SIRT1: A promising therapeutic target for chronic pain

Song, Fan‐He; Liu, Dai‐Qiang; Zhou, Ya‐Qun; Mei, Wei

doi:10.1111/cns.13838

Title: SIRT1: A promising therapeutic target for chronic pain

Journal Article · 08 April 2022 · CNS Neuroscience & Therapeutics

DOI: https://doi.org/10.1111/cns.13838 · OSTI ID:1862588

Song, Fan‐He ^[1]; Liu, Dai‐Qiang ^[1]; Zhou, Ya‐Qun ^[1];

^[1]

Anesthesiology Institute Tongji Hospital Tongji Medical College Huazhong University of Science and Technology Wuhan China, Department of Anesthesiology and Pain Medicine Tongji Hospital Tongji Medical College Huazhong University of Science and Technology Wuhan China

Abstract Chronic pain remains an unresolved problem. Current treatments have limited efficacy. Thus, novel therapeutic targets are urgently required for the development of more effective analgesics. An increasing number of studies have proved that sirtuin 1 (SIRT1) agonists can relieve chronic pain. In this review, we summarize recent progress in understanding the roles and mechanisms of SIRT1 in mediating chronic pain associated with peripheral nerve injury, chemotherapy‐induced peripheral neuropathy, spinal cord injury, bone cancer, and complete Freund's adjuvant injection. Emerging studies have indicated that SIRT1 activation may exert positive effects on chronic pain relief by regulating inflammation, oxidative stress, and mitochondrial dysfunction. Therefore, SIRT1 agonists may serve as potential therapeutic drugs for chronic pain.

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Sponsoring Organization:: USDOE

OSTI ID:: 1862588

Journal Information:: CNS Neuroscience & Therapeutics, Journal Name: CNS Neuroscience & Therapeutics Journal Issue: 6 Vol. 28; ISSN 1755-5930

