Engineered protein–iron oxide hybrid biomaterial for MRI-traceable drug encapsulation

Journal Article · 01 August 2022 · Molecular Systems Design & Engineering

DOI: https://doi.org/10.1039/D2ME00002D · OSTI ID:1868130

Hill, Lindsay K.  ^[1]; Britton, Dustin  ^[2]; Jihad, Teeba  ^[2]; Punia, Kamia ^[2]; Xie, Xuan  ^[2]; Delgado-Fukushima, Erika  ^[2]; Liu, Che Fu  ^[2]; Mishkit, Orin  ^[3]; Liu, Chengliang  ^[2]; Hu, Chunhua  ^[4]; Meleties, Michael  ^[2]; Renfrew, P. Douglas  ^[5]; Bonneau, Richard  ^[6]; Wadghiri, Youssef Z.  ^[3]; Montclare, Jin Kim  ^[7]

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1. Department of Chemical and Biomolecular Engineering; New York University; Tandon School of Engineering; Brooklyn; New York; 11201; USA; Department of Biomedical Engineering; SUNY Downstate Medical Center; Brooklyn; New York; 11203; USA; Center for Advanced Imaging Innovation and Research (CAI2R); New York University; School of Medicine; New York; New York; 10016; USA; Bernard and Irene Schwartz Center for Biomedical Imaging; Department of Radiology; New York University; School of Medicine; New York; New York; 10016; USA
2. Department of Chemical and Biomolecular Engineering, New York University, Tandon School of Engineering, Brooklyn, New York, 11201, USA
3. Center for Advanced Imaging Innovation and Research (CAI2R), New York University, School of Medicine, New York, New York, 10016, USA, Bernard and Irene Schwartz Center for Biomedical Imaging, Department of Radiology, New York University, School of Medicine, New York, New York, 10016, USA
4. Department of Chemistry, New York University, New York, New York, 10012, USA
5. Center for Computational Biology, Flatiron Institute, Simons Foundation, New York, New York, 10010, USA
6. Center for Computational Biology, Flatiron Institute, Simons Foundation, New York, New York, 10010, USA, Center for Genomics and Systems Biology, New York University, New York, New York, 10003, USA, Courant Institute of Mathematical Sciences, Computer Science Department, New York University, New York, New York, 10009, USA
7. Department of Chemical and Biomolecular Engineering, New York University, Tandon School of Engineering, Brooklyn, New York, 11201, USA, Bernard and Irene Schwartz Center for Biomedical Imaging, Department of Radiology, New York University, School of Medicine, New York, New York, 10016, USA, Department of Chemistry, New York University, New York, New York, 10012, USA, Department of Biomaterials, New York University, College of Dentistry, New York, New York, 10010, USA

This protein–iron oxide hybrid biomaterial aims to integrate the drug encapsulating potential of a coiled-coil protein with peptide-driven iron oxide biomineralization to serve as drug-carrying, MRI-detectable mesofiber.

• Sponsoring Organization: USDOE
• Grant/Contract Number: SC0012704
• OSTI ID: 1868130
• Journal Information: Molecular Systems Design & Engineering, Journal Name: Molecular Systems Design & Engineering Journal Issue: 8 Vol. 7; ISSN MSDEBG; ISSN 2058-9689
• Publisher: Royal Society of Chemistry (RSC)Copyright Statement
• Country of Publication: United Kingdom
• Language: English