Engineering robust microorganisms for organic acid production

Tran, Vinh G.; Zhao, Huimin

doi:10.1093/jimb/kuab067

Title: Engineering robust microorganisms for organic acid production

Journal Article · 21 September 2021 · Journal of Industrial Microbiology and Biotechnology

DOI: https://doi.org/10.1093/jimb/kuab067 · OSTI ID:1863114

Tran, Vinh G. ^[1]; Zhao, Huimin ^[2]

Department of Chemical and Biomolecular Engineering, U.S. Department of Energy Center for Bioenergy and Bioproducts Innovation (CABBI), Carl R. Woese Institute for Genomic Biology, University of Illinois at Urbana-Champaign, Urbana, IL 61801, USA
Department of Chemical and Biomolecular Engineering, U.S. Department of Energy Center for Bioenergy and Bioproducts Innovation (CABBI), Carl R. Woese Institute for Genomic Biology, University of Illinois at Urbana-Champaign, Urbana, IL 61801, USA, Departments of Chemistry, Biochemistry, and Bioengineering, University of Illinois at Urbana-Champaign, Urbana, IL 61801, USA

Abstract Organic acids are an important class of compounds that can be produced by microbial conversion of renewable feedstocks and have huge demands and broad applications in food, chemical, and pharmaceutical industries. An economically viable fermentation process for production of organic acids requires robust microbial cell factories with excellent tolerance to low pH conditions, high concentrations of organic acids, and lignocellulosic inhibitors. In this review, we summarize various strategies to engineer robust microorganisms for organic acid production and highlight their applications in a few recent examples.

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Sponsoring Organization:: USDOE

Grant/Contract Number:: SC0018420; SC0018260

OSTI ID:: 1863114

Journal Information:: Journal of Industrial Microbiology and Biotechnology, Journal Name: Journal of Industrial Microbiology and Biotechnology Journal Issue: 2 Vol. 49; ISSN 1367-5435

Publisher:: Oxford University PressCopyright Statement

Country of Publication:: Germany

Language:: English

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