Title: Viscoelastic Particle Focusing and Separation in a Spiral Channel

Journal Article · · Micromachines
DOI: https://doi.org/10.3390/mi13030361 · OSTI ID:1846699

As one type of non-Newtonian fluid, viscoelastic fluids exhibit unique properties that contribute to particle lateral migration in confined microfluidic channels, leading to opportunities for particle manipulation and separation. In this paper, particle focusing in viscoelastic flow is studied in a wide range of polyethylene glycol (PEO) concentrations in aqueous solutions. Polystyrene beads with diameters from 3 to 20 μm are tested, and the variation of particle focusing position is explained by the coeffects of inertial flow, viscoelastic flow, and Dean flow. We showed that particle focusing position can be predicted by analyzing the force balance in the microchannel, and that particle separation resolution can be improved in viscoelastic flows.

Research Organization:
Univ. of Utah, Salt Lake City, UT (United States)
Sponsoring Organization:
USDOE; USDOE Office of Science (SC), Basic Energy Sciences (BES)
Grant/Contract Number:
SC0019285
OSTI ID:
1846699
Journal Information:
Micromachines, Journal Name: Micromachines Journal Issue: 3 Vol. 13; ISSN 2072-666X
Publisher:
MDPI AGCopyright Statement
Country of Publication:
Switzerland
Language:
English

References (42)

Particle separation by dielectrophoresis journal July 2002
Dielectrophoretic separation of bioparticles in microdevices: A review: Microfluidics and Miniaturization journal February 2014
Three Dimensional, Sheathless, and High-Throughput Microparticle Inertial Focusing Through Geometry-Induced Secondary Flows journal November 2012
High shear rate viscometry journal April 2008
Particle separation and sorting in microfluidic devices: a review journal November 2013
Sperm-like-particle (SLP) behavior in curved microfluidic channels journal December 2018
Polymeric fully inertial lab-on-a-chip with enhanced-throughput sorting capabilities journal February 2019
Microfluidics for cell separation journal April 2010
Particle Dispersion and Separation Resolution of Pinched Flow Fractionation journal January 2008
Particle Focusing Mechanisms in Curving Confined Flows journal September 2009
Viscoelastic Separation of Particles by Size in Straight Rectangular Microchannels: A Parametric Study for a Refined Understanding journal December 2016
Exosome Isolation: Cyclical Electrical Field Flow Fractionation in Low-Ionic-Strength Fluids journal October 2018
The origins and the future of microfluidics journal July 2006
Inertio-elastic focusing of bioparticles in microchannels at high throughput journal June 2014
Viscoelastic microfluidics: progress and challenges journal December 2020
An automated instrument for intrauterine insemination sperm preparation journal December 2020
Multiplex Particle Focusing via Hydrodynamic Force in Viscoelastic Fluids journal November 2013
Particle Focusing in Curved Microfluidic Channels journal November 2013
Inertial focusing in non-rectangular cross-section microchannels and manipulation of accessible focusing positions journal January 2016
High efficiency rare sperm separation from biopsy samples in an inertial focusing device journal January 2021
A bioinspired, passive microfluidic lobe filtration system journal January 2021
Continuous flow separations in microfluidic devices journal January 2007
Continuous particle separation in spiral microchannels using dean flows and differential migration journal January 2008
Inertial microfluidics for continuous particle separation in spiral microchannels journal January 2009
Inertial microfluidics journal January 2009
Standing surface acoustic wave (SSAW) based multichannel cell sorting journal January 2012
Fundamentals of inertial focusing in microchannels journal January 2013
Inertial microfluidic physics journal January 2014
Optical trapping journal September 2004
Inertial focusing of non-spherical microparticles journal July 2011
An analytical solution for Dean flow in curved ducts with rectangular cross section journal May 2013
Viscoelastic second normal stress difference dominated multiple-stream particle focusing in microfluidic channels journal December 2019
Microparticle transport along a planar electrode array using moving dielectrophoresis journal July 2021
Inertial microfluidics in contraction–expansion microchannels: A review journal July 2021
Continuous inertial focusing, ordering, and separation of particles in microchannels journal November 2007
Tunable Nonlinear Viscoelastic “Focusing” in a Microfluidic Device journal June 2007
Inertial Focusing in Microfluidics journal July 2014
Microfluidic—based sperm sorting & analysis for treatment of male infertility journal July 2018
Dielectrophoresis: Using Inhomogeneous AC Electrical Fields to Separate and Manipulate Cells journal January 1996
Sorting of Particles Using Inertial Focusing and Laminar Vortex Technology: A Review journal September 2019
Inertial Microfluidics Enabling Clinical Research journal March 2021
Modeling Brownian Microparticle Trajectories in Lab-on-a-Chip Devices with Time Varying Dielectrophoretic or Optical Forces journal October 2021