Host receptor-targeted therapeutic approach to counter pathogenic New World mammarenavirus infections

Hickerson, Brady T.; Daniels-Wells, Tracy R.; Payes, Cristian; Clark, Lars E.; Candelaria, Pierre V.; Bailey, Kevin W.; Sefing, Eric J.; Zink, Samantha; Ziegenbein, James; Abraham, Jonathan; Helguera, Gustavo; Penichet, Manuel L.; Gowen, Brian B.

doi:10.1038/s41467-021-27949-3

Title: Host receptor-targeted therapeutic approach to counter pathogenic New World mammarenavirus infections

Journal Article · 27 January 2022 · Nature Communications

DOI: https://doi.org/10.1038/s41467-021-27949-3 · OSTI ID:1847155

Hickerson, Brady T. ^[1];

^[2]; Payes, Cristian ^[3];

^[4]; Candelaria, Pierre V. ^[2]; Bailey, Kevin W. ^[1]; Sefing, Eric J. ^[1];

^[2]; Ziegenbein, James ^[2];

^[5];

^[6]; Penichet, Manuel L. ^[7];

^[1]

Utah State Univ., Logan, UT (United States)
Univ. of California, Los Angeles, CA (United States)
Inst. de Biología y Medicina Experimental (IBYME CONICET), Buenos Aires (Argentina)
Harvard Medical School, Boston, MA (United States)
Harvard Medical School, Boston, MA (United States); Brigham and Women’s Hospital, Boston, MA (United States)
Inst. de Biología y Medicina Experimental (IBYME CONICET), Buenos Aires (Argentina); Univ. of California, Los Angeles, CA (United States)
Univ. of California, Los Angeles, CA (United States); UCLA Molecular Biology Institute, Los Angeles, CA (United States); UCLA Jonsson Comprehensive Cancer Center, Los Angeles, CA (United States); UCLA AIDS Inst., Los Angeles, CA (United States)

Five New World mammarenaviruses (NWMs) cause life-threatening hemorrhagic fever (HF). Cellular entry by these viruses is mediated by human transferrin receptor 1 (hTfR1). Here, we demonstrate that an antibody (ch128.1/IgG1) which binds the apical domain of hTfR1, potently inhibits infection of attenuated and pathogenic NWMs in vitro. Computational docking of the antibody Fab crystal structure onto the known structure of hTfR1 shows an overlapping receptor-binding region shared by the Fab and the viral envelope glycoprotein GP1 subunit that binds hTfR1, and we demonstrate competitive inhibition of NWM GP1 binding by ch128.1/IgG1 as the principal mechanism of action. Importantly, ch128.1/IgG1 protects hTfR1-expressing transgenic mice against lethal NWM challenge. Additionally, the antibody is well-tolerated and only partially reduces ferritin uptake. Our findings provide the basis for the development of a novel, host receptor-targeted antibody therapeutic broadly applicable to the treatment of HF of NWM etiology.

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Research Organization:: Argonne National Laboratory (ANL), Argonne, IL (United States). Advanced Photon Source (APS)

Sponsoring Organization:: USDOE Office of Science (SC), Basic Energy Sciences (BES). Scientific User Facilities Division; National Institutes of Health (NIH)

Grant/Contract Number:: AC02-06CH11357

OSTI ID:: 1847155

Journal Information:: Nature Communications, Journal Name: Nature Communications Journal Issue: 1 Vol. 13; ISSN 2041-1723

Publisher:: Nature Publishing GroupCopyright Statement

Country of Publication:: United States

Language:: ENGLISH

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