Publisher:: Wiley-BlackwellCopyright Statement

Country of Publication:: Country unknown/Code not available

Language:: English

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Gastrodia elata Blume Polysaccharides Attenuate Vincristine-Evoked Neuropathic Pain through the Inhibition of Neuroinflammation Xie, Hengtao; Chen, Yingying; Wu, Wei Mediators of Inflammation, Vol. 2021 https://doi.org/10.1155/2021/9965081	journal	July 2021
Clinical Features of Metastatic Bone Disease and Risk of Skeletal Morbidity Coleman, Robert E. Clinical Cancer Research, Vol. 12, Issue 20 https://doi.org/10.1158/1078-0432.CCR-06-0931	journal	October 2006
SIRT Inhibitors Induce Cell Death and p53 Acetylation through Targeting Both SIRT1 and SIRT2 Peck, Barrie; Chen, Chun-Yuan; Ho, Ka-Kei Molecular Cancer Therapeutics, Vol. 9, Issue 4 https://doi.org/10.1158/1535-7163.MCT-09-0971	journal	April 2010
SIRT1 attenuates high glucose-induced insulin resistance via reducing mitochondrial dysfunction in skeletal muscle cells Zhang, Hao-Hao; Ma, Xiao-Jun; Wu, Li-Na Experimental Biology and Medicine, Vol. 240, Issue 5 https://doi.org/10.1177/1535370214557218	journal	February 2015
CREB-regulated transcription coactivator 1 enhances CREB-dependent gene expression in spinal cord to maintain the bone cancer pain in mice Liang, Ying; Liu, Yue; Hou, Bailing Molecular Pain, Vol. 12 https://doi.org/10.1177/1744806916641679	journal	January 2016
Icariin, a flavonoid with anti-cancer effects, alleviated paclitaxel-induced neuropathic pain in a SIRT1-dependent manner Gui, Yulong; Zhang, Jie; Chen, Liang Molecular Pain, Vol. 14 https://doi.org/10.1177/1744806918768970	journal	January 2018
Epigenetic modifications in neuropathic pain Luo, Danzhi; Li, Xiaohong; Tang, Simin Molecular Pain, Vol. 17 https://doi.org/10.1177/17448069211056767	journal	January 2021
Vaspin inhibits cytokine-induced nuclear factor-kappa B activation and adhesion molecule expression via AMP-activated protein kinase activation in vascular endothelial cells Jung, Chang Hee; Lee, Min Jung; Kang, Yu Mi Cardiovascular Diabetology, Vol. 13, Issue 1 https://doi.org/10.1186/1475-2840-13-41	journal	February 2014
Characterization of recovery, repair, and inflammatory processes following contusion spinal cord injury in old female rats: is age a limitation? Hooshmand, Mitra J.; Galvan, Manuel D.; Partida, Elizabeth Immunity & Ageing, Vol. 11, Issue 1 https://doi.org/10.1186/1742-4933-11-15	journal	October 2014
Downregulation of Selective microRNAs in Trigeminal Ganglion Neurons Following Inflammatory Muscle Pain Bai, Guang; Ambalavanar, Rajini; Wei, Dong Molecular Pain, Vol. 3 https://doi.org/10.1186/1744-8069-3-15	journal	January 2007
Prevention of Paclitaxel-Induced Allodynia by Minocycline: Effect on Loss of Peripheral Nerve Fibers and Infiltration of Macrophages in Rats Liu, Cui-Cui; Lu, Ning; Cui, Yu Molecular Pain, Vol. 6 https://doi.org/10.1186/1744-8069-6-76	journal	January 2010
Targeting Adenosine Monophosphate-Activated Protein Kinase (AMPK) in Preclinical Models Reveals a Potential Mechanism for the Treatment of Neuropathic Pain Melemedjian, Ohannes K.; Asiedu, Marina N.; Tillu, Dipti V. Molecular Pain, Vol. 7 https://doi.org/10.1186/1744-8069-7-70	journal	January 2011
Anti-inflammatory T-cell shift in neuropathic pain Luchting, Benjamin; Rachinger-Adam, Banafscheh; Heyn, Jens Journal of Neuroinflammation, Vol. 12, Issue 1 https://doi.org/10.1186/s12974-014-0225-0	journal	January 2015
miR-124a and miR-155 enhance differentiation of regulatory T cells in patients with neuropathic pain Heyn, Jens; Luchting, Benjamin; Hinske, Ludwig C. Journal of Neuroinflammation, Vol. 13, Issue 1 https://doi.org/10.1186/s12974-016-0712-6	journal	September 2016
The Chinese herb-derived Sparstolonin B suppresses HIV-1 transcription Deng, Xin; Zhang, Yaping; Jiang, Feng Virology Journal, Vol. 12, Issue 1 https://doi.org/10.1186/s12985-015-0339-8	journal	July 2015
Antioxidant and anti-inflammatory effects of intravenously injected adipose derived mesenchymal stem cells in dogs with acute spinal cord injury Kim, Yongsun; Jo, Sung-ho; Kim, Wan Hee Stem Cell Research & Therapy, Vol. 6, Issue 1 https://doi.org/10.1186/s13287-015-0236-5	journal	November 2015
Rapid Temporal Control of Foxp3 Protein Degradation by Sirtuin-1 van Loosdregt, Jorg; Brunen, Diede; Fleskens, Veerle PLoS ONE, Vol. 6, Issue 4 https://doi.org/10.1371/journal.pone.0019047	journal	April 2011
SIRT1 Activators Suppress Inflammatory Responses through Promotion of p65 Deacetylation and Inhibition of NF-κB Activity Yang, Hongying; Zhang, Wei; Pan, Heng PLoS ONE, Vol. 7, Issue 9 https://doi.org/10.1371/journal.pone.0046364	journal	September 2012
