Engineering lanmodulin's selectivity for actinides over lanthanides by controlling solvent coordination and second-sphere interactions

Mattocks, Joseph A.; Cotruvo, Joseph A.; Deblonde, Gauthier J. -P.

doi:10.1039/D2SC01261H

Title: Engineering lanmodulin's selectivity for actinides over lanthanides by controlling solvent coordination and second-sphere interactions

Journal Article · 24 May 2022 · Chemical Science

DOI: https://doi.org/10.1039/D2SC01261H · OSTI ID:1866659

^[1];

^[2]

Department of Chemistry, The Pennsylvania State University, University Park, Pennsylvania 16802, USA
Physical and Life Sciences Directorate, Lawrence Livermore National Laboratory, Livermore, California 94550, USA, Glenn T. Seaborg Institute, Lawrence Livermore National Laboratory, Livermore, California 94550, USA

Nature’s most potent protein for f-elements, lanmodulin, relies on subtle first-sphere/second-sphere interactions to bind metal ions. Dissecting lanmodulin’s binding mechanism yielded variants with enhanced actinide/lanthanide selectivity.

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Research Organization:: Lawrence Livermore National Laboratory (LLNL), Livermore, CA (United States)

Sponsoring Organization:: USDOE; USDOE National Nuclear Security Administration (NNSA)

Grant/Contract Number:: AC52-07NA27344; SC0021007

OSTI ID:: 1866659

Report Number(s):: LLNL-JRNL-831983

Journal Information:: Chemical Science, Journal Name: Chemical Science Journal Issue: 20 Vol. 13; ISSN 2041-6520; ISSN CSHCBM

Publisher:: Royal Society of Chemistry (RSC)Copyright Statement

Country of Publication:: United Kingdom

Language:: English

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