Exposure pathways and bioaccumulation of per- and polyfluoroalkyl substances in freshwater aquatic ecosystems: Key considerations

Lewis, Asa J.; Yun, Xiaoyan; Spooner, Daniel E.; Kurz, Marie J.; McKenzie, Erica R.; Sales, Christopher M.

doi:10.1016/j.scitotenv.2022.153561

Title: Exposure pathways and bioaccumulation of per- and polyfluoroalkyl substances in freshwater aquatic ecosystems: Key considerations

Journal Article · 28 January 2022 · Science of the Total Environment

DOI: https://doi.org/10.1016/j.scitotenv.2022.153561 · OSTI ID:1854459

Lewis, Asa J. ^[1]; Yun, Xiaoyan ^[2]; Spooner, Daniel E. ^[3];

^[4]; McKenzie, Erica R. ^[2]; Sales, Christopher M. ^[1]

Drexel Univ., Philadelphia, PA (United States)
Temple Univ., Philadelphia, PA (United States)
Lock Haven Univ., PA (United States)
Drexel Univ., Philadelphia, PA (United States); Oak Ridge National Lab. (ORNL), Oak Ridge, TN (United States)

We report that due to the bioaccumulative behavior, toxicity, and recalcitrance to degradation, per- and polyfluoroalkyl substances (PFAS) are a focus for many researchers investigating freshwater aquatic ecosystems. PFAS are a diverse set of chemicals that accumulate and transport quite differently in the environment depending on the length of their fluoroalkyl chains and their functional groups. This diversity in PFAS chemical characteristics combined with varying environmental factors also impact the bioaccumulation of these compounds in different organisms. In this review, we evaluate environmental factors (such as organic carbon, proteins, lipids, and dissolved cations) as well as PFAS characteristics (head group, chain-length, and concentration) that contribute to the significant variation seen in the literature of bioaccumulation metrics reported for organisms in aquatic ecosystems. Of the factors evaluated, it was found that PFAS concentration, dissolved organic matter, sediment organic matter, and biotransformation of precursor PFAS tended to significantly impact reported bioaccumulation metrics the most. Based on this review, it is highly suggested that future studies provide sufficient details of important environmental factors, specific organism traits/ behavior, and PFAS concentrations/compounds when reporting on bioaccumulation metrics to further fill data gaps and improve our understanding of PFAS in aquatic ecosystems.

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Research Organization:: Oak Ridge National Laboratory (ORNL), Oak Ridge, TN (United States)

Sponsoring Organization:: Strategic Environmental Research and Development Program (SERDP); USDOE

Grant/Contract Number:: AC05-00OR22725

OSTI ID:: 1854459

Journal Information:: Science of the Total Environment, Journal Name: Science of the Total Environment Journal Issue: 0 Vol. 822; ISSN 0048-9697

