Antifouling Surface Coatings from Self‐Assembled Zwitterionic Aramid Amphiphile Nanoribbons

Christoff‐Tempesta, Ty; Deiss‐Yehiely, Elad; Dromel, Pierre C.; Uliassi, Linnaea D.; Chazot, Cécile A. C.; Postelnicu, Eveline; Hart, A. John; Spector, Myron; Hammond, Paula T.; Ortony, Julia H.

doi:10.1002/admi.202200311

Title: Antifouling Surface Coatings from Self‐Assembled Zwitterionic Aramid Amphiphile Nanoribbons

Journal Article · 29 June 2022 · Advanced Materials Interfaces

DOI: https://doi.org/10.1002/admi.202200311 · OSTI ID:1874623

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Department of Materials Science and Engineering Massachusetts Institute of Technology Cambridge MA 02139 USA
Department of Materials Science and Engineering Massachusetts Institute of Technology Cambridge MA 02139 USA, Koch Institute for Integrative Cancer Research Massachusetts Institute of Technology Cambridge MA 02139 USA
Department of Materials Science and Engineering Massachusetts Institute of Technology Cambridge MA 02139 USA, Schepens Eye Research Institute Mass Eye and Ear Harvard Medical School Boston MA 02114 USA
Department of Materials Science and Engineering Massachusetts Institute of Technology Cambridge MA 02139 USA, Department of Mechanical Engineering Massachusetts Institute of Technology Cambridge MA 02139 USA
Department of Mechanical Engineering Massachusetts Institute of Technology Cambridge MA 02139 USA
VA Boston Healthcare System Brigham and Women's Hospital Harvard Medical School Boston MA 02130 USA
Koch Institute for Integrative Cancer Research Massachusetts Institute of Technology Cambridge MA 02139 USA, Department of Chemical Engineering Massachusetts Institute of Technology Cambridge MA 02139 USA, Institute for Soldier Nanotechnologies Massachusetts Institute of Technology Cambridge MA 02139 USA

Abstract Zwitterionic surfaces are increasingly explored as antifouling coatings due to their propensity to resist protein, bacterial, and cell adhesion and are typically applied as polymeric systems. Here, the self‐assembly of strongly interacting small molecule amphiphiles is reported to produce nanoribbons for antifouling applications. Synthesized amphiphiles spontaneously form micrometers‐long nanoribbons with nanometer‐scale cross‐sections and intrinsically display a dense coating of zwitterionic moieties on their surfaces. Substrates coated with nanoribbons demonstrate concentration‐dependent thicknesses and near superhydrophilicity. These surface coatings are then probed for antifouling properties and substantial reductions are demonstrated in protein adsorption, bacterial biofilm formation, and cell adhesion relative to uncoated controls. Harnessing cohesive small molecule self‐assembling nanomaterials for surface coatings offers a facile route to effective antifouling surfaces.

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Sponsoring Organization:: USDOE

Grant/Contract Number:: AC02-06CH11357

OSTI ID:: 1874623

Journal Information:: Advanced Materials Interfaces, Journal Name: Advanced Materials Interfaces Journal Issue: 22 Vol. 9; ISSN 2196-7350

Publisher:: Wiley Blackwell (John Wiley & Sons)Copyright Statement

Country of Publication:: Germany

Language:: English

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