Galactic Cosmic Rays Simpson, J. A. Annual Review of Nuclear and Particle Science, Vol. 33, Issue 1 https://doi.org/10.1146/annurev.ns.33.120183.001543	journal	December 1983
Effects of dietary aspirin on high-LET radiation-induced prostaglandin E2 levels and gastrointestinal tumorigenesis in Apc mice Suman, Shubhankar; Kumar, Santosh; Moon, Bo-Hyun Life Sciences in Space Research, Vol. 31 https://doi.org/10.1016/j.lssr.2021.09.001	journal	November 2021
Emtricitabine and tenofovir alafenamide vs emtricitabine and tenofovir disoproxil fumarate for HIV pre-exposure prophylaxis (DISCOVER): primary results from a randomised, double-blind, multicentre, active-controlled, phase 3, non-inferiority trial Mayer, Kenneth H.; Molina, Jean-Michel; Thompson, Melanie A. The Lancet, Vol. 396, Issue 10246 https://doi.org/10.1016/S0140-6736(20)31065-5	journal	July 2020
CDDO-Me Protects against Space Radiation-Induced Transformation of Human Colon Epithelial Cells Eskiocak, Ugur; Kim, Sang Bum; Roig, Andres I. Radiation Research, Vol. 174, Issue 1 https://doi.org/10.1667/RR2155.1	journal	May 2010
Avasopasem manganese synergizes with hypofractionated radiation to ablate tumors through the generation of hydrogen peroxide Sishc, Brock J.; Ding, Lianghao; Nam, Taek-Keun Science Translational Medicine, Vol. 13, Issue 593 https://doi.org/10.1126/scitranslmed.abb3768	journal	May 2021
Hallmarks of cancer—the new testament Senga, Sasi S.; Grose, Richard P. Open Biology, Vol. 11, Issue 1 https://doi.org/10.1098/rsob.200358	journal	January 2021
Pegfilgrastim Improves Survival of Lethally Irradiated Nonhuman Primates Hankey, Kim G.; Farese, Ann M.; Blaauw, Erica C. Radiation Research, Vol. 183, Issue 6 https://doi.org/10.1667/RR13940.1	journal	June 2015
A review of radiation countermeasures focusing on injury-specific medicinals and regulatory approval status: part II. Countermeasures for limited indications, internalized radionuclides, emesis, late effects, and agents demonstrating efficacy in large animals with or without FDA IND status Singh, Vijay K.; Garcia, Melissa; Seed, Thomas M. International Journal of Radiation Biology, Vol. 93, Issue 9 https://doi.org/10.1080/09553002.2017.1338782	journal	June 2017
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Systematic review of amifostine for the management of oral mucositis in cancer patients Nicolatou-Galitis, Ourania; Sarri, Triantafyllia; Bowen, Joanne Supportive Care in Cancer, Vol. 21, Issue 1 https://doi.org/10.1007/s00520-012-1613-6	journal	October 2012
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