Publisher:: ElsevierCopyright Statement

Country of Publication:: United States

Language:: English

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Generation of Perfluoroalkyl Acids from Aerobic Biotransformation of Quaternary Ammonium Polyfluoroalkyl Surfactants Mejia-Avendaño, Sandra; Vo Duy, Sung; Sauvé, Sébastien Environmental Science & Technology, Vol. 50, Issue 18 https://doi.org/10.1021/acs.est.6b00140	journal	August 2016
Long-Chain Perfluoroalkyl acids (PFAAs) Affect the Bioconcentration and Tissue Distribution of Short-Chain PFAAs in Zebrafish ( Danio rerio ) Wen, Wu; Xia, Xinghui; Hu, Diexuan Environmental Science & Technology, Vol. 51, Issue 21 https://doi.org/10.1021/acs.est.7b03647	journal	October 2017
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Trophodynamics of Per- and Polyfluoroalkyl Substances in the Food Web of a Large Atlantic Slope River Penland, Tiffany N.; Cope, W. Gregory; Kwak, Thomas J. Environmental Science & Technology, Vol. 54, Issue 11 https://doi.org/10.1021/acs.est.9b05007	journal	April 2020
Detection of Poly- and Perfluoroalkyl Substances (PFASs) in U.S. Drinking Water Linked to Industrial Sites, Military Fire Training Areas, and Wastewater Treatment Plants Hu, Xindi C.; Andrews, David Q.; Lindstrom, Andrew B. Environmental Science & Technology Letters, Vol. 3, Issue 10 https://doi.org/10.1021/acs.estlett.6b00260	journal	August 2016
Perfluorooctanesulfonate and Related Fluorinated Hydrocarbons in Marine Mammals, Fishes, and Birds from Coasts of the Baltic and the Mediterranean Seas Kannan, Kurunthachalam; Corsolini, Simonetta; Falandysz, Jerzy Environmental Science & Technology, Vol. 36, Issue 15 https://doi.org/10.1021/es020519q	journal	June 2002
Biotransformation of N -Ethyl Perfluorooctanesulfonamide by Rainbow Trout ( Onchorhynchus mykiss ) Liver Microsomes Tomy, Gregg T.; Tittlemier, Sheryl A.; Palace, Vince P. Environmental Science & Technology, Vol. 38, Issue 3 https://doi.org/10.1021/es034550j	journal	December 2003
Perfluorinated Compounds in the Plasma of Loggerhead and Kemp's Ridley Sea Turtles from the Southeastern Coast of the United States Keller, Jennifer M.; Kannan, Kurunthachalam; Taniyasu, Sachi Environmental Science & Technology, Vol. 39, Issue 23 https://doi.org/10.1021/es050690c	journal	December 2005
Bioaccumulation of Perfluorochemicals in Sediments by the Aquatic Oligochaete Lumbriculus variegatus Higgins, Christopher P.; McLeod, Pamela B.; MacManus-Spencer, Laura A. Environmental Science & Technology, Vol. 41, Issue 13 https://doi.org/10.1021/es062792o	journal	June 2007
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Novel Perspectives on the Bioaccumulation of PFCs – the Concentration Dependency Liu, Changhui; Gin, Karina Y. H.; Chang, Victor W. C. Environmental Science & Technology, Vol. 45, Issue 22 https://doi.org/10.1021/es202078n	journal	October 2011
Oxidative Conversion as a Means of Detecting Precursors to Perfluoroalkyl Acids in Urban Runoff Houtz, Erika F.; Sedlak, David L. Environmental Science & Technology, Vol. 46, Issue 17 https://doi.org/10.1021/es302274g	journal	August 2012
Effects of Carbon Nanotubes, Chars, and Ash on Bioaccumulation of Perfluorochemicals by Chironomus plumosus Larvae in Sediment Xia, Xinghui; Chen, Xi; Zhao, Xiuli Environmental Science & Technology, Vol. 46, Issue 22 https://doi.org/10.1021/es303024x	journal	November 2012
Zwitterionic, Cationic, and Anionic Fluorinated Chemicals in Aqueous Film Forming Foam Formulations and Groundwater from U.S. Military Bases by Nonaqueous Large-Volume Injection HPLC-MS/MS Backe, Will J.; Day, Thomas C.; Field, Jennifer A. Environmental Science & Technology, Vol. 47, Issue 10 https://doi.org/10.1021/es3034999	journal	May 2013
Bioaccumulation of Perfluoroalkyl Substances by Daphnia magna in Water with Different Types and Concentrations of Protein Xia, Xinghui; Rabearisoa, Andry H.; Jiang, Xiaoman Environmental Science & Technology, Vol. 47, Issue 19 https://doi.org/10.1021/es401442y	journal	September 2013
Persistence of Perfluoroalkyl Acid Precursors in AFFF-Impacted Groundwater and Soil Houtz, Erika F.; Higgins, Christopher P.; Field, Jennifer A. Environmental Science & Technology, Vol. 47, Issue 15 https://doi.org/10.1021/es4018877	journal	August 2013
Bioaccumulation of Perfluorinated Alkyl Acids: Observations and Models Ng, Carla A.; Hungerbühler, Konrad Environmental Science & Technology, Vol. 48, Issue 9 https://doi.org/10.1021/es404008g	journal	April 2014
Perfluoroalkyl Contaminants in an Arctic Marine Food Web: Trophic Magnification and Wildlife Exposure Kelly, Barry C.; Ikonomou, Michael G.; Blair, Joel D. Environmental Science & Technology, Vol. 43, Issue 11 https://doi.org/10.1021/es9003894	journal	April 2009
Isomer-Specific Biotransformation Rates of a Perfluorooctane Sulfonate (PFOS)-Precursor by Cytochrome P450 Isozymes and Human Liver Microsomes Benskin, Jonathan P.; Holt, Andrew; Martin, Jonathan W. Environmental Science & Technology, Vol. 43, Issue 22 https://doi.org/10.1021/es901915f	journal	October 2009
Phytoremediation of Polychlorinated Biphenyls: New Trends and Promises ^† Aken, Benoit Van; Correa, Paola A.; Schnoor, Jerald L. Environmental Science & Technology, Vol. 44, Issue 8 https://doi.org/10.1021/es902514d	journal	April 2010
Perfluorinated Compounds in Human Blood, Water, Edible Freshwater Fish, and Seafood in China: Daily Intake and Regional Differences in Human Exposures Zhang, Tao; Sun, Hongwen; Lin, Yan Journal of Agricultural and Food Chemistry, Vol. 59, Issue 20 https://doi.org/10.1021/jf2007216	journal	September 2011
Root Uptake and Translocation of Perfluorinated Alkyl Acids by Three Hydroponically Grown Crops Felizeter, Sebastian; McLachlan, Michael S.; De Voogt, Pim Journal of Agricultural and Food Chemistry, Vol. 62, Issue 15 https://doi.org/10.1021/jf500674j	journal	April 2014
Biomagnification of perfluoroalkyl acids (PFAAs) in the food web of an urban river: assessment of the trophic transfer of targeted and unknown precursors and implications Simonnet-Laprade, Caroline; Budzinski, Hélène; Maciejewski, Kevin Environmental Science: Processes & Impacts, Vol. 21, Issue 11 https://doi.org/10.1039/C9EM00322C	journal	January 2019
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Unraveling the role of land use and microbial activity in shaping dissolved organic matter characteristics in stream ecosystems Williams, Clayton J.; Yamashita, Youhei; Wilson, Henry F. Limnology and Oceanography, Vol. 55, Issue 3 https://doi.org/10.4319/lo.2010.55.3.1159	journal	March 2010

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bioaccumulation
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