Spinal SIRT1 Activation Attenuates Neuropathic Pain in Mice Shao, Haijun; Xue, Qingsheng; Zhang, Fujun PLoS ONE, Vol. 9, Issue 6 https://doi.org/10.1371/journal.pone.0100938	journal	June 2014
Disrupted TH17/Treg Balance in Patients with Chronic Low Back Pain Luchting, Benjamin; Rachinger-Adam, Banafscheh; Zeitler, Julia PLoS ONE, Vol. 9, Issue 8 https://doi.org/10.1371/journal.pone.0104883	journal	August 2014
SIRT1 Decreases Emotional Pain Vulnerability with Associated CaMKIIα Deacetylation in Central Amygdala Zhou, Chenghua; Wu, Yuqing; Ding, Xiaobao The Journal of Neuroscience, Vol. 40, Issue 11 https://doi.org/10.1523/JNEUROSCI.1259-19.2020	journal	January 2020
Essential Role of SIRT1 Signaling in the Nucleus Accumbens in Cocaine and Morphine Action Ferguson, D.; Koo, J. W.; Feng, J. Journal of Neuroscience, Vol. 33, Issue 41 https://doi.org/10.1523/JNEUROSCI.1284-13.2013	journal	October 2013
The Neuroimmunology of Chronic Pain: From Rodents to Humans Grace, Peter M.; Tawfik, Vivianne L.; Svensson, Camilla I. The Journal of Neuroscience, Vol. 41, Issue 5 https://doi.org/10.1523/JNEUROSCI.1650-20.2020	journal	November 2020
Epigenetic Modification of Spinal miR-219 Expression Regulates Chronic Inflammation Pain by Targeting CaMKII Pan, Z.; Zhu, L. -J.; Li, Y. -Q. Journal of Neuroscience, Vol. 34, Issue 29 https://doi.org/10.1523/JNEUROSCI.5346-13.2014	journal	July 2014
Epigenetic Gene Silencing Underlies C-Fiber Dysfunctions in Neuropathic Pain Uchida, H.; Ma, L.; Ueda, H. Journal of Neuroscience, Vol. 30, Issue 13 https://doi.org/10.1523/JNEUROSCI.5541-09.2010	journal	March 2010
Astragaloside IV Inhibits Mitochondrial-Dependent Apoptosis of the Dorsal Root Ganglion in Diabetic Peripheral Neuropathy Rats Through Modulation of the SIRT1/p53 Signaling Pathway Ben, Ying; Hao, Juan; Zhang, Zhihong Diabetes, Metabolic Syndrome and Obesity: Targets and Therapy, Vol. Volume 14 https://doi.org/10.2147/DMSO.S301068	journal	January 2021
Resveratrol inhibits paclitaxel-induced neuropathic pain by the activation of PI3K/Akt and SIRT1/PGC1α pathway Li, Xiaoning; Yang, Shuhong; Wang, Liang Journal of Pain Research, Vol. Volume 12 https://doi.org/10.2147/JPR.S185873	journal	January 2019
Targeting Cytokines for Morphine Tolerance: A Narrative Review Liu, Dai-Qiang; Zhou, Ya-Qun; Gao, Feng Current Neuropharmacology, Vol. 17, Issue 4 https://doi.org/10.2174/1570159X15666171128144441	journal	March 2019
Neuropharmacological and Neurogenetic Correlates of Opioid Use Disorder (OUD) As a Function of Ethnicity: Relevance to Precision Addiction Medicine Abijo, Tomilowo; Blum, Kenneth; Gondré-Lewis, Marjorie C. Current Neuropharmacology, Vol. 18, Issue 7 https://doi.org/10.2174/1570159X17666191118125702	journal	July 2020
Comprehensive analysis of neurobehavior associated with histomorphological alterations in a chronic constrictive nerve injury model through use of the CatWalk XT system: Laboratory investigation Chiang, Chien-Yi; Sheu, Meei-Ling; Cheng, Fu-Chou Journal of Neurosurgery, Vol. 120, Issue 1 https://doi.org/10.3171/2013.9.JNS13353	journal	January 2014
SIRT1 Antagonizes Oxidative Stress in Diabetic Vascular Complication Meng, Teng; Qin, Weifeng; Liu, Baohua Frontiers in Endocrinology, Vol. 11 https://doi.org/10.3389/fendo.2020.568861	journal	November 2020
Sirtuins in Neuroendocrine Regulation and Neurological Diseases Fujita, Yuki; Yamashita, Toshihide Frontiers in Neuroscience, Vol. 12 https://doi.org/10.3389/fnins.2018.00778	journal	October 2018
Uncovering the Mechanisms of Adenosine Receptor-Mediated Pain Control: Focus on the A3 Receptor Subtype Coppi, Elisabetta; Cherchi, Federica; Lucarini, Elena International Journal of Molecular Sciences, Vol. 22, Issue 15 https://doi.org/10.3390/ijms22157952	journal	July 2021
Resveratrol attenuates inflammatory hyperalgesia by inhibiting glial activation in mice spinal cords Wang, Lin-Lin; Shi, Dong-Ling; Gu, Hui-Yao Molecular Medicine Reports, Vol. 13, Issue 5 https://doi.org/10.3892/mmr.2016.5027	journal	March 2016
Micro RNAs in the development of non-alcoholic fatty liver disease Gerhard, Glenn S. World Journal of Hepatology, Vol. 7, Issue 2 https://doi.org/10.4254/wjh.v7.i2.226	journal	January 2014
Novel targets for Spinal Cord Injury related neuropathic pain Ahmed, Mostafa M.; King, Kevin C.; Pearce, Shane M. Annals Of Neurosciences, Vol. 18, Issue 4 https://doi.org/10.5214/ans.0972.7531.1118413	journal	August 2